Doxorubicin-SMCC

Name: Doxorubicin-SMCC
Brand: MedChemExpress
SKU: HY-116063
Rating: 4.5 (1 reviews)

Cat. No.: HY-116063 Purity: 98.80%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Doxorubicin-SMCC is a agent-linker conjugate for ADC. Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin.

For research use only. We do not sell to patients.

Doxorubicin-SMCC Chemical Structure

CAS No. : 400647-59-8

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Doxorubicin-SMCC

•ACS Omega. 2025 Feb 6;10(6):5730-5743. [Abstract]

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Biological Activity
Purity & Documentation
References
Customer Review

Description

Doxorubicin-SMCC is a agent-linker conjugate for ADC. Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin^[1].

IC₅₀ & Target^[1]

Daunorubicins/Doxorubicins

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

762.76

Formula

C₃₉H₄₂N₂O₁₄

CAS No.

400647-59-8

Appearance

Solid

Color

Orange to red

SMILES

C[C@@H]1O[C@H](C[C@@H]([C@@H]1O)NC(C2CCC(CC2)CN3C(C=CC3=O)=O)=O)O[C@H]4C[C@](O)(C(CO)=O)CC5=C(O)C(C(C6=C7C(OC)=CC=C6)=O)=C(C7=O)C(O)=C45

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (163.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3110 mL	6.5551 mL	13.1103 mL
5 mM	0.2622 mL	1.3110 mL	2.6221 mL
10 mM	0.1311 mL	0.6555 mL	1.3110 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.80%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (253 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3110 mL	6.5551 mL	13.1103 mL	32.7757 mL
	5 mM	0.2622 mL	1.3110 mL	2.6221 mL	6.5551 mL
	10 mM	0.1311 mL	0.6555 mL	1.3110 mL	3.2776 mL
	15 mM	0.0874 mL	0.4370 mL	0.8740 mL	2.1850 mL
	20 mM	0.0656 mL	0.3278 mL	0.6555 mL	1.6388 mL
	25 mM	0.0524 mL	0.2622 mL	0.5244 mL	1.3110 mL
	30 mM	0.0437 mL	0.2185 mL	0.4370 mL	1.0925 mL
	40 mM	0.0328 mL	0.1639 mL	0.3278 mL	0.8194 mL
	50 mM	0.0262 mL	0.1311 mL	0.2622 mL	0.6555 mL
	60 mM	0.0219 mL	0.1093 mL	0.2185 mL	0.5463 mL
	80 mM	0.0164 mL	0.0819 mL	0.1639 mL	0.4097 mL
	100 mM	0.0131 mL	0.0656 mL	0.1311 mL	0.3278 mL