Search Result
Results for "
amide bond
" in MedChemExpress (MCE) Product Catalog:
62
Biochemical Assay Reagents
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Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-137425
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Biochemical Assay Reagents
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Others
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N-Biotinyl-12-aminododecanoic acid is a compound formed by linking biotin and 12-aminododecanoic acid through an amide bond. N-Biotinyl-12-aminododecanoic acid is used as a biotinylation reagent to test the ligation activity of SimL .
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- HY-W800632
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Biochemical Assay Reagents
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Others
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4-Azide-TFP-Amide-SS-propionic acid contains an aryl azide, a cleavable disulfide bond, and a carboxylic acid. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond. The disulfide bond can be cleaved via reducing agents.
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- HY-W800648
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Biochemical Assay Reagents
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Others
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Mal-PEG2-Amide is a PEG linker with a maleimide group which can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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- HY-174921B
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Biochemical Assay Reagents
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Others
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Maleimide-PEG-COOH (MW 3400) is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
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- HY-174921C
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Biochemical Assay Reagents
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Others
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Maleimide-PEG-COOH (MW 5000) is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
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- HY-174921
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Biochemical Assay Reagents
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Others
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Maleimide-PEG-COOH (MW 1000) is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
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- HY-174921A
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Biochemical Assay Reagents
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Others
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Maleimide-PEG-COOH (MW 2000) is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
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- HY-174904
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Biochemical Assay Reagents
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Others
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Dde Biotin-PEG4-COOH is a PEG derivative composed of Biotin, 5 PEG units, and a carboxyl group (-COOH). Biotin can form a stable non-covalent bond with streptavidin. The carboxyl group can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group.
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- HY-W190916
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Biochemical Assay Reagents
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Others
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3-[[2-[(4-azidobenzoyl)amino]ethyl]dithio]propanoicacid contains an aryl azide, a cleavable disulfide bond, and a carboxylic acid. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond. The disulfide bond can be cleaved via reducing agents.
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- HY-P4331
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Fluorescent Dye
Ser/Thr Protease
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Cardiovascular Disease
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Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for factor XIIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
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- HY-P4333
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Fluorescent Dye
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Cardiovascular Disease
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Boc-Glu(OBzl)-Gly-Arg-AMC is a fluorogenic substrate for factors IXa and XIIa. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
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- HY-P4332
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Fluorescent Dye
Ser/Thr Protease
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Cardiovascular Disease
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Boc-Glu(OBzl)-Ala-Arg-AMC is a fluorogenic substrate for coagulation factor XIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
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- HY-W1048918B
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mPEG-COOH (MW 10000)
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Biochemical Assay Reagents
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Others
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mPEG-CM (MW 10000) (mPEG-COOH (MW 10000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 10000) can be used for drug delivery .
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- HY-W1048918C
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mPEG-COOH (MW 20000)
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Biochemical Assay Reagents
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Others
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mPEG-CM (MW 20000) (mPEG-COOH (MW 20000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 20000) can be used for drug delivery .
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- HY-W1048558A
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mPEG-COOH (MW 2000)
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Biochemical Assay Reagents
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Others
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mPEG-CM (MW 2000) (mPEG-COOH (MW 2000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 2000) can be used for drug delivery .
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- HY-W1048918
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mPEG-COOH (MW 1000)
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Biochemical Assay Reagents
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Others
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mPEG-CM (MW 1000) (mPEG-COOH (MW 1000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 1000) can be used for drug delivery .
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- HY-W1048918A
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mPEG-COOH (MW 5000)
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Biochemical Assay Reagents
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Others
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mPEG-CM (MW 5000) (mPEG-COOH (MW 5000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 5000) can be used for drug delivery .
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- HY-W1048918D
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mPEG-COOH (MW 40000)
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Biochemical Assay Reagents
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Others
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mPEG-CM (MW 40000) (mPEG-COOH (MW 40000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 40000) can be used for drug delivery .
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- HY-W1048918E
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mPEG-COOH (MW 3400)
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Biochemical Assay Reagents
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Others
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mPEG-CM (MW 3400) (mPEG-COOH (MW 3400)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 3400) can be used for drug delivery .
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- HY-W190951
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Biochemical Assay Reagents
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Others
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3-((2-(2,2,2-Trifluoroacetamido)ethyl)disulfanyl)propanoic acid is a cleavable linker containing a carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The disulfide bond can be cleaved via reduction reactions.
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- HY-W700975
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Biochemical Assay Reagents
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Others
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12-Ketostearic acid sodium is a synthetic membrane probe that binds to the hydrophobic regions in lipid bilayer membranes. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
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- HY-W591461
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Liposome
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Cancer
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DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
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- HY-W800683
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Biochemical Assay Reagents
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Others
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4-Azide-TFP-Amide-SS-Sulfo-NHS consists of an aryl azide, a cleavable disulfide bond, and an NHS ester. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The NHS ester reacts with amines. The disulfide bond can be cleaved by reducing agents.
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- HY-W800726
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Biochemical Assay Reagents
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Others
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BB1-NHS ester is amine reactive at pH 7-9 to form a stable, irreversible amide bond. It was used in a unique chemselective "unclickable' bioconjugation strategy to site specifically modify proteins.
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- HY-134110
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Endogenous Metabolite
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Metabolic Disease
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Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
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- HY-W1123939
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Biochemical Assay Reagents
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Others
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Silane-PEG-COOH (MW 1000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .
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- HY-W1123939A
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Biochemical Assay Reagents
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Others
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Silane-PEG-COOH (MW 2000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .
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- HY-W1123939C
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Biochemical Assay Reagents
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Others
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Silane-PEG-COOH (MW 5000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .
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- HY-W1123939B
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Biochemical Assay Reagents
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Others
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Silane-PEG-COOH (MW 3400) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .
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- HY-Y1703
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Biochemical Assay Reagents
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Others
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HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU can be used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds .
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- HY-W592008
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Biochemical Assay Reagents
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Others
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C18-PEG5-Acid is a hybrid linker featuring a hydrophobic C18 chain and hydrophilic PEG5 spacer with a carboxylic acid. The carboxylic acid is reactive with amines to form a stable amide bond.
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- HY-W671472
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Biochemical Assay Reagents
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Others
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10-Oxononadecanedioic acid is a long alkane linker with two terminal carboxylic acid groups. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
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- HY-134055
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Arachidonic acid-N,N-dimethyl amide
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Cannabinoid Receptor
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Metabolic Disease
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Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 μM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
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- HY-W806655
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Fluorescent Dye
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Others
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Cy3.5 carboxylic acid is a fluorophore featuring a carboxylic acid. The carboxylic acid is readily attacked by amines to form a stable amide bond. Cy3.5 is a cyanine dye with excitation and emission maxima at 576 nm and 603 nm respectively.
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- HY-W1048549A
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HOOC-PEG-Thiol (MW 2000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 2000) (HOOC-PEG-Thiol (MW 2000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549B
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HOOC-PEG-Thiol (MW 3400)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 3400) (HOOC-PEG-Thiol (MW 3400)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549C
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HOOC-PEG-Thiol (MW 5000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549E
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HOOC-PEG-Thiol (MW 20000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 20000) (HOOC-PEG-Thiol (MW 20000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549D
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HOOC-PEG-Thiol (MW 10000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-174364B
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 3400) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-W440927
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Liposome
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Others
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Stearic acid-PEG-NHS, MW 2,000 is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond. Reagent grade, for research purpose.
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- HY-174364E
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 20000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364C
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 5000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 1000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-D2764
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Fluorescent Dye
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Others
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Difluorocarboxyfluorescein cadaverine, 5-isomer is a carbonyl reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond.
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- HY-174364H
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 40000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364D
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 10000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364A
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 2000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-W585390
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Fluorescent Dye
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Others
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BDP 581/591 hydrazide hydrochloride is a BDP linker containing a hydrazide. The BDP 581/591 is very photostable. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W105737
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Biochemical Assay Reagents
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Others
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18-Methoxy-18-oxooctadecanoic acid is a long alkane linker with a terminal carboxylic acid group. The terminal carboxylic acid group can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
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- HY-101884A
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Biochemical Assay Reagents
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Neurological Disease
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Biotinylated-D-lysine TFA is a conjugate of L-biotin and D-lysine, where the carboxylate of L-biotin is coupled with the ϵ-amine of D-lysine via a secondary amide bond. Biotinylated-D-lysine TFA is an isomer of the neuroanatomical tracer Biocyte.
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- HY-155070
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DNA/RNA Synthesis
Apoptosis
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Cancer
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SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer .
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- HY-169794
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DNA/RNA Synthesis
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Others
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N-Palmitoyl-phenylalanine is an N-acyl amide that contains the long-chain saturated fatty acid Palmitic acid (HY-N0830) conjugated via an amide bond to the essential amino acid L-Phenylalanine (HY-N0215). N-Palmitoyl-phenylalanine inhibits pre-mRNA splicing in HeLa cell nuclear lysates (IC50 ＞ 400 μM) but has no splicing activity in intact HeLa cells .
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- HY-W800635
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Biochemical Assay Reagents
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Others
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4-Azide-TFP-Amide-PEG4-acid contains an aryl azide and a carboxylic acid with a PEG spacer to increase aqueous solubility and decrease steric hinderance during ligation. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond.
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- HY-W888710C
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Folate-PEG-COOH (MW 1000)
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Biochemical Assay Reagents
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Others
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FA-PEG-COOH (MW 1000) (Folate-PEG-COOH (MW 1000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
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- HY-W888710A
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Folate-PEG-COOH (MW 400)
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Biochemical Assay Reagents
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Others
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FA-PEG-COOH (MW 400) (Folate-PEG-COOH (MW 400)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
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- HY-W888710D
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Folate-PEG-COOH (MW 2000)
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Biochemical Assay Reagents
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Others
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FA-PEG-COOH (MW 2000) (Folate-PEG-COOH (MW 2000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
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- HY-W888710E
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Folate-PEG-COOH (MW 3400)
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Biochemical Assay Reagents
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Others
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FA-PEG-COOH (MW 3400) (Folate-PEG-COOH (MW 3400)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
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- HY-W888710B
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Folate-PEG-COOH (MW 600)
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Biochemical Assay Reagents
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Others
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FA-PEG-COOH (MW 600) (Folate-PEG-COOH (MW 600)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
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- HY-W888710H
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Folate-PEG-COOH (MW 5000)
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Biochemical Assay Reagents
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Others
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FA-PEG-COOH (MW 5000) (Folate-PEG-COOH (MW 5000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
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- HY-W800722
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Biochemical Assay Reagents
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Others
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N-(PEG1-acid)-L-Lysine-amido-Mal is a PEG based linker with terminal malimide and carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W888710I
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Folate-PEG-COOH (MW 10000)
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Biochemical Assay Reagents
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Others
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FA-PEG-COOH (MW 10000) (Folate-PEG-COOH (MW 10000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
|
-
- HY-155885
-
|
mPEG-NH2 (MW 40000)
|
Biochemical Assay Reagents
|
Others
|
|
mPEG-amine (MW 40000) (mPEG-NH2 (MW 40000)) is a monofunctional polyPEG with a terminal amine. The coupling between NHS ester and amine produces a stable amide bond. The amine moieties is also reactive with carboxyl in the presence of activating agent .
|
-
- HY-116833
-
|
|
Drug Derivative
|
Metabolic Disease
|
|
4-Chloro-3,5-dimethylphenoxyacetic acid (compound 602 UC) is a product of masked amide bond hydrolysis of auxin analog 602 (compound 602). Auxin can effectively stimulate hypocotyl growth in wild-type seedlings .
|
-
- HY-W585383
-
|
|
Fluorescent Dye
|
Others
|
|
BDP TR hydrazide is a BDP TR linker with a hydrazide group. The BDP dye is popular for the microscopy and fluorescence polarization assays. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W800825
-
|
|
Liposome
|
Cancer
|
|
Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
|
-
- HY-126584
-
|
Val-val
|
Drug Intermediate
|
Others
|
|
H-VAL-VAL-OH (Val-val) is a dipeptide in which two valine (Val) residues are linked by an amide bond. H-VAL-VAL-OH can be used for the synthesis of some important compounds such as Poststatin (HY-125432) .
|
-
- HY-W190752
-
|
|
Biochemical Assay Reagents
|
Others
|
|
m-PEG13-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
|
-
- HY-34643
-
|
Hept-6-ynoic acid
|
Biochemical Assay Reagents
|
Others
|
|
6-Heptynoic acid (Hept-6-ynoic acid) is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.
|
-
- HY-P2498A
-
|
|
Cathepsin
|
Cancer
|
|
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
|
-
- HY-W800676
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-N-bis(PEG4-acid) is a branched click chemistry reagent. The DBCO group enables copper-free Click Chemistry reactions. carboxylic acid groups allows for reactions with primary amine groups using activators such as EDC or HATU to form a stable amide bond.
|
-
- HY-P2498
-
|
|
Cathepsin
|
Others
|
|
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
|
-
- HY-W1048547A
-
|
HOOC-PEG-Amine (MW 2000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 2000) (HOOC-PEG-Amine (MW 2000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547J
-
|
HOOC-PEG-Amine (MW 40000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 40000) (HOOC-PEG-Amine (MW 40000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547H
-
|
HOOC-PEG-Amine (MW 1000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 1000) (HOOC-PEG-Amine (MW 1000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547E
-
|
HOOC-PEG-Amine (MW 20000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 20000) (HOOC-PEG-Amine (MW 20000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547I
-
|
HOOC-PEG-Amine (MW 3400)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 3400) (HOOC-PEG-Amine (MW 3400)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547C
-
|
HOOC-PEG-Amine (MW 5000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 5000) (HOOC-PEG-Amine (MW 5000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547D
-
|
HOOC-PEG-Amine (MW 10000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 10000) (HOOC-PEG-Amine (MW 10000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W585384
-
|
|
Fluorescent Dye
|
Others
|
|
BDP 558/568 carboxylic acid is a BDP linker containing a carboxylic acid. The BDP 558/568 has similar excitation and emission wavelengths to Cy3. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-D1169
-
|
|
Fluorescent Dye
|
Others
|
|
BDP R6G carboxylic acid is a borondipyrromethene dye (Excitation: 530 nM; Emission: 548 nM). BDP R6G carboxylic acid terminal carboxylic acid can react with primary amine groups in the presence of activators to form a stable amide bond, for subsequent labeling reactions like Steglich esterification .
|
-
- HY-W190910
-
|
|
Biochemical Assay Reagents
|
Others
|
|
AZD-PEG2-acid is a PEG linker containing an AZD group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-174264
-
|
DMG-PEG2000-NHS
|
Biochemical Assay Reagents
|
Others
|
|
DMG-PEG-NHS, MW 2000 is a compound composed of Myristic acid (HY-N2041) and PEG linked by an amide bond, with NHS as an active ester group attached to the end of the PEG chain. DMG-PEG-NHS, MW 2000 can be used for protein/biomolecule modification, gene delivery and biosensor applications.
|
-
- HY-W440706
-
|
|
Liposome
|
Cancer
|
|
Cholesterol-PEG-alcohol (MW 2000) is a pegylated lipids which can be used for preparation of liposome or nanoparticle. The lipophilic moiety can encapsulate hydrophobic drugs whereas the hydrophilic PEG chain helps the overal water solubility of the micelles. The amine can react with an activated NHS ester to form a stable amide bond.
|
-
- HY-W800713
-
|
|
Biochemical Assay Reagents
|
Others
|
|
SPDP-Gly-Pro-acid is a linker with SPDP and carboxylic acid moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W800721
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyltetrazine-amido-bis-(carboxyethoxymethyl)-methane is a click chemistry PEG reagent which contains three carboxylic acid groups and a methyltetrazine group. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W190947
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Iodoacetamido-PEG8-acid is a PEG reagent containing an Iodoacetamide group and a carboxlic acid moiety. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group.
|
-
- HY-140895B
-
|
Biotin-PEG-NH2 (MW 10000)
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-Amine (MW 10000) (Biotin-PEG-NH2 (MW 10000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-140895C
-
|
Biotin-PEG-NH2 (MW 20000)
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-Amine (MW 20000) (Biotin-PEG-NH2 (MW 20000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-140895D
-
|
Biotin-PEG-NH2 (MW 40000)
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-Amine (MW 40000) (Biotin-PEG-NH2 (MW 40000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-W143822
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-(Tritylthio)hexanoic acid is a linker with a Tst group and a terminal carboxylic acid. The Tst group can be deprotected under acidic conditions to obtain the free thiol which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-D1650
-
|
|
Fluorescent Dye
|
Others
|
|
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λex=630 nm, λem=650 nm) .
|
-
- HY-133053
-
|
Hydroxy-PEG8-acid
|
Biochemical Assay Reagents
|
Others
|
|
HO-PEG8-CH2CH2COOH (Hydroxy-PEG8-acid) is a PEG derivative containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators to form a stable amide bond .
|
-
- HY-101884
-
|
(+)-Biocytin
|
Endogenous Metabolite
|
Neurological Disease
|
|
Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the -amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays .
|
-
- HY-140895A
-
|
Biotin-PEG-NH2 (MW 5000)
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-Amine (MW 5000) (Biotin-PEG-NH2 (MW 5000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-W510032
-
|
|
Biochemical Assay Reagents
|
Infection
|
|
9-Ethoxy-9-oxononanoic acid is a C-11 fatty acid that has an ethyl ester group at the end of the saturated tail. The carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Azelaic Acid Monoethyl Ester has antifungal activity against Cladosporium herbarum.
|
-
- HY-W800718
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyltetrazine-amido-Tri-(acid-PEG1-ethoxymethyl)-methane is a click chemistry PEG reagent which contains three carboxylic acid groups and a methyltetrazine group. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W190865
-
|
Biotin-PEG5-COOH
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG5-acid (Biotin-PEG5-COOH) is a biotin-PEG compound containing a carboxyl group (-COOH) that can be used to react with an amine group (NH2) to form a stable amide bond. Biotin-PEG5-acid can be used for protein labeling and drug delivery research .
|
-
- HY-W190934
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-Ala-Pro-OH is a linker with an Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-116027A
-
|
Biotin-PEG10-COOH
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG10-acid (Biotin-PEG10-COOH) is a biotin-PEG compound containing a carboxyl group (-COOH) that can be used to react with an amine group (NH2) to form a stable amide bond. Biotin-PEG10-acid can be used for protein labeling and drug delivery research .
|
-
- HY-116027B
-
|
Biotin-PEG11-COOH
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG11-acid (Biotin-PEG11-COOH) is a biotin-PEG compound containing a carboxyl group (-COOH) that can be used to react with an amine group (NH2) to form a stable amide bond. Biotin-PEG11-acid can be used for protein labeling and drug delivery research .
|
-
- HY-140015A
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid(COOH) group. The terminal carboxylic acid is reactive with primary amine groups to form a stable amide bond. (S)-TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-W572763
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tos-PEG6-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
|
-
- HY-W160298
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-Cbz-7-Aminoheptanoic acid is a six carbon linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
|
-
- HY-W190958
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Boc-NH-Tri-(carbonylethoxymethyl)-methane is a branched PEG linker with a Boc-protected amino and three terminal carboxilic acid groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-23629
-
|
|
PROTAC Linkers
|
Cancer
|
|
16-Aminohexadecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 16-Aminohexadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
|
-
- HY-W401143
-
|
|
PROTAC Linkers
|
Cancer
|
|
15-Aminopentadecanoic Acid can be used as a PROTAC linker in the synthesis of PROTACs. 15-Aminopentadecanoic Acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
|
-
- HY-W1048549J
-
|
HOOC-PEG-Thiol (MW 40000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549H
-
|
HOOC-PEG-Thiol (MW 1000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W591402
-
|
|
ADC Linker
|
Cancer
|
|
3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
|
-
- HY-108913
-
|
|
Beta-lactamase
Antibiotic
Bacterial
|
Infection
|
|
Nitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic β-lactamase substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .
|
-
- HY-W800706
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Azidobutanamide-tri-(carboxyethoxymethyl)-methane is a aqueous soluble PEG linker with an azide group with three terminal carboxylic acids. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W105727
-
|
|
PROTAC Linkers
|
Cancer
|
|
9-Aminononanoic acid can be used as a PROTAC linker and other conjugation in the synthesis of PROTACs. 9-Aminononanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
|
-
- HY-W105744
-
|
|
PROTAC Linkers
|
Cancer
|
|
10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
|
-
- HY-P4920
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .
|
-
- HY-108913R
-
|
|
Beta-lactamase
Reference Standards
Antibiotic
|
Infection
|
|
Nitrocefin (Standard) is the analytical standard of Nitrocefin. This product is intended for research and analytical applications. Nitrocefin is a chromogenic β-lactamase substrate that undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .
|
-
- HY-W800653
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-(Azido-PEG3)-NH-PEG3-t-butyl ester is a click chemistry reagent with a terminal azide group and secondary amine NH group. NH group is reactive with NHS ester, The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The azide group can participate in Click Chemistry.
|
-
- HY-101884R
-
|
(+)-Biocytin (Standard)
|
Reference Standards
Endogenous Metabolite
|
Neurological Disease
|
|
Biocytin (Standard) is the analytical standard of Biocytin. This product is intended for research and analytical applications. Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the -amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays[1][2].
|
-
- HY-P1883
-
|
|
Fluorescent Dye
|
Infection
|
|
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
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- HY-131699
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Biochemical Assay Reagents
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Others
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t-Butyl ester-PEG4-CH2COOH is a PEG linker containing a t-butyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl group can be deprotected under acidic conditions.
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- HY-W440954
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Liposome
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Others
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Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
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- HY-W800813
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Biochemical Assay Reagents
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Others
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Carboxy-Amido-PEG5-N-Boc is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-P1883A
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Fluorescent Dye
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Infection
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Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
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- HY-W097128
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PROTAC Linkers
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Cancer
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Fmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W005828
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PROTAC Linkers
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Cancer
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9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. 9-(Boc-amino)nonanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W591982
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Biochemical Assay Reagents
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Others
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t-Boc-N-amido-PEG12-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-141161A
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PROTAC Linkers
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Cancer
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(S)-TCO-PEG8-acid is a click chemistry PEG linker with a terminal carboxylic acid(COOH) group. The terminal carboxylic acid is reactive with primary amine groups to form a stable amide bond. (S)-TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. (S)-TCO-PEG8-acid is longer than (S)-TCO-PEG3-acid .
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- HY-W591967
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PROTAC Linkers
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Cancer
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N-Boc-15-aminopentadecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. N-Boc-15-aminopentadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-400361
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Biochemical Assay Reagents
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Others
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BocNH-PEG2-CH2COONHS ester is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W111228
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PROTAC Linkers
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Cancer
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Fmoc-9-aminononanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and and other conjugation applications. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W089232
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PROTAC Linkers
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Cancer
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Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W101723
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PROTAC Linkers
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Cancer
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Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W012001
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PROTAC Linkers
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Cancer
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Boc-7-Aminoheptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-7-Aminoheptanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W097110
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PROTAC Linkers
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Cancer
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Fmoc-11-aminoundecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-11-aminoundecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W403327
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Biochemical Assay Reagents
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Others
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CbzNH-PEG4-CH2COOH is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
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- HY-W591968
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PROTAC Linkers
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Cancer
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14-(Fmoc-amino)-tetradecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. 14-(Fmoc-amino)-tetradecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W009030
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PROTAC Linkers
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Cancer
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N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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-
- HY-W009056
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PROTAC Linkers
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Cancer
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Fmoc-7-amino-heptanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. Fmoc-7-amino-heptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-130695
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ADC Linker
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Cancer
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N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG derivative containing an amino group with two terminal carboxylic acids. The amino group is reactive with carboxylic acids, activated NHS esters. The terminal carboxylic acids can react with primary amine groups in the presence of activators to form a stable amide bond. N-(Amino-PEG5)-N-bis(PEG4-acid) can be useful in the development of antibody drug conjugates (ADCs) .
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- HY-W800667
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Biochemical Assay Reagents
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Others
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Hydroxy-PEG4-acid sodium is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
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- HY-W800709
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Biochemical Assay Reagents
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Others
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N-(acid-PEG10)-N-bis(PEG10-azide) is a very popular PEG reagent containing a terminal carboxylic acid and two azide groups. The hydrophilic PEG spacer increases solubility in aqueous media. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W041856
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Boc-8-aminooctanoic acid
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PROTAC Linkers
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Cancer
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N-Boc-8-amino-octanoic acid (Boc-8-aminooctanoic acid) can be used as a PROTAC linker in the synthesis of PROTACs. N-Boc-8-amino-octanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-151820
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ADC Linker
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Others
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DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
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- HY-W800839
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Biochemical Assay Reagents
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Others
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TCO-PEG4-TFP Ester is an amine-reactive labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. A 2,3,5,6-tetrafluorophenol (TFP) is a reactive ester that displays much better stability toward hydrolysis in aqueous media resulting in more efficiency and better reproducible labeling of biopolymers. TFP ester of carboxylic acids react with primary amines at the same rate as NHS ester forming covalent amide bond that is identical to one formed by the reaction between primary amines and NHS esters or sulfo-NHS esters.
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- HY-D2751
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Fluorescent Dye
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Others
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BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. BP Fluor 488 dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.
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- HY-151821
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ADC Linker
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Others
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Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
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- HY-D2765
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Biochemical Assay Reagents
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Others
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BP Fluor 405 Cadaverine is a carbonyl-reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. Another common application for BP Fluor 405 Cadaverine is cell fixing by treatment with formaldehyde or glutaraldehyde.
BP Fluor 405 is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode.
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- HY-148840
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Biochemical Assay Reagents
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Others
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Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
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- HY-79647
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N-(Fmoc-oxy)succinimide
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Biochemical Assay Reagents
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Others
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Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .
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- HY-Y0623
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HOSu; 1-Hydroxy-2,5-pyrrolidinedione
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Biochemical Assay Reagents
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Others
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N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .
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- HY-148840A
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Biochemical Assay Reagents
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Others
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Sulfo DBCO-PEG3-NHS ester TEA is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester (TEA) is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
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-
- HY-151833
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ADC Linker
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Others
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Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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-
- HY-112624J
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Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)
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Bacterial
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Others
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Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
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-
- HY-112624K
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Dextran 5; Dextran D5; Dextran T5(MW 4500-5500)
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Apoptosis
Autophagy
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Others
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|
Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
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-
- HY-158685
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MDM-2/p53
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Cancer
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|
RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1α by binding HTRF assay, respectively. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels .
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- HY-D2738
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Fluorescent Dye
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Others
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BP Fluor 532 NHS ester is an amine reactive, yellow-emitting dye routinely used to label proteins or antibodies through primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond.
BP Fluor 532 is a bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.
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-
- HY-D2772
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Biochemical Assay Reagents
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Others
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5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3).
Although the mixed isomers of 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. Purification of 5(6)-TAMRA labeled peptide and nucleotides might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer TAMRA usually give better resolution in HPLC purification that is often required in the conjugation processes.
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-
- HY-D2745
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Fluorescent Dye
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Others
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|
BP Fluor 594 NHS ester is the most popular tool for modifying proteins or antibodies through the primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules with BP Fluor 594 label. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 594 dye can be used for proteins labeling at high molar ratios without significant self-quenching, enabling brighter conjugates and more sensitive detection.
BP Fluor 594 is bright, water-soluble, and pH-insensitive from pH 4 to pH 10 red-fluorescent dye with absorption and emission maxima at 590 and 617 nm, respectively. It can be used with the 561 nm and 594 nm laser lines. BP Fluor 594 dye conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates often used for generation of stable signal in imaging and flow cytometry.
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- HY-112624E
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|
Dextran 0.8; Dextran D0.8; Dextran T0.8(MW 640-960)
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Biochemical Assay Reagents
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Others
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|
Dextran T0.8 (Dextran 0.8; Dextran T0.8(MW 640-960)) is a food additive with a porous network structure that exhibits strong hydration capacity and low browning activity. Dextran T0.8 (MW 800) can improve the coagulation of dairy products and is used as a prebiotic in baked goods. Dextran T0.8 (MW 800) is non-toxic to HeLa cells at a concentration of ~500 μg/mL and has a low relative browning rate in the Maillard reaction. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
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- HY-151738
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ADC Linker
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Others
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Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-112624B
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Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)
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Bacterial
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Others
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|
Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.
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-
- HY-112624I
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Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
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Bacterial
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Others
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|
Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
|
-
- HY-112624H
-
|
Dextran 2; Dextran D2; Dextran T2(MW 1600-2400)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T2 (Dextran 2; Dextran T2(MW 1600-2400)) is a natural high molecular weight polysaccharide, the glycosidic bonds in its structure can be recognized by endo-dextranase and exo-dextranase. Dextran T2 (MW 2,000) breaks the glycosidic bonds in the enzymatic hydrolysis mechanism, releasing products such as D-glucose, Isomaltose (IM2), and Isomaltotriose (IM3). Dextran T2 (MW 2,000) can be used as a model substrate to characterize the catalytic properties of dextranase (such as optimal pH, temperature and product specificity), and to study enzymatic mechanism research and polysaccharide degradation pathways in glycobiology. The Dextran series of compounds are also a natural polysaccharide drug carrier, which can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D1169
-
|
|
Fluorescent Dyes/Probes
|
|
BDP R6G carboxylic acid is a borondipyrromethene dye (Excitation: 530 nM; Emission: 548 nM). BDP R6G carboxylic acid terminal carboxylic acid can react with primary amine groups in the presence of activators to form a stable amide bond, for subsequent labeling reactions like Steglich esterification .
|
-
- HY-W806655
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3.5 carboxylic acid is a fluorophore featuring a carboxylic acid. The carboxylic acid is readily attacked by amines to form a stable amide bond. Cy3.5 is a cyanine dye with excitation and emission maxima at 576 nm and 603 nm respectively.
|
-
- HY-D2764
-
|
|
Fluorescent Dyes/Probes
|
|
Difluorocarboxyfluorescein cadaverine, 5-isomer is a carbonyl reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond.
|
-
- HY-W585390
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 581/591 hydrazide hydrochloride is a BDP linker containing a hydrazide. The BDP 581/591 is very photostable. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W585383
-
|
|
Fluorescent Dyes/Probes
|
|
BDP TR hydrazide is a BDP TR linker with a hydrazide group. The BDP dye is popular for the microscopy and fluorescence polarization assays. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W585384
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 558/568 carboxylic acid is a BDP linker containing a carboxylic acid. The BDP 558/568 has similar excitation and emission wavelengths to Cy3. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-D1650
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λex=630 nm, λem=650 nm) .
|
-
- HY-D2751
-
|
|
Fluorescent Dyes/Probes
|
|
BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. BP Fluor 488 dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.
|
-
- HY-D2765
-
|
|
Fluorescent Dyes/Probes
|
|
BP Fluor 405 Cadaverine is a carbonyl-reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. Another common application for BP Fluor 405 Cadaverine is cell fixing by treatment with formaldehyde or glutaraldehyde.
BP Fluor 405 is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode.
|
-
- HY-D2738
-
|
|
Fluorescent Dyes/Probes
|
|
BP Fluor 532 NHS ester is an amine reactive, yellow-emitting dye routinely used to label proteins or antibodies through primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond.
BP Fluor 532 is a bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.
|
-
- HY-D2772
-
|
|
Fluorescent Dyes/Probes
|
|
5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3).
Although the mixed isomers of 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. Purification of 5(6)-TAMRA labeled peptide and nucleotides might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer TAMRA usually give better resolution in HPLC purification that is often required in the conjugation processes.
|
-
- HY-D2745
-
|
|
Fluorescent Dyes/Probes
|
|
BP Fluor 594 NHS ester is the most popular tool for modifying proteins or antibodies through the primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules with BP Fluor 594 label. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 594 dye can be used for proteins labeling at high molar ratios without significant self-quenching, enabling brighter conjugates and more sensitive detection.
BP Fluor 594 is bright, water-soluble, and pH-insensitive from pH 4 to pH 10 red-fluorescent dye with absorption and emission maxima at 590 and 617 nm, respectively. It can be used with the 561 nm and 594 nm laser lines. BP Fluor 594 dye conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates often used for generation of stable signal in imaging and flow cytometry.
|
| Cat. No. |
Product Name |
Type |
-
- HY-137425
-
|
|
Biochemical Assay Reagents
|
|
N-Biotinyl-12-aminododecanoic acid is a compound formed by linking biotin and 12-aminododecanoic acid through an amide bond. N-Biotinyl-12-aminododecanoic acid is used as a biotinylation reagent to test the ligation activity of SimL .
|
-
- HY-174921B
-
|
|
Drug Delivery
|
|
Maleimide-PEG-COOH (MW 3400) is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174921C
-
|
|
Drug Delivery
|
|
Maleimide-PEG-COOH (MW 5000) is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174921
-
|
|
Drug Delivery
|
|
Maleimide-PEG-COOH (MW 1000) is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174921A
-
|
|
Drug Delivery
|
|
Maleimide-PEG-COOH (MW 2000) is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174904
-
|
|
Drug Delivery
|
|
Dde Biotin-PEG4-COOH is a PEG derivative composed of Biotin, 5 PEG units, and a carboxyl group (-COOH). Biotin can form a stable non-covalent bond with streptavidin. The carboxyl group can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group.
|
-
- HY-W1048918B
-
|
mPEG-COOH (MW 10000)
|
Drug Delivery
|
|
mPEG-CM (MW 10000) (mPEG-COOH (MW 10000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 10000) can be used for drug delivery .
|
-
- HY-W1048918C
-
|
mPEG-COOH (MW 20000)
|
Drug Delivery
|
|
mPEG-CM (MW 20000) (mPEG-COOH (MW 20000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 20000) can be used for drug delivery .
|
-
- HY-W1048558A
-
|
mPEG-COOH (MW 2000)
|
Drug Delivery
|
|
mPEG-CM (MW 2000) (mPEG-COOH (MW 2000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 2000) can be used for drug delivery .
|
-
- HY-W1048918
-
|
mPEG-COOH (MW 1000)
|
Drug Delivery
|
|
mPEG-CM (MW 1000) (mPEG-COOH (MW 1000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 1000) can be used for drug delivery .
|
-
- HY-W1048918A
-
|
mPEG-COOH (MW 5000)
|
Drug Delivery
|
|
mPEG-CM (MW 5000) (mPEG-COOH (MW 5000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 5000) can be used for drug delivery .
|
-
- HY-W1048918D
-
|
mPEG-COOH (MW 40000)
|
Drug Delivery
|
|
mPEG-CM (MW 40000) (mPEG-COOH (MW 40000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 40000) can be used for drug delivery .
|
-
- HY-W1048918E
-
|
mPEG-COOH (MW 3400)
|
Drug Delivery
|
|
mPEG-CM (MW 3400) (mPEG-COOH (MW 3400)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 3400) can be used for drug delivery .
|
-
- HY-W1123939
-
|
|
Drug Delivery
|
|
Silane-PEG-COOH (MW 1000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .
|
-
- HY-W1123939A
-
|
|
Drug Delivery
|
|
Silane-PEG-COOH (MW 2000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .
|
-
- HY-W1123939C
-
|
|
Drug Delivery
|
|
Silane-PEG-COOH (MW 5000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .
|
-
- HY-W1123939B
-
|
|
Drug Delivery
|
|
Silane-PEG-COOH (MW 3400) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .
|
-
- HY-W1048549A
-
|
HOOC-PEG-Thiol (MW 2000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 2000) (HOOC-PEG-Thiol (MW 2000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549B
-
|
HOOC-PEG-Thiol (MW 3400)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 3400) (HOOC-PEG-Thiol (MW 3400)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549C
-
|
HOOC-PEG-Thiol (MW 5000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549E
-
|
HOOC-PEG-Thiol (MW 20000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 20000) (HOOC-PEG-Thiol (MW 20000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549D
-
|
HOOC-PEG-Thiol (MW 10000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-174364B
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 3400) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364E
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 20000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364C
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 5000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 1000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364H
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 40000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364D
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 10000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364A
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 2000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-W888710C
-
|
Folate-PEG-COOH (MW 1000)
|
Drug Delivery
|
|
FA-PEG-COOH (MW 1000) (Folate-PEG-COOH (MW 1000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
|
-
- HY-W888710A
-
|
Folate-PEG-COOH (MW 400)
|
Drug Delivery
|
|
FA-PEG-COOH (MW 400) (Folate-PEG-COOH (MW 400)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
|
-
- HY-W888710D
-
|
Folate-PEG-COOH (MW 2000)
|
Drug Delivery
|
|
FA-PEG-COOH (MW 2000) (Folate-PEG-COOH (MW 2000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
|
-
- HY-W888710E
-
|
Folate-PEG-COOH (MW 3400)
|
Drug Delivery
|
|
FA-PEG-COOH (MW 3400) (Folate-PEG-COOH (MW 3400)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
|
-
- HY-W888710B
-
|
Folate-PEG-COOH (MW 600)
|
Drug Delivery
|
|
FA-PEG-COOH (MW 600) (Folate-PEG-COOH (MW 600)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
|
-
- HY-W888710H
-
|
Folate-PEG-COOH (MW 5000)
|
Drug Delivery
|
|
FA-PEG-COOH (MW 5000) (Folate-PEG-COOH (MW 5000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
|
-
- HY-W888710I
-
|
Folate-PEG-COOH (MW 10000)
|
Drug Delivery
|
|
FA-PEG-COOH (MW 10000) (Folate-PEG-COOH (MW 10000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
|
-
- HY-155885
-
|
mPEG-NH2 (MW 40000)
|
Drug Delivery
|
|
mPEG-amine (MW 40000) (mPEG-NH2 (MW 40000)) is a monofunctional polyPEG with a terminal amine. The coupling between NHS ester and amine produces a stable amide bond. The amine moieties is also reactive with carboxyl in the presence of activating agent .
|
-
- HY-W1048547A
-
|
HOOC-PEG-Amine (MW 2000)
|
Drug Delivery
|
|
HOOC-PEG-NH2 (MW 2000) (HOOC-PEG-Amine (MW 2000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547J
-
|
HOOC-PEG-Amine (MW 40000)
|
Drug Delivery
|
|
HOOC-PEG-NH2 (MW 40000) (HOOC-PEG-Amine (MW 40000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547H
-
|
HOOC-PEG-Amine (MW 1000)
|
Drug Delivery
|
|
HOOC-PEG-NH2 (MW 1000) (HOOC-PEG-Amine (MW 1000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547E
-
|
HOOC-PEG-Amine (MW 20000)
|
Drug Delivery
|
|
HOOC-PEG-NH2 (MW 20000) (HOOC-PEG-Amine (MW 20000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547I
-
|
HOOC-PEG-Amine (MW 3400)
|
Drug Delivery
|
|
HOOC-PEG-NH2 (MW 3400) (HOOC-PEG-Amine (MW 3400)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547C
-
|
HOOC-PEG-Amine (MW 5000)
|
Drug Delivery
|
|
HOOC-PEG-NH2 (MW 5000) (HOOC-PEG-Amine (MW 5000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547D
-
|
HOOC-PEG-Amine (MW 10000)
|
Drug Delivery
|
|
HOOC-PEG-NH2 (MW 10000) (HOOC-PEG-Amine (MW 10000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-174264
-
|
DMG-PEG2000-NHS
|
Drug Delivery
|
|
DMG-PEG-NHS, MW 2000 is a compound composed of Myristic acid (HY-N2041) and PEG linked by an amide bond, with NHS as an active ester group attached to the end of the PEG chain. DMG-PEG-NHS, MW 2000 can be used for protein/biomolecule modification, gene delivery and biosensor applications.
|
-
- HY-140895B
-
|
Biotin-PEG-NH2 (MW 10000)
|
Drug Delivery
|
|
Biotin-PEG-Amine (MW 10000) (Biotin-PEG-NH2 (MW 10000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-140895C
-
|
Biotin-PEG-NH2 (MW 20000)
|
Drug Delivery
|
|
Biotin-PEG-Amine (MW 20000) (Biotin-PEG-NH2 (MW 20000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-140895D
-
|
Biotin-PEG-NH2 (MW 40000)
|
Drug Delivery
|
|
Biotin-PEG-Amine (MW 40000) (Biotin-PEG-NH2 (MW 40000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-140895A
-
|
Biotin-PEG-NH2 (MW 5000)
|
Drug Delivery
|
|
Biotin-PEG-Amine (MW 5000) (Biotin-PEG-NH2 (MW 5000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-W190865
-
|
Biotin-PEG5-COOH
|
Drug Delivery
|
|
Biotin-PEG5-acid (Biotin-PEG5-COOH) is a biotin-PEG compound containing a carboxyl group (-COOH) that can be used to react with an amine group (NH2) to form a stable amide bond. Biotin-PEG5-acid can be used for protein labeling and drug delivery research .
|
- HY-116027A
-
|
Biotin-PEG10-COOH
|
Drug Delivery
|
|
Biotin-PEG10-acid (Biotin-PEG10-COOH) is a biotin-PEG compound containing a carboxyl group (-COOH) that can be used to react with an amine group (NH2) to form a stable amide bond. Biotin-PEG10-acid can be used for protein labeling and drug delivery research .
|
- HY-116027B
-
|
Biotin-PEG11-COOH
|
Drug Delivery
|
|
Biotin-PEG11-acid (Biotin-PEG11-COOH) is a biotin-PEG compound containing a carboxyl group (-COOH) that can be used to react with an amine group (NH2) to form a stable amide bond. Biotin-PEG11-acid can be used for protein labeling and drug delivery research .
|
- HY-W1048549J
-
|
HOOC-PEG-Thiol (MW 40000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
- HY-W1048549H
-
|
HOOC-PEG-Thiol (MW 1000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
- HY-79647
-
|
N-(Fmoc-oxy)succinimide
|
Biochemical Assay Reagents
|
|
Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .
|
- HY-Y0623
-
|
HOSu; 1-Hydroxy-2,5-pyrrolidinedione
|
Biochemical Assay Reagents
|
|
N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .
|
- HY-112624J
-
|
Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)
|
Thickeners
|
|
Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
|
- HY-112624K
-
|
Dextran 5; Dextran D5; Dextran T5(MW 4500-5500)
|
Thickeners
|
|
Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
|
- HY-112624E
-
|
Dextran 0.8; Dextran D0.8; Dextran T0.8(MW 640-960)
|
Thickeners
|
|
Dextran T0.8 (Dextran 0.8; Dextran T0.8(MW 640-960)) is a food additive with a porous network structure that exhibits strong hydration capacity and low browning activity. Dextran T0.8 (MW 800) can improve the coagulation of dairy products and is used as a prebiotic in baked goods. Dextran T0.8 (MW 800) is non-toxic to HeLa cells at a concentration of ~500 μg/mL and has a low relative browning rate in the Maillard reaction. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
|
- HY-112624B
-
|
Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)
|
Drug Delivery
Thickeners
|
|
Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.
|
- HY-112624I
-
|
Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
|
Thickeners
|
|
Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
|
- HY-112624H
-
|
Dextran 2; Dextran D2; Dextran T2(MW 1600-2400)
|
Thickeners
|
|
Dextran T2 (Dextran 2; Dextran T2(MW 1600-2400)) is a natural high molecular weight polysaccharide, the glycosidic bonds in its structure can be recognized by endo-dextranase and exo-dextranase. Dextran T2 (MW 2,000) breaks the glycosidic bonds in the enzymatic hydrolysis mechanism, releasing products such as D-glucose, Isomaltose (IM2), and Isomaltotriose (IM3). Dextran T2 (MW 2,000) can be used as a model substrate to characterize the catalytic properties of dextranase (such as optimal pH, temperature and product specificity), and to study enzymatic mechanism research and polysaccharide degradation pathways in glycobiology. The Dextran series of compounds are also a natural polysaccharide drug carrier, which can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-126584
-
|
Val-val
|
Drug Intermediate
|
Others
|
|
H-VAL-VAL-OH (Val-val) is a dipeptide in which two valine (Val) residues are linked by an amide bond. H-VAL-VAL-OH can be used for the synthesis of some important compounds such as Poststatin (HY-125432) .
|
-
- HY-P2498A
-
|
|
Cathepsin
|
Cancer
|
|
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
|
-
- HY-P4920
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .
|
-
- HY-P1883A
-
|
|
Fluorescent Dye
|
Infection
|
|
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
|
-
- HY-P5481
-
|
|
Peptides
|
Others
|
|
DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)
|
-
- HY-P4331
-
|
|
Fluorescent Dye
Ser/Thr Protease
|
Cardiovascular Disease
|
|
Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for factor XIIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
|
-
- HY-P4333
-
|
|
Fluorescent Dye
|
Cardiovascular Disease
|
|
Boc-Glu(OBzl)-Gly-Arg-AMC is a fluorogenic substrate for factors IXa and XIIa. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
|
-
- HY-P4332
-
|
|
Fluorescent Dye
Ser/Thr Protease
|
Cardiovascular Disease
|
|
Boc-Glu(OBzl)-Ala-Arg-AMC is a fluorogenic substrate for coagulation factor XIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
|
-
- HY-P2498
-
|
|
Cathepsin
|
Others
|
|
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
|
-
- HY-P1883
-
|
|
Fluorescent Dye
|
Infection
|
|
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
|
Classification |
-
- HY-151820
-
|
|
|
DBCO
|
|
DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
|
-
- HY-151821
-
|
|
|
DBCO
|
|
Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
|
-
- HY-148840
-
|
|
|
DBCO
|
|
Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
|
-
- HY-151833
-
|
|
|
Tetrazine
|
|
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-151738
-
|
|
|
Azide
|
|
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W591461
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
|
-
- HY-W440927
-
|
|
|
Pegylated Lipids
|
|
Stearic acid-PEG-NHS, MW 2,000 is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond. Reagent grade, for research purpose.
|
-
- HY-112624B
-
|
Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)
|
|
Polymers
|
|
Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.
|
-
- HY-W800825
-
|
|
|
Cationic Lipids
|
|
Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
|
-
- HY-W440706
-
|
|
|
Pegylated Lipids
|
|
Cholesterol-PEG-alcohol (MW 2000) is a pegylated lipids which can be used for preparation of liposome or nanoparticle. The lipophilic moiety can encapsulate hydrophobic drugs whereas the hydrophilic PEG chain helps the overal water solubility of the micelles. The amine can react with an activated NHS ester to form a stable amide bond.
|
-
- HY-W440954
-
|
|
|
Pegylated Lipids
|
|
Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
|
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