endo-S-cGAFMP 

endo-S-cGAFMP (Compound 3) is a STING agonist. endo-S-cGAFMP induces the production of interferon regulatory factors and proinflammatory cytokines by activating the cGAS-STING pathway, thereby enhancing innate and adaptive immune responses. endo-S-cGAFMP has potent immunostimulatory capacity in THP1 monocytes and RAW macrophages (EC₅₀ values of 2.45 μM and 5.54 μM, respectively). endo-S-cGAFMP has significant antitumor activity. endo-S-cGAFMP can be used as a potential cancer immunotherapeutic agent, especially for studies of systemic administration^[1].

692.47

C₂₀H₂₃FN₁₀O₁₁P₂S

F[C@@H]1[C@H](O2)[C@@H](CSP(O)(O[C@@H]3[C@H](O)[C@@H](COP2(O)=O)O[C@H]3N(C=N4)C5=C4C(NC(N)=N5)=O)=O)O[C@H]1N6C=NC7=C6N=CN=C7N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Simpa K. Yeboah, et al. 5′-Phosphorothioester Linked Cyclic Dinucleotides, Endo-S-CDNs, Displaying Impressive Antitumor Activities In Vivo when Dosed Subcutaneously. ACS Bio & Med Chem Au 0, 0, pp.