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Isoforms Recommended:	Topo II

Results for "

topoisomerase-ii

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Topoisomerase (179) ADC Payload (13) Aldose Reductase (2) AMPK (3) Androgen Receptor (3) Antibiotic (35) Apoptosis (57) Autophagy (29) Bacterial (45) Bcl-2 Family (1) c-Met/HGFR (1) c-Myc (3) Casein Kinase (1) Caspase (3) Cathepsin (1) DNA/RNA Synthesis (16) Drug-Linker Conjugates for ADC (6) EGFR (4) Endogenous Metabolite (12) Estrogen Receptor/ERR (4) FLT3 (1) Fungal (6) HBV (3) HIV (3) Influenza Virus (3) Isotope-Labeled Compounds (12) MicroRNA (1) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) Mitophagy (8) Mitosis (1) Molecular Glues (2) NO Synthase (1) Orthopoxvirus (9) P2X Receptor (1) p38 MAPK (2) Parasite (7) Phosphatase (4) PKC (8) Reactive Oxygen Species (ROS) (2) Reference Standards (20) Reverse Transcriptase (3) SARS-CoV (3) Sirtuin (3) SOD (2) TMV (1) VEGFR (2) Virus Protease (1)
By Research Areas:	Cancer (170) Cardiovascular Disease (3) Endocrinology (2) Infection (64) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (10)

By Targets:

Topoisomerase (179)

ADC Payload (13)

Aldose Reductase (2)

AMPK (3)

Androgen Receptor (3)

Antibiotic (35)

Apoptosis (57)

Autophagy (29)

Bacterial (45)

Bcl-2 Family (1)

c-Met/HGFR (1)

c-Myc (3)

Casein Kinase (1)

Caspase (3)

Cathepsin (1)

DNA/RNA Synthesis (16)

Drug-Linker Conjugates for ADC (6)

EGFR (4)

Endogenous Metabolite (12)

Estrogen Receptor/ERR (4)

FLT3 (1)

Fungal (6)

HBV (3)

HIV (3)

Influenza Virus (3)

Isotope-Labeled Compounds (12)

MicroRNA (1)

Microtubule/Tubulin (4)

Mitochondrial Metabolism (1)

Mitophagy (8)

Mitosis (1)

Molecular Glues (2)

NO Synthase (1)

Orthopoxvirus (9)

P2X Receptor (1)

p38 MAPK (2)

Parasite (7)

Phosphatase (4)

PKC (8)

Reactive Oxygen Species (ROS) (2)

Reference Standards (20)

Reverse Transcriptase (3)

SARS-CoV (3)

Sirtuin (3)

SOD (2)

TMV (1)

VEGFR (2)

Virus Protease (1)

By Research Areas:

Cancer (170)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (64)

Inflammation/Immunology (8)

Metabolic Disease (1)

Neurological Disease (10)

202

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Topoisomerase Photosystem II CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158061

Topoisomerase II inhibitor 20	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 20 (Compound 3e) is a potent topoisomerase II (Topoisomerase II) inhibitor with an IC₅₀ of 0.98 µM. Topoisomerase II inhibitor 20 induces apoptosis and has broad-spectrum anticancer activity .

HY-153401

Topoisomerase II inhibitor 13	Topoisomerase	Cancer
Topoisomerase II inhibitor 13 is a *topoisomerase II* (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis .

HY-W278582

Topoisomerase II inhibitor 14	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 14 is a potent *topoisomerase II* inhibtor. Topoisomerase II inhibitor 14 induces apoptosis and arrests cell cycle at S phase and G2-M phases. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO. Topoisomerase II inhibitor 14 can be used for the study of neck squamous cell carcinoma (HNSCC) .

HY-146316

Topoisomerase II inhibitor 6	Topoisomerase	Cancer
Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of *topoisomerase II. Topoisomerase II* inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .

HY-155645

Topoisomerase II inhibitor 15	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 15 (compound 2g) is a *Topoisomerase II* inhibitor. Topoisomerase II inhibitor 15 potently is an apoptotic inducer with greater selectivity against head and neck tumors .

HY-147877

Topoisomerase II inhibitor 12	Topoisomerase	Cancer
Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity .

HY-146163

Topoisomerase II inhibitor 7	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC₅₀ of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis .

HY-126333

Topoisomerase II inhibitor 1	Topoisomerase	Cancer
Topoisomerase II inhibitor 1 (compound 89) is a highly efficient and selective topoisomerase IIα inhibitor .

HY-143281

Topoisomerase II inhibitor 5	Topoisomerase	Cancer
Topoisomerase II inhibitor 5 (Compound E24) is a DNA *topoisomerase II* inhibitor with anticancer activities .

HY-162381

Topoisomerase II inhibitor 19	Topoisomerase	Cancer
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and *topoisomerase II* inhibitor (IC₅₀ value of 0.34 μM). Topoisomerase II inhibitor 19 would induce detectable potent damage in ctDNA .

HY-162380

Topoisomerase II inhibitor 18	Topoisomerase	Cancer
Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits *topoisomerase II* with IC₅₀ of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer .

HY-174404

Topoisomerase II inhibitor 23	Topoisomerase Apoptosis Bcl-2 Family	Cancer
Topoisomerase II inhibitor 23 is a potent *topoisomerase II* inhibitor (IC₅₀= 0.94 μM). Topoisomerase II inhibitor 23 shows high selectivity and exceptional cytotoxic activity in MCF-7, HepG2, and HCT116 cells. Topoisomerase II inhibitor 23 induces cell cycle arrest at the G1 phase, leading to inhibition of cell proliferation. Topoisomerase II inhibitor 2 induces apoptosis by up-regulating the pro-apoptotic Bax level and down-regulating the anti-apoptotic Bcl-2 level.

HY-155693

Topoisomerase II inhibitor 16	Topoisomerase Parasite	Infection
Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research .

HY-143280

Topoisomerase II inhibitor 4	Topoisomerase	Cancer
Topoisomerase II inhibitor 4 (compound E17) is a potent *Topoisomerase II* inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect .

HY-146188

Topoisomerase II inhibitor 8	Topoisomerase	Cancer
Topoisomerase II inhibitor 8 (compound 22) is a potent *topoisomerase II* inhibitor, with an IC₅₀ of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase .

HY-158061A

Topoisomerase II inhibitor 20 TFA	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 20 TFA is a potent *topoisomerase II* inhibitor with IC₅₀ of 0.98 µM. Topoisomerase II inhibitor 20 TFA can induce apoptosis and has broad-spectrum anticancer activity .

HY-147861

Topoisomerase II inhibitor 11	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 11 (compound 3d) is a potent *Topoisomerase II* inhibitor, with an IC₅₀ of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC₅₀ of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity .

HY-147839

Topoisomerase II inhibitor 10	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 10 (compound 32a) is a potent *topoisomerase II* inhibitor with an IC₅₀ value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells .

HY-146189

Topoisomerase II inhibitor 9	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC₅₀ of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC₅₀ of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells .

HY-163118

Topoisomerase II inhibitor 17	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 17 (compound 4c) is an inhibitor of thiazolopyrimidine topoisomerase (Topoisomerase) Top II (IC₅₀: 0.23 μM). Topoisomerase II inhibitor 17 can significantly cause cell cycle disruption and apoptosis .

HY-147801

Topoisomerase IIα-IN-3	Topoisomerase Apoptosis	Cancer
Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis .

HY-175853

Topoisomerase II-IN-24	Topoisomerase Apoptosis Caspase	Cancer
Topoisomerase II-IN-24 is a Topoisomerase IIα inhibitor with an IC₅₀ of 41.67 μM. Topoisomerase II-IN-24 can inhibit cancer cells proliferation, induce G2/M phase arrest and induce apoptosis. Topoisomerase II-IN-24 can be used for the research of cancer, such as colon cancer .

HY-157402

Topoisomerase II/EGFR-IN-1	Topoisomerase EGFR	Cancer
Topoisomerase II/EGFR-IN-1 is *topoisomerase II/EGFR* dual inhibitor. Topoisomerase II/EGFR-IN-1 has superior cytotoxic activity to MCF-7, A549 and HCT-116 cell lines, displays strong apoptotic activity and can be used for the research of cancer .

HY-143279

Topoisomerase II inhibitor 3	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 3 (Compound 6 h ) is a acridone derivatives, as well as a Type II DNA topoisomerase (topo II) inhibitor , as a topo IIα/β inhibitor with the value of IC₅₀ is 0.17 μM for topo IIα and the value of IC₅₀ is 0.23 μM for topo IIβ subtypes, caused obvious DNA damage, and induced apoptosis by triggering the loss of mitochondrial membrane potential .

HY-152473

Topoisomerase IIα-IN-6	Topoisomerase	Cancer
Topoisomerase IIα-IN-6 (Compound 47d) is an inhibitor of *DNA topoisomerase IIα/β. Topoisomerase IIα-IN-6 inhibits human topoisomerase IIα and human topoisomerase IIβ with IC₅₀* values of 0.67 µM and 0.55 µM, respectively. Topoisomerase IIα-IN-6 has stable metabolism .

HY-152187

Topoisomerase IIα-IN-5	Topoisomerase Apoptosis	Others
Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629) .

HY-174837

Topoisomerase IIα-IN-11	Topoisomerase	Cancer
Topoisomerase IIα-IN-11 (Compound 16h) is a potent Topoisomerase IIα inhibitor. Topoisomerase IIα-IN-11 shows significant inhibition on melanoma A2058 cell lines (IC₅₀ 3-6 μM). Topoisomerase IIα-IN-11 is promising for research of cancers (especially melanoma) .

HY-152479

Topoisomerase IIα-IN-7	Topoisomerase	Cancer
Topoisomerase IIα-IN-7 is an *DNA topoisomerase IIα* inhibitor with an IC₅₀ value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability .

HY-170557

Topoisomerase IIα-IN-10	Topoisomerase Apoptosis Mitochondrial Metabolism	Cancer
Topoisomerase IIα-IN-10 (Compound 13r) is an inhibitor of Topoisomerase IIα. It binds to the active site of DNA when complexed with Topoisomerase IIα, and this binding is stabilized through interactions with DNA base pairs and amino acid residues. Topoisomerase IIα-IN-10 can induce Apoptosis by intercalating DNA and inhibiting Topoisomerase IIα, thereby disrupting the mitochondrial membrane potential and inhibiting the growth of HCT116 cell lines, with an IC₅₀ of 4.37 μM against HCT116 cells. Topoisomerase IIα-IN-10 can be used for research in the field of cancer treatment .

HY-146020

Topoisomerase IIα-IN-1	Topoisomerase	Cancer
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines .

HY-146021

Topoisomerase IIα-IN-2	Topoisomerase	Cancer
Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase .

HY-151453

Topoisomerase IIα-IN-4	Topoisomerase Apoptosis	Cancer
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC₅₀ value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer .

HY-W178011

Topoisomerase IIα-IN-9 4,4'-Sulfonylbis(2-methylphenol)	Topoisomerase	Cancer
Topoisomerase IIα-IN-9 (NSC85582) is a bisphenol compound that has a moderate inhibitory effect on DNA topoisomerase *Topoisomerase II* (IC₅₀: 571 μM). *Topoisomerase IIα-IN-9 also exhibits a certain cell growth inhibitory effect, with IC₅₀*s of 117 μM and 218 μM for K562 and CHO, respectively .

HY-W031307

Topoisomerase IIα-IN-8	Topoisomerase	Cancer
Topoisomerase IIα-IN-8 (compound 15) is a weak *human DNA topoisomerase* IIa (htIIa) inhibitor, with an IC₅₀** of 462 ± 38.0 μM .

HY-146227

*DNA topoisomerase II* inhibitor 1**	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-106307

Retelliptine BD84	Topoisomerase	Cancer
Retelliptine (BD84), a derivative of ellipticine, is an inhibitor of *Topoisomerase II* with anticancer activity. Retelliptine can bind to DNA and inhibit *Topoisomerase II* during DNA replication .

HY-124552

Epolactaene	DNA/RNA Synthesis Topoisomerase	Others
Epolactaene is a potent *Topoisomerase II* and DNA Polymerase inhibitor with IC₅₀ values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively .

HY-113642

CP-67804	Topoisomerase	Cancer
CP-67804 is a quinolone derivative, is a *topoisomerase II*-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent .

HY-19024

Merbarone NSC 336628	Topoisomerase	Cancer
Merbarone (NSC 336628) is an orally active inhibitor of *topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo* II-DNA covalent complexes. Merbarone is an anticancer agent .

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Microtubule/Tubulin	Cancer
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-117543

Ethonafide AMP-53; 6-Ethoxyazonafide	Topoisomerase	Cancer
Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits *topoisomerase II* activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β .

HY-13761

Teniposide 10+ Cited Publications VM26	Topoisomerase	Cancer
Teniposide is a podophyllotoxin derivative, acts as a *topoisomerase II* inhibitor, and used as a chemotherapeutic agent.

HY-N8473

Pericosine A (+)-Pericosine A	Topoisomerase	Cancer
Pericosine A ((+)-Pericosine A) is a topoisomerase II (Topoisomerase II) inhibitor that can be isolated from the Periconia byssoides strain. Pericosine A has significant antitumor activity in vitro and in vivo and can be used in cancer research. Pericosine A also inhibits the protein kinase epidermal growth factor receptor .

HY-B0067A

Amrubicin hydrochloride SM-5887 hydrochloride	Topoisomerase Bacterial	Cancer
Amrubicin (SM-5887) hydrochloride is a DNA *topoisomerase II* inhibitor, used for the research of cancer.

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Topoisomerase	Cancer
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-B0067

Amrubicin SM-5887	Topoisomerase Bacterial	Cancer
Amrubicin (SM-5887) is a DNA *topoisomerase II* inhibitor, used for the research of cancer.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Topoisomerase	Cancer
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-N11698

Bakuchicin Allopsoralen	Topoisomerase	Infection
Bakuchicin (Allopsoralen) is a compound that can be found in Psoralea corylifolia. It has certain inhibitory activity against *topoisomerase II. In the cell model infected with Simian virus 40 (SV40), the IC₅₀* of Bakuchicin against *topoisomerase II* is 404 μM. Bakuchicin can be used in the research of the anti-infection field .

HY-106702A

Fostriecin PD 110161; CL 1565A; CI-920	Antibiotic Bacterial Topoisomerase Phosphatase	Infection
Fostriecin is a triene antibiotic. Fostriecin is a *topoisomerase II* and protein phosphatase PP2A inhibitor .

HY-13727A

Pixantrone 3 Publications Verification BBR 2778	Topoisomerase	Cancer
Pixantrone (BBR 2778) dimaleate is a *topoisomerase II* inhibitor and DNA intercalator, with anti-tumor activity.

Cat. No.	Product Name	Type

HY-16700G

PNU-159682 (GMP)	Fluorescent Dye
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Cat. No.	Product Name	Type

HY-16700G

PNU-159682 (GMP)	Biochemical Assay Reagents
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-124552

Epolactaene	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis Topoisomerase
Epolactaene is a potent *Topoisomerase II* and DNA Polymerase inhibitor with IC₅₀ values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively .

HY-N8473

Pericosine A (+)-Pericosine A	Structural Classification Natural Products Microorganisms Source classification	Topoisomerase
Pericosine A ((+)-Pericosine A) is a topoisomerase II (Topoisomerase II) inhibitor that can be isolated from the Periconia byssoides strain. Pericosine A has significant antitumor activity in vitro and in vivo and can be used in cancer research. Pericosine A also inhibits the protein kinase epidermal growth factor receptor .

HY-N11698

Bakuchicin Allopsoralen	Structural Classification Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants	Topoisomerase
Bakuchicin (Allopsoralen) is a compound that can be found in Psoralea corylifolia. It has certain inhibitory activity against *topoisomerase II. In the cell model infected with Simian virus 40 (SV40), the IC₅₀* of Bakuchicin against *topoisomerase II* is 404 μM. Bakuchicin can be used in the research of the anti-infection field .

HY-106702A

Fostriecin PD 110161; CL 1565A; CI-920	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Topoisomerase Phosphatase
Fostriecin is a triene antibiotic. Fostriecin is a *topoisomerase II* and protein phosphatase PP2A inhibitor .

HY-N15319

Eupolauridine Canangine	Structural Classification Alkaloids Other Alkaloids Cananga odorata Source classification Plants Annonaceae	Topoisomerase Fungal
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC₅₀ values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases .

HY-N12747

Dichlorogelignate	Structural Classification Source classification Phenols Polyphenols Plants Boraginaceae Arnebia euchroma (Royle) Johnst.	Topoisomerase
Dichlorogelignate (compound 4) is a selective inhibitor of topoisomerase II (Topo II). Dichlorogelignate has 100% inhibition at 50 μM .

HY-15552R

Podofilox (Standard) Podophyllotoxin (Standard)	Structural Classification Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae	Reference Standards Microtubule/Tubulin
Podofilox (Standard) is the analytical standard of Podofilox. This product is intended for research and analytical applications. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-15753R

Ellipticine (Standard)	Apocynaceae Alkaloids Structural Classification Marine natural products Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Indole Alkaloids	Topoisomerase
Ellipticine (Standard) is the analytical standard of Ellipticine. This product is intended for research and analytical applications. Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753AR

Ellipticine hydrochloride (Standard)	Apocynaceae Alkaloids Structural Classification Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Indole Alkaloids	Topoisomerase
Ellipticine (hydrochloride) (Standard) is the analytical standard of Ellipticine (hydrochloride). This product is intended for research and analytical applications. Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-N4329

Nidulalin A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Topoisomerase
Nidulalin A is a DNA topoisomerase II inhibitor with an IC₅₀ of 2.2 μM. Nidulalin A has an IC₅₀ of 172 μM for *DNA topoisomerase* I**. Nidulalin A has certain cytotoxicity .

HY-116933

Murrayanol	Alkaloids Structural Classification Rutaceae Murraya koenigii (L.) Spreng Plants Indole Alkaloids	Topoisomerase Bacterial
Murrayanol is a natural carbazole alkaloid with a variety of biological activities. Murrayanol shows anti-inflammatory, topoisomerase I and *topoisomerase II* (Topoisomerase) inhibition activities. Murrayanol also as a mosquitocidal and antimicrobial .

HY-118726

Luotonin F	Structural Classification Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Source classification Quinoline Alkaloids Plants	Topoisomerase
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human *topoisomerase II* .

HY-19825

Rebeccamycin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Topoisomerase ADC Payload Antibiotic
Rebeccamycin, an antitumor antibiotic, inhibits *DNA topoisomerase* I*. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase* I and has negligible effect on protein kinase C and topoisomerase II .

HY-13629

Etoposide 135+ Cited Publications VP-16; VP-16-213	Infection Structural Classification Monophenols Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Source classification Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits *topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis* and autophagy .

HY-N6800

Netropsin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic DNA/RNA Synthesis Bacterial Influenza Virus Orthopoxvirus
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity .

HY-N6800A

Netropsin dihydrochloride	Classification of Application Fields Inflammation/Immunology Disease Research Fields	Antibiotic DNA/RNA Synthesis Bacterial Influenza Virus Orthopoxvirus
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity .

HY-121309

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human *DNA topoisomerase* I** and topoisomerase II* inhibitor* with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-N12129

6,6′-Dihydroxythiobinupharidine	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Plants Nuphar pumila (Timm) de Candolle Nymphaeaceae	Cathepsin
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .

HY-119458

Luotonin A	Structural Classification Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Source classification Quinoline Alkaloids Plants	Topoisomerase TMV Fungal
Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and *topoisomerase II*. Luotonin A shows antitumor activity .

HY-13629R

Etoposide (Standard) 1 Publications Verification VP-16 (Standard); VP-16-213 (Standard)	Structural Classification Monophenols Sinopodophyllum hexandrum (Royle) Ying Source classification Lignans Phenols Phenylpropanoids Plants Berberidaceae	Reference Standards Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits *topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis* and autophagy .

HY-121309R

Doxorubicinone (Standard) Adriamycin aglycone (Standard); Adriamycinone (Standard)	Quinones Structural Classification Anthraquinones Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Doxorubicinone (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 558 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human *DNA topoisomerase* I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis** and autophagy .

HY-13062A

Daunorubicin Daunomycin; RP 13057; Rubidomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Payload Autophagy Bacterial Antibiotic Apoptosis
Daunorubicin (Daunomycin) is a *topoisomerase II* inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13062

Daunorubicin hydrochloride 30+ Cited Publications Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (Daunomycin) hydrochloride is a *topoisomerase II* inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13502B

Mitoxantrone diacetate Mitozantrone diacetate; NSC 301739 diacetate	Infection Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone diacetate is a potent *topoisomerase II* inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity . Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502

Mitoxantrone 35+ Cited Publications Mitozantrone; NSC 301739	Infection Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone is a potent *topoisomerase II* inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502A

Mitoxantrone dihydrochloride 35+ Cited Publications Mitozantrone dihydrochloride; NSC 301739 dihydrochloride	Infection Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone dihydrochloride is a potent *topoisomerase II* inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits *topoisomerase II* with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy . Doxorubicin inhibits human *DNA topoisomerase* I with an IC₅₀** of 0.8 μM .

HY-N6714

Alternariol	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis
Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, *topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis*, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-15142R

Doxorubicin hydrochloride (Standard) 2 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human *DNA topoisomerase* I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis** and autophagy .

HY-13062R

Daunorubicin hydrochloride (Standard) Daunomycin hydrochloride (Standard); RP 13057 hydrochloride (Standard); Rubidomycin hydrochloride (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Source classification Phenols Polyphenols	Reference Standards Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (hydrochloride) (Standard) is the analytical standard of Daunorubicin (hydrochloride). This product is intended for research and analytical applications. Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-N0354

Anthraquinone	Seeds of Cassia tora Linn. Quinones Structural Classification other families Classification of Application Fields Leguminosae Anthraquinones Source classification Other Diseases Plants Disease Research Fields	Virus Protease Topoisomerase Apoptosis
Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis .

HY-13502AR

Mitoxantrone dihydrochloride (Standard) Mitozantrone dihydrochloride (Standard); NSC 301739 dihydrochloride (Standard)	Quinones Structural Classification Anthraquinones Source classification Endogenous metabolite	Reference Standards Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone (dihydrochloride) (Standard) is the analytical standard of Mitoxantrone (dihydrochloride). This product is intended for research and analytical applications. Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502R

Mitoxantrone (Standard) Mitozantrone (Standard); NSC 301739 (Standard)	Quinones Structural Classification Anthraquinones Source classification Endogenous metabolite	Reference Standards Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone (Standard) is the analytical standard of Mitoxantrone. This product is intended for research and analytical applications. Mitoxantrone is a potent *topoisomerase II* inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-N6714R

Alternariol (Standard)	Structural Classification Microorganisms Source classification Phenols Polyphenols	Reference Standards Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis
Alternariol (Standard) is the analytical standard of Alternariol. This product is intended for research and analytical applications. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-N0311

Emodin-8-glucoside 1 Publications Verification	Quinones Structural Classification other families Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Aldose Reductase Topoisomerase SOD p38 MAPK
Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and *topoisomerases II* with IC₅₀s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .

HY-N0311R

Emodin-8-glucoside (Standard)	Quinones Structural Classification other families Anthraquinones Source classification Phenols Polyphenols Plants	Reference Standards Aldose Reductase Topoisomerase SOD p38 MAPK
Emodin-8-glucoside (Standard) is the analytical standard of Emodin-8-glucoside. This product is intended for research and analytical applications. Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and *topoisomerases II* with IC₅₀s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .

Cat. No.	Compare	Product Name	Species	Source

HY-P704742

	TOP2A Protein, Human TOP2A; DNA topoisomerase 2-alpha; TOP2; DNA topoisomerase ii; alpha isozyme	Human	E. coli
	TOP2A Protein, Human is the recombinant human-derived TOP2A protein, expressed by E. coli, with tag free tag.

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Cat. No.	Product Name	Chemical Structure

HY-13562AS

Banoxantrone-d12 dihydrochloride
Banoxantrone-d₁₂ (dihydrochloride) is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-B0526S

Flumequine-13C3
Flumequine- ¹³C₃ is the ¹³C₃ labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

HY-15552S

Podofilox-d6
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II .

HY-13562S

Banoxantrone-d12
Banoxantrone-d₁₂ is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-121309S

Doxorubicinone-d3
Doxorubicinone-d₃ is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human?DNA topoisomerase I?and?topoisomerase II?inhibitor with?IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-13629S1

Etoposide-13C,d3
Etoposide- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-13629S

Etoposide-d3
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits *topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis* and autophagy .

HY-121309S1

Doxorubicinone-13C,d3
Doxorubicinone- ¹³C,d₃ (Adriamycin aglycone- ¹³C,d₃) is ¹³C labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human *DNA topoisomerase* I and topoisomerase II inhibitor with IC₅₀**s of 0.8 μM and 2.67 μM, respectively.

HY-W744243

Etoposide-d4
Etoposide-d₄ (VP-16-d₄; VP-16-213-d₄) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-B0330DS

(R)-Ofloxacin-d3

(R)-Ofloxacin-d₃ is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502AS1

Mitoxantrone-d8 hydrochloride

Mitoxantrone-d₈ (hydrochloride) (Mitozantrone-d₈ (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-W653896

Alternariol-d2

Alternariol-d₂ is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80980

	Topoisomerase II alpha Antibody (YA3544) DNA topoisomerase ii; DNA topoisomerase ii-alpha; TOP2; TP2A; alpha isozyme, topoisomerase ii alpha	WB, IHC-P, IP	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA3544) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P85929

	Topoisomerase II alpha Antibody (YA5621) alpha isozyme; ATP hydrolyzing DNA topoisomerase ii alfa; DNA gyrase; DNA topoisomerase; ATP hydrolyzing; DNA topoisomerase 2 alpha; DNA topoisomerase 2-alpha; DNA topoisomerase ii 170 kD; DNA topoisomerase ii alpha isozyme; DNA topoisomerase ii; DNA topoisomerase2; TOP 2A; TOP2; TOP2A; TOP2A_HUMAN; topoisomerase DNA ii alpha 170 kDa; TP2A	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA5621) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P86048

	Topoisomerase II alpha Antibody (YA5740) DNA topoisomerase 2-alpha; DNA topoisomerase ii, alpha isozyme;	IHC-P, ELISA	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA5740) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P84062

	Topoisomerase II alpha Antibody (YA3759) TOP2; TP2A	WB, ICC/IF, FC, ELISA	Human, Rat
	Topoisomerase II alpha Antibody (YA3759) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P87126

	TopBP1 Antibody (YA6819) DNA topoisomerase 2 binding protein 1 antibody; DNA topoisomerase 2-binding protein 1 antibody; DNA topoisomerase ii binding protein 1 antibody; DNA topoisomerase ii binding protein antibody; DNA topoisomerase ii-beta-binding protein 1 antibody; DNA topoisomerase ii-binding protein 1 antibody; DNA topoisomerase iibeta binding protein 1 antibody; Hypothetical protein KIAA0259 [Fragment] antibody; KIAA0259 antibody; TOP2BP1 antibody; DNA topoisomerase 2 binding protein 1 antibody; DNA topoisomerase 2-binding protein 1 antibody; DNA topoisomerase ii binding protein 1 antibody; DNA topoisomerase ii binding protein antibody; DNA topoisomerase ii-beta-binding protein 1 antibody; DNA topoisomerase ii-binding protein 1 antibody; DNA topoisomerase iibeta binding protein 1 antibody; Hypothetical protein KIAA0259 [Fragment] antibody; KIAA0259 antibody; TOP2BP1 antibody; TOPB1_HUMAN antibody; TOPBP 1 antibody; TopBP1 antibody; topoisomerase (DNA) ii binding protein 1 antibody; topoisomerase ii binding protein 1 antibody;	WB, IHC-P	Human
	TopBP1 Antibody (YA6819) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TopBP1.