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binder

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118

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8

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148433
    SpdSyn binder-1

    		Parasite Infection Inflammation/Immunology
    SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria .
    SpdSyn binder-1
  • HY-149934
    DCAF1 binder 1

    		Ligands for E3 Ligase Cancer
    DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD) .
    DCAF1 binder 1
  • HY-158123
    PSMA binder-1

    		PSMA Cancer
    PSMA binder-1 is a ligand for PSMA and can be used to synthesize PSMA targeting molecule, such as Ac-PSMA-trillium .
    PSMA binder-1
  • HY-156970
    Phosphatase Binder-1

    		Phosphatase Cancer
    Phosphatase Binder-1 (comppund i-196) provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Phosphatase Binder-1 plays an important role in cancer .
    Phosphatase Binder-1
  • HY-152243
    YEATS4 binder-1

    		Histone Methyltransferase Others
    YEATS4 binder-1(4e) is a potent and selective YEATS4 binder that binds to the KAc recognition site of the YEATS structural domain with a Ki value of 37 nM .
    YEATS4 binder-1
  • HY-174237
    PBRM1/SMARCA2,4 binder-1

    		Epigenetic Reader Domain Cancer
    PBRM1/SMARCA2,4 binder-1 is a binder of PBRM1, SMARCA2, and SMARCA4 (IC50: 0.083, 0.153, and 0.046 μM, respectively) .
    PBRM1/SMARCA2,4 binder-1
  • HY-161626
    PSMA binder-3

    		PSMA Cancer
    PSMA binder-3 is a binder of PSMA.
    PSMA binder-3
  • HY-172902
    RNA binder 1

    		DNA/RNA Synthesis Neurological Disease
    RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly(GA) and poly(GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly(PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD) .
    RNA binder 1
  • HY-164344
    PCSK9 allosteric binder-1

    		PCSK9 Cardiovascular Disease
    PCSK9 allosteric binder-1 (example 70) is a PCSK9 allosteric binder. PCSK9 allosteric binder-1 can be used in the study of cardiovascular diseases .
    PCSK9 allosteric binder-1
  • HY-W595340
    E3 ubiquitin ligase binder-1

    		Ligands for E3 Ligase Cancer
    E3 ubiquitin ligase binder-1 (compound 11) is a potent E3 ubiquitin ligase binder. E3 ubiquitin ligase binder-1 is a ligand for E3 Ligase .
    E3 ubiquitin ligase binder-1
  • HY-160116
    α-Synuclein aggregate binder 1

    		Radionuclide-Drug Conjugates (RDCs) Fluorescent Dye α-synuclein Neurological Disease
    α-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for α-synuclein aggregates and can inhibit α-synuclein aggregation. α-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit α-synuclein fibril formation by blocking the aggregation process. α-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. α-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinson's disease and Lewy body dementia .
    α-Synuclein aggregate binder 1
  • HY-146186
    JAK2 JH2 binder-1

    		JAK Cancer
    JAK2 JH2 binder-1 (compound 11) is a potent and selective JAK2 JH2 binder, with a Kd of 37.1 nM. JAK2 JH2 binder-1 has the potential for various myeloproliferative neoplasms research .
    JAK2 JH2 binder-1
  • HY-156743
    DCAF1 binder 2

    		Ligands for E3 Ligase Btk Epigenetic Reader Domain Others
    DCAF1 binder 2, a ligands for E3 Ligase, involves in BRD9, kinase and selective BTK degration.
    DCAF1 binder 2
  • HY-158125
    PSMA binder-2

    		PSMA Cancer
    PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
    PSMA binder-2
  • HY-P10672
    SEI144

    		Biochemical Assay Reagents Others
    SEI144 is a low nanomolar binder of USP15 and does not inhibit USP15 activity .
    SEI144
  • HY-156215
    NCI-B16

    		HCV Infection
    NCI-B16 is a small molecule RNA binder and inhibits HCV viral replication .
    NCI-B16
  • HY-152242
    YEATS4-IN-1

    		Histone Methyltransferase Others
    YEATS4-IN-1 (Compound 4d) is a potent and selective YEATS4 binder that binds to the KAc recognition site of the YEATS structural domain with a Ki value of 33 nM .
    YEATS4-IN-1
  • HY-126782
    Lexitropsin 1

    		DNA Alkylator/Crosslinker Infection
    Lexitropsin 1 is a DNA minor groove binder with a delta G degree of 65 kJ/mol at 303 K. Lexitropsin 1 has antiviral activity .
    Lexitropsin 1
  • HY-141536
    PSMA-ALB-56

    		Drug-Linker Conjugates for ADC Cancer
    PSMA-ALB-56 is a PSMA-targeting radioligand designed by combining the glutamate-urea PSMA-binding entity and an albumin binder .
    PSMA-ALB-56
  • HY-112939
    Colestilan

    MCI-196; Colestimide

    		 Others Metabolic Disease
    Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research .
    Colestilan
  • HY-153910
    AGPS-IN-1

    		Others Cancer
    AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesenchymal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells .
    AGPS-IN-1
  • HY-N1428C
    Ferric citrate
    1 Publications Verification

    Iron(III) citrate; Zerenex

    		 Reactive Oxygen Species Antibiotic Metabolic Disease
    Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research .
    Ferric citrate
  • HY-B2225C
    Starch (pregelatinized)

    Edible corn starch (pregelatinized)

    		 Biochemical Assay Reagents Others
    Starch pregelatinized can be used as an excipient, such as Glidants, diluents, disintegrants, binders, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
    Starch (pregelatinized)
  • HY-145287
    S-MGB-234

    		DNA/RNA Synthesis Parasite Infection
    S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines .
    S-MGB-234
  • HY-116785
    BRD32048

    		DNA/RNA Synthesis Cancer
    BRD32048 is a direct binder of ETV1 with a KD of 17.1 μM. BRD32048 modulates both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 inhibits ETV1 acetylation and promotes its degradation. BRD32048 acts as a top candidate ETV1 perturbagen .
    BRD32048
  • HY-W250721D
    Carbomer

    Carboxy polymethylene

    		 Biochemical Assay Reagents Others
    Carbomer can be used as an excipient, such as Bioadhesives, emulsifiers, release modifiers, suspending agents, tablet binders, viscosity enhancers, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
    Carbomer
  • HY-W250721G
    Carbomer interpolymer

    Carboxy polymethylene (interpolymer)

    		 Biochemical Assay Reagents Others
    Carbomer interpolymer can be used as an excipient, such as Bioadhesives, emulsifiers, release modifiers, suspending agents, tablet binders, viscosity enhancers, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
    Carbomer interpolymer
  • HY-W250721E
    Carbomer copolymer

    Carboxy polymethylene (copolymer)

    		 Biochemical Assay Reagents Others
    Carbomer copolymer can be used as an excipient, such as Bioadhesives, emulsifiers, release modifiers, suspending agents, tablet binders, viscosity enhancers, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
    Carbomer copolymer
  • HY-W250721F
    Carbomer homopolymer

    Carboxy polymethylene (homopolymer)

    		 Biochemical Assay Reagents Others
    Carbomer homopolymer can be used as an excipient, such as Bioadhesives, emulsifiers, release modifiers, suspending agents, tablet binders, viscosity enhancers, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
    Carbomer homopolymer
  • HY-133821
    N-Methylmesoporphyrin IX

    		G-quadruplex Neurological Disease
    N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies .
    N-Methylmesoporphyrin IX
  • HY-B0327A
    Irsogladine maleate

    Dicloguamine maleate; MN1695

    		 mAChR Phosphodiesterase (PDE) Inflammation/Immunology
    Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
    Irsogladine maleate
  • HY-B0327
    Irsogladine
    2 Publications Verification

    Dicloguamine

    		 mAChR Phosphodiesterase (PDE) Inflammation/Immunology
    Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
    Irsogladine
  • HY-163467
    CHEMBL4224880

    		Estrogen Receptor/ERR Cancer
    CHEMBL4224880 is an estrogen receptor-α (ER-α) binder .
    CHEMBL4224880
  • HY-156499
    RNF114 ligand 1

    		Others Others
    RNF114 ligand 1 is a E3 Ubiquitin ligase binder .
    RNF114 ligand 1
  • HY-169497
    MTDB

    		Drug Intermediate Others
    MTDB is a synthetic intermediate in the synthesis of the clickable RNA pseudoknot binder MTDB-Alkyne.
    MTDB
  • HY-139645
    MtDTBS-IN-1

    		Bacterial Antibiotic Infection
    MtDTBS-IN-1 is a particularly potent binder (KD = 57 nM) and inhibitor (Ki = 5 μM) of MtDTBS.
    MtDTBS-IN-1
  • HY-139620
    MS83

    		PROTACs Cancer
    MS83 is a proof-of-concept PROTAC by linking the KEAP1 ligand to a BRD4/3/2 binder.
    MS83
  • HY-N1428CA
    Ferric citrate,suitable for cell culture

    		Biochemical Assay Reagents Others
    Ferric citrate, suitable for cell culture is an orally active iron supplement and an effective phosphate binder suitable for cell culture .
    Ferric citrate,suitable for cell culture
  • HY-144983
    E3 ligase Ligand 22

    		Ligands for E3 Ligase Cancer
    E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .
    E3 ligase Ligand 22
  • HY-144980
    E3 ligase Ligand 21

    		Ligands for E3 Ligase Cancer
    E3 ligase Ligand 21 (compound 2) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .
    E3 ligase Ligand 21
  • HY-146382
    WRNA10

    		HIV Inflammation/Immunology
    WRNA10 is a potent HIV-1 TAR RNA binder with an IC50 of 10 µM and an CC50 of 40 µM .
    WRNA10
  • HY-144985
    E3 ligase Ligand 23

    		Ligands for E3 Ligase Cancer
    E3 ligase Ligand 23 (compound 17-6) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .
    E3 ligase Ligand 23
  • HY-139325A
    NHS-Modified MMAF TFA

    		Drug-Linker Conjugates for ADC Cancer
    NHS-Modified MMAF (intermediat 210) TFA is an intermediate which can be used for producing the anti-mesothelin binder-agent conjugates (ADCs) .
    NHS-Modified MMAF TFA
  • HY-123885
    NSC243928 mesylate

    		TNF Receptor Cancer
    NSC243928 mesylate is a human lymphocyte antigen 6 (LY6) binder, which also acts as an inhibitor of cell growth and has anticancer activity .
    NSC243928 mesylate
  • HY-139325
    NHS-Modified MMAF

    		Drug-Linker Conjugates for ADC Others
    NHS-Modified MMAF (WO2012143499A2, intermediat 210) is an intermediate which can be used for producing the anti-mesothelin binder-agent conjugates (ADCs) .
    NHS-Modified MMAF
  • HY-47030
    Ferric citrate hydrate

    		Biochemical Assay Reagents Metabolic Disease
    Ferric citrate hydrate, an orally active iron supplement, is an efficacious phosphate binder. Ferric citrate hydrate can be used for iron deficiency anemia and chronic kidney disease (CKD) research .
    Ferric citrate hydrate
  • HY-149306
    MS78

    		Histone Acetyltransferase MDM-2/p53 Cancer
    MS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. MS78 recruits histone acetyltransferase p300/CBP to acetylate the p53Y220C mutant. MS78 upregulates TRAIL apoptotic genes and downregulates DNA damage response pathways. MS78 contains a CBP/p300 binder, a p53Y220C binder and a linker .
    MS78
  • HY-45072
    Croscarmellose sodium

    		Biochemical Assay Reagents Others
    Croscarmellose sodium is a commonly used pharmaceutical additive approved by the US Food and Drug Administration (FDA). Croscarmellose sodium is used as excipients, such as the suspending agent, binder, glidant, antiadherent, and disintegrants .
    Croscarmellose sodium
  • HY-156746
    DBt-10

    		PROTACs Btk Cancer
    DBt-10 is a potent BTK PROTAC degrader (DC50: 137 nM). Blue: DCAF1 binder (HY-149934); Black: linker; Pink: BTK ligand .
    DBt-10
  • HY-161452
    SOS1 Ligand intermediate-3

    		Ligands for Target Protein for PROTAC SOS1 Cancer
    SOS1 Ligand intermediate-3 (Compound 5) is an SOS1 binder that can be used together with pomalidomide (HY-10984) for the synthesis of SOS1 PROTACs .
    SOS1 Ligand intermediate-3

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