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microtubule inhibitor

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (264) Cardiovascular Disease (3) Infection (16) Inflammation/Immunology (12) Neurological Disease (11)
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296

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Microtubule/Tubulin Microtubule‐associated serine/threonine kinase (MAST) MARK MASTL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145828

Microtubule inhibitor 2	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 2 is a potent and selective, orally active *microtubule* inhibitor. Microtubule inhibitor 2 triggers cell death through ferroptosis . Microtubule inhibitor 2 shows antitumor activity .

HY-161075

Microtubule inhibitor 8	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 8 (MP-HJ-1b) is a potent inhibitor of *microtubule. Microtubule* inhibitor 8 triggers cell death through ferroptosis. Microtubule inhibitor 8 has anti-tumor effect .

HY-147727

Microtubule inhibitor 6	Microtubule/Tubulin	Cancer
Microtubule inhibitor 6 (compound 17o) is a potent *microtubule* inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC₅₀s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization .

HY-147726

Microtubule inhibitor 5	Microtubule/Tubulin	Cancer
Microtubule inhibitor 5 (compound 17f) is a potent *microtubule* inhibitor. Microtubule inhibitor 5 shows cytotoxicity with an IC₅₀ value of 154.5 nM for NCI-H460 cells. Microtubule inhibitor 5 shows good cell permeability .

HY-161734

Microtubule inhibitor 11	Microtubule/Tubulin	Cancer
Microtubule inhibitor 11 (compound 33) is a microtubule inhibitor with a mechanism of action similar to colchicine (HY-N0282). Microtubule inhibitor 11 can be used in cancer-related research .

HY-147725

Microtubule inhibitor 4	Microtubule/Tubulin	Cancer
Microtubule inhibitor 4 (compound 2) is a potent *microtubule* inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC₅₀s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization .

HY-114313

Microtubule inhibitor 1	Microtubule/Tubulin	Cancer
Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC₅₀ value of 9-16 nM in cancer cells .

HY-168714

Microtubule inhibitor 12	Microtubule/Tubulin Apoptosis	Cancer
Microtubule inhibitor 12 (Compound 2k) is an inhibitor for microtubule polymerization with an IC₅₀ of 22.23 μM. Microtubule inhibitor 12 arrests the cell cycle of B16-F10 at G2/M phase, induces apoptosis in B16-F10, and inhibits cell migration. Microtubule inhibitor 12 inhibits the proliferation of cancer cells B16-f10, A549, HepG2 and MCF-7, with IC₅₀s of 0.098, 0.135, 0.109, and 0.259 μM, respectively. Microtubule inhibitor 12 exhibits antitumor efficacy in mouse model .

HY-161153

Microtubule inhibitor 9	Apoptosis	Cancer
Microtubule inhibitor 9 (Compound O-7) is a 2-Aryl-1H-benzo [d] imidazole derivative with in vitro anticancer activity. Microtubule inhibitor 9 can induce cell cycle arrest at the G2/M phase and early apoptosis. Microtubule inhibitor 9 inhibits cancer cell migration by inhibiting wound healing and colony formation .

HY-147728

Microtubule inhibitor 7	Microtubule/Tubulin	Cancer
Compounds 17O (ic₅₀= 14.0 nm, NCI-H460) and 17p (ic₅₀= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

HY-147724

Microtubule inhibitor 3	Microtubule/Tubulin	Cancer
Compounds 17O (ic₅₀= 14.0 nm, NCI-H460) and 17p (ic₅₀= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

HY-138819

IMB5046	Apoptosis	Cancer
IMB5046 is a *microtubule* inhibitor that induces apoptosis by blocking the G2/M phase of the cell cycle. IMB5046 has anti-tumor activity .

HY-171165

JC168	Microtubule/Tubulin	Cancer
JC168 is a phenyl analog of peloruside and serves as a *microtubule* inhibitor, demonstrating antiproliferative and anticancer activities. JC168 promotes tubulin polymerization, thereby interfering with microtubule dynamics, and can be utilized in research related to microtubule-associated disorders .

HY-147317

Epothilone E	Microtubule/Tubulin	Cancer
Epothilone E is a related compound of epothilone, which inhibits microtubule protein function and blocks cell division, and has anti-tumor activity .

HY-122151

MPT0B002	Microtubule/Tubulin Apoptosis	Cancer
MPT0B002 is a potent *microtubule* inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase .

HY-15583

Auristatin F	ADC Cytotoxin Microtubule/Tubulin	Cancer
Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent *microtubule* inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

HY-15583S

Auristatin F-d8	Isotope-Labeled Compounds ADC Cytotoxin Microtubule/Tubulin	Cancer
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent *microtubule* inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

HY-155956

GM-90257	Microtubule/Tubulin Apoptosis Bcl-2 Family JNK PARP	Cancer
GM-90257 is a microtubule acetylation inhibitor. GM-90257 binds directly to α-tubulin. GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes Apoptosis, downregulates BCl-2, and activates JNK and PARP. GM-90257 has anticancer activity against breast cancer .

HY-121434

N-Deacetylcolchicine	Microtubule/Tubulin
N-Deacetylcolchicine is a microtubule polymerization inhibitor with an IC₅₀ of 3 μM against bovine brain microtubules. It is a derivative of the microtubule polymerization inhibitor Colchicine (HY-16569) and activates the GTPase activity of microtubules ^[1][2].

HY-131873

Dynapyrazole-A	Dynamin	Infection
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity .

HY-13442

Eribulin 4 Publications Verification B1939; E7389; ER-086526	Microtubule/Tubulin Apoptosis ADC Cytotoxin	Cancer
Eribulin (E7389) is a *microtubule* targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

HY-13442A

Eribulin mesylate 4 Publications Verification B1939 mesylate; E7389 mesylate; ER-086526 mesylate	Microtubule/Tubulin Apoptosis	Cancer
Eribulin (E7389) mesylate is a *microtubule* targeting agent that is used for the research of metastatic breast cancer. Eribulin mesylate inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

HY-159891

Microtubule destabilizing agent-2	Microtubule/Tubulin Apoptosis Caspase	Cancer
Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective antitumor compound targeting *microtubule* protein. Microtubule destabilizing agent-2 destabilizes *microtubule* proteins and inhibits microtubule polymers. Microtubule destabilizing agent-2 arrests the G0/G1 phase in human tumor cells. Microtubule destabilizing agent-2 induces Apoptosis by activating the cascade pathway of caspases. Microtubule destabilizing agent-2 has anti-inflammatory activity, as inhibiting TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 reduces tumors growth in xenograft mice .

HY-13760

Tasidotin hydrochloride ILX651	Microtubule/Tubulin	Cancer
Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics.

HY-130959

Tubulysin IM-2	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-2 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-130960

Tubulysin IM-3	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-3 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-130958

Tubulysin IM-1	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-1 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis .

HY-121908

FCPT	ATP Synthase	Cancer
FCPT, an ATP competitive inhibitor, induces a tight-binding of kinesin-5 onto microtubules and induced loss of microtubules selectively at the poles of Xenopus extract spindles without altering microtubule dynamics .

HY-14934

Rosabulin STA 5312	Microtubule/Tubulin	Cancer
Rosabulin (STA 5312) is a potent and orally active *microtubule* inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity .

HY-N0488

Vincristine sulfate 50+ Cited Publications Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate	Microtubule/Tubulin Apoptosis	Cancer
Vincristine sulfate is an antitumor vinca alkaloid which inhibits *microtubule* formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to *microtubule* with a K_i of 85 nM.

HY-119587

Alestramustine	Microtubule/Tubulin	Cancer
Alestramustine is an antineoplastic cytostatic agent that disrupts microtubule function by binding to microtubule-associated proteins and β-tubulin through its active metabolites, effectively inhibiting cell division.

HY-13520

Nocodazole 80+ Cited Publications Oncodazole; R17934	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis	Cancer
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of *microtubule. Nocodazole binds to β-tubulin and disrupts microtubule* assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-N0488A

Vincristine Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Microtubule/Tubulin Antibiotic Mitosis	Cancer
Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine is used to research hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas .

HY-119692

Curvulin	Microtubule/Tubulin	Others
Curvulin is a phytotoxin . Curvularin inhibits *microtubule* assembly and inhibits iNOS expression.

HY-164837

VcMMAE-Eribulin SMP13432	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
VcMMAE-Eribulin is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule MMAE (HY-15162) (Microtubule inhibitor) and Eribulin (HY-13442) (Microtubule inhibitor). VcMMAE-Eribulin can be used for ADC synthesis.

HY-105273

Erbulozole R 55104	Microtubule/Tubulin	Cancer
Erbulozole (R 55104) is a *microtubule* inhibitor with antitumoral effects .

HY-145616

Sudocetaxel	Microtubule/Tubulin	Cancer
Sudocetaxel is a *microtubule* depolymerization inhibitor for pH-sensitive docetaxel delivery.

HY-146692

IQTub4P	Microtubule/Tubulin	Cancer
IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC₅₀ of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo .

HY-163737

ST-401	Microtubule/Tubulin	Cancer
ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant microtubule (MT) assembly inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity .

HY-128870

Mal-PEG2-VCP-Eribulin	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates .

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Microtubule/Tubulin	Cancer
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-117473

DAT-230	Microtubule/Tubulin Apoptosis	Cancer
DAT-230 is a *microtubule* inhibitor. DAT-230 induces cell apoptosis and results in microtubule de-polymerization and G2/M phase arrest. DAT-230 inhibits cell growth in vitro and in vivo .

HY-16569S

Colchicine-d6	Isotope-Labeled Compounds Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-16569S1

Colchicine-d3	Isotope-Labeled Compounds Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-161145

EGFR/microtubule-IN-1	EGFR Apoptosis Microtubule/Tubulin	Cancer
EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC₅₀ for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis .

HY-112266

MARK-IN-4	MARK AMPK	Neurological Disease
MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC₅₀ of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease .

HY-N0488S2

Vincristine-d6 sulfate Leurocristine-d₆ sulfate; NSC-67574-d₆ sulfate; 22-Oxovincaleukoblastine-d₆ sulfate	Isotope-Labeled Compounds Microtubule/Tubulin Apoptosis	Cancer
Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.

HY-128224

Antiproliferative agent-13	Others	Cancer
Antiproliferative agent-13 (compound 16c) shows an antiproliferative activity against human A375 cells with an IC₅₀ value of 32.7 nM. Antiproliferative agent-13 can be used for the research of cancer .

HY-106399A

Acodazole hydrochloride	Microtubule/Tubulin	Cancer
Acodazole hydrochloride is an anticancer agent that exerts its anticancer activity by inhibiting microtubule polymerization .

HY-17435

4'-Demethylepipodophyllotoxin 2 Publications Verification 4'-O-demethylepipodophyllotoxin; 4'-DMEP	Microtubule/Tubulin	Cancer
4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

Cat. No.	Product Name	Type

HY-D2341

6FC-GABA-Taxol

Fluorescent Dyes/Probes

6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors .

HY-78738G

MC-Val-Cit-PAB (GMP)	Fluorescent Dye
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

Cat. No.	Product Name	Type

HY-16569B

Colchicine,suitable for plant cell culture

Cell Assay Reagents

Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture .

HY-78738G

MC-Val-Cit-PAB (GMP)	Biochemical Assay Reagents
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

Cat. No.	Product Name	Target	Research Area

HY-105066

Davunetide 1 Publications Verification	Microtubule/Tubulin Amyloid-β	Neurological Disease
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a *microtubule-stabilizing* peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .

Cat. No.	Product Name	Target	Research Area

HY-P99205

Glembatumumab	ADC Antibody	Cancer
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .

HY-132253

Polatuzumab vedotin	Antibody-Drug Conjugates (ADCs)	Cancer
Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL) .

HY-P99829

Cofetuzumab pelidotin PF-06647020; ABBV-647; h6M24-vc0101	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC₅₀ of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .

HY-P99682

Ladiratuzumab hLIV22	ADC Antibody	Cancer
Ladiratuzumab (hLIV22) is a humanized monoclonal antibody against zinc transporter LIV-1/ZIP6. Ladiratuzumab is conjugated to MMAE (HY-15162) via a cleavable dipeptide linker to synthesize an antibody-drug conjugate (ADC) Ladiratuzumab vedotin (HY-P99683). Ladiratuzumab vedotin selectively targets LIV-1 protein overexpressed on the surface of tumor cells, enters cells through antibody-mediated receptor endocytosis, releases MMAE to inhibit microtubule polymerization, and kills adjacent tumor cells with a bystander effect. Ladiratuzumab can be used in the study of solid tumors such as metastatic triple-negative breast cancer (mTNBC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0488

Vincristine sulfate 50+ Cited Publications Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Anti-aging Source classification Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin Apoptosis
Vincristine sulfate is an antitumor vinca alkaloid which inhibits *microtubule* formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to *microtubule* with a K_i of 85 nM.

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-17435

4'-Demethylepipodophyllotoxin 2 Publications Verification 4'-O-demethylepipodophyllotoxin; 4'-DMEP	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N0488A

Vincristine Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin Antibiotic Mitosis
Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine is used to research hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas .

HY-N0488R

Vincristine (sulfate) (Standard)	Apocynaceae Alkaloids Structural Classification Source classification Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don	Microtubule/Tubulin Apoptosis
Vincristine (sulfate) (Standard) is the analytical standard of Vincristine (sulfate). This product is intended for research and analytical applications. Vincristine sulfate is an antitumor vinca alkaloid which inhibits *microtubule* formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to *microtubule* with a K_i of 85 nM.

HY-N2346

Tubulysin E	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7049

Tubulysin F	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2348

Tubulysin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-77574

7-xylosyltaxol 7-Xylosylpaclitaxel; Taxol-7-xyloside	Classification of Application Fields Terpenoids Source classification Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin
7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

HY-15739

Ansamitocin P-3 5+ Cited Publications Antibiotic C 15003P3; Maytansinol isobutyrate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Microtubule/Tubulin ADC Cytotoxin Bacterial Antibiotic
Ansamitocin P-3 (Antibiotic C 15003P3) is a *microtubule* inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

HY-15552R

Podofilox (Standard)	Structural Classification Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae	Microtubule/Tubulin
Podofilox (Standard) is the analytical standard of Podofilox. This product is intended for research and analytical applications. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-N1450

Aristolochic acid C	Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Phospholipase
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A₂ (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-13780

Vinblastine sulfate 10+ Cited Publications Vincaleukoblastine sulfate salt	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin nAChR Autophagy
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-16569

Colchicine 35+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a *microtubule* disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-119407

Terpendole E	Structural Classification Microorganisms Iridoids Terpenoids Source classification	Kinesin
Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase .

HY-17435R

4'-Demethylepipodophyllotoxin (Standard)	Structural Classification Monophenols Source classification Lignans Phenols Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae	Microtubule/Tubulin
4'-Demethylepipodophyllotoxin (Standard) is the analytical standard of 4'-Demethylepipodophyllotoxin. This product is intended for research and analytical applications. 4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

HY-16569R

Colchicine (Standard)	Structural Classification Natural Products other families Source classification Plants	Reference Standards Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-127166

Colchiceine O10-Demethylcolchicine	Colchicaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Colchicum autumnale L.	Microtubule/Tubulin
Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-N1171

Taxinine B Taxinin B	Structural Classification Natural Products Taxus cuspidata Siebold & Zucc. Taxaceae Source classification Plants	Microtubule/Tubulin
Taxinine B is a taxoid that can be isolated from Japanese Yew Taxus Cuspid. Taxinine B inhibits CaCl₂-induced depolymerization of *microtubule*. Taxinine B is useful for overcoming multidrug resistance in tumor cells .

HY-N0282

Demecolcine 3 Publications Verification	Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Plants Inflammation/Immunology Disease Research Fields	Microtubule/Tubulin Apoptosis
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N1450R

Aristolochic acid C (Standard)	Structural Classification Monophenols other families Source classification Phenols Plants	Phospholipase
Aristolochic acid C (Standard) is the analytical standard of Aristolochic acid C. This product is intended for research and analytical applications. Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-13780R

Vinblastine sulfate (Standard) Vincaleukoblastine sulfate salt (Standard)	Apocynaceae Alkaloids Structural Classification Source classification Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don	Microtubule/Tubulin Autophagy nAChR
Vinblastine (sulfate) (Standard) is the analytical standard of Vinblastine (sulfate). This product is intended for research and analytical applications. Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-15739R

Ansamitocin P-3 (Standard) Antibiotic C 15003P3 (Standard); Maytansinol isobutyrate (Standard)	Structural Classification Microorganisms Antibiotics Source classification Disease Research Anticancer Other Antibiotics	Microtubule/Tubulin ADC Cytotoxin Bacterial Antibiotic
Ansamitocin P-3 (Standard) is the analytical standard of Ansamitocin P-3. This product is intended for research and analytical applications. Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

HY-N1098R

Velutin (Standard)	Structural Classification Flavonoids Microorganisms other families Flavones Source classification Phenols Polyphenols Plants	HIF/HIF Prolyl-Hydroxylase
Colchiceine (Standard) is the analytical standard of Colchiceine. This product is intended for research and analytical applications. Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-127166R

Colchiceine (Standard)	Colchicaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Colchicum autumnale L.	Microtubule/Tubulin
Colchiceine (Standard) is the analytical standard of Colchiceine. This product is intended for research and analytical applications. Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-N3028

Taccalonolide B	Structural Classification Classification of Application Fields Source classification Schizocapsa plantaginea Hance Plants Disease Research Fields Taccaceae Steroids Cancer	Microtubule/Tubulin
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-N0282R

Colcemid (Standard)	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	Microtubule/Tubulin Apoptosis
Colcemid (Standard) is the analytical standard of Colcemid. This product is intended for research and analytical applications. Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-B0011

Docetaxel Maximum Cited Publications 113 Publications Verification RP-56976	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a *microtubule depolymerization* inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus wallichiana Zucc. Cancer	Microtubule/Tubulin
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N2500

Deoxypodophyllotoxin	Infection Cardiovascular Disease Structural Classification other families Classification of Application Fields Centaurea ornata Source classification Lignans Phenylpropanoids Umbelliferae Plants Disease Research Fields	Microtubule/Tubulin Apoptosis Autophagy
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the *microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors* of angiogenesis . Deoxypodophyllotoxin induces cell autophagy and apoptosis . Deoxypodophyllotoxin evokes increase of intracellular Ca ²⁺ concentrations in DRG neurons .

HY-13716

Noscapine 1 Publications Verification (S,R)-Noscapine	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Quinoline Alkaloids Papaver somniferum Linn. Plants Inflammation/Immunology Disease Research Fields Papaveraceae	Opioid Receptor Apoptosis
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-N1243

Tubulysin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis
Tubulysin B is a highly cytotoxic peptide and potent *microtubule* destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC₅₀ values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties .Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-B0011R

Docetaxel (Standard) RP-56976 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a *microtubule depolymerization* inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-12033

2-Methoxyestradiol 25+ Cited Publications 2-ME2; NSC-659853	Structural Classification Monophenols Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize *microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD)* inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-N14734

Disorazol A	Structural Classification Natural Products Microorganisms Source classification	Apoptosis Fungal Microtubule/Tubulin Mitosis
Disorazol A1 is an tubulin inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis, thus arresting the cell cycle at the G₂/M phase and inducing apoptosis. Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC₅₀ value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers .

HY-13716R

Noscapine (Standard) (S,R)-Noscapine (Standard)	Structural Classification Alkaloids Source classification Quinoline Alkaloids Papaver somniferum Linn. Plants Papaveraceae	Reference Standards Opioid Receptor Apoptosis
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .

HY-N1391R

10-Deacetyltaxol (Standard)	Structural Classification Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus wallichiana Zucc.	Microtubule/Tubulin
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N0060AR

Ferulic acid (sodium) (Standard)	Structural Classification Monophenols other families Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Endogenous metabolite	FGFR Endogenous Metabolite Reactive Oxygen Species (ROS)
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

Cat. No.	Product Name	Chemical Structure

HY-15583S

Auristatin F-d8
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent *microtubule* inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

HY-16569S

Colchicine-d6
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-N0488S1

Vincristine-d3-ester sulfate
Vincristine-d₃-ester (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a K_i of 85 nM .

HY-12522S

PF-06380101-d8 2 Publications Verification
PF-06380101-d₈ is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue .

HY-16569S1

Colchicine-d3
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-N0488S2

Vincristine-d6 sulfate
Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.

HY-N0488S

Vincristine-d3 sulfate
Vincristine-d₃ (sulfate)is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a K_i of 85 nM .

HY-15552S

Podofilox-d6
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II .

HY-115364S

Parbendazole-d3
Parbendazole-d₃ is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-W014240S1

Chlorpropham-d7
Chlorpropham-d₇ is the deuterium labeled Chlorpropham . Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .

HY-136610S

Chlorpyrifos-oxon-d10
Chlorpyrifos-oxon-d₁₀ is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function .

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

HY-13716S

Noscapine-13C,d3

Noscapine- ¹³C,d₃ is a ¹³C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

Cat. No.	Product Name		Classification

HY-16062

ARQ 621		Alkynes
ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity . ARQ 621 is a kinesin inhibitor . ARQ 621 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.