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SD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) AAK1 (1) Acyltransferase (1) Adrenergic Receptor (2) Akt (2) Anaplastic lymphoma kinase (ALK) (1) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (3) Apelin Receptor (APJ) (1) Apoptosis (8) Autophagy (3) Bacterial (5) Biochemical Assay Reagents (2) c-Fms (1) Calcium Channel (1) Caspase (1) Cholinesterase (ChE) (1) COX (1) DNA/RNA Synthesis (2) Dopamine Receptor (2) Drug Derivative (1) E3 Ligase Ligand-Linker Conjugates (3) Endogenous Metabolite (4) Epoxide Hydrolase (1) ERK (1) Estrogen Receptor/ERR (1) Factor Xa (1) FLT3 (1) FOXO (1) Fungal (1) FXR (1) GLP Receptor (1) GSK-3 (1) HCV (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (4) Histone Demethylase (1) HIV (1) HIV Integrase (1) HSV (1) Influenza Virus (1) Insecticide (2) Integrin (1) Isotope-Labeled Compounds (5) JAK (3) Ligands for E3 Ligase (3) Ligands for Target Protein for PROTAC (3) Lipase (1) mAChR (1) MDM-2/p53 (1) MMP (5) Molecular Glues (1) Monoamine Oxidase (2) Neprilysin (3) NF-κB (3) NO Synthase (5) P2Y Receptor (1) p38 MAPK (2) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (1) Potassium Channel (2) PROTACs (4) Reactive Oxygen Species (ROS) (2) Reference Standards (4) Small Interfering RNA (siRNA) (2) Sodium Channel (1) Somatostatin Receptor (1) STAT (11) TAM Receptor (1) TGF-beta/Smad (1) TGF-β Receptor (2) TNF Receptor (1) Toll-like Receptor (TLR) (2) Transthyretin (TTR) (1) Wnt (1) β-catenin (2)
By Research Areas:	Cancer (34) Cardiovascular Disease (20) Endocrinology (3) Infection (8) Inflammation/Immunology (16) Metabolic Disease (4) Neurological Disease (21)
Click Chemistry:	PROTAC Synthesis (2) Azide (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-11087

SD 0006 SD-06	p38 MAPK Autophagy	Inflammation/Immunology
SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC₅₀ of 110 nM for p38α .

HY-107595

SD-1008 1 Publications Verification	JAK STAT Apoptosis	Cancer
SD-1008 is a potent JAK inhibitor. SD-1008 inhibits tyrosyl phosphorylation of STAT3, JAK2 and Src. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhances apoptosis induced by Paclitaxel in ovarian cancer cells via directly blocking the JAK-STAT3 signaling pathway .

HY-112391

SD-1029 1 Publications Verification	JAK STAT	Cancer
SD-1029 is a JAK2/STAT3 inhibitor . SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation .

HY-W015445

SD-169	p38 MAPK	Metabolic Disease
SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC₅₀ of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC₅₀ of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation .

HY-161906

SD-066-4	Acyltransferase	Cancer
SD-066-4 is an orally active acyltransferase inhibitor. SD-066-4 can be used in cancer research .

HY-129602

SD-36 5+ Cited Publications	PROTACs STAT Apoptosis	Cancer
SD-36 is a potent and efficacious STAT3 PROTAC degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase . SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-110116

SD-2590 hydrochloride	MMP	Cardiovascular Disease Inflammation/Immunology Cancer
SD-2590 hydrochloride is a potent MMP inhibitor with IC₅₀ values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats .

HY-149212

SD-6	Cholinesterase (ChE)	Neurological Disease
SD-6 is an orally active inhibitor of hAChE and hBChE with IC₅₀ values of 0.907 µM and 1.579 µM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease .

HY-167092

SD-1077	Isotope-Labeled Compounds	Neurological Disease
SD-1077 is a selectively deuterated precursor of dopamine (DA). SD-1077 can be used for the study of Parkinson's disease .

HY-13227R

SD-208 (Standard)	TGF-β Receptor	Cancer
SD-208 (Standard) is the analytical standard of SD-208. This product is intended for research and analytical applications. SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-βRII.

HY-121522

SD-70	Histone Demethylase	Cancer
SD-70 is an inhibitor for histone demethylase JMJD2C and exhibits antitumor efficacy. SD-70 inhibits viability of cancer cells CWR22Rv1 (9% cell survival at 10 μM), PC3 (14% cell survival at 2 μM) and DU145 (26% cell survival at 2 μM) .

HY-169360

SD-436	PROTACs STAT
SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC₅₀: 0.5 μM), with IC₅₀ of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361); Blue: E3 ligase ligand (HY-43722); Black: linker (HY-147052) .

HY-108054

Cindunistat SD-6010	NO Synthase	Inflammation/Immunology
Cindunistat (SD-6010) is a potent, orally active and selective iNOS inhibitor .

HY-13227

SD-208 Maximum Cited Publications 8 Publications Verification	TGF-β Receptor	Cancer
SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII.

HY-121690

Semotiadil SD-3211	Calcium Channel	Cardiovascular Disease
Semotiadil (SD-3211), a benzothiazine compound, is a Ca ²⁺ antagonist. Semotiadil exerts antiplatelet activity .

HY-172946

SD-2301	PROTACs STAT	Cancer
SD-2301 is a PROTAC based STAT3 degrader (Red: STAT3 inhibitor (HY-172947), black: linker, Blue: E3 ligase ligand) .

HY-150251

SD-91 STAT3 degrader-2	PROTACs STAT	Cancer
SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a K_i of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) .

HY-164525

SD-7300 SC-81490; PF-02881307	MMP	Cancer
SD-7300 (SC-81490) is an orally active inhibitor of MMP-2, MMP-9, and MMP-13 with K_i values ??of 0.03, 0.01, and 0.03 nM, respectively. SD-7300 can reduce the degradation of extracellular matrix by tumor cells, thereby inhibiting the invasion and metastasis of tumor cells. In addition, SD-7300 is also a dose-dependent inhibitor of mouse corneal angiogenesis and an inhibitor of interleukin-1-induced bovine cartilage degradation. SD-7300 can be used in breast cancer research .

HY-148542

EpoY SD-142	Endogenous Metabolite	Cardiovascular Disease Cancer
EpoY (SD-142) acts as an irreversible inhibitor of the brain's primary tubulin tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and the small vasohibin binding protein (SVBP). By inhibiting TCP with an IC₅₀ value of approximately 500 nM, EpoY effectively decreases levels of detyrosinated alpha-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition leads to significant differentiation defects and has been linked to underlying issues associated with cancer and cardiomyopathies.

HY-B1567

Bromocyclen SD 2774; ENT 23393; Alugan	Insecticide	Others
Bromocyclen is a pesticide found in the muscle tissue of rainbow trout from Danish fisheries and in three species of fish (grill, crucian carp and pike) from the River Stell in northern Germany. High concentrations were detected ranging from 0.09 to 1.23 mg/kg fat .

HY-B1567R

Bromocyclen (Standard) SD 2774 (Standard); ENT 23393 (Standard); Alugan (Standard)	Insecticide Reference Standards	Others
Bromocyclen (Standard) is the analytical standard of Bromocyclen. This product is intended for research and analytical applications. Bromocyclen is a pesticide found in the muscle tissue of rainbow trout from Danish fisheries and in three species of fish (grill, crucian carp and pike) from the River Stell in northern Germany. High concentrations were detected ranging from 0.09 to 1.23 mg/kg fat .

HY-108054A

Cindunistat ((hydrochloride) maleate) SD-6010 hydrochloride maleate	NO Synthase	Inflammation/Immunology
Cindunistat hydrochloride maleate is a potent, orally active and selective iNOS inhibitor .

HY-119698

BAP9THP SD 8339; N-Benzyl-9-(tetrahydro-2h-pyran-2-yl)adenine	Drug Derivative	Others
BAP9THP is a synthetic cytokinin derivative and a growth regulator. BAP9THP promotes chlorophyll retention (and senescence delay) in plant tissues exceptionally strongly, and growth of tobacco callus almost as strongly as 6-Benzylaminopurine (BAP). BAP9THP induces adventitious shoot formation ignificantly more strongly than N6-isopentenyladenine or Kinetin .

HY-Y1422J

Lipase PS-SD	Biochemical Assay Reagents Lipase	Others
Lipase PS-SD comes from Burkholderiacepacia and can be used for catalytic reaction .

HY-W145523

ι-Carrageenan Viscarin SD 309	Biochemical Assay Reagents	Others
ι-Carrageenan (Viscarin SD 309) is a biochemical reagent. ι-Carrageenan can be isolated from Eucheuma serra or red algae H. musciformis and S. filiformis. ι-Carrageenan has potential application in protein emulsion flocculation and stability .

HY-172948

VHL Ligand 36	Ligands for E3 Ligase	Cancer
VHL Ligand 36 is a von Hippel-Lindau (VHL) ligand. VHL Ligand 36 can be used to synthesize SD-2301 (HY-172946) .

HY-169361

STAT3 ligand 5	STAT Ligands for Target Protein for PROTAC	Cancer
STAT3 ligand 5 is a ligand for STAT3, that can be used as target protein ligand for synthesis of PROTAC degrader SD-436 (HY-169360) .

HY-176506

Deoxy-thalidomide-alkyne-hexanoic acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Deoxy-thalidomide-alkyne-hexanoic acid is a E3 ligase ligand-linker conjugate that can be used for synthesis of PROTAC degrader SD-91 (HY-150251) .

HY-18211

CGS 35601	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC₅₀s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats .

HY-W274194

Antioxidant agent-7	Reactive Oxygen Species (ROS)	Others
Antioxidant agent-7 (SD-7) is a benzodiazepine derivative with antioxidant activity with an IC₅₀ value of 470 nM to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical .

HY-172947

STAT3-IN-42	Ligands for Target Protein for PROTAC	Cancer
STAT3-IN-42 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). STAT3-IN-42 can be used for the synthesis of SD-2301 (HY-172946) .

HY-172949

E3 Ligase Ligand-linker Conjugate 187	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 187 is a CRBN E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 187 can be used to synthesize PROTAC SD-2301 (HY-172946) .

HY-43722

Lenalidomide-Br	Ligands for E3 Ligase	Cancer
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602) .

HY-169362

Lenalidomide-Pip-butyn	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-Pip-butyn is Lenalidomide (HY-A0003)-based E3 ligase ligand-linker conjugate, and is used in the recruitment of CRBN protein. Lenalidomide-Pip-butyn can be connected to the ligand for protein to form PROTACs, such as the PROTAC STAT3 degrader SD-436 (HY-169360) .

HY-RS11650

RANGAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RANGAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for RANGAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RANGAP1 Human Pre-designed siRNA Set A RANGAP1 Human Pre-designed siRNA Set A

HY-146942S

CER5-2’S-d9	Isotope-Labeled Compounds	Others
CER5-2’S-d₉ is deuterium labeled CER5-2’S.

HY-146905S

CER6-2’S-d9	Isotope-Labeled Compounds	Others
CER6-2’S-d₉ is deuterium labeled CER6-2’S.

HY-146937S

CER11-2’S-d9	Isotope-Labeled Compounds	Others
CER11-2’S-d₉ is deuterium labeled CER11-2’S.

HY-129603

SI-109	STAT Ligands for Target Protein for PROTAC	Cancer
SI-109 is a potent STAT3 SH2 domain inhibitor (K_i=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC₅₀=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader *SD-36* .

HY-160695

PT-179	Ligands for E3 Ligase Molecular Glues	Cancer
PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms .

HY-169127

Seganserin	5-HT Receptor	Neurological Disease
Seganserin is an orally active 5-HT receptor antagonist with a plasma half-life of 26.1 ± 12.9 (S.D.) h. Seganserin can be utilized in neurological research .

HY-Y0470

Semicarbazide hydrochloride Aminourea hydrochloride; Hydrazinecarboxamide hydrochloride	Monoamine Oxidase	Cardiovascular Disease Inflammation/Immunology Endocrinology
Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles .

HY-B1497

Silver sulfadiazine AgSD	Bacterial DNA/RNA Synthesis Antibiotic	Infection
Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication .

HY-B1110AR

Nomifensine maleate (Standard)	Dopamine Receptor Adrenergic Receptor	Neurological Disease
Nomifensine (maleate) (Standard) is the analytical standard of Nomifensine (maleate). This product is intended for research and analytical applications. Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-174383

PDE3/4-IN-2	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE3/4-IN-2 (Compound 1) is a PDE3/PDE4 dual-target inhibitor, with IC₅₀ values of 0.13 nM and 50 nM against PDE3A and PDE4B1, respectively. PDE3/4-IN-2 can be used in the research of PDE-related diseases, such as asthma, obstructive pulmonary disease, sepsis, and nephritis .

HY-B1110A

Nomifensine maleate 5 Publications Verification (±)-Nomifensine maleate; Nomifensin maleate	Dopamine Receptor Adrenergic Receptor	Neurological Disease
Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-D2868

DAPI 4',6-Diamidino-2-phenylindole	Sodium Channel	Neurological Disease
DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment .

HY-105090R

Lerisetron (Standard)	Reference Standards 5-HT Receptor	Cardiovascular Disease Neurological Disease Cancer
Lerisetron (Standard) is the analytical standard of Lerisetron. This product is intended for research and analytical applications. Lerisetron is a potent 5-HT3 antagonists and possess high-affinity binding for the 5-HT3 receptors with pKi value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats .

HY-105090

Lerisetron	5-HT Receptor	Cardiovascular Disease Neurological Disease
Lerisetron is a potent 5-HT₃ antagonists and possess high-affinity binding for the 5-HT₃ receptors with pK_i value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats .

HY-168713

LZ-007	FXR	Metabolic Disease
LZ-007 is an agonist for farnesoid X receptor (FXR) with an EC₅₀ of 51 nM measuring by TR-FRET assay, or an EC₅₀ of 76 nM in HepG2 cell. LZ-007 exhibits good pharmacokinetic characheristics in SD rats. LZ-007 ameliorates western diet and CCl4 (HY-Y0298)-induced mice metabolic dysfunction-associated steatohepatitis

Cat. No.	Product Name	Type

HY-D2868

DAPI 4',6-Diamidino-2-phenylindole	Fluorescent Dyes/Probes
DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment .

Cat. No.	Product Name	Type

HY-W145523

ι-Carrageenan Viscarin SD 309	Carbohydrates
ι-Carrageenan (Viscarin SD 309) is a biochemical reagent. ι-Carrageenan can be isolated from Eucheuma serra or red algae H. musciformis and S. filiformis. ι-Carrageenan has potential application in protein emulsion flocculation and stability .

Cat. No.	Product Name	Target	Research Area

HY-P10318

SHR-2042	GLP Receptor	Endocrinology
SHR-2042 is a selective agonist of the GLP-1 receptor.SHR-2042 improves glycemic control by activating the GLP-1 receptor, enhancing insulin secretion and inhibiting glucagon secretion. SHR-2042 combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) promotes monomerization through the formation of micelles and improves oral absorption efficiency .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2021A

Phosphoramidon disodium	Cardiovascular Disease Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite
Phosphoramidon disodium, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC₅₀ of 0.4 μg/mL. Phosphoramidon disodium also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC₅₀ values of 3.5, 0.034, and 78 μM, respectively .

HY-N0108

Physcion 5+ Cited Publications Parietin; Rheochrysidin	Structural Classification Classification of Application Fields Polygonaceae Marine natural products Source classification Plants Biological Pesticide Research Agricultural Research Infection Quinones Microorganisms Anthraquinones Rheum officinale Baill. Phenols Polyphenols Marine microorganism Inflammation/Immunology Disease Research Fields Cancer	Bacterial Toll-like Receptor (TLR) NF-κB Apoptosis Autophagy Antibiotic
Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC₅₀ and K_d values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells .

HY-15449

Kaempferide 3 Publications Verification Kaempferol 4'-O-methyl ether	Infection Flavonols Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Zingiberaceae	Estrogen Receptor/ERR Autophagy Bacterial Influenza Virus Apoptosis PI3K Akt GSK-3 FOXO β-catenin
Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research .

HY-N2021

Phosphoramidon	Structural Classification Microorganisms Ketones, Aldehydes, Acids	MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite
Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC₅₀ of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC₅₀ values of 3.5, 0.034, and 78 μM, respectively .

HY-N2021AR

Phosphoramidon Disodium (Standard)	Alkaloids Structural Classification Microorganisms Source classification Indole Alkaloids	Reference Standards MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite
Indole-3-butyric acid (Standard) is the analytical standard of Indole-3-butyric acid. This product is intended for research and analytical applications. Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process .

Species:	Human (1) Virus (5)
Tag:	His (5) Fc (1)
Source:	HEK293 (5) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P702982

	RANGAP1 Protein, Human (His) KIAA1835; SD	Human	E. coli
	RANGAP1 Protein, Human (His) is the recombinant human-derived RANGAP1, expressed by E. coli , with His labeled tag. ,

HY-P7432

	SARS-CoV-2 S protein RBD-SD1 (HEK293, mFc) 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	SARS-CoV-2 S protein RBD-SD1 (HEK293, mFc) produced in HEK293 cells is a recombinant 2019-nCoV S protein receptor-binding domain (RBD) to conserved subdomains SD1 fragment with C-mFc tag.

HY-P7433

	SARS-CoV-2 S protein RBD-SD1 (HEK293, His) 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	SARS-CoV-2 S protein RBD-SD1 (HEK293, His) produced in HEK293 cells is a recombinant 2019-nCoV S protein receptor-binding domain (RBD) to conserved subdomains SD1 fragment with His tag.

HY-P73785

	NA/Neuraminidase Protein, H1N1 (ATB53863, HEK293, His) NA; Neuraminidase; NA/Neuraminidase Protein, H1N1 (A/swine/Alberta/SD0154/2016, HEK293, His)	Virus	HEK293
	NA (neuraminidase) proteins play a key role in viral transmission by catalyzing the removal of terminal sialic acid residues from viral and cellular glycoconjugates. NA plays a role in determining host range, limiting replication, and virulence. NA is associated with the development and progression of type 2 diabetes mellitus (T2D). NA/Neuraminidase Protein, H1N1 (ATB53863, HEK293, His) is the recombinant Virus-derived NA/Neuraminidase protein, expressed by HEK293 , with N-His labeled tag.

HY-P74045

	HA/Hemagglutinin Protein, H1N1 (ALZ46477, HEK293, His) HA; Hemagglutinin; HA/Hemagglutinin Protein, H1N1 (A/swine/Saskatchewan/SD0056/2014, HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis.HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions.HA/Hemagglutinin Protein, H1N1 (ALZ46477, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P74724

	NA/Neuraminidase Protein, H1N2 (QAX25989, HEK293, His) Influenza A H1N2 (A/swine/Alberta/SD0217/2017) Neuraminidase / NA (HEK293, His)	Virus	HEK293
	NA/Neuraminidase Protein is a receptor-destroying enzyme that cleaves terminal sialic acids from cellular receptors, potentially facilitating viral invasion of the upper airways by targeting sialic acid moieties on airway epithelial cell mucin.NA plays a pivotal role in viral propagation by catalyzing the removal of terminal sialic acid residues from both viral and cellular glycoconjugates.Moreover, the sialidase activity in late endosome/lysosome traffic appears to enhance virus replication.NA/Neuraminidase Protein, H1N2 (QAX25989, HEK293, His) is the recombinant Virus-derived NA/Neuraminidase protein, expressed by HEK293 , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-146905S

CER6-2’S-d9
CER6-2’S-d₉ is deuterium labeled CER6-2’S.

HY-167092

SD-1077
SD-1077 is a selectively deuterated precursor of dopamine (DA). SD-1077 can be used for the study of Parkinson's disease .

HY-146942S

CER5-2’S-d9
CER5-2’S-d₉ is deuterium labeled CER5-2’S.

HY-146937S

CER11-2’S-d9
CER11-2’S-d₉ is deuterium labeled CER11-2’S.

HY-W741021

(S)-4-Benzyl-3-propionyloxazolidin-2-one-d3
(S)-4-Benzyl-3-propionyloxazolidin-2-one-d₃ (2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-, (4S)-d₃) is the deuterium labeled (S)-4-Benzyl-3-propionyloxazolidin-2-one (HY-W008304).

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HY-P81054

	DXd Antibody (YA897) Dxd, OQM5SD32BQ, UNII-OQM5SD32BQ, Exatecan derivative, Exatecan derivative for ADC	ELISA	Species independent
	DXd Antibody (YA897) is an unconjugated, mouse-derived, anti-DXd (YA897) monoclonal antibody. DXd Antibody (YA897) can be used for: ELISA expriments in species-independent background without labeling.

HY-P82155

	RanGAP1 Antibody (YA1900) SD; Fug1; RANGAP	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	RanGAP1 Antibody (YA1900) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1900), targeting RanGAP1, with a predicted molecular weight of 64 kDa (observed band size: 64,90 kDa). RanGAP1 Antibody (YA1900) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-129602

SD-36 5+ Cited Publications		PROTAC Synthesis
SD-36 is a potent and efficacious STAT3 PROTAC degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase . SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-150251

SD-91 STAT3 degrader-2		PROTAC Synthesis
SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a K_i of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) .

HY-162356

PD-L1-IN-4		Azide
PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC₅₀ = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC₅₀ = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer .

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