Search Result
Results for "
RAW macrophages
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N2620
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- HY-125531
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Others
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Others
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Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells .
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- HY-N0569
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- HY-N7012
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5-Hydroxy-3',4',7-trimethoxyflavone
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Lipoxygenase
TNF Receptor
Interleukin Related
COX
Fungal
Parasite
Apoptosis
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Infection
Inflammation/Immunology
Cancer
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7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities sup>[4]sup>[5].
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- HY-N10297
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Others
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Inflammation/Immunology
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Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC50 value of 5.31 μM .
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- HY-W201317
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PPAR
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Metabolic Disease
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E17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs ). E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet .
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- HY-168935
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NO Synthase
TNF Receptor
Interleukin Related
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Inflammation/Immunology
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Anti-inflammatory agent 95 (Compound 2e) is an anti-inflammatory agent that exhibits the most potent anti-inflammatory activity in LPS (HY-D1056)-induced RAW 264.7 mouse macrophages.
It significantly inhibits the production of NO, with an IC50 of 8.8 μM, and reduces the secretion of TNF-α and IL-1β, with inhibition rates reaching 60% and over 90%, respectively, at a concentration of 100 μM.
Anti-inflammatory agent 95 holds promise for research in the field of inflammatory diseases .
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- HY-N8160
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Keap1-Nrf2
Reactive Oxygen Species (ROS)
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Inflammation/Immunology
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Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .
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- HY-N2838
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NO Synthase
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Inflammation/Immunology
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Alismol is a natural sesquiterpene. Alismol shows promising inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells .
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- HY-N11548
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NO Synthase
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Inflammation/Immunology
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Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages .
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- HY-N11544
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NO Synthase
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Inflammation/Immunology
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Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages .
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- HY-N1912
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Others
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Cancer
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Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .
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- HY-W573700
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Others
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Others
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Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .
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- HY-N12283
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NF-κB
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Inflammation/Immunology
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NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .
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- HY-N3289A
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Others
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Inflammation/Immunology
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(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes .
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- HY-N10114
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Others
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Inflammation/Immunology
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Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.
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- HY-N13138
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NO Synthase
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Inflammation/Immunology
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Angulasaponin B, a natural product, can be obtained from Vigna angularis. Angulasaponin B inhibits nitric oxide production in LPS-activated RAW264.7 macrophages with IC50 values ranging from 13 μM to 24 μM .
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- HY-34748
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- HY-N3383
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Ligstroside
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Mitochondrial Metabolism
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Neurological Disease
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Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages .
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- HY-N9000
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TNF Receptor
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Inflammation/Immunology
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Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .
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- HY-129151
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TNF Receptor
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Inflammation/Immunology
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Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells) .
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- HY-N10865
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NO Synthase
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Inflammation/Immunology
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Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages .
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- HY-N11570
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Others
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Inflammation/Immunology
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Phaeocaulisin E (Compound 5) is a guaiane-type sesquiterpene that inhibits LPS HY-(HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC50 of 10.3 μM .
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- HY-153762
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NO Synthase
NF-κB
COX
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Inflammation/Immunology
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COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM) .
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- HY-N6893
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NF-κB
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Inflammation/Immunology
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Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .
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- HY-N11058
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Lipoxygenase
NO Synthase
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Inflammation/Immunology
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Damnacanthol is a natural product that can be isolated from Damnacanthus major . Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells .
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- HY-N12394
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Reactive Oxygen Species (ROS)
NO Synthase
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Inflammation/Immunology
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Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity. Norwogonin-8-O-glucuronide is a flavone glycoside. Norwogonin-8-O-glucuronide inhibits NO production in macrophage RAW264.7 cells with an IC50 above 30 μM .
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- HY-N2535
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4-Hydroxy-3-methoxycinnamaldehyde
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Keap1-Nrf2
Apoptosis
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Inflammation/Immunology
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Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .
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- HY-115770
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Bacterial
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Inflammation/Immunology
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8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth . 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages .
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- HY-N15221
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NO Synthase
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Inflammation/Immunology
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12-Acetoxyganoderic acid D is a triterpenoid compound found in Ganoderma sinense. 12-Acetoxyganoderic acid D exhibits certain anti-inflammatory activity and inhibits NO production in LPS (HY-D1056) stimulated RAW 264.7 macrophages .
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- HY-N0223
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- HY-124508
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- HY-153330
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- HY-N12767
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- HY-N11262
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p38 MAPK
ERK
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Inflammation/Immunology
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Sudachitin, a polymethoxyflavone that can be isolated from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells. Sudachitin can activate the p38MAPK pathway and inhibit the ERK1/2 pathway in HaCaT cells .
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- HY-168336
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PPAR
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Metabolic Disease
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E0924G is an orally active activator for PPARδ with EC50 of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models .
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- HY-N3552
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NF-κB
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Inflammation/Immunology
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Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .
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- HY-169974
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SARS-CoV
Virus Protease
NO Synthase
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Infection
Inflammation/Immunology
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SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages .
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- HY-N2535R
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4-Hydroxy-3-methoxycinnamaldehyde (Standard)
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Reference Standards
Keap1-Nrf2
Apoptosis
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Inflammation/Immunology
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Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .
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- HY-155821
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NF-κB
NO Synthase
TNF Receptor
Interleukin Related
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Inflammation/Immunology
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Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .
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- HY-155820
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NF-κB
NO Synthase
TNF Receptor
Interleukin Related
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Inflammation/Immunology
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Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .
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- HY-N15502
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NO Synthase
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Inflammation/Immunology
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Cycloneroside A is a sesquiterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Cycloneroside A has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is approximately 100 µM. Cycloneroside A can be used in the research of the anti-inflammatory field .
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- HY-N7422
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ent-Kauran-16β,17-diol
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Apoptosis
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Inflammation/Immunology
Cancer
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Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .
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- HY-126211
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HDAC
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Inflammation/Immunology
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KBH-A42 is a novel histone deacetylase (HDAC) inhibitor with significant anti-inflammatory properties. KBH-A42 against TNF-α and NO production with IC50 values of 1.10 and 2.71 µM, respectively, in the LPS-induced murine macrophage RAW 264.7 cells .
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- HY-N15508
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NO Synthase
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Inflammation/Immunology
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Harzianoside B is a diterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Harzianoside B has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value is close to the maximum tested concentration of 100 µM. It can be used in the research of the anti-inflammatory field .
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- HY-N15506
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NO Synthase
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Inflammation/Immunology
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Cycloneroside E is a sesquiterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Cycloneroside E has the activity of inhibiting the production of NO. In macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is 48.0 µM. Cycloneroside E can be used in the research of the anti-inflammatory field .
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- HY-N15501
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NO Synthase
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Inflammation/Immunology
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Trichaspside F is a sesquiterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Trichaspside F has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is 54.8 µM. Trichaspside F can be used in the research of the anti-inflammatory field .
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- HY-13982
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JSH-23
Maximum Cited Publications
110 Publications Verification
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NF-κB
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Metabolic Disease
Inflammation/Immunology
Cancer
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JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
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- HY-128776
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TNF Receptor
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Cancer
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Antitumor agent-19 is an antitumor agent that targets tumor-associated macrophages (TAMs) and can be used as a potent TAMs modulator. Antitumor agent-19 can increase TNF-alpha levels in tumor cells with EC50 values???of 17.18 μM and 18.87 μM in RAW 264.7 cells and BMDM cells, respectively .
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- HY-W746847
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- HY-129113
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COX
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Inflammation/Immunology
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α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .
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- HY-N2939
-
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Others
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Others
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Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC50 value of 48.6 mM .
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- HY-N15505
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NO Synthase
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Inflammation/Immunology
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Cycloneroside D is a novel sesquiterpene aminoglycoside compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Cycloneroside D has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is 42.0 μM. Cycloneroside D can be used in the research of the anti - inflammatory field .
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- HY-N15504
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NO Synthase
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Inflammation/Immunology
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Cycloneroside C is a novel sesquiterpene aminoglycoside compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Cycloneroside C has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is 57.1 μM. Cycloneroside C can be used in the research of the anti - inflammatory field .
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- HY-159669
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HIV Protease
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Infection
Inflammation/Immunology
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Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .
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- HY-N10156
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- HY-105825
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SH-G 318AB
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Endogenous Metabolite
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Inflammation/Immunology
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Sermetacin (SH-G 318AB) is an anti-inflammatory agent with biocompatibility and anti-inflammatory activity. Sermetacin is stable in saline and suitable for compound delivery. Sermetacin exhibits good biocompatibility in the RAW 264.7 mouse macrophage cell line. The anti-inflammatory response of sermetacin is comparable to that of its parent compound, indomethacin. Sermetacin may show potential in future applications of self-delivery of compound delivery .
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- HY-N0569R
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Reference Standards
NO Synthase
COX
TNF Receptor
Interleukin Related
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Inflammation/Immunology
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Madecassic acid (Standard) is the analytical standard of Madecassic acid. This product is intended for research and analytical applications. Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .
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- HY-B0386R
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Reference Standards
COX
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Inflammation/Immunology
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Flunixin (meglumine) (Standard) is the analytical standard of Flunixin (meglumine). This product is intended for research and analytical applications. Flunixin meglumine is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin meglumine shows anti-inflammatory effects .
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- HY-121046
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Sch 14714
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COX
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Inflammation/Immunology
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Flunixin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin shows anti-inflammatory effects .
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- HY-B0386
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COX
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Inflammation/Immunology
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Flunixin meglumine is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin meglumine shows anti-inflammatory effects .
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- HY-158402
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Bacterial
Fungal
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Infection
Inflammation/Immunology
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Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
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- HY-13982R
-
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NF-κB
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Metabolic Disease
Inflammation/Immunology
Cancer
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JSH-23 (Standard) is the analytical standard of JSH-23. This product is intended for research and analytical applications. JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
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- HY-W082785A
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- HY-131626
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1a,1b-Dihomo PGE2
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COX
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Metabolic Disease
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1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
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- HY-163355
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COX
Lipoxygenase
NF-κB
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Inflammation/Immunology
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COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities .
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- HY-129113R
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Reference Standards
COX
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Inflammation/Immunology
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α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .
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- HY-146346
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PROTACs
HDAC
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Inflammation/Immunology
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HD-TAC7 is a potent PROTAC HDAC degrader with IC50 values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 can decreases NF-κB p65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD) .
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- HY-N1482
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Parasite
TNF Receptor
Interleukin Related
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Inflammation/Immunology
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Methyl palmitate is a naturally occurring fatty acid ester. Methyl palmitate is a potent inhibitor of ΙκB phosphorylation. Methyl palmitate modulates macrophage activity and down-regulates pro-inflammatory mediators such as TNF-α and nitric oxide (NO). Methyl palmitate possesses anti-inflammatory and antifibrotic effects. Methyl palmitate can inhibit LPS (HY-D1056)-induced Kupffer cells and rat peritoneal macrophages. Methyl palmitate is able to inhibit the phagocytic function of RAW cells. Methyl palmitate is antagonistic to muscarinic receptors. Methyl palmitate exerts cardioprotective effects against ischemia/reperfusion injury in vivo. Methyl palmitate is highly toxic against adult T. cinnabarinus .
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- HY-N3364
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Flavivirus
Dengue Virus
TNF Receptor
NF-κB
NO Synthase
COX
JNK
p38 MAPK
IKK
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Infection
Inflammation/Immunology
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Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM) .
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- HY-W341547
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Adrenergic Receptor
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Inflammation/Immunology
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3,4-Dihydro-6,7-isoquinolinediol (compound 7) is a β2-AR agonist with an EC50 of 106.9 μM in CH-K1/GA1S cells. 3,4-Dihydro-6,7-isoquinolinediol can also inhibit the production of NO in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide, showing anti-inflammatory activity .
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- HY-146066
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nAChR
JAK
STAT
NO Synthase
Interleukin Related
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Inflammation/Immunology
|
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .
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-
- HY-148553
-
|
Others
|
Inflammation/Immunology
|
Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation .
|
-
- HY-N4137
-
-
- HY-N4137R
-
-
- HY-113099R
-
Indole-3-lactic acid (Standard)
|
Reference Standards
Endogenous Metabolite
|
Inflammation/Immunology
|
Indolelactic acid (Standard) is the analytical standard of Indolelactic acid. This product is intended for research and analytical applications. Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity[1][3][4].
|
-
- HY-113099
-
Indole-3-lactic acid
|
Endogenous Metabolite
|
Inflammation/Immunology
|
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity .
|
-
- HY-138989
-
|
Lipoxygenase
|
Inflammation/Immunology
|
15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation .
|
-
- HY-N1546
-
|
Others
|
Inflammation/Immunology
|
Protoplumericin A is a bioactive ingredient of Plumeria obtusa L. attenuates. Protoplumericin A mitigated lipopolysaccharide (LPS) -induced acute lung injury in mice. Protoplumericin A can be used to study the LPS-induced anti-inflammatory effect .
|
-
- HY-P2624
-
|
PAK
|
Metabolic Disease
|
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .
|
-
- HY-N3001
-
|
STAT
VEGFR
Bcl-2 Family
Survivin
IAP
NF-κB
Apoptosis
Caspase
|
Neurological Disease
Inflammation/Immunology
Cancer
|
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .
|
-
- HY-176256
-
|
STING
|
Cancer
|
endo-S-cGAFMP (Compound 3) is a STING agonist. endo-S-cGAFMP induces the production of interferon regulatory factors and proinflammatory cytokines by activating the cGAS-STING pathway, thereby enhancing innate and adaptive immune responses. endo-S-cGAFMP has potent immunostimulatory capacity in THP1 monocytes and RAW macrophages (EC50 values of 2.45 μM and 5.54 μM, respectively). endo-S-cGAFMP has significant antitumor activity. endo-S-cGAFMP can be used as a potential cancer immunotherapeutic agent, especially for studies of systemic administration .
|
-
- HY-N8719
-
7-Hydroxy-4'-methoxyflavone
|
NF-κB
|
Inflammation/Immunology
|
Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer .
|
-
- HY-W013435
-
|
Fluorescent Dye
|
Others
|
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .
|
-
- HY-151614
-
|
Bacterial
|
Infection
|
Anti-infective agent 7 is a potent anti-infectious agent. Anti-infective agent 7 has anti-infection activity against P. falciparum (IC50=2.5 μM) and M. tuberculosis (MIC=9 μM) .
|
-
- HY-151188
-
|
NO Synthase
TNF Receptor
|
Inflammation/Immunology
|
DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1 .
|
-
- HY-151612
-
|
Parasite
|
Infection
|
Anti-infective agent 6 (compound 28) is a potent anti-infectious agent. Anti-infective agent 6 shows a good activity against P. falciparum F32-ART (IC50=1.4 μM) with a good selectivity index (SI>36). Anti-infective agent 6 also shows a potency against L. donovani (IC50=3.5 μM) .
|
-
- HY-169859
-
|
Prostaglandin Receptor
Interleukin Related
|
Inflammation/Immunology
Cancer
|
EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD 8+ T cells into tumors in a CT26 murine colon cancer model .
|
-
- HY-146066A
-
|
nAChR
JAK
STAT
NO Synthase
|
Others
|
(R)-α7 nAchR-JAK2-STAT3 agonist 1 is the R-enantiomer of α7 nAchR-JAK2-STAT3 agonist 1 (HY-146066). α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .
|
-
- HY-100911
-
|
Calmodulin
|
Neurological Disease
|
W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC50 value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912) .
|
-
- HY-155031
-
|
Reactive Oxygen Species (ROS)
COX
|
Inflammation/Immunology
Cancer
|
MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA) .
|
-
- HY-124958
-
|
NF-κB
Dipeptidyl Peptidase
|
Metabolic Disease
Inflammation/Immunology
|
NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al .
|
-
- HY-N0222
-
-
- HY-W587743
-
AMK hydrochloride
|
Prostaglandin Receptor
PGE synthase
COX
Reactive Oxygen Species (ROS)
|
Neurological Disease
Metabolic Disease
|
N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin (HY-B0075). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinson's disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases
|
-
Cat. No. |
Product Name |
Type |
-
- HY-W013435
-
|
Fluorescent Dyes/Probes
|
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .
|
Cat. No. |
Product Name |
Type |
-
- HY-34748
-
Ethylideneacetone; (3Z)-pent-3-en-2-one
|
Cell Assay Reagents
|
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .
|
-
- HY-159669
-
|
Cell Assay Reagents
|
Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P2624
-
|
PAK
|
Metabolic Disease
|
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N2620
-
-
-
- HY-125531
-
-
-
- HY-N0569
-
-
-
- HY-N7012
-
5-Hydroxy-3',4',7-trimethoxyflavone
|
Structural Classification
Monophenols
Flavonoids
Classification of Application Fields
Flavones
Labiatae
Source classification
Phenols
Plants
Swartzia polyphylla DC.
Inflammation/Immunology
Disease Research Fields
|
Lipoxygenase
TNF Receptor
Interleukin Related
COX
Fungal
Parasite
Apoptosis
|
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities sup>[4]sup>[5].
|
-
-
- HY-N1912
-
-
-
- HY-N10297
-
-
-
- HY-N8160
-
-
-
- HY-N2838
-
-
-
- HY-N11548
-
-
-
- HY-N11544
-
-
-
- HY-W573700
-
-
-
- HY-N12283
-
-
-
- HY-N3289A
-
-
-
- HY-N10114
-
-
-
- HY-N13138
-
-
-
- HY-N3383
-
-
-
- HY-N9000
-
-
-
- HY-129151
-
-
-
- HY-N10865
-
-
-
- HY-N11570
-
-
-
- HY-N6893
-
-
-
- HY-N11058
-
-
-
- HY-N12394
-
-
-
- HY-N2535
-
-
-
- HY-115770
-
-
-
- HY-N15221
-
-
-
- HY-N0223
-
-
-
- HY-124508
-
-
-
- HY-N12767
-
-
-
- HY-N11262
-
-
-
- HY-N3552
-
-
-
- HY-N2535R
-
-
-
- HY-N15502
-
-
-
- HY-N7422
-
-
-
- HY-N15508
-
-
-
- HY-N15506
-
-
-
- HY-N15501
-
-
-
- HY-129113
-
-
-
- HY-N2939
-
-
-
- HY-N15505
-
|
Structural Classification
Microorganisms
Terpenoids
Sesquiterpenes
Source classification
|
NO Synthase
|
Cycloneroside D is a novel sesquiterpene aminoglycoside compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Cycloneroside D has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is 42.0 μM. Cycloneroside D can be used in the research of the anti - inflammatory field .
|
-
-
- HY-N15504
-
|
Structural Classification
Microorganisms
Terpenoids
Sesquiterpenes
Source classification
|
NO Synthase
|
Cycloneroside C is a novel sesquiterpene aminoglycoside compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Cycloneroside C has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is 57.1 μM. Cycloneroside C can be used in the research of the anti - inflammatory field .
|
-
-
- HY-N10156
-
-
-
- HY-N0569R
-
-
-
- HY-129113R
-
-
-
- HY-N1482
-
-
-
- HY-N3364
-
-
-
- HY-N4137
-
-
-
- HY-N4137R
-
-
-
- HY-113099R
-
-
-
- HY-113099
-
-
- HY-N1546
-
-
- HY-N3001
-
-
- HY-N8719
-
-
- HY-N0222
-
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W746847
-
|
Epibetulinic acid-d3 is the deuterium labeled Epibetulinic acid (HY-N0223). Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity .
|
-
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