2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. ON 01500

ON 01500 is a tubulin inhibitor with a Kd of 21 nM. ON 01500 exerts microtubule-destabilizing effects in cells. ON 01500 can be used the study of cancers.

For research use only. We do not sell to patients.

ON 01500

ON 01500 Chemical Structure

CAS No. : 592542-50-2

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Based on 1 publication(s) in Google Scholar

ON 01500 Related Antibodies

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Description

ON 01500 is a tubulin inhibitor with a Kd of 21 nM. ON 01500 exerts microtubule-destabilizing effects in cells. ON 01500 can be used the study of cancers[1][2].

In Vitro

ON 01500 (1 μM) completely inhibits tubulin polymerization in MAP-rich tubulin samples[1].
ON 01500 (7-15 nM, 3-5 days) sensitizes cells to knockdown of TACC3 or overexpression of KIF2C and protects cells from overexpression of TACC3 or knockdown of KIF2C, with high toxicity[2].
ON 01500 (10 nM, 3-7 days) induces enrichment of L240F TUBB-expressing (mCherry-positive) K562 cells relative to wild-type cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ON 01500 Related Antibodies
Molecular Weight

393.45

Formula

C19H23NO6S
CAS No.
Appearance

Solid

SMILES

NC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

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Purity & Documentation
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ON 01500 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ON 01500592542-50-2ON01500ON-01500Microtubule/TubulinCancerstubulinInhibitorinhibitorinhibit

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