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glycosylation

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By Targets:	Acyltransferase (1) Akt (1) Amino Acid Derivatives (1) Aminotransferases (Transaminases) (1) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (2) Apoptosis (2) Bacterial (3) Biochemical Assay Reagents (18) Complement System (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (2) Drug Metabolite (3) Drug-Linker Conjugates for ADC (1) EGFR (1) Endogenous Metabolite (16) ERK (1) Estrogen Receptor/ERR (3) Fluorescent Dye (11) Fungal (5) GABA Receptor (1) Glucose-6-Phosphate Isomerase (GPI) (1) Glucosylceramide Synthase (GCS) (2) Glycosidase (2) Glycosyltransferase (3) HCV (2) HIV (2) HIV Integrase (2) Influenza Virus (4) JNK (1) Mitochondrial Metabolism (1) Monoamine Oxidase (1) Mucin (1) NF-κB (1) Notch (1) Nucleoside Antimetabolite/Analog (1) OGT (2) Oxidative Phosphorylation (1) PD-1/PD-L1 (1) Phosphomannose Isomerase (PMI) (2) PKC (3) Reference Standards (3) SARS-CoV (1) Ser/Thr Protease (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (33) Cardiovascular Disease (3) Infection (13) Inflammation/Immunology (10) Metabolic Disease (15) Neurological Disease (7)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (2) Alkynes (3)
Oligonucleotides:	Nucleotide Analogs (1) Nucleoside Analogs (1) Cytidine Nucleotide (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W040294

Methyl α-D-glucoside Methyl α-D-glucopyranoside	Biochemical Assay Reagents	Others
Methyl α-D-glucoside (Methyl α-D-glucopyranoside) can be used for protein glycosylation modification. Methyl α-D-glucoside is a kind of biological materials or organic compounds that are widely used in life science research .

HY-113230B

Galactosylhydroxylysine hydrochloride 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Galactosylhydroxylysine hydrochloride is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine hydrochloride is released during bone resorption and has been shown to be elevated in metabolic bone loss .

HY-P0095

Acetyl tetrapeptide-5	Angiotensin-converting Enzyme (ACE)	Others
Acetyl tetrapeptide-5 inhibits *glycosylation* and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .

HY-138802

ML089 1 Publications Verification	Phosphomannose Isomerase (PMI)	Metabolic Disease
ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC₅₀ of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia .

HY-125732

Decarestrictine D	Antibiotic	Infection
Decarestrictine D exhibits inhibitory activity against cholesterol levels. Decarestrictine D is utilized as receptor for glycosylation reactions to synthesize novel hybrid antibiotics .

HY-113230

Galactosylhydroxylysine	Endogenous Metabolite	Metabolic Disease
Galactosylhydroxylysine is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine is released during bone resorption and has been shown to be elevated in metabolic bone loss .

HY-164869

1-Hex-GlcNAlk	Biochemical Assay Reagents	Others
1-Hex-GlcNAlk is a metabolic chemical reporter (MCR) utilized in glycosylation research. 1-Hex-GlcNAlk exhibits robust labeling over background with negligible amounts of nonspecific chemical labeling in cell lysates .

HY-157461

Glycation-IN-1	Glycosyltransferase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Glycation-IN-1 (Compound 3) is an inhibitor of *glycosylation* reactions, which has a strong inhibitory effect on the synthesis of initial, intermediate, and final products of glycosylation reactions. Glycion-IN-1 can be used in the research of various chronic diseases, such as diabetes, immune inflammation, cardiovascular diseases and neurodegenerative diseases .

HY-164390

6′SLN Neu5Acα2-6Galβ1-4GlcNAc	Endogenous Metabolite	Infection Cancer
6′SLN is a cancer-related extracellular vesicle (EVs) surface glycan that serves as a key form of protein glycosylation in EVs. 6′SLN is also a sialic acid derivative that can interact with hemagglutinins (HAs) from human and avian influenza virus strains, making it useful for research into anti-influenza drugs .

HY-W415798

Ac4GalNAlk	Endogenous Metabolite	Others
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .

HY-N1347

Robinetin 3,3',4',5',7-Pentahydroxyflavone	Fungal HIV Integrase Bacterial	Infection
Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation .

HY-116392E

D-threo-PDMP	Glucosylceramide Synthase (GCS) Apoptosis	Neurological Disease Metabolic Disease Cancer
D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP can be used to study diseases related to targeted glycosphingolipid metabolism .

HY-N1347R

Robinetin (Standard) 3,3',4',5',7-Pentahydroxyflavone (Standard)	Reference Standards Fungal HIV Integrase Bacterial	Infection
Robinetin (Standard) is the analytical standard of Robinetin. This product is intended for research and analytical applications. Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation .

HY-W009783A

Deoxymannojirimycin hydrochloride	HIV Influenza Virus	Infection Cancer
Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . Deoxymannojirimycin hydrochloride increases high mannose structures. Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer .

HY-137042

Cyanine5 alkyne Alkyne-Cy5	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
Cyanine5 alkyne (Alkyne-Cy5) is a fluorescent dye used to label azide proteins and can be used to analyse post-translational modifications of proteins, glycosylation etc. Cyanine5 alkyne can also be used as a mitochondrial OXPHOS inhibitor to inhibit the growth of cancer stem cells (CSC) . Cyanine5 alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W009783

1-Deoxymannojirimycin hydrochloride 1 Publications Verification	HIV Influenza Virus	Infection Cancer
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. 1-Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . 1-Deoxymannojirimycin hydrochloride increases high mannose structures. 1-Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer .

HY-175697

Glycosyltransferase-IN-2	Glycosyltransferase SARS-CoV Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis	Infection
Glycosyltransferase-IN-2 (Compound 20) is a Glycosyltransferase inhibitor. Glycosyltransferase-IN-2 has a broad-spectrum anticoronavirus activity with IC₅₀s of 11.3, 5.5 and ~16.2 μM for MHV, HCoV-NL63 and SARS-CoV-2, respectively. Glycosyltransferase-IN-2 interferes with the coronavirus infectivity, alters viral protein glycosylation with inhibition of interaction with the ACE2 receptor or SC-VLP secretion, and inhibits RNA replication. Glycosyltransferase-IN-2 can be used for coronavirus infections research .

HY-E70292

N-Acetylgalactosaminyltransferase 11 GALNT11	Notch Endogenous Metabolite	Cardiovascular Disease
N-Acetylgalactosaminyltransferase 11 (GALNT11) is a glycosylation transferase capable of activating the Notch signal .

HY-W423080

TAMRA alkyne,5-isomer	Biochemical Assay Reagents Fluorescent Dye	Others
TAMRA alkyne, 5-isomer (Compound 3) is an alkyne derivative of TAMRA and can be used for the enrichment, in-gel fluorescence detection, and identification of O-GlcNAc-modified proteins. TAMRA alkyne, 5-isomer contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Azide groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-156862

(+)-Chloroquine	Angiotensin Receptor	Others
(+)-Chloroquine is a aminoquinoline drug impairs in vitro the terminal glycosylation of angiotensin-converting enzyme 2 (ACE-2) .

HY-41588

2,3,4,6-Tetra-O-acetyl-D-glucopyranose, 96%	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-acetyl-D-glucopyranose, 96% can be used in simulated glycosylation experiments.

HY-125849

Chrysin 7-O-beta-gentiobioside Chrysin 7-O-β-gentiobioside	Drug Derivative	Cancer
Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) is the glycosylation product of Chrysin .

HY-175674

NGI-235	NF-κB	Inflammation/Immunology
NGI-235 is a selective OST-A inhibitor that inhibits NF-κB inflammatory signaling by blocking TLR4 glycosylation .

HY-NP163D

Wheat germ agglutinin-AF594 WGA-AF594	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF594 (WGA-AF594) is a plant lectin that contains the fluorescent dye AF594, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF594 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163A

Wheat germ agglutinin-AF488 WGA-AF488	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF488 (WGA-AF488) is a plant lectin that contains the fluorescent dye AF488, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF488 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163

Wheat germ agglutinin-AF350 WGA-AF350	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF350 (WGA-AF350) is a plant lectin that contains the fluorescent dye AF350, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF350 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163B

Wheat germ agglutinin-AF532 WGA-AF532	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF532 (WGA-AF532) is a plant lectin that contains the fluorescent dye AF532, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF532 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163I

Wheat germ agglutinin-AF680 WGA-AF 680	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF680 (WGA-AF 680) is a plant lectin that contains the fluorescent dye AF680, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF680 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163H

Wheat germ agglutinin-AF750 WGA-AF750	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF750 (WGA-AF750) is a plant lectin that contains the fluorescent dye AF750, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF750 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163J

Wheat germ agglutinin-AF405 WGA-AF 405	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF405 (WGA-AF 405) is a plant lectin that contains the fluorescent dye AF405, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF405 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163K

Wheat germ agglutinin-AF430 WGA-AF 430	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF430 (WGA-AF 430) is a plant lectin that contains the fluorescent dye AF430, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF430 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163E

Wheat germ agglutinin-AF647 WGA-AF647	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF647 (WGA-AF647) is a plant lectin that contains the fluorescent dye AF647, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF647 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-NP163C

Wheat germ agglutinin-AF555 WGA-AF555	Fluorescent Dye	Cancer
Wheat germ agglutinin-AF555 (WGA-AF555) is a plant lectinthat contains the fluorescent dye AF555, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF555 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA .

HY-W674039

6-Azido-6-deoxy-D-glucose, 95%	Biochemical Assay Reagents	Others
6-Azido-6-deoxy-D-glucose, 95% is used for visualizing protein-specific glycosylation in living cells.

HY-W039855A

1,2,3,4-Tetra-O-benzyl-β-D-glucopyranoside, 98%	Biochemical Assay Reagents	Others
1,2,3,4-Tetra-O-benzyl-β-D-glucopyranoside is a substrate for enzymatic glycosylation reactions and glycosyltransferase assays.

HY-E70290

N-Acetylgalactosaminyltransferase 1 GALNT1	Endogenous Metabolite β-catenin Wnt	Cancer
N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .

HY-E70104

α-Rhamnosidase α-L-Rhamnosidase	Glycosidase	Others
α-Rhamnosidase is a glycoside hydrolase. α-Rhamnosidase is able to finish the enzymatic de-glycosylation of many nature flavone glycosides .

HY-W661016

1-Azido-1-deoxy-β-D-galactopyranoside, 97% 1-Azido-1-deoxy-beta-D-galactopyranoside, 97%	Biochemical Assay Reagents	Others
1-Azido-1-deoxy-β-D-galactopyranoside, 97% is extensively used in research on glycosylation processes and enzyme mechanisms.

HY-W039939

2-Azido-2-deoxy-D-glucose, 98% 2-ADG, 98%	Biochemical Assay Reagents	Others
2-Azido-2-deoxy-D-glucose, 98% is a glycosylation inhibitor, which can be used to study the mechanisms of glycosylating enzymes.

HY-W378863

Methyl 2,3,5-tri-O-benzyl-β-D-ribofuranoside	Biochemical Assay Reagents
Methyl 2,3,5-tri-O-benzyl-β-D-ribofuranoside is a glycosylation reagent that can be used in the synthesis of oligosaccharides and polysaccharides .

HY-129389

Benzyl-α-GalNAc 4 Publications Verification	Glycosyltransferase	Cancer
Benzyl-α-GalNAc is a potent *O-glycosylation* inhibitor. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, which has good potential for investigation in liver fibrosis. Benzyl-α-GalNAc also significantly enhances the anti-tumour activity of 5-Fluorouracil (HY-90006) (e.g. pancreatic cancer) by inhibiting O-glycosylation .

HY-W718137

6-Azido-6-deoxy-D-galactose，95%	Biochemical Assay Reagents	Others
6-Azido-6-deoxy-D-galactose, 95% can be used as a substrate in enzymology to study the activity and specificity of galactosyltransferases and other glycosylation enzymes.

HY-W047324

4-Aminophenyl-α-D-mannopyranoside, 98% 4-Aminophenylmannoside, 98%	Biochemical Assay Reagents	Others
4-Aminophenyl-α-D-mannopyranoside, 98% is a synthetic glycoside primarily used as a molecular tool in biochemical research for studying glycosylation processes and enzyme-substrate interactions.

HY-123628

3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate)	Drug Intermediate	Metabolic Disease
3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions .

HY-N13299

Glucoberteroin	Endogenous Metabolite	Others
Glucoberteroin is a glucosinolate, which could be isolated from Degenia velebitica. Glucoberteroin inhibits protein glycosylation and carbonylation, decreases the production of carbonyl protein, and contributes to the preventation of skin-aging .

HY-113131B

Dihydroxyacetone phosphate dilithium DHAP	Biochemical Assay Reagents Endogenous Metabolite	Others
Dihydroxyacetone phosphate dilithium (DHAP) is used for studies of fructose metabolism, trioses and glycosylation. Dihydroxyacetone phosphate dilithium is used for studies involving the metabolism of trisaccharide pools and their roles in physiological and physical processes .

HY-W013707

Cytidine-5'-triphosphate disodium dihydrate 2 Publications Verification Cytidine triphosphate disodium dihydrate; 5'-CTP disodium dihydrate	Endogenous Metabolite	Metabolic Disease
Cytidine-5'-triphosphate disodium dihydrate (5'-CTP disodium dihydrate) is a molecule of high energy, and acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation .

HY-156905

6-Azido-N-acetylgalactosamine-UDP	Biochemical Assay Reagents	Cancer
6-Azido-N-acetylgalactosamine-UDP (compound 5) is an active sugar donor in the beta-1, 3-N-Acetylhexaminyltransferase (LgtA)-catalyzed glycosylation of lactose .

HY-176559

LacNAc-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
LacNAc-VC-PAB-MMAE is a component of an Antibody-Drug Conjugate (ADC). LacNAc-VC-PAB-MMAE is assembled onto the N-glycosylation site of Trastuzumab (HY-P9907) by WT Endo-S2 .

HY-N7603

Rubrofusarin triglucoside	Monoamine Oxidase	Neurological Disease
Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC₅₀ of 85.5 μM .

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Species:	Human (10) Mouse (4) Cynomolgus (1)
Tag:	His (11) Tag Free (2) Myc (1) Fc (2)
Source:	HEK293 (5) P. pastoris (1) E. coli (9)


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glycosylation

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

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MCE Kits

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NaturalProducts

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