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Polyvinylpyrrolidone, averageMw～10000 is a multifunctional synthetic polymer with an average molecular weight of 10,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Polyoxyethylene (10) stearyl ether (Polyethylene glycol octadecyl ether, n～10, averageMn～711) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Polyoxyethylene (100) stearyl ether (Polyethylene glycol octadecyl ether, n～100, averageMn～4670) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
Polyethylenimine (branched) (30% in water) is a organic macromolecule with high cationic-charge-density potential. Polyethylenimine (branched) (30% in water) can ensnare DNA as well as attach to cell membrane. Polyethylenimine (branched) (30% in water) also retains a substantial buffering capacity at virtually any pH. Polyethylenimine (branched) (30% in water) is widely used as transfection reagent .
Polyacrylamide, averageMn 150000 (PAM, averageMn 150000) is a multifunctional polymer with moisturizing properties. Polyacrylamide,averageMn 150000 is a kind of biological materials or organic compounds that are widely used in life science research .
Polyacrylamide, averageMn 40000 (PAM, averageMn 40000) is a multifunctional polymer with moisturizing properties. Polyacrylamide,averageMn 40000 is a kind of biological materials or organic compounds that are widely used in life science research .
Polyoxyethylene(7) oleyl ether (Polyethylene glycol oleyl ether, averageMn～577; Polyethylene glycol monooleyl ether, n～7) is a nonionic surfactant. Polyoxyethylene(7) oleyl ether can be used as cosmetic raw .
Polyoxyethylene(2) oleyl ether (Polyethylene glycol oleyl ether, averageMn～357; Polyethylene glycol monooleyl ether, n～2) is a nonionic surfactant. Polyoxyethylene(2) oleyl ether promoting the formation of spherical-shaped nanosystems with a narrow size distribution. Polyoxyethylene(2) oleyl ether can be used for the delivery of several active compounds .
OHC-PEG-COOH (MW 10000) (OHC-PEG-carboxyl (MW 10000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 10000) can be used for drug delivery .
N3-PEG-SCM (MW 10000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 10000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
BOC-NH-PEG-NH2 (MW 10000) (Boc-NH-PEG-Amine (MW 10000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 10000) is an important cross-linker with PEG chains .
Boc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 10000) is an important cross-linker with PEG chains .
Acrylate-PEG-acrylate (MW 10000) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Mal-PEG-OH (MW 10000) (Maleimide-PEG-Hydroxy (MW 10000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 10000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .
Polyethylenimine (branched) (MW 25000) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
H2N-PEG-SH (MW 10000) (Amine-PEG-Thiol (MW 10000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 10000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
Biotin-PEG-COOH (MW 10000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 10000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Polyvinylpyrrolidone, average Mw~40000 is a multifunctional synthetic polymer with an average molecular weight of 40,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Polyvinylpyrrolidone, average Mw～55000 is a multifunctional synthetic polymer with an average molecular weight of 55,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Polyvinylpyrrolidone, average Mw～360000 is a multifunctional synthetic polymer with an average molecular weight of 360,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Fmoc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 10000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
Polyvinylpyrrolidone, average Mw~1300000 is a multifunctional synthetic polymer with an average molecular weight of 1,300,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
MN-25 (compound 4a) is an orally active indolpyridone that serves as a novel cannabinoid ligand. MN-25 has Ki of 245 nM and 11 nM for CB1 and CB2. MN-25 has CB2 agonist activity and inhibits TNF-R release in human peripheral blood mononuclear cells in vitro with an IC50 of 33 μM. MN-25 shows efficacy in a mouse acute inflammation model at oral doses up to 50 mg/kg >[1].
Mal-PEG-SCM (MW 10000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 10000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models .
Mal-PEG-NH2 TFA (MW 10000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
DSPE-PEG-CHO ammonium (MW 10000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 10000) can be used for drug delivery .
Phospholipid-PEG-Biotin (MW 10000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
Mn007 is a potent inhibitor of bovine pancreatic DNase I, with the IC50 of 45 μM, by forming molecular aggregation. Mn007 shows suppression of S. pyogenes growth in human whole blood .
Dextran T10 MW 10,000 (Dextran D10; Dextran T10 MW 8000-12000) is a polymer of anhydroglucose with the average molecular weight of 10000. Dextran T10 MW 10,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery .
Mn(II) protoporphyrin IX is a potential intravenous paramagnetic magnetic resonance contrast agent. Mn(II) protoporphyrin IX maintains strong paramagnetic properties .
PCL-PEG-PCL diacrylate (MW 800) is an amphiphilic triblock copolymer composed of PEG and two polycaprolactones (PCL). PCL-PEG-PCL diacrylate (MW 800) can be cross-linked by free radical polymerization and/or photopolymerization to form a cross-linked hydrogel network .
PCL-PEG-PCL diacrylate (MW 800) is an amphiphilic triblock copolymer composed of PEG and two polycaprolactones (PCL). PCL-PEG-PCL diacrylate (MW 800) can be cross-linked by free radical polymerization and/or photopolymerization to form a cross-linked hydrogel network .
Linear B trisaccharide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
Poly(ethylene glycol) diacrylate (MW 10000) (PEGDA (MW 10000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 10000) can be used in the formation of a cross-linked polymers .
PEG10000 (Polyethylene glycol 10000) can be used as a solubilizer. PEG10000 is a kind of biological materials or organic compounds that are widely used in life science research .
mPEG-SS (MW 10000) (mPEG-Succinimidyl Succinate ester (MW 10000)) is a mPEG-NHS ester reagent with a C2 aliphatic ester bond between PEG and NHS ester. mPEG-SS (MW 10000) can be used for drug delivery .
MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity .
Denibulin (MN-029) hydrochloride is an anti-angiogenic agent with anticancer activity. It can cause rapid closure of blood vessels in solid tumors and lead to dose-dependent killing of tumor cells, effectively enhancing the antitumor effects of radiation and cisplatin chemotherapy .
Cholesterol-PEG-Cholesterol (MW 10000) (CLS-PEG-CLS (MW 10000)) is a cholesterol-modified PEG derivative. Cholesterol-PEG-Cholesterol (MW 10000) can be combined with liposomes to form nanolipid carriers for drug delivery .
mPEG-CM (MW 10000) (mPEG-COOH (MW 10000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 10000) can be used for drug delivery .
m-PEG-Vinylsulfone (MW 10000) (m-PEG-VS (MW 10000)) is a PEG derivative that modulates the release of drugs from microparticle systems for parenteral administration. m-PEG-Vinylsulfone (MW 10000) can be used in drug delivery studies .
DBCO-PEG-FA (MW 10000) (DBCO-PEG-Folate (MW 10000)) is a copolymer that uses PEG as a bridge to connect dibenzocyclooctyne (DBCO) and Folic acid (FA) (HY-16637). DBCO-PEG-FA (MW 10000) can be used in a variety of bioconjugation and drug delivery .
Blue dextran (MW 10000) (Dextran blue (MW 10000)) is a conjugate of dextran and Cibacron Blue 3G-A ligand, mainly used for purification of human serum albumin .
Hyaluronic acid methacryloyl (MW 10000) (HAMA (MW 10000)) is a Hyaluronic acid (HY-B0633A) derivative. Hyaluronic acid methacryloyl-based material system has been applied in many biomedical research fields .
DBCO-PEG-SH (MW 10000) (DBCO-PEG-Thiol (MW 10000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
RB-PEG-COOH (MW 10000) (Rhodamine B-PEG-COOH (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a COOH. RRB-PEG-COOH (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
RB-PEG-OH (MW 10000) (Rhodamine B-PEG-OH (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a Hydroxyl group. RB-PEG-OH (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
8-Arm PEG-SH (MW 10000) (8-Arm PEG-Thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW 10000) can be used for drug delivery .
RB-PEG-DSPE (MW 10000) (Rhodamine B-PEG-DSPE (MW 10000)) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG-DSPE (MW 10000) can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em = 546/610 nm) .
RB-PEG-RB (MW 10000) (Rhodamine B-PEG-Rhodamine B (MW 10000)) a fluorescent dye composed of two Rhodamine B (HY-Y0016) and PEG. RB-PEG-RB (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
RB-PEG-Mal (MW 10000) (Rhodamine B-PEG-Mal (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Maleimide (HY-W007324) (Mal). RB-PEG-Mal (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
FITC-HA (FITC-Hyaluronate) (MW 10000) is a fluorescent dye composed of FITC (HY-66019) and Hyaluronic acid (HY-B0633A) (HA). FITC-HA (FITC-Hyaluronate) (MW 10000) can be used for cell tracing and drug delivery .
Biotin-PEG-SH (MW 10000) (Biotin-PEG-Thiol (MW 10000)) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
RB-PEG-NHS (MW 10000) (Rhodamine B-PEG-NHS (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a hydroxysuccinimide (NHS) group. The NHS group can react with amine-containing groups. RB-PEG-NHS (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 10000) (Rhodamine B-PEG-FA (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 10000) can be used for cell imaging, folate receptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-Biotin (MW 10000) (Rhodamine B-PEG-Biotin (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a Biotin. Biotin can bind with high affinity to streptavidin or avidin. RB-PEG-Biotin (MW 10000) plays an important role in the specific capture and detection of biomolecules (Ex/Em = 546/610 nm) .
FITC-mPEG (MW 10000) is a fluorescent dye composed of methoxypolyethylene glycol (mPEG) and FITC (HY-66019). FITC-mPEG (MW 10000) can be used for fluorescent labeling and imaging .
Dopamine-PEG-N3 (MW 10000) (Dopamine-PEG-Azide (MW 10000)) is a compound composed of dopamine, PEG segments and an azide group (-N3). Dopamine-PEG-N3 (MW 10000) can be used as a crosslinker to connect different materials together to build new composite materials and improve the performance of materials. Dopamine-PEG-N3 (MW 10000) is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group.
4Arm-PEG-RB (MW 10000) (4Arm-PEG-Rhodamine B (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016) and PEG with a four-arm structure. 4Arm-PEG-RB (MW 10000) can be used for drug delivery and fluorescence imaging (Ex/Em = 546/610 nm) .
Amine-PEG-OH (MW 10000) (H2N-PEG-OH (MW 10000)) is a heteroterminal bifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces .
MN1 Human Pre-designed siRNA Set A contains three designed siRNAs for MN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mn1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mn1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Rhodamine-PEG (MW 10000) a fluorescent PEG derivative composed of Rhodamine B (HY-Y0016) and PEG. Rhodamine-PEG (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
4-Arm PEG-Azide (MW 10000) (4-Arm PEG-N3 (MW 10000)) is a multi-arm PEG derivative with an azide group at each end of four arms attached to a pentaerythritol core .
N3-PEG-NH2 (MW 10000) (Azide-PEG-Amine (MW 10000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 10000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
PLGA10000-PEG3000-VS (PLGA10000-PEG3000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLGA10000-PEG2000-VS (PLGA10000-PEG2000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLLA10000-PEG1000-VS (PLLA10000-PEG1000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLLA10000-PEG3000-VS (PLLA10000-PEG3000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLLA10000-PEG5000-VS (PLLA10000-PEG5000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLLA10000-PEG2000-VS (PLLA10000-PEG2000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
FITC-PEG-COOH (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a COOH. FITC-PEG-COOH (MW 10000) can be used for fluorescent labeling and imaging .
FITC-PEG-OH (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Hydroxyl group. FITC-PEG-OH (MW 10000) can be used for fluorescent labeling and imaging .
FITC-PEG-SH (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a sulfhydryl (SH). FITC-PEG-SH (MW 10000) can be used for fluorescent labeling and imaging .
FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
Cy5 HA (MW 10000) is a hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 633/670 nm).
Cy3 HA (MW 10000) is a hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 550/570 nm).
Cy7 HA (MW 10000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
BOC-NH-PEG-FA (MW 10000) (BOC-NH-PEG-Folate (MW 10000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folate receptors and can be used for cell membrane receptors for targeted drug delivery .
DSPE-PEG-Maleimide (MW 10000) ammonium has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide (MW 10000) ammonium can be used in drug delivery research .
Cholesterol-PEG-alcohol (MW 10000) is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG-alcohol (MW 10000) can be used in drug delivery research .
FITC-PEG-biotin (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Biotin (HY-B0511). FITC-PEG-biotin (MW 10000) can be used for fluorescent labeling and imaging .
4-Arm-PEG-DA (MW 10000) (4-Arm-PEG-Acrylate (MW 10000)) is a polymer consisting of a four-arm PEG core structure with acrylate groups attached to the ends of each PEG chain by chemical reaction, which can be used for drug delivery .
Leucoberbelin blue I (LBB) is a leuco base that is oxidized by manganese through a hydrogen atom transfer reaction forming a colored complex. Leucoberbelin blue I can be used to quantify or confirm the Mn (II) oxides formation .
DSPE-PEG-FITC (MW 10000) is an amphiphile PEG polymer which has unsaturated lipid tails. DSPE-PEG-FITC (MW 10000) can form micelles in an aqueous solution and can be used to prepare liposome/nano particles for drug nanocarriers .
FITC-PEG-MAL (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and Maleimide (HY-W007324) (MAL). FITC-PEG-MAL (MW 10000) can be used for fluorescent labeling and imaging .
Biotin-PEG-Amine (MW 10000) (Biotin-PEG-NH2 (MW 10000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
RB-PEG-SH (MW 10000) (Rhodamine B-PEG-SH (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em = 546/610 nm) .
DBCO-PEG-OH (MW 10000) is a PEG derivative composed of DBCO, PEG, and hydroxyl groups. DBCO-PEG-OH (MW 10000) contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
PLLA10000-PEG5000-BIO is a polylactic acid derivative that can form micelles in water. In addition, PLLA10000-PEG5000-BIO can bind tightly to avidin or streptavidin for protein labeling. PLLA10000-PEG5000-BIO can be used in drug delivery research .
PLLA10000-PEG1000-BIO is a polylactic acid derivative that can form micelles in water. In addition, PLLA10000-PEG1000-BIO can bind tightly to avidin or streptavidin for protein labeling. PLLA10000-PEG1000-BIO can be used in drug delivery research .
PLLA10000-PEG2000-BIO is a polylactic acid derivative that can form micelles in water. In addition, PLLA10000-PEG2000-BIO can bind tightly to avidin or streptavidin for protein labeling. PLLA10000-PEG2000-BIO can be used in drug delivery research .
2-Arm PEG-Mal (MW 10000) is a multi-arm PEG derivative with maleimide groups at each end of the eight arms. 2-Arm PEG-Mal (MW 10000) can be used for drug delivery .
8-Arm PEG-Mal (MW 10000) is a multi-arm PEG derivative with maleimide groups at each end of the eight arms. 8-Arm PEG-Mal (MW 10000) can be used for drug delivery .
8-Arm-PEG-Biotin (MW 10000) is a multiarmed PEG derivative with biotin at each terminal of the eight arms. 8-Arm-PEG-Biotin (MW 10000) is for PEGylation by binding to streptavidin and avidin with high affinity and specificity .
4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
MN551 is a potent inhibitor of cysteine-directed electrophilic covalent that plays important roles in the biology of SOCS2 and its CRL5 complex, and as E3 ligase handles in proteolysis targeting chimera (PROTACs) to induce targeted protein degradation .
Dextran sulfate sodium salt (DSS) (MW 6500-10000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 6500-10000) has antiviral activity against HIV-1 and HIV-2. Dextran sulfate sodium salt (MW 6500-10000) blocks the binding of virions to CD4 ⁺ T lymphocytes and inhibits syncytia formation. Dextran sulfate sodium salt (MW 6500-10000) also prevents experimental urolithiasis due to its cytoprotective actions. Moreover, because of its biocompatible and highly charged properties, Dextran sulfate sodium salt (MW 6500-10000) is a suitable choice for pharmaceutical systems .
HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
Silane-PEG-N3 (MW 10000) (Silane-PEG-azide (MW 10000)) is a PEG derivative composed of silane, PEG units, and azide groups, which can be used to modify glass, silicon, or other surfaces by reacting hydroxyl groups with ethoxy (methoxy) silanes. Silane-PEG-N3 (MW 10000) contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
FITC-PEG-NH2 (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and an amino group. FITC-PEG-NH2 (MW 10000) can be used for fluorescent labeling and imaging .
4Arm-PEG-FITC (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG) and 4 FITC (HY-66019) groups. 4Arm-PEG-FITC (MW 10000) can be used for fluorescent labeling and imaging .
4-Arm-PEG-FA (MW 10000) (4-Arm-PEG-folate (MW 10000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folate receptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 10000) (8-Arm-PEG-folate (MW 10000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folate receptors and can be used for targeted drug delivery to cell membrane receptors .
HOOC-PEG-COOH (MW 10000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 10000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
DBCO-PEG-LA (MW 10000) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
DMG-PEG-Mal (MW 10000) is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG-Mal (MW 10000) can be used for drug delivery .
Bedoradrine (MN-221) sulfate is a highly selective β2-adrenergic receptor agonist. Bedoradrine sulfate can effectively relieve airway spasm in asthma patients, dilate airway smooth muscle cells, reduce airway inflammation, and thus improve respiratory function. Bedoradrine sulfate can be used in research on asthma treatment .
8-Arm-PEG-Cholesterol (MW 10000) is a PEG derivative that attaches cholesterol (Cholesterol) to the end of eight-arm polyethylene glycol (8-Arm PEG). 8-arm-PEG-Cholesterol (MW 10000) can be used for drug delivery .
Poly(ethylene glycol) distearate (Mn 930) is a derivative of polyethylene glycol, which can be used as a cross-linking agent and click chemistry reaction .
Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing Maleimide (HY-W007324). Due to the Maleimide functional group, Poly(ethylene glycol) methyl ether maleimide (Mn 2000) can be used to conjugate biomolecules containing thiol groups.
FA-PEG-COOH (MW 10000) (Folate-PEG-COOH (MW 10000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
4-Arm-PEG-DSPE (MW 10000) is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG-DSPE (MW 10000) can be used for drug delivery, gene transfection, and vaccine delivery .
8-Arm-PEG-DSPE (MW 10000) is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG-DSPE (MW 10000) can be used for drug delivery, gene transfection, and vaccine delivery .
6-Arm-PEG-DSPE (MW 10000) is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG-DSPE (MW 10000) can be used for drug delivery, gene transfection, and vaccine delivery .
PLLA10000-PEG1000-RhB is a terminal rhodamine-labeled polylactic acid derivative. PLLA10000-PEG1000-RhB can be used to label nanomicelles for real-time monitoring of drug release in vivo .
PLLA10000-PEG2000-RhB is a terminal rhodamine-labeled polylactic acid derivative. PLLA10000-PEG2000-RhB can be used to label nanomicelles for real-time monitoring of drug release in vivo .
PLLA10000-PEG3000-RhB is a terminal rhodamine-labeled polylactic acid derivative. PLLA10000-PEG3000-RhB can be used to label nanomicelles for real-time monitoring of drug release in vivo .
PLLA10000-PEG5000-RhB is a terminal rhodamine-labeled polylactic acid derivative. PLLA10000-PEG5000-RhB can be used to label nanomicelles for real-time monitoring of drug release in vivo .
PLLA10000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG5000-SPDP can be used in drug delivery research .
PLLA10000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG1000-SPDP can be used in drug delivery research .
PLLA10000-PEG2000-Thiol is a polylactic acid derivative that forms micelles in water and initiates biodegradation by attacking ester bonds through hydrolysis. PLLA10000-PEG2000-Thiol can be used in drug delivery research .
PLLA10000-PEG3000-Thiol is a polylactic acid derivative that forms micelles in water and initiates biodegradation by attacking ester bonds through hydrolysis. PLLA10000-PEG3000-Thiol can be used in drug delivery research .
PLLA10000-PEG1000-Thiol is a polylactic acid derivative that forms micelles in water and initiates biodegradation by attacking ester bonds through hydrolysis. PLLA10000-PEG1000-Thiol can be used in drug delivery research .
PLLA10000-PEG5000-Thiol is a polylactic acid derivative that forms micelles in water and initiates biodegradation by attacking ester bonds through hydrolysis. PLLA10000-PEG5000-Thiol can be used in drug delivery research .
PLLA10000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG3000-SPDP can be used in drug delivery research .
PLLA10000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG2000-SPDP can be used in drug delivery research .
Cy3 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 550/570 nm).
Cy5 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 633/670 nm).
Cy7 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 740/770 nm).
DSPE-PEG-DBCO (MW 10000) is a phospholipid-PEG polymer that can be used to form micelles as lipid nanoparticles for drug delivery . DSPE-PEG-DBCO (MW 10000) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
RB-PEG-N3 (MW 10000) (Rhodamine B-PEG-N3 (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
PLLA10000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA10000-PEG5000-FOL can be used in drug delivery research .
PLLA10000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA10000-PEG2000-FOL can be used in drug delivery research .
Cy5.5 HA (MW 10000) is a hyaluronic acid labeled with CY5.5 (HY-D0924). Cy5.5 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 680/710 nm).
Cy7.5 HA (MW 10000) is a hyaluronic acid labeled with CY7.5 (HY-D0926). Cy7.5 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 770/820 nm).
Cy3 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Cy7 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY7 (HY-D0825). Cy7 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 740/770 nm).
Cy5 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Cy3-PEG-DSPE (MW 10000) is a compound for the labeling and visualization of nanoparticles or other materials. Cy3-PEG-DSPE (MW 10000) has a variety of applications including drug delivery, cellular imaging, tracing of bioprocesses, and the study of interactions at the molecular level.
8-Arm PEG-NH2 (MW 10000) (8-Arm PEG-Amine (MW 10000)) HCL is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .
8-Arm PEG-NH2 (MW 10000) (8-Arm PEG-Amine (MW 10000)) is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .
DSPE-PEG-OH (MW 10000) is a hydroxy-terminated phospholipid PEG polymer. The hydrophobic tails that allows the encapsulation and aggregation of other hydrophobic drugs, and the hydroxy-terminated can be further reacted. DSPE-PEG-OH (MW 10000) can prepare liposomes or lipid nanoparticles, which can be used in drug delivery and promoting drug absorption research .
Poly(acrylic acid) (MW 10000-60000) is a polyacrylic acid with a molecular weight of 10000-60000. Poly(acrylic acid) (MW 10000-60000) is an anionic polymer. Poly(acrylic acid) (MW 10000-60000) can be used as a corrosion-mitigating and surface-stabilizing agent .
Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
Sodium carboxymethyl cellulose (average Mw 90000, DS=0.7, Viscosity:50-200 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent .
FITC-PEG-FA (MW 10000) is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG-FA (MW 10000) can be used for fluorescent labeling and imaging .
DBCO-PEG-NHS (MW 10000) is a PEG derivative consisting of DBCO, PEG units, and NHS ester. NHS ester can bind to amino acids or other molecules containing amino groups. DBCO-PEG-NHS (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
4-Arm-PEG-OH (MW 10000) is a PEG derivative with a four-arm structure and a hydroxyl (OH) functional group. 4-Arm-PEG-OH (MW 10000) reacts with functional groups on biomolecules (such as proteins, peptides, antibodies, etc.) through hydroxyl groups and can be used for drug delivery .
4-Arm PEG-NH2 (MW 10000) (4-Arm PEG-amine (MW 10000)) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .
4-Arm PEG-NH2 HCl (MW 10000) (4-Arm PEG-amine HCL salt (MW 10000)) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .
PLLA10000-PEG3000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG3000-N3 can be used in drug delivery research .
PLLA10000-PEG5000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG5000-N3 can be used in drug delivery research .
PLLA10000-PEG2000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG2000-N3 can be used in drug delivery research .
PLLA10000-PEG1000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG1000-N3 can be used in drug delivery research .
HOOC-PEG-NH2 (MW 10000) (HOOC-PEG-Amine (MW 10000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
RB-PEG-NH2 (MW 10000) (Rhodamine B-PEG-NH2 (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em = 546/610 nm) .
FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
Poly(ethylene glycol) dithiol (Mn 1500) is a thiol-modified PEG that can be used to synthesize dithiol-terminated amphiphilic diblock copolymers for drug delivery .
Poly(ethylene glycol) dithiol (Mn1000) is a thiol-modified PEG that can be used to synthesize dithiol-terminated amphiphilic diblock copolymers for drug delivery .
ICG PEG DSPE (MW 10000) is a PEG phospholipid with Indocyanine green (ICG) (HY-D0711) dye used in protein/nucelic acid labeling and fluorescence microscopy. ICG PEG DSPE (MW 10000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em = 785/813 nm).
PLLA10000-PEG3000-NH2 is a block copolymer based on polylactic acid derivatives that can self-assemble in water. PLLA10000-PEG3000-NH2 can be used in drug delivery research .
PLLA10000-PEG2000-NH2 is a block copolymer based on polylactic acid derivatives that can self-assemble in water. PLLA10000-PEG2000-NH2 can be used in drug delivery research .
PLLA10000-PEG5000-NH2 is a block copolymer based on polylactic acid derivatives that can self-assemble in water. PLLA10000-PEG5000-NH2 can be used in drug delivery research .
PLLA10000-PEG1000-NH2 is a block copolymer based on polylactic acid derivatives that can self-assemble in water. PLLA10000-PEG1000-NH2 can be used in drug delivery research .
Cy7.5 HA biotin (MW 10000) is a biotinylated hyaluronic acid labeled with CY7.5 (HY-D0926). Cy7.5 HA biotin (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 770/820 nm).
Mn(III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity.
mPEG-SCM (MW 10000) is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
6-Arm-PEG-FA (MW 10000) (6-Arm-PEG-Folate (MW 10000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folate receptors and can be used for cell membrane receptors for targeted drug delivery .
PLGA38000-PEG10000 is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
Cy5.5 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY5.5 (HY-D0924). Cy5.5 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 680/710 nm).
Azide-PEG-azide (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG-azide (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
m-PEG-azide (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG-azide (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
mPEG-N3 (MW 10000) can be used to modify proteins, peptides, and other materials. The azide group can react with alkynes in aqueous solution catalyzed by copper. It can also be easily reduced to an amine group. PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins. mPEG-N3 (MW 10000) can also inhibit the nonspecific binding of charged molecules to the modified surface .
Cy7.5 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY7.5 (HY-D0926). Cy7.5 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 770/820 nm).
Cy5.5 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY5.5 (HY-D0924). Cy5.5 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 680/710 nm).
Cy5-PEG-DSPE (MW 10000) is a PEG phospholipid with Cy5 (HY-D0821) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5-PEG-DSPE (MW 10000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
DBCO-PEG-Biotin (MW 10000) is a click chemistry biotinylation that can enable copper-free click chemistry with azide molecules to form a stable triazole linkage .
Poly(L-lactide) (MW 10000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
Cy3-PEG-SH (MW 10000) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 10000) is absorbed at 550nm and has high solubility and end-group substitution rate .
mPEG-NPC (MW 10000) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
HO-PEG-SCM (MW 10000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
Biotin-PEG-Alk (MW 10000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; Alk (Alkyne), acyclic (branched or unbranched) aliphatic hydrocarbon, can react with azido, which improve the efficiency of biotin binding targets. Biotin-PEG-Alk (MW 10000) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
ICG PEG NH2 (MW 10000) is a polyethylene glycol derivative containing Indocyanine green (ICG) (HY-D0711) fluorescent dye and polyethylene glycol (PEG) and an amino group. The Indocyanine green fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. ICG PEG NH2 (MW 10000) can be used for fluorescence imaging, fluorescence tracing and fluorescence labeling (Ex/Em = 785/813 nm).
DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 10000 (ammonium) can be converted into aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
FITC-PEG-N3 (MW 10000) is an azide fluorescent dye containing polyethylene glycol (PEG) and FITC (HY-66019). FITC-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cholesterol-PEG-Mal (MW 10000) is a PEG derivative composed of Cholesterol, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
8-Arm-PEG-CHO (MW 10000) is a polyethylene glycol derivative with multiple active aldehyde groups, which can be used to construct drug delivery carriers .
Cy5.5-PEG-DSPE (MW 10000) is a PEG phospholipid with Cy5.5 (HY-D0924) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5.5-PEG-DSPE (MW 10000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
TPP-PEG-Mal (MW 10000) is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
Cy7.5-PEG-DSPE (MW 10000) is a PEG phospholipid with CY7.5 (HY-D0926) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy7.5-PEG-DSPE (MW 10000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em = 770/820 nm).
mPEG-Alkyne (MW 10000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
DSPE-PEG-NHS (ammonium) (MW 10000) is one of the most commonly used reactive phospholipids for coupling antibodies, proteins, peptides or other substrates to the surface of liposomes and other lipid PEG nanoparticles .
ICG PEG N3 (MW 10000) is a Indocyanine green (ICG) (HY-D0711)-azide fluorescent dye used to label for protein and nucleic acid. ICG PEG N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 785/813 nm).
Alkyne-PEG-COOH (MW 10000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
Cy3-PEG-NH2 (MW 10000) is a polyethylene glycol derivative containing Cy3 (HY-D0822) fluorescent dye and polyethylene glycol (PEG) and an amino group. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Cy3-PEG-NH2 (MW 10000) can be used for fluorescence imaging, fluorescence tracing and fluorescence labeling .
mPEG-CHO (MW 10000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
6-Arm-PEG-DA (MW 10000) is a polymer consisting of a four-arm PEG core structure with acrylate groups attached to the ends of each PEG chain by chemical reaction, which can be used for drug delivery .
FITC-PEG-CL (MW 10000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).
FITC-PEG-Br (MW 10000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).
Cy3-PEG-N3 (MW 10000) is a Cy3 (HY-D0822)-azide fluorescent dye used to label for protein and nucleic acid. Cy3-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cy5-PEG-N3 (MW 10000) is a Cy5 (HY-D0821)-azide fluorescent dye used to label for protein and nucleic acid. Cy5-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
4-Arm-PEG-Silane (MW 10000) is a silane-modified PEG derivative that can be used to modify glass, silicon or other surfaces by reacting hydroxyl groups with ethoxy (methoxy) silane. PEG can inhibit nonspecific surface binding .
6-Arm-PEG-Silane (MW 10000) is a silane-modified PEG derivative that can be used to modify glass, silicon or other surfaces by reacting hydroxyl groups with ethoxy (methoxy) silane. PEG can inhibit nonspecific surface binding .
Poloxamer 403 P123 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 5750. Poloxamer 403 P123 exhibits muscular toxicity .
4-Arm PEG-alkyne (MW 10000) is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 2000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn1000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 5000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 3400) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
m-PEG-OH (MW 10000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.
Ibudilast (Standard) is the analytical standard of Ibudilast. This product is intended for research and analytical applications. Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
6-Arm-PEG-Mal (MW 10000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
mPEG-PEI-Cy5 (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Biotin (HY-B0511). mPEG-PEI-Cy5 (MW 10000) can be used for fluorescent labeling and imaging .
mPEG-pALD (MW 10000) is an important unilaterally active PEG derivative whose reactive groups can react with amines, peptides and the N-termini of proteins to form imines containing C=N double bonds, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can be used for reversible PEGylation by reacting with hydrazine or hydrazine to form hydrolyzed acylhydrazone bonds .
Cy5.5-PEG-N3 (MW 10000) is a Cy5.5 (HY-D0924)-azide fluorescent dye used to label for protein and nucleic acid. Cy5.5-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cy5.5-PEG-NH2 (MW 10000) is a polyethylene glycol derivative containing Cy5.5 (HY-D0924) fluorescent dye and polyethylene glycol (PEG) and an amino group. The Cy5.5 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy5.5 has an emission maximum around 710 nm. Cy5.5-PEG-NH2 (MW 10000) can be used for fluorescence imaging, fluorescence tracing and fluorescence labeling.
Alkyne-PEG-NH2 (MW 10000) is an alkyne-functionalized bifunctional PEG derivative that can be used to modify proteins, peptides, and other materials. The alkyne group reacts with azides in aqueous solution in a copper-catalyzed manner. PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins .
Cy5-PEG-SH (MW 10000) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
Cy3 Dextran (MW 10000) is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Dextran (HY-112624). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Dextran has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander (Ex/Em = 550/570 nm) .
Poloxamer 182 (L62) can be used as an excipient, such as Emulsifier, solubilizer, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
Cy5.5-PEG-SH (MW 10000) is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
Poloxamer 105 L35 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1900 Da. Poloxamer 105 L35 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Polyvinyl alcohol (Mw 9000-10000, 80% hydrolyzed) also known as PVA, is a vinyl water-soluble polymer that can be used as a non-ionic surfactant. Polyvinyl alcohol (Mw 9000-10000, 80% hydrolyzed) can be used as a biodegradable polymer and can be used in adhesives, coatings, textiles, ceramics, and cosmetics. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A) .
NH2-PEG-NH2 (MW 10000) is a polyethylene glycol derivative containing two primary amine groups. The amino group can react quickly with activated carboxylic acid or carboxyl groups such as NHS esters to form stable amide bonds. The PEGylation of NH2-PEG-NH2 can increase solubility and stability, and reduce the immunogenicity of peptides and proteins, so it is mostly used to modify proteins, peptides and other substances.
Poloxamer 338 F108 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 14600. Poloxamer 338 F108 reduces the aggregation of red blood cells, inhibits proliferation of human lymphocyte cell IIBR1. Poloxamer 338 F108 exhibits short-term and subchronic toxicity in rats .
Ibudilast-d7-1 is the deuterium labeled Ibudilast . Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8 AM and Quest Rhod-4 AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .
Polyoxyethylene(10) oleyl ether, also known as POE(10) monooleate, is a nonionic surfactant consisting of a polyethylene glycol chain with 10 ethylene oxide units and an oleic acid residue. It has excellent emulsifying, wetting and dispersing properties, making it suitable for a variety of applications including personal care products and pharmaceutical formulations. POE(10) monooleate is commonly used as a solubilizer to improve the solubility and bioavailability of poorly soluble drugs. Furthermore, it is biodegradable and has low toxicity, making it an environmentally friendly ingredient suitable for various industrial applications.
Hydroxy tipelukast (Compound MN-002), the metabolite of Compound MN-001, is an orally active phenoxyalkylcarboxylic acid. Hydroxy tipelukast inhibits liver steatosis, lobular inflammation, hepatic ballooning, and hepatic scarring, and reduces liver hydroxyproline levels. Hydroxy tipelukast is promising for research of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) .
Pullulan (Pullulan standard 5800) (Mw 362-480 kDa; Mn 100-200 kDa) is a class of orally active and water-soluble linear glucosic polysaccharide. Pullulan can be isolated from the polymorphic fungus Aureobasidium pullulans. Pullulan is composed of maltotriose repeating units linked by α-1,6 linkages and is an amorphous slime matter. Pullulan is widely used in food, environment, pharmaceutical, manufacturing, and electronics .
Manganese peroxidase is a heme protein that oxidizes Mn2+ to Mn3+. Manganese peroxidase catalyzes plant lignin de-polymerization. Manganese peroxidase can be used for the biodegradation of hazardous environmental contaminants, and especially for dye wastewater decolorization .
Tipelukast (KCA 757) is a sulfidopeptide leukotriene receptor antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma.
Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death. Concanavalin A can be used to induce acute hepatic injury .
Pak6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pak6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion .
Hirudonucleodisulfide B is a heterocyclic compound that can be found in Whitmania pigra. Hirudonucleodisulfide B shows moderately anti-anoxic activity .
Chitosan-Cy5.5 (MW 1000) is a fluorescent dye composed of CY5.5 (HY-D0924) and chitosan. Chitosan-Cy5.5 (MW 1000) can be used for bioimaging, drug delivery and biomaterial research (Ex/Em = 680/710 nm) .
8-arm-PEG-FITC (MW 20000) is a fluorescent dye composed of FITC (HY-66019) and eight-arm polyethylene glycol (8-Arm PEG). 8-arm-PEG-FITC (MW 20000) can be used to modify proteins, peptides and other materials with active groups (Ex/Em = 488/525 nm) .
Concanavalin A-HRP (Con A-HRP) is a HRP-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis .
Concanavalin A-AF488 (Con A-AF488) is an AF488-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .
hCAIX-IN-7 (compound 6c) is a potent and selective hCAIX inhibitor with KIs of >10000, >10000, 43.0, 410.6 nM for hCAI, hCAII, hCAIV, hCAIX, respectively .
hCAIX-IN-5 (compound 6b) is a potent and selective hCAIX inhibitor with KIs of >10000, >10000, 130.7, 829.1 nM for hCAI, hCAII, hCAIV, hCAIX, respectively .
hCAXII-IN-5 (compound 6o) is a potent and selective hCAXII inhibitor with Ki values of >10000, >10000, 286.1, 1.0 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .
hCAIX/XII-IN-2 (compound 6a) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 30.0, 3.6 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .
DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.
hCAIX/XII-IN-3 (compound 6q) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .
Concanavalin A-Cy5.5 (Con A-Cy5.5) is a Cy5.5 (HY-D0924)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
Ibudilast-d7 is the deuterium labeled Ibudilast. Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor .
hCAIX/XII-IN-4 (compound 6c) is a potent CAIX/XII inhibitor with the Ki values of 4.5 nM, 23.6 nM, >10000 nM and >10000 nM for CAXII, CAIX, CAI and CAⅡ, respectively .
Perlapine is a potent muscarinic DREADD (Designer Receptors Exclusively Activated by Designer agents) agonist Perlapine exhibits >10000-fold selectivity for hM3Dq over hM3 receptors .
BRD6257 is an orally active inhibitor for protein phosphatase, Mg2+/Mn2+ dependent 1D PPM1D with an IC50 of 5 nM. BRD6257 activates p53 signaling pathway with an EC50 of 51 nM, increases the p21 expression, inhibits the proliferation of cancer cell MOLM13 (IC50=2.8 μM). BRD6257 exhibits good metabolic stability in human and rat liver microsomes .
Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1MN, HIV-1SF2 and HIV-189.6 with IC50 values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection .
Zifaxaban is an orally active, competitively and selective Factor Xa (FXa) inhibitor with an IC50 of 11.1 nM for human FXa. Zifaxaban shows >10000-fold greater selectivity than other serine proteases. Zifaxaban can be used for the arterial and venous thrombosis research .
Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.
(±)-Marmesin is a good precursor of the linear furanocoumarins. (±)-Marmesin derivatives have high degree of acetylcholinesterase inhibitory property .
Padanamide A is a linear tetrapeptide without proteinogenic amino acids. Padanamide A has the activity of inhibiting the biosynthesis of cysteine and methionine .
Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
Bac2A TFA is an antimicrobial and immunomodulatory peptide. Bac2A TFA is a linear variant of bactenecin and is very effective against fungal pathogens.
Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an averageGI50 of 34 nM in NCI-60 cell line screening .
J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors .
pppApA is a linear dinucleotide intermediate in the enzymatic production of the bacterial signalling nucleotide c-diAMP. pppApA is formed by conjugation between two molecules of ATP .
pppApA sodium is a linear dinucleotide intermediate in the enzymatic production of the bacterial signalling nucleotide c-diAMP. pppApA sodium is formed by conjugation between two molecules of ATP .
Maltoheptaose hydrate is the hydrate form of Maltoheptaose (HY-127018). Maltoheptaose hydrate is a linear oligosaccharide composed of seven glucose units and belongs to the class of malto-oligosaccharides .
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
Poloxamer 101 L31 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1100. Poloxamer 101 L31 forms hydrogel, that is utilized as surfactants and emulsifying agents. Poloxamer 101 L31 induces slight alveolitis .
Dextran T200 (MW 200,000) is a polymer of anhydroglucose with the average molecular weight of 200000. Dextran T200 (MW 200,000) exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Corynoxine B is an alkaloid-based autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances α-synuclein (α-syn) clearance in Parkinson's disease mice .
Acrylate-PEG-acrylate (MW 1000) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Acrylate-PEG-acrylate (MW 3400) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Acrylate-PEG-acrylate (MW 2000) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Marmesinin ((-)-Marmesinin), a natural coumarin, is a biosynthetic precursor of psoralen and linear furanocoumarins. Marmesinin exhibits significant neuroprotective activities against glutamate-induced toxicity .
Acrylate-PEG-acrylate (MW 5000) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Poloxamer 334 P104 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 5900. Poloxamer 334 P104 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 185 P65 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 3400. Poloxamer 185 P65 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 125 L45 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2400. Poloxamer 125 L45 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 234 P84 is is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4200. Poloxamer 234 P84 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 123 L43 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1850. Poloxamer 123 L43 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 215 P75 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4150. Poloxamer 215 P75 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 212 L72 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2750. Poloxamer 212 L72 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Caffeoyl alcohol is a monomer constituting Catechyl lignin. Catechyl lignin is a linear homopolymer of caffeyl alcohol, a natural source of carbon fiber and high-value chemicals .
λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn2+. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase
Silk Fibroin Methacryloyl (FibMA) is methacrylated silk fibroin with excellent biocompatibility, stable mechanical properties and good processing properties, and was selected as the substrate for multifunctional microneedle (MN) patches. . MN patches made of Silk Fibroin Methacryloyl exhibit excellent biocompatibility, sustained drug release, pro-angiogenic, antioxidant and antibacterial properties depending on the specific drug encapsulated . Silk Fibroin Methacryloyl needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Biotin-PEG-Biotin (MW 40000) can be used for crosslinking PEGylation by binding to two streptavidin and avidin. Biotin is conjugated to a linear PEG through a stable amide linker .
SHP2-IN-31 is a SHP2 inhibitor, with IC50s of 13 nM (Wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K) . SHP2-IN-31 inhibits pERK in a panel of tumor cells. SHP2-IN-31 inhibits tumor growth in RTK/KRAS-driven xenograft models .
TdT-IN-1 (Compound 8c) is a selective and non-nucleoside terminal deoxynucleotidyl transferase (TdT) inhibitor with IC50 s of 0.11 and 0.19 μM for Mg 2+ and Mn2+. TdT-IN-1 can be used for leukaemias and skin cancer research .
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an averageEC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease .
BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an averageEC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease .
N3-PEG-SCM (MW 20000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 20000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 3400) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 3400)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 2000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 2000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 1000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 1000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 5000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 5000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM .
N3-PEG-SCM (MW 40000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 40000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
Poloxamer 402 L122 (PEG-PPG-PEG, 5000 Averag) is a synthetic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO). Poloxamer 402 L122 forms thermoreversible gel, which remains fluid at room temperature but becomes more viscous gel at body temperature. Poloxamer 402 L122 is utilized in drug delivery, tissue regeneration and generation of micellar system .
Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD50 of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].
YLT-11 is a potent, selective and orally active PLK4 inhibitor with Kd values of >10000, 653, >10000, 5.2 nM for PLK1, PLK2, PLK3, PLK4, respectively. YLT-11 shows antiproliferative activity. YLT-11 induces Apoptosis and cell cycle arrest at G2/M phase. YLT-11 show anticancer activity .
Cyclam is a metal chelator that forms metal complexes with a variety of metal ions. Cyclam metal complexes exhibits anti-HIV (such as AMD3100), nitric oxide (NO) releasing and scavenging (such as Zn(II)-Cyclam and Ru(II)-Cyclam), and SOD mimetic (such as Mn(III)-Cyclam and Zn(II)-Cyclam) activities .
Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. Cecropin A TFA exhibits anti-bacterial, anti-inflammatory and anti-cancer activity .
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral LD50 of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .
mPEG-LA (MW 3400) is a linear block copolymer consisting of methoxy polyethylene glycol (mPEG) capped at one end and Lactic Acid (LA). mPEG-LA (MW 3400) can be used for drug delivery .
mPEG-LA (MW 2000) is a linear block copolymer consisting of methoxy polyethylene glycol (mPEG) capped at one end and Lactic Acid (LA). mPEG-LA (MW 2000) can be used for drug delivery .
mPEG-LA (MW 5000) is a linear block copolymer consisting of methoxy polyethylene glycol (mPEG) capped at one end and Lactic Acid (LA). mPEG-LA (MW 5000) can be used for drug delivery .
Fluorescent polyamine probe-1 (compound 15) is a linear polyamine probe with high uptake efficiency. Fluorescent polyamine probe-1 can be used for the research of transport system into cancer cells .
mPEG-LA (MW 1000) is a linear block copolymer consisting of methoxy polyethylene glycol (mPEG) capped at one end and Lactic Acid (LA). mPEG-LA (MW 1000) can be used for drug delivery .
NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 antagonizes Quinpirole-stimulated mitogenesis .
RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile .
NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis .
AF 555 carboxylic acid is a derivative of the orange fluorescent dye AF 555. AF 555 carboxylic acid is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .
Sabizabulin hydrochloride is a potent orally bioavailable microtubule inhibitor with activity that interacts with the colchicine binding site. Sabizabulin hydrochloride demonstrated significant inhibition of melanoma tumor growth with an averageIC50 of 5.2 nM in melanoma and prostate cancer cell lines. Pharmacological screening of Sabizabulin hydrochloride shows it has a low risk of potential side effects .
AFP aptamer sodium is an aptamer that specifically targets the liver cancer biomarker alpha-fetoprotein (AFP). AFP aptamer sodium can be used as a recognition molecule for AFP, with a linear detection range of 12.5-800 ng/mL .
N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide .
Otenabant Hydrochloride is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.
UNC0737 is an orthosteric choline kinase inhibitor. UNC0737 is also a poor inhibitor of G9a (IC50 = 5000 nM) and GLP (IC50 > 10000 nM) in the SAHH-coupled assays .
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.
Dextran T150 MW 150,000 (Dextran D150; Dextran T150 MW 130000-170000) is a polymer of anhydroglucose with the average molecular weight of 150000. Dextran T150 MW 150,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T200 MW 200,000 (Dextran D200; Dextran T200 MW 180000-220000) is a polymer of anhydroglucose with the average molecular weight of 1000. Dextran T1 MW 1,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
RO5353 is an orally active inhibitor for p53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wild-type p53 cancer cells with an averageIC50 of 7 nM. RO5353 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice .
Mal-PEG3-NH2 is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 is a useful crosslinking reagent with a PEG spacer .
Mast Cell Degranulating Peptide HR-2, a 14-membered linear peptide isolated from the venom of the giant hornet Vespa orientalis, is capable of degranulating mast cells and thus initiating histamine release .
HPMC (Hypromellose) (Type I, Viscosity: 4000mPa.s) is a primary sodium alginate and controlled release hydrophilic polymer with an average viscosity of 4000mPa.s. The viscosity of HPMC may change due to concentration, pH, temperature or the presence of metal ions. When the pH is above 10, the viscosity decreases .
Dextran T7 MW 7,000 (Dextran 7; Dextran D7; Dextran T7 MW 5600-8400) is a polymer of anhydroglucose with the average molecular weight of 7000. Dextran T7 MW 7,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T1 MW 1,000 (Dextran 1; Dextran D1; Dextran T1 MW 800-1200) is a polymer of anhydroglucose with the average molecular weight of 1000. Dextran T1 MW 1,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
OHC-PEG-COOH (MW 40000) (OHC-PEG-carboxyl (MW 40000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 40000) can be used for drug delivery .
OHC-PEG-COOH (MW 1000) (OHC-PEG-carboxyl (MW 1000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 1000) can be used for drug delivery .
Nostosin G is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal. Nostosin G has potent trypsin inhibitory property with an IC50 value of 0.1 μM .
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .
L-Diguluronic acid is a linear polysaccharide copolymer composed of two L-guluronic acid (G) and can be used to from Alginate . Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of antifungal agents delivery carries .
OHC-PEG-COOH (MW 3400) (OHC-PEG-carboxyl (MW 3400)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 3400) can be used for drug delivery .
OHC-PEG-COOH (MW 2000) (OHC-PEG-carboxyl (MW 2000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 2000) can be used for drug delivery .
OHC-PEG-COOH (MW 20000) (OHC-PEG-carboxyl (MW 20000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 20000) can be used for drug delivery .
α1-2 Fucosidase (EC 3.2.1.51) is a highly specific exoglycosidase that catalyzes the hydrolysis of linear α1-2 linked fucose residues from oligosaccharides .
OHC-PEG-COOH (MW 5000) (OHC-PEG-carboxyl (MW 5000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 5000) can be used for drug delivery .
Corynoxine B Standard is an analytical standard for Corynoxine B. This product is intended for research and analytical applications. Corynoxine B is an alkaloid-type autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances the clearance of α-synuclein (α-syn) in Parkinson's disease mice .
Boc-NH-PEG-COOH (MW 1000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 1000) is an important cross-linker with PEG chains .
L-Triguluronic acid is a linear polysaccharide copolymer composed of three L-guluronic acid (G) and can be used to from Alginate . Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of anti-fungal agents delivery carries .
Boc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 40000) is an important cross-linker with PEG chains .
HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM . HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro .
CooP is a linear glioblastoma-targeting nonapeptide. CooP binds to the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) in the glioblastoma cells and its associated vasculature. CooP is used for the targeted delivery of chemotherapy and different nanoparticles .
Boc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 2000) is an important cross-linker with PEG chains .
Boc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 5000) is an important cross-linker with PEG chains .
Boc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 20000) is an important cross-linker with PEG chains .
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations .
Boc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 3400) is an important cross-linker with PEG chains .
Dextran T500 MW 500,000 (Dextran 500; Dextran D500; Dextran T500 MW 440000-560000) is a polymer of anhydroglucose with the average molecular weight of 500,000. Dextran T500 MW 500,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T800 MW 800,000 (Dextran 800; Dextran D800; Dextran T800 MW 750000-850000) is a polymer of anhydroglucose with the average molecular weight of 800,000. Dextran T800 MW 800,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T20 MW 20,000 (Dextran 20; Dextran D20; Dextran T20 MW 16000-24000) is a polymer of anhydroglucose with the average molecular weight of 20,000. Dextran T20 MW 20,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T60 MW 60,000 (Dextran 60; Dextran D60; Dextran T60 MW 54000-66000) is a polymer of anhydroglucose with the average molecular weight of 60,000. Dextran T60 MW 60,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain .
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .
Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .
Oxalate decarboxylase, Microorganism (EC 4.1.1.2), a stress-response enzyme in certain soil bacteria, is a Mn-dependent enzyme in the cupin superfamily and is found in fungi and soil bacteria. Oxalate decarboxylase catalyzes the decarboxylation of the oxalate mono-anion in the soil bacterium Bacillus subtilis. Enzymatic activity of OxDC is strongly pH dependent, with a maximum at around pH 4.0 .
IRE1α kinase-IN-9 (compound 2) is a potent IRE-1α inhibitor，exhibits an averageIC50 value of <0.1 μM. IRE1α kinase-IN-9 can be used for research in diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) .
AC Antibody affinity resin is AC commonly used packing. AC Antibody affinity resin has highly cross-linked agarose matrix with 85 μm of average particle size. AC Antibody affinity resin has alkali-resistant protein A derivative (E. coli) ligand. AC Antibody affinity resin can be used for antibody affinity chromatography .
AF 555 NHS ester is a bright, orange-red fluorescence probe. AF 555 NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. AF 555 exhibits average excitation wavelengths under green laser and red laser of 552 nm and 566 nm, respectively .
RSV604 (A-60444) is an inhibitor of respiratory syncytial virus (RSV) replication. RSV604 targets the nucleocapsid protein, with a Kd of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (averageEC50s=0.8 μM) .
RS 49676 is an N-substituted imidazole compound that exhibits strong in vitro activity against endogenous amoebae (ED50 < 0.1 ng/mL), but is ineffective against exogenous amoebae (epimastigotes). In vivo, RS 49676 (100 mg/kg/d, sc, 2 times) can prolong the average survival time of mice infected with Trypanosoma cruzi to more than 11 weeks.
Mal-PEG-NH2 TFA (MW 5000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
(E/Z)-HOIPIN-1 ((E/Z)-JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value >2.8 μM. HOIPIN-1 inhibits LUBAC-mediated NF-kB activation.
Mal-PEG-NH2 TFA (MW 40000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 2000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 3400) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 20000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 1000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Cenerimod (ACT-334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC50 of 1 nM. Cenerimod shows more than 36 fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC50s=>10000, 228, 2134, and 36 nM, respectively). Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous .
Edoxaban-d6 is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment .
L-Diguluronic acid disodium is a linear polysaccharide copolymer composed of two L-guluronic acid. L-Diguluronic acid disodium can be used to form Alginate. L-Diguluronic acid disodium is a generic name of unbranched polyanionic polysaccharides and it can be used for the research of antifungal agents delivery carries .
Felotaxel (SHR110008) is a derivate of Docetaxel (HY-B0011), with antitumor activity and specific pharmacokinetic properties in rats. Felotaxel is rapidly distributed to normal tissues. The kidney is the major excretion organ, and its plasma protein binding capacity is nearly linearly related to concentration.
Poloxamer 183 L63 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2650. Poloxamer 183 L63 exhibits antimicrobial activity, that inihibits 83% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 183 L63 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 122 L42 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1630. Poloxamer 122 L42 exhibits antimicrobial activity, that inihibits 56% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 122 L42 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 181 L61 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2000. Poloxamer 181 L61 exhibits antimicrobial activity, that inihibits 91% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 181 L61 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 333 P103 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4950. Poloxamer 333 P103 exhibits antimicrobial activity, that inihibits 90% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 333 P103 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
cis-ACBD is a potent and selective inhibitor of the high-affinity, Na +-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate .
Microginin 527 is a linear cyanobacterial peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity. Microginin 527 also exhibits inhibitory effects on protein phosphatases and leucine aminopeptidase. With an IC50 value of 31 μM, Microginin 527 is the most active component in this class of compounds .
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity .
Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG crosslinker with Maleimide (HY-W007324) and amine. Mal-PEG3-NH2 TFA is a non-degradable (non-cleavable) PROTAC linker .
Bulevirtide (Myrcludex B) is a NTCP inhibitor, a linear lipopeptide of 47 amino acids. Bulevirtide inhibits HBV and HDV entry into liver cells, blocks HBV infection in hepatocytes, and participates in HBV transcriptional suppression. Bulevirtide can be used in HDV infection and compensated cirrhosis research .
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC50: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC50: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC50: 50 nM) .
Anticancer agent 252 (compound 1) is a benzamide compound with selective anti-cancer activity against small cell lung cancer (SCLC) cells. Anticancer agent 252 inhibits murine SCLC (mSCLC) cell lines with an average EC50 of 3.21 μM. Anticancer agent 252 also inhibits human SCLC cell lines, H889, H2107, and H128 .
Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8 .
Azide-PEG-Silane, MW 10,000 enables surface modification of various substrate through reaction between hydroxyl and ethoxyl silane. The polymer can be used for click chemistry with alkyne containing molecule. Reagent grade, for research use only.
Levophencynonate is a muscarinic receptor antagonist with anticholinergic activity. The biological activity of levophencynonate makes it a key target for the determination of its concentration in human plasma in medical research. Levophencynonate was analyzed by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and showed good specificity and linearity .
Tasiamide B is a Cathepsin D inhibitor, which is a linear peptide found in the marine cyanobacteria Symploca sp.. Tasiamide B is proved as a good template for the development of aspartic proteases inhibitors. Tasiamide B is effective against skin cancer by strongly interacting with the target protein HSP90 .
Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis .
Levophencynonate is a muscarinic receptor antagonist with anticholinergic activity. The biological activity of levophencynonate makes it a key target for the determination of its concentration in human plasma in medical research. Levophencynonate was analyzed by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and showed good specificity and linearity .
Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
SCH442416 (Standard) is the analytical standard of SCH442416. This product is intended for research and analytical applications. SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain .
CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors .
Fmoc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 2000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
TelN Protelomerase is a prokaryotic telomerase of bacteriophage N15. TelN Protelomerase is an enzyme with cleaving-joining activity, which is required for the formation of linear prophage DNA with closed ends in lysogenic bacteria. TelN Protelomerase cleaves both DNA strands and joins the resulting ends to form covalently closed hairpin structures .
L-γ-Glutamyl-L-glutamic acid (γ-Glu-Glu) is the isomer of D-γ-Glutamyl-D-glutamic acid (HY-118090A), and can be used as an experimental control. D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain .
Fmoc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 5000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
Fmoc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 40000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .
DHT/KLH is a conjugate of DHT (dihydrotestosterone) and keyhole limpet hemocyanin (KLH). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt linear epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
Fmoc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 3400) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
Fmoc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 20000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
DSPE-PEG-OH, MW 5000 is a linear phospholipid PEG polymer. The lipid tails allow encapsulation of hdyrophobic therapeutics while the PEG chain maintains its hydrophilicity. The polymer can be used for drug nanocarrier, such as liposomal anti cancer drug or mRNA/DNA vaccine. Reagent grade, for research use only.
LDV-FITC TFA, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC TFA binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC TFA can be used to detect α4β1 integrin affinity .
AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity .
Dimethicone is an orally active biochemical assay reagents consisting of a fully methylated linear siloxane polymer whose ends are blocked by trimethylsiloxane units. Dimethicone can lubricate hair and physically block the respiratory system of lice to remove lice. Dimethicone has potential applications in cosmetics and daily cleaning products .
BOC-NH-PEG-NH2 (MW 1000) (Boc-NH-PEG-Amine (MW 1000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 1000) is an important cross-linker with PEG chains .
BOC-NH-PEG-NH2 (MW 20000) (Boc-NH-PEG-Amine (MW 20000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 20000) is an important cross-linker with PEG chains .
5-Methyl-2-thiophenecarboxaldehyde (Standard) is the analytical standard of 5-Methyl-2-thiophenecarboxaldehyde. This product is intended for research and analytical applications. 5-Methyl-2-thiophenecarboxaldehyde acts as a candidate to microscopic third order non-linear optical (NLO) material[1].
Biotin-PEG-COOH (MW 20000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 20000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
BOC-NH-PEG-NH2 (MW 40000) (Boc-NH-PEG-Amine (MW 40000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 40000) is an important cross-linker with PEG chains .
Biotin-PEG-COOH (MW 40000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 401000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
BOC-NH-PEG-NH2 (MW 3400) (Boc-NH-PEG-Amine (MW 3400)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 3400) is an important cross-linker with PEG chains .
BOC-NH-PEG-NH2 (MW 5000) (Boc-NH-PEG-Amine (MW 5000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 5000) is an important cross-linker with PEG chains .
Biotin-PEG-COOH (MW 1000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 1000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Biotin-PEG-COOH (MW 2000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 2000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Biotin-PEG-COOH (MW 3400) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 3400) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Biotin-PEG-COOH (MW 5000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 5000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 10 5 /M) and thereby increases the length of linear DNA .
BOC-NH-PEG-NH2 (MW 2000) (Boc-NH-PEG-Amine (MW 2000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 2000) is an important cross-linker with PEG chains .
CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors .
AB-680 ammonium is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity .
AF 555 azide is a fluorescent dye and is the azide of AF 555. It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .
Poloxamer 335 P105 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 6500. Poloxamer 335 P105 exhibits antimicrobial activity, that inihibits 86% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 334 P104 exhibits muscular toxicity. Poloxamer 334 P104 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection .
Diacetamide is shown to form a variety of new compounds with a general formula [M(C4H7O2N) 3](ClO4)2, where M = Mn(II), Fe(II), Co(II), Ni(II), or Zn(II). Diacetamide ligands can be used in uranium extraction from wastewater. Diacetamide can be used for amidase synthesis .
Biotin-PEG-maleimide (MW 3400) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 3400) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Biotin-PEG-maleimide (MW 5000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 5000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Phospholipid-PEG-Biotin (MW 3400) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
Biotin-PEG-maleimide (MW 1000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 1000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 10 5 /M) and thereby increases the length of linear DNA .
Biotin-PEG-maleimide (MW 2000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 2000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Phospholipid-PEG-Biotin (MW 20000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
Phospholipid-PEG-Biotin (MW 1000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with averageEC50 values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
HPMC (Hypromellose) (Type I, Viscosity: 400mPa.s) is a first-grade sodium alginate with an average viscosity of 400 mPa.s. Typically, a 1% w/v HPMC aqueous solution has a viscosity of 20-400mPa.s (20-400cp) at 20°C. The viscosity of HPMC may vary depending on concentration, pH, temperature, or the presence of metal ions. Viscosity decreases at pH values above 10 .
VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC50 of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer .
(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6 . (Z)-Ligustilide is orally active, it inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) . (Z)-Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer .
Cefbuperazone sodium is an antibacterial agent that demonstrates significant activity against bacterial infections. Cefbuperazone sodium exhibits a linear pharmacokinetic profile, allowing for effective dosage determination in clinical settings. Cefbuperazone sodium reaches peak concentrations in human plasma following intravenous infusion, indicating its rapid absorption and distribution. Cefbuperazone sodium is primarily excreted unchanged in urine, highlighting its efficiency in renal elimination.
ODN INH-18 sodium is a linear 24-mer class B INH-ODN in which the 5' INH-ODN 4084-F sequence was followed by a random stretch of 12 nucleotides lacking the ability to form significant secondary structures. ODN INH-18 sodium showes inhibitory potency for TLR9 ligand-induced IFN-α production.
ODN INH-18 is a linear 24-mer class B INH-ODN in which the 5' INH-ODN 4084-F sequence was followed by a random stretch of 12 nucleotides lacking the ability to form significant secondary structures. ODN INH-18 showes inhibitory potency for TLR9 ligand-induced IFN-α production.
NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM).
PI-3065 is a potent inhibitor of PI3K p110δ, with IC50 and Ki values of 5 nM and 1.5 nM, and exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM.
Poloxamer 184 L64 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2900. Poloxamer 184 L64 exhibts short-term dermal toxicity characterized by slight erythema and intradermal inflammatory response. Poloxamer 184 L64 exhibits antimicrobial activity, that inihibits 60% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 184 L64 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Cross-linked dextran G 50, medium is a gel filtration medium. Cross-linked dextran G 50, medium can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, medium are microspheres with an average particle size of D50 = 220-250 μm .
Cross-linked dextran G 50, fine is a gel filtration medium. Cross-linked dextran G 50, fine can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, fineThe average particle size is D50=110-130 μmof microspheres .
Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM .
Sialidase (α2-3-6-8-9) is a broadly specific sialidase that cuts linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. Sialidase (α2-3-6-8-9) can be used for in vitro and in vivo polysaccharide analysis and characterization as well as complete glycoprotein remodeling .
T4 UvsX Recombinase helps initiate DNA replication on a double-stranded DNA template by catalyzing synapsis between the template and a homologous DNA single strand that serves as primer. T4 UvsX Recombinase greatly amplifies the snap-back (hairpin-primed) DNA synthesis that is catalyzed by the T4 DNA polymerase holoenzyme on linear, single-stranded DNA templates .
ODN INH-18 triethylamine is a linear 24-mer class B INH-ODN in which the 5' INH-ODN 4084-F sequence was followed by a random stretch of 12 nucleotides lacking the ability to form significant secondary structures. ODN INH-18 triethylamine showes inhibitory potency for TLR9 ligand-induced IFN-α production.
Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes .
Alogliptin Benzoate (SYR-322) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin Benzoate can be used for the research of type 2 diabetes .
Mal-PEG-SCM (MW 3400) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 3400) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 2000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 2000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 40000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 40000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 5000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 5000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
HCV Core Protein (107-114) is a least immunogenic residue of the major linearHCV core regions. HCV Core Protein (107-114) is identified as the binding site within the region 101-118, which contains two residues differing between genotypes Ⅰ/Ⅱ and Ⅲ/Ⅵ. HCV Core Protein (107-114) might be a potential site for dissemination of HCV serotypes .
BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50=8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.
Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids .
Mal-PEG-SCM (MW 20000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 20000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 1000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 1000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel blocker with an IC50value of 160 nM for Cav3.1. Cav 3.1 blocker 1 weakly inhibits Cav 3.2 (IC50 of 5000 nM), and shows no inhibition on Cav 3.3 and Cav 1.2 (IC50 of >10000 nM) .
CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2 .
HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a Ki value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC50s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively .
JNJ-42259152 is a phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer that is specific for PDE10A activity. JNJ-42259152 can be dynamically scanned in healthy volunteers to assess its kinetic properties in the brain. The half-life of JNJ-42259152 in the blood is an average of 90 minutes. JNJ-42259152 has demonstrated reliable binding potential (BPND) in different target areas (such as the lentiform nucleus, caudate nucleus, ventral striatum, etc.), providing an important tool for studying neuropsychiatric diseases .
SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM .
H2N-PEG-SH (MW 3400) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 3400) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
H2N-PEG-SH (MW 2000) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 2000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells .
H2N-PEG-SH (MW 5000) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 5000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
CGP 20712 (dihydrochloride) (Standard) is the analytical standard of CGP 20712 (dihydrochloride). This product is intended for research and analytical applications. CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors .
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders .
AMG-151 (ARRY-403) is a glucokinase agonist with fasting plasma glucose (FPG) lowering activity. AMG-151 showed a significant linear dose-response trend compared with placebo in a randomized, placebo-controlled Phase IIa study. The use of AMG-151 was associated with a higher incidence of hypoglycemia and hypertriglyceridemia. AMG-151 may serve as a potential compound for the inhibition of type 1 diabetes .
Mal-PEG-OH (MW 20000) (Maleimide-PEG-Hydroxy (MW 20000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 20000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .
Mal-PEG-OH (MW 40000) (Maleimide-PEG-Hydroxy (MW 40000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 40000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .
Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.
Mal-PEG-OH (MW 3400) (Maleimide-PEG-Hydroxy (MW 3400)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 3400) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .
CGP 20712 A (Standard) is the analytical standard of CGP 20712 A. This product is intended for research and analytical applications. CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors .
Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research .
Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research .
Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research .
Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban tosylate can be used for preventing thromboembolic disease research .
DSPE-PEG-CHO ammonium (MW 3400) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 3400) can be used for drug delivery .
DSPE-PEG-CHO ammonium (MW 5000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 5000) can be used for drug delivery .
H2N-PEG-SH (MW 1000) (Amine-PEG-Thiol (MW 1000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 1000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
H2N-PEG-SH (MW 20000) (Amine-PEG-Thiol (MW 20000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 20000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
DSPE-PEG-CHO ammonium (MW 1000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 1000) can be used for drug delivery .
H2N-PEG-SH (MW 40000) (Amine-PEG-Thiol (MW 40000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 40000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
DSPE-PEG-CHO ammonium (MW 20000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 20000) can be used for drug delivery .
DSPE-PEG-CHO ammonium (MW 40000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 40000) can be used for drug delivery .
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .
DSPE-PEG-CHO ammonium (MW 2000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 2000) can be used for drug delivery .
Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
Alogliptin-d3 is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes .
Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin .
S2.2 aptamer sodium is a nucleic acid aptamer targeting the mucin MUC1 and can be used for targeted imaging of MCF-7 cancer cells. S2.2 aptamer sodium was labeled with Cy5, and when fluorescent silicon nanodots (SiND) were present, the fluorescence was quenched; when MUC1 was also present, the fluorescence was restored. S2.2 aptamer sodium detects MUC1 with a linear range of 3.33-250 nM .
Ro 31-1118 Free base is a compound exhibiting weak antihypertensive activity in patients with mild hypertension. Ro 31-1118 Free base demonstrated a reduction in heart rates and blood pressure post-exercise at varying doses. Ro 31-1118 Free base exhibited linear pharmacokinetics within the 10-80 mg dose range. Ro 31-1118 Free base showed no significant impact on diastolic blood pressure or adverse effects during the study.
HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC .
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin .
Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC50s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch .
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively .
Alogliptin (Standard) is the analytical standard of Alogliptin. This product is intended for research and analytical applications. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes .
JNK3 inhibitor-8 is a potent, delective, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 21, 2203, >10000 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-8 shows significant neuroprotective effects. JNK3 inhibitor-8 has the potential for the research of Alzheimer’s disease (AD) .
[Arg14,Lys15]Nociceptin TFA is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin TFA displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively .
Alogliptin (Benzoate) (Standard) is the analytical standard of Alogliptin (Benzoate). This product is intended for research and analytical applications. Alogliptin Benzoate (SYR-322) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin Benzoate can be used for the research of type 2 diabetes .
Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
UCSF686 is a probe with which to study the function of the 5-HT5AR. UCSF686 loses affinity at 5-HT5AR (>10 000 nM) but not at 5-HT1AR, 5-HT2BR, and 5-HT7R. UCSF686 controls for off-target effects .
Zgwatinib (SOMG-833) is a potent, selective, and ATP-competitive c-MET inhibitor, with an IC50 of 0.93 nM against c-MET, over 10,000-fold more potent compared with 19 tyrosine kinases (including c-MET family members and highly homologous kinases). Zgwatinib potently inhibits c-MET-driven cell proliferation. Zgwatinib as a potential candidate agent for c-MET-driven human cancers research .
Bexarotene- 13C6 (LGD1069- 13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
PSB 0777 ammonium hydrate is a potent and selective adenosine A2A receptor full agonist with Ki values of 44.4 nM, 360 nM for rat and human A2A receptors, respectively. PSB 0777 ammonium hydrate has Ki values of ≥10000 nM, 541 nM for rat and human A1 receptors, respectively. PSB 0777 ammonium hydrate shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium hydrate has the potential for inflammatory bowel disease (IBS) research research .
PSB 0777 ammonium is a potent and selective adenosine A2A receptor full agonist with Ki values of 44.4 nM, 360 nM for rat and human A2A receptors, respectively. PSB 0777 ammonium has Ki values of ≥10000 nM, 541 nM for rat and human A1 receptors, respectively. PSB 0777 ammonium shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium has the potential for inflammatory bowel disease (IBS) research research .
Siponimod (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4, with EC50s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research - .
PLK1-IN-12 is a highly selective and orally active PLK1 inhibitor with an IC50 of 20 nM. PLK1-IN-12 shows more selective for PLK1 than PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer potency across a broad spectrum of cell lines. PLK1-IN-12 can be used in anti-leukemia research .
Edoxaban (Standard) is the analytical standard of Edoxaban. This product is intended for research and analytical applications. Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research .
Bexarotene (Standard) is the analytical standard of Bexarotene. This product is intended for research and analytical applications. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
Sacituzumab (powder) is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab (powder) demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab (powder) can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
Bexarotene- 13C4 (LGD1069- 13C4) is the 13C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli .
HDAC-IN-31 is a potent, selective and orally active HDAC inhibitor with IC50s of 84.90, 168.0, 442.7, >10000 nM for HDAC1, HDAC2, HDAC3, HDAC8, respectively. HDAC-IN-31 induces apoptosis and cell cycle arrests at G2/M phase. HDAC-IN-31 shows good antitumor efficacy. HDAC-IN-31 has the potential for the research of diffuse large B-cell lymphoma .
AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis .
Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research .
Sancycline (Standard) is the analytical standard of Sancycline. This product is intended for research and analytical applications. Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].
BFE-37 is a yeast introduction with heat resistance activity. The survival rate change of BFE-37 after heating at 55 °C for 5 minutes was 6.53 log CFU/mL, showing its strong heat resistance in acidic orange juice. The dynamic behavior of BFE-37 at different temperatures showed a first-order logarithmic linear inactivation characteristic, which indicates its stability in heat treatment. The study of BFE-37 helps to understand the effect of mild heat treatment on juice and provide guidance for microbial control in the food industry .
CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways .
1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin is a polychlorinated dibenzo-p-dioxin (PCDD) congener. 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin can cause pale (fatty) livers, gastrointestinal hemorrhage and early death in H/W and line A rats at the highest dose (10,000 μg/kg). 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin also induces sinusoidal distension, and even severe peliosis in line B .
JAK3-IN-18 is an orally active JAK3 and TEC inhibitor, with IC50s of 0.5391 nM and 12.40 nM, respectively. JAK3-IN-18 demonstrates outstanding selectivity over AK1, AK2, and TYk2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 demonstrates excellent therapeutic efficacy in the experimental autoimmune encephalomyelitis (EAE) mouse model. JAK3-IN-18 can be used for the study of multiple sclerosis .
Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Spike Glycoprotein (1147-1162) is a linear and broadly neutralizing peptide in the S2 protein of SARS-CoV-2. Spike Glycoprotein (1147-1162) is conserved across SARS-CoV, BatCoV RaTG13, SARS-CoV-2, and SARS-CoV-2 variants. Spike Glycoprotein (1147-1162)-targeting mAbs can neutralize both SARS-CoV-2 and SARS-CoV by preventing fusion between the virus and cell membrane. Spike Glycoprotein (1147-1162) can be used for universal vaccines against SARS-CoV-2 mutants research .
HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
Siponimod (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4, with EC50s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research - .
Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4, with EC50s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .
CDK9-IN-33 (compound C35) is a potent, selective and orally active CDK9 inhibitor with IC50 values of 17.44, 160, 316.30, 1771.00, >10000 nM for CDK9, CDK7, CDK2, CDK4, CDK6 respectively. CDK9-IN-33 induces apoptosis. CDK9-IN-33 decreases the protein expression of RPB1 CTD Ser2, RPB1, MCL1. CDK9-IN-33 shows anti-tumor activity .
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .
HDAC-IN-56 ((S)-17b) is an orally active class I histone deacetylase (HDAC) inhibitor with IC50 values of 56.0 ± 6.0, 90.0 ± 5.9, 422.2 ± 105.1, >10000 nM for HDAC1, HDAC2, HDAC3, and HDAC4-11, respectively. HDAC-IN-56 has potent inhibitory activity while strongly increasing intracellular levels of acetylhistone H3 and P21 and effectively inducing G1 cell cycle arrest and apoptosis.HDAC-IN-56 has antitumor activity .
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .
T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay .
GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects .
RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1α by binding HTRF assay, respectively. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels .
Melperone hydrochloride is a butyrophenone with atypical antipsychotic properties. Melperone hydrochloride is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone hydrochloride has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone hydrochloride can be used for the study of schizophrenia, and agitation in the elderly .
Melperone is a butyrophenone with atypical antipsychotic properties. Melperone is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone is also a CYP2D6 inhibitor. Melperone can be used for the study of schizophrenia, and agitation in the elderly .
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3] 2+) is an electrochemiluminescent (ECL) probe that can be used to modify the electrode surface to detect sulfate (S2O82-) and oxalate. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can generate excited state species based on electrochemical reactions and release photons through irreversible redox reactions. When used as a cathode to detect persulfate, it can avoid the interference of hydrogen evolution. At the same time, the anode shows a wide linear range for oxalate. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to construct a regenerable ECL sensor .
Melperone (Standard) is the analytical standard of Melperone (HY-B2169). This product is intended for research and analytical applications. Melperone is a butyrophenone with atypical antipsychotic properties. Melperone is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone is also a CYP2D6 inhibitor. Melperone can be used for the study of schizophrenia, and agitation in the elderly.
Melperone-d4 hydrochloride is the deuterium labeled Melperone hydrochloride (HY-103109) . Melperone hydrochloride is a butyrophenone with atypical antipsychotic properties. Melperone hydrochloride is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone hydrochloride has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone hydrochloride can be used for the study of schizophrenia, and agitation in the elderly .
(12R)-1,12-Octadecanediol ((12R)-Octadecane-1,12-diol) is a compound characterized by a linear chain of 18 carbon atoms with two hydroxyl groups (C18H38O2). This colorless substance has unique properties owing to the presence of two hydroxyl groups in its molecular structure.
Whether derived from natural sources or synthesized chemically, 12-Octadecanediol finds applications in various industries. It is often utilized in the formulation of cosmetics, personal care products, and pharmaceuticals due to its emollient properties, enhancing moisturization and conditioning effects in different formulations. The compound's distinctive structure may make it suitable for specific uses in research or industrial processes.
In industrial contexts, 12-Octadecanediol serves as a valuable chemical intermediate for synthesizing other compounds. Its specialized structure and adaptability in formulations make it a significant component across diverse industries, contributing to the development of products for various purposes.
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells .
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
19F-NMR has proved to be a detection mode in fragment-based drug discovery (FBDD) for studies of protein structure and interactions. 19F shows high sensitivity for NMR detection, and the exquisite sensitivity of 19F chemical shifts and linewidths to ligand binding all make it a valuable approach in FBDD.F (Fluorine) -Fragments can be used for 19F-NMR detection after binding to target proteins, and can be used as an effective 19F-NMR tool for FBDD.
MCE designs a unique collection of 5,109 F-fragments, all of which obey a heuristic rule called the “Rule of Three (RO3)”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This F-fragments library is an important source of lead-like drugs.
Life Chemicals presents a number of exclusive Pre-Plated Diversity Sets composed of 50,240 novel compounds with optimal physicochemical properties selected from Life Chemicals collection of newly synthesized items by dissimilarity search with an average Tanimoto threshold of 82%. These Diverse Screening Sets are ideal starting points for customers looking for a wide range of dissimilarity to screen against a number of targets from different classes or where little information is available on targeted protein structure.
FCH Group Screening Library Collection contains about 2,244,487 lead-like compounds for biological screening. This brand new collection comprises polar molecules with pharmacologically important groups such as free carboxylic and amino groups.
MCE 50K Diversity Library consists of 50,000 lead-like compounds with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120). These compounds were selected by dissimilarity search with an average Tanimoto Coefficient of 0.52. There are 36,857 unique scaffolds and each scaffold 1 to 7 compounds. What’s more, compounds with the same scaffold have as many functional groups as possible, which make abundant chemical spaces. This exceptionally diverse library is highly recommended for random screening against new as well as popular targets based its novel, diverse scaffolds, abundant chemical spaces and the convenience for subsequent modification.
Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. 3-dimensionality (3D) diversity is pivotal because the molecular shape is one of the most important factors in molecular recognition by a biomolecule. There is a developing appreciation that 3D fragments could offer opportunities that are not provided by 2D fragments.
MCE 3D Diverse Fragment Library consists of 5,400 non-flat fragment-like molecules (average Fsp3 value 0.58). More than 4,700 fragment compounds contain at least one chiral center in the structure. The key concepts that underlie the library design were 3D shape, structural diversity, reactive functionality and fragment-like. This 3D Diverse Fragment Library brings higher fragment hit optimization and increases the likelihood to find innovative hits in FBDD.
Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function; it can cover broad swaths of chemical space and allows the use of creative chemistry. Fragment-based drug discovery is well-established in industry and has resulted in a variety of drugs entering clinical trials, with two, vemurafenib and venetoclax, already approved. FBDD also has key attractions for academia. Notably, it is able to tackle difficult or novel targets for which no chemical matter may be found in existing HTS collections.
MCE designs a unique collection of 23,337 fragment compounds, all of which obey a heuristic rule called the “Rule of Three (RO3) ”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This library is an important source of lead-like drugs.
Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.
MCE 10K Natural Product-like Compound Library consists of 10,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).
The most prominent mechanism of action of kinase inhibitors is their competition with ATP by binding to the hinge region of the kinase protein. Once the kinase is blocked by an inhibitor, it loses the ability to transfer phosphate groups from ATP to other molecules, resulting in the loss of kinase activity.
The hinge-binding region of kinase inhibitors mimics the interaction pattern between the ATP nucleobase and the kinase. MCE extracted thousands of kinase inhibitors from the ChEMBL database and isolated their molecular fragments. In certain cases, the amino and amide groups on the molecular fragments are crucial for binding in the hinge region. Therefore, we enhanced the diversity of the collected results by adding these two groups to unoccupied positions on the ring system. Subsequently, the fragments were assessed for their hinge region binding ability via docking at distinct kinases, we also applied pharmacophore constraints to ensure interactions with key amino acids in the kinase hinge region, ultimately obtaining kinase-related molecular fragments.
MCE provides over 10,000 kinase fragment molecules that meet the above requirements and are available off the shelf, serving as an effective tool for screening and developing drugs targeting kinases.
RB-PEG-COOH (MW 10000) (Rhodamine B-PEG-COOH (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a COOH. RRB-PEG-COOH (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
RB-PEG-OH (MW 10000) (Rhodamine B-PEG-OH (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a Hydroxyl group. RB-PEG-OH (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
RB-PEG-DSPE (MW 10000) (Rhodamine B-PEG-DSPE (MW 10000)) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG-DSPE (MW 10000) can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em = 546/610 nm) .
RB-PEG-RB (MW 10000) (Rhodamine B-PEG-Rhodamine B (MW 10000)) a fluorescent dye composed of two Rhodamine B (HY-Y0016) and PEG. RB-PEG-RB (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
RB-PEG-Mal (MW 10000) (Rhodamine B-PEG-Mal (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Maleimide (HY-W007324) (Mal). RB-PEG-Mal (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
FITC-HA (FITC-Hyaluronate) (MW 10000) is a fluorescent dye composed of FITC (HY-66019) and Hyaluronic acid (HY-B0633A) (HA). FITC-HA (FITC-Hyaluronate) (MW 10000) can be used for cell tracing and drug delivery .
RB-PEG-NHS (MW 10000) (Rhodamine B-PEG-NHS (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a hydroxysuccinimide (NHS) group. The NHS group can react with amine-containing groups. RB-PEG-NHS (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 10000) (Rhodamine B-PEG-FA (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 10000) can be used for cell imaging, folate receptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-Biotin (MW 10000) (Rhodamine B-PEG-Biotin (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and a Biotin. Biotin can bind with high affinity to streptavidin or avidin. RB-PEG-Biotin (MW 10000) plays an important role in the specific capture and detection of biomolecules (Ex/Em = 546/610 nm) .
FITC-mPEG (MW 10000) is a fluorescent dye composed of methoxypolyethylene glycol (mPEG) and FITC (HY-66019). FITC-mPEG (MW 10000) can be used for fluorescent labeling and imaging .
4Arm-PEG-RB (MW 10000) (4Arm-PEG-Rhodamine B (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016) and PEG with a four-arm structure. 4Arm-PEG-RB (MW 10000) can be used for drug delivery and fluorescence imaging (Ex/Em = 546/610 nm) .
Rhodamine-PEG (MW 10000) a fluorescent PEG derivative composed of Rhodamine B (HY-Y0016) and PEG. Rhodamine-PEG (MW 10000) can be used for fluorescent labeling and imaging (Ex/Em = 546/610 nm) .
FITC-PEG-COOH (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a COOH. FITC-PEG-COOH (MW 10000) can be used for fluorescent labeling and imaging .
FITC-PEG-OH (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Hydroxyl group. FITC-PEG-OH (MW 10000) can be used for fluorescent labeling and imaging .
FITC-PEG-SH (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a sulfhydryl (SH). FITC-PEG-SH (MW 10000) can be used for fluorescent labeling and imaging .
FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
Cy5 HA (MW 10000) is a hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 633/670 nm).
Cy3 HA (MW 10000) is a hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 550/570 nm).
Cy7 HA (MW 10000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
FITC-PEG-biotin (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Biotin (HY-B0511). FITC-PEG-biotin (MW 10000) can be used for fluorescent labeling and imaging .
DSPE-PEG-FITC (MW 10000) is an amphiphile PEG polymer which has unsaturated lipid tails. DSPE-PEG-FITC (MW 10000) can form micelles in an aqueous solution and can be used to prepare liposome/nano particles for drug nanocarriers .
FITC-PEG-MAL (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and Maleimide (HY-W007324) (MAL). FITC-PEG-MAL (MW 10000) can be used for fluorescent labeling and imaging .
RB-PEG-SH (MW 10000) (Rhodamine B-PEG-SH (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em = 546/610 nm) .
FITC-PEG-NH2 (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and an amino group. FITC-PEG-NH2 (MW 10000) can be used for fluorescent labeling and imaging .
4Arm-PEG-FITC (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG) and 4 FITC (HY-66019) groups. 4Arm-PEG-FITC (MW 10000) can be used for fluorescent labeling and imaging .
Cy3 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 550/570 nm).
Cy5 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 633/670 nm).
Cy7 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 740/770 nm).
RB-PEG-N3 (MW 10000) (Rhodamine B-PEG-N3 (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
Cy5.5 HA (MW 10000) is a hyaluronic acid labeled with CY5.5 (HY-D0924). Cy5.5 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 680/710 nm).
Cy7.5 HA (MW 10000) is a hyaluronic acid labeled with CY7.5 (HY-D0926). Cy7.5 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 770/820 nm).
Cy3 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Cy7 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY7 (HY-D0825). Cy7 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 740/770 nm).
Cy5 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Cy3-PEG-DSPE (MW 10000) is a compound for the labeling and visualization of nanoparticles or other materials. Cy3-PEG-DSPE (MW 10000) has a variety of applications including drug delivery, cellular imaging, tracing of bioprocesses, and the study of interactions at the molecular level.
FITC-PEG-FA (MW 10000) is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG-FA (MW 10000) can be used for fluorescent labeling and imaging .
RB-PEG-NH2 (MW 10000) (Rhodamine B-PEG-NH2 (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em = 546/610 nm) .
ICG PEG DSPE (MW 10000) is a PEG phospholipid with Indocyanine green (ICG) (HY-D0711) dye used in protein/nucelic acid labeling and fluorescence microscopy. ICG PEG DSPE (MW 10000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em = 785/813 nm).
Cy7.5 HA biotin (MW 10000) is a biotinylated hyaluronic acid labeled with CY7.5 (HY-D0926). Cy7.5 HA biotin (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 770/820 nm).
Cy5.5 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY5.5 (HY-D0924). Cy5.5 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 680/710 nm).
Cy7.5 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY7.5 (HY-D0926). Cy7.5 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 770/820 nm).
Cy5.5 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY5.5 (HY-D0924). Cy5.5 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 680/710 nm).
Cy5-PEG-DSPE (MW 10000) is a PEG phospholipid with Cy5 (HY-D0821) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5-PEG-DSPE (MW 10000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
Cy3-PEG-SH (MW 10000) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 10000) is absorbed at 550nm and has high solubility and end-group substitution rate .
ICG PEG NH2 (MW 10000) is a polyethylene glycol derivative containing Indocyanine green (ICG) (HY-D0711) fluorescent dye and polyethylene glycol (PEG) and an amino group. The Indocyanine green fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. ICG PEG NH2 (MW 10000) can be used for fluorescence imaging, fluorescence tracing and fluorescence labeling (Ex/Em = 785/813 nm).
FITC-PEG-N3 (MW 10000) is an azide fluorescent dye containing polyethylene glycol (PEG) and FITC (HY-66019). FITC-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cy5.5-PEG-DSPE (MW 10000) is a PEG phospholipid with Cy5.5 (HY-D0924) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5.5-PEG-DSPE (MW 10000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
Cy7.5-PEG-DSPE (MW 10000) is a PEG phospholipid with CY7.5 (HY-D0926) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy7.5-PEG-DSPE (MW 10000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em = 770/820 nm).
ICG PEG N3 (MW 10000) is a Indocyanine green (ICG) (HY-D0711)-azide fluorescent dye used to label for protein and nucleic acid. ICG PEG N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 785/813 nm).
Cy3-PEG-NH2 (MW 10000) is a polyethylene glycol derivative containing Cy3 (HY-D0822) fluorescent dye and polyethylene glycol (PEG) and an amino group. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Cy3-PEG-NH2 (MW 10000) can be used for fluorescence imaging, fluorescence tracing and fluorescence labeling .
FITC-PEG-CL (MW 10000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).
Cy3-PEG-N3 (MW 10000) is a Cy3 (HY-D0822)-azide fluorescent dye used to label for protein and nucleic acid. Cy3-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cy5-PEG-N3 (MW 10000) is a Cy5 (HY-D0821)-azide fluorescent dye used to label for protein and nucleic acid. Cy5-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
mPEG-PEI-Cy5 (MW 10000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Biotin (HY-B0511). mPEG-PEI-Cy5 (MW 10000) can be used for fluorescent labeling and imaging .
Cy5.5-PEG-N3 (MW 10000) is a Cy5.5 (HY-D0924)-azide fluorescent dye used to label for protein and nucleic acid. Cy5.5-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cy5.5-PEG-NH2 (MW 10000) is a polyethylene glycol derivative containing Cy5.5 (HY-D0924) fluorescent dye and polyethylene glycol (PEG) and an amino group. The Cy5.5 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy5.5 has an emission maximum around 710 nm. Cy5.5-PEG-NH2 (MW 10000) can be used for fluorescence imaging, fluorescence tracing and fluorescence labeling.
Cy5-PEG-SH (MW 10000) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
Cy3 Dextran (MW 10000) is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Dextran (HY-112624). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Dextran has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander (Ex/Em = 550/570 nm) .
Cy5.5-PEG-SH (MW 10000) is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
Chitosan-Cy5.5 (MW 1000) is a fluorescent dye composed of CY5.5 (HY-D0924) and chitosan. Chitosan-Cy5.5 (MW 1000) can be used for bioimaging, drug delivery and biomaterial research (Ex/Em = 680/710 nm) .
8-arm-PEG-FITC (MW 20000) is a fluorescent dye composed of FITC (HY-66019) and eight-arm polyethylene glycol (8-Arm PEG). 8-arm-PEG-FITC (MW 20000) can be used to modify proteins, peptides and other materials with active groups (Ex/Em = 488/525 nm) .
Fluorescent polyamine probe-1 (compound 15) is a linear polyamine probe with high uptake efficiency. Fluorescent polyamine probe-1 can be used for the research of transport system into cancer cells .
AF 555 carboxylic acid is a derivative of the orange fluorescent dye AF 555. AF 555 carboxylic acid is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .
AF 555 NHS ester is a bright, orange-red fluorescence probe. AF 555 NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. AF 555 exhibits average excitation wavelengths under green laser and red laser of 552 nm and 566 nm, respectively .
AF 555 azide is a fluorescent dye and is the azide of AF 555. It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3] 2+) is an electrochemiluminescent (ECL) probe that can be used to modify the electrode surface to detect sulfate (S2O82-) and oxalate. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can generate excited state species based on electrochemical reactions and release photons through irreversible redox reactions. When used as a cathode to detect persulfate, it can avoid the interference of hydrogen evolution. At the same time, the anode shows a wide linear range for oxalate. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to construct a regenerable ECL sensor .
Polyvinylpyrrolidone, averageMw～10000 is a multifunctional synthetic polymer with an average molecular weight of 10,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Polyoxyethylene (10) stearyl ether (Polyethylene glycol octadecyl ether, n～10, averageMn～711) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Polyoxyethylene (100) stearyl ether (Polyethylene glycol octadecyl ether, n～100, averageMn～4670) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
Polyacrylamide, averageMn 150000 (PAM, averageMn 150000) is a multifunctional polymer with moisturizing properties. Polyacrylamide,averageMn 150000 is a kind of biological materials or organic compounds that are widely used in life science research .
Polyacrylamide, averageMn 40000 (PAM, averageMn 40000) is a multifunctional polymer with moisturizing properties. Polyacrylamide,averageMn 40000 is a kind of biological materials or organic compounds that are widely used in life science research .
Polyoxyethylene(7) oleyl ether (Polyethylene glycol oleyl ether, averageMn～577; Polyethylene glycol monooleyl ether, n～7) is a nonionic surfactant. Polyoxyethylene(7) oleyl ether can be used as cosmetic raw .
Polyoxyethylene(2) oleyl ether (Polyethylene glycol oleyl ether, averageMn～357; Polyethylene glycol monooleyl ether, n～2) is a nonionic surfactant. Polyoxyethylene(2) oleyl ether promoting the formation of spherical-shaped nanosystems with a narrow size distribution. Polyoxyethylene(2) oleyl ether can be used for the delivery of several active compounds .
OHC-PEG-COOH (MW 10000) (OHC-PEG-carboxyl (MW 10000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 10000) can be used for drug delivery .
N3-PEG-SCM (MW 10000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 10000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
BOC-NH-PEG-NH2 (MW 10000) (Boc-NH-PEG-Amine (MW 10000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 10000) is an important cross-linker with PEG chains .
Boc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 10000) is an important cross-linker with PEG chains .
Acrylate-PEG-acrylate (MW 10000) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Mal-PEG-OH (MW 10000) (Maleimide-PEG-Hydroxy (MW 10000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 10000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .
H2N-PEG-SH (MW 10000) (Amine-PEG-Thiol (MW 10000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 10000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
Biotin-PEG-COOH (MW 10000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 10000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Polyvinylpyrrolidone, average Mw~40000 is a multifunctional synthetic polymer with an average molecular weight of 40,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Polyvinylpyrrolidone, average Mw～55000 is a multifunctional synthetic polymer with an average molecular weight of 55,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Polyvinylpyrrolidone, average Mw～360000 is a multifunctional synthetic polymer with an average molecular weight of 360,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Fmoc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 10000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
Polyvinylpyrrolidone, average Mw~1300000 is a multifunctional synthetic polymer with an average molecular weight of 1,300,000. Polyvinylpyrrolidone is widely used to synthesize nanoparticles .
Mal-PEG-SCM (MW 10000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 10000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models .
Mal-PEG-NH2 TFA (MW 10000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
DSPE-PEG-CHO ammonium (MW 10000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 10000) can be used for drug delivery .
Phospholipid-PEG-Biotin (MW 10000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
Dextran T10 MW 10,000 (Dextran D10; Dextran T10 MW 8000-12000) is a polymer of anhydroglucose with the average molecular weight of 10000. Dextran T10 MW 10,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery .
PCL-PEG-PCL diacrylate (MW 800) is an amphiphilic triblock copolymer composed of PEG and two polycaprolactones (PCL). PCL-PEG-PCL diacrylate (MW 800) can be cross-linked by free radical polymerization and/or photopolymerization to form a cross-linked hydrogel network .
PCL-PEG-PCL diacrylate (MW 800) is an amphiphilic triblock copolymer composed of PEG and two polycaprolactones (PCL). PCL-PEG-PCL diacrylate (MW 800) can be cross-linked by free radical polymerization and/or photopolymerization to form a cross-linked hydrogel network .
Linear B trisaccharide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
Poly(ethylene glycol) diacrylate (MW 10000) (PEGDA (MW 10000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 10000) can be used in the formation of a cross-linked polymers .
PEG10000 (Polyethylene glycol 10000) can be used as a solubilizer. PEG10000 is a kind of biological materials or organic compounds that are widely used in life science research .
mPEG-SS (MW 10000) (mPEG-Succinimidyl Succinate ester (MW 10000)) is a mPEG-NHS ester reagent with a C2 aliphatic ester bond between PEG and NHS ester. mPEG-SS (MW 10000) can be used for drug delivery .
Cholesterol-PEG-Cholesterol (MW 10000) (CLS-PEG-CLS (MW 10000)) is a cholesterol-modified PEG derivative. Cholesterol-PEG-Cholesterol (MW 10000) can be combined with liposomes to form nanolipid carriers for drug delivery .
mPEG-CM (MW 10000) (mPEG-COOH (MW 10000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 10000) can be used for drug delivery .
m-PEG-Vinylsulfone (MW 10000) (m-PEG-VS (MW 10000)) is a PEG derivative that modulates the release of drugs from microparticle systems for parenteral administration. m-PEG-Vinylsulfone (MW 10000) can be used in drug delivery studies .
DBCO-PEG-FA (MW 10000) (DBCO-PEG-Folate (MW 10000)) is a copolymer that uses PEG as a bridge to connect dibenzocyclooctyne (DBCO) and Folic acid (FA) (HY-16637). DBCO-PEG-FA (MW 10000) can be used in a variety of bioconjugation and drug delivery .
Blue dextran (MW 10000) (Dextran blue (MW 10000)) is a conjugate of dextran and Cibacron Blue 3G-A ligand, mainly used for purification of human serum albumin .
Hyaluronic acid methacryloyl (MW 10000) (HAMA (MW 10000)) is a Hyaluronic acid (HY-B0633A) derivative. Hyaluronic acid methacryloyl-based material system has been applied in many biomedical research fields .
DBCO-PEG-SH (MW 10000) (DBCO-PEG-Thiol (MW 10000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
8-Arm PEG-SH (MW 10000) (8-Arm PEG-Thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW 10000) can be used for drug delivery .
Biotin-PEG-SH (MW 10000) (Biotin-PEG-Thiol (MW 10000)) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
Dopamine-PEG-N3 (MW 10000) (Dopamine-PEG-Azide (MW 10000)) is a compound composed of dopamine, PEG segments and an azide group (-N3). Dopamine-PEG-N3 (MW 10000) can be used as a crosslinker to connect different materials together to build new composite materials and improve the performance of materials. Dopamine-PEG-N3 (MW 10000) is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group.
Amine-PEG-OH (MW 10000) (H2N-PEG-OH (MW 10000)) is a heteroterminal bifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces .
4-Arm PEG-Azide (MW 10000) (4-Arm PEG-N3 (MW 10000)) is a multi-arm PEG derivative with an azide group at each end of four arms attached to a pentaerythritol core .
N3-PEG-NH2 (MW 10000) (Azide-PEG-Amine (MW 10000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 10000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
PLGA10000-PEG3000-VS (PLGA10000-PEG3000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLGA10000-PEG2000-VS (PLGA10000-PEG2000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLLA10000-PEG1000-VS (PLLA10000-PEG1000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLLA10000-PEG3000-VS (PLLA10000-PEG3000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLLA10000-PEG5000-VS (PLLA10000-PEG5000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
PLLA10000-PEG2000-VS (PLLA10000-PEG2000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .
BOC-NH-PEG-FA (MW 10000) (BOC-NH-PEG-Folate (MW 10000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folate receptors and can be used for cell membrane receptors for targeted drug delivery .
DSPE-PEG-Maleimide (MW 10000) ammonium has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide (MW 10000) ammonium can be used in drug delivery research .
Cholesterol-PEG-alcohol (MW 10000) is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG-alcohol (MW 10000) can be used in drug delivery research .
4-Arm-PEG-DA (MW 10000) (4-Arm-PEG-Acrylate (MW 10000)) is a polymer consisting of a four-arm PEG core structure with acrylate groups attached to the ends of each PEG chain by chemical reaction, which can be used for drug delivery .
Leucoberbelin blue I (LBB) is a leuco base that is oxidized by manganese through a hydrogen atom transfer reaction forming a colored complex. Leucoberbelin blue I can be used to quantify or confirm the Mn (II) oxides formation .
Biotin-PEG-Amine (MW 10000) (Biotin-PEG-NH2 (MW 10000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
DBCO-PEG-OH (MW 10000) is a PEG derivative composed of DBCO, PEG, and hydroxyl groups. DBCO-PEG-OH (MW 10000) contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
PLLA10000-PEG5000-BIO is a polylactic acid derivative that can form micelles in water. In addition, PLLA10000-PEG5000-BIO can bind tightly to avidin or streptavidin for protein labeling. PLLA10000-PEG5000-BIO can be used in drug delivery research .
PLLA10000-PEG1000-BIO is a polylactic acid derivative that can form micelles in water. In addition, PLLA10000-PEG1000-BIO can bind tightly to avidin or streptavidin for protein labeling. PLLA10000-PEG1000-BIO can be used in drug delivery research .
PLLA10000-PEG2000-BIO is a polylactic acid derivative that can form micelles in water. In addition, PLLA10000-PEG2000-BIO can bind tightly to avidin or streptavidin for protein labeling. PLLA10000-PEG2000-BIO can be used in drug delivery research .
2-Arm PEG-Mal (MW 10000) is a multi-arm PEG derivative with maleimide groups at each end of the eight arms. 2-Arm PEG-Mal (MW 10000) can be used for drug delivery .
8-Arm PEG-Mal (MW 10000) is a multi-arm PEG derivative with maleimide groups at each end of the eight arms. 8-Arm PEG-Mal (MW 10000) can be used for drug delivery .
8-Arm-PEG-Biotin (MW 10000) is a multiarmed PEG derivative with biotin at each terminal of the eight arms. 8-Arm-PEG-Biotin (MW 10000) is for PEGylation by binding to streptavidin and avidin with high affinity and specificity .
4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
Dextran sulfate sodium salt (DSS) (MW 6500-10000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 6500-10000) has antiviral activity against HIV-1 and HIV-2. Dextran sulfate sodium salt (MW 6500-10000) blocks the binding of virions to CD4 ⁺ T lymphocytes and inhibits syncytia formation. Dextran sulfate sodium salt (MW 6500-10000) also prevents experimental urolithiasis due to its cytoprotective actions. Moreover, because of its biocompatible and highly charged properties, Dextran sulfate sodium salt (MW 6500-10000) is a suitable choice for pharmaceutical systems .
HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
Silane-PEG-N3 (MW 10000) (Silane-PEG-azide (MW 10000)) is a PEG derivative composed of silane, PEG units, and azide groups, which can be used to modify glass, silicon, or other surfaces by reacting hydroxyl groups with ethoxy (methoxy) silanes. Silane-PEG-N3 (MW 10000) contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
4-Arm-PEG-FA (MW 10000) (4-Arm-PEG-folate (MW 10000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folate receptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 10000) (8-Arm-PEG-folate (MW 10000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folate receptors and can be used for targeted drug delivery to cell membrane receptors .
HOOC-PEG-COOH (MW 10000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 10000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
DBCO-PEG-LA (MW 10000) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
DMG-PEG-Mal (MW 10000) is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG-Mal (MW 10000) can be used for drug delivery .
8-Arm-PEG-Cholesterol (MW 10000) is a PEG derivative that attaches cholesterol (Cholesterol) to the end of eight-arm polyethylene glycol (8-Arm PEG). 8-arm-PEG-Cholesterol (MW 10000) can be used for drug delivery .
Poly(ethylene glycol) distearate (Mn 930) is a derivative of polyethylene glycol, which can be used as a cross-linking agent and click chemistry reaction .
Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing Maleimide (HY-W007324). Due to the Maleimide functional group, Poly(ethylene glycol) methyl ether maleimide (Mn 2000) can be used to conjugate biomolecules containing thiol groups.
FA-PEG-COOH (MW 10000) (Folate-PEG-COOH (MW 10000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folate receptor and can be used to target cell membrane receptors for drug delivery .
4-Arm-PEG-DSPE (MW 10000) is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG-DSPE (MW 10000) can be used for drug delivery, gene transfection, and vaccine delivery .
8-Arm-PEG-DSPE (MW 10000) is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG-DSPE (MW 10000) can be used for drug delivery, gene transfection, and vaccine delivery .
6-Arm-PEG-DSPE (MW 10000) is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG-DSPE (MW 10000) can be used for drug delivery, gene transfection, and vaccine delivery .
PLLA10000-PEG1000-RhB is a terminal rhodamine-labeled polylactic acid derivative. PLLA10000-PEG1000-RhB can be used to label nanomicelles for real-time monitoring of drug release in vivo .
PLLA10000-PEG2000-RhB is a terminal rhodamine-labeled polylactic acid derivative. PLLA10000-PEG2000-RhB can be used to label nanomicelles for real-time monitoring of drug release in vivo .
PLLA10000-PEG3000-RhB is a terminal rhodamine-labeled polylactic acid derivative. PLLA10000-PEG3000-RhB can be used to label nanomicelles for real-time monitoring of drug release in vivo .
PLLA10000-PEG5000-RhB is a terminal rhodamine-labeled polylactic acid derivative. PLLA10000-PEG5000-RhB can be used to label nanomicelles for real-time monitoring of drug release in vivo .
PLLA10000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG5000-SPDP can be used in drug delivery research .
PLLA10000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG1000-SPDP can be used in drug delivery research .
PLLA10000-PEG2000-Thiol is a polylactic acid derivative that forms micelles in water and initiates biodegradation by attacking ester bonds through hydrolysis. PLLA10000-PEG2000-Thiol can be used in drug delivery research .
PLLA10000-PEG3000-Thiol is a polylactic acid derivative that forms micelles in water and initiates biodegradation by attacking ester bonds through hydrolysis. PLLA10000-PEG3000-Thiol can be used in drug delivery research .
PLLA10000-PEG1000-Thiol is a polylactic acid derivative that forms micelles in water and initiates biodegradation by attacking ester bonds through hydrolysis. PLLA10000-PEG1000-Thiol can be used in drug delivery research .
PLLA10000-PEG5000-Thiol is a polylactic acid derivative that forms micelles in water and initiates biodegradation by attacking ester bonds through hydrolysis. PLLA10000-PEG5000-Thiol can be used in drug delivery research .
PLLA10000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG3000-SPDP can be used in drug delivery research .
PLLA10000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG2000-SPDP can be used in drug delivery research .
DSPE-PEG-DBCO (MW 10000) is a phospholipid-PEG polymer that can be used to form micelles as lipid nanoparticles for drug delivery . DSPE-PEG-DBCO (MW 10000) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
PLLA10000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA10000-PEG5000-FOL can be used in drug delivery research .
PLLA10000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA10000-PEG2000-FOL can be used in drug delivery research .
8-Arm PEG-NH2 (MW 10000) (8-Arm PEG-Amine (MW 10000)) HCL is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .
8-Arm PEG-NH2 (MW 10000) (8-Arm PEG-Amine (MW 10000)) is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .
Sodium carboxymethyl cellulose (average Mw 90000, DS=0.7, Viscosity:50-200 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent .
DBCO-PEG-NHS (MW 10000) is a PEG derivative consisting of DBCO, PEG units, and NHS ester. NHS ester can bind to amino acids or other molecules containing amino groups. DBCO-PEG-NHS (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
4-Arm-PEG-OH (MW 10000) is a PEG derivative with a four-arm structure and a hydroxyl (OH) functional group. 4-Arm-PEG-OH (MW 10000) reacts with functional groups on biomolecules (such as proteins, peptides, antibodies, etc.) through hydroxyl groups and can be used for drug delivery .
4-Arm PEG-NH2 (MW 10000) (4-Arm PEG-amine (MW 10000)) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .
4-Arm PEG-NH2 HCl (MW 10000) (4-Arm PEG-amine HCL salt (MW 10000)) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .
PLLA10000-PEG3000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG3000-N3 can be used in drug delivery research .
PLLA10000-PEG5000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG5000-N3 can be used in drug delivery research .
PLLA10000-PEG2000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG2000-N3 can be used in drug delivery research .
PLLA10000-PEG1000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG1000-N3 can be used in drug delivery research .
HOOC-PEG-NH2 (MW 10000) (HOOC-PEG-Amine (MW 10000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
Poly(ethylene glycol) dithiol (Mn 1500) is a thiol-modified PEG that can be used to synthesize dithiol-terminated amphiphilic diblock copolymers for drug delivery .
Poly(ethylene glycol) dithiol (Mn1000) is a thiol-modified PEG that can be used to synthesize dithiol-terminated amphiphilic diblock copolymers for drug delivery .
PLLA10000-PEG3000-NH2 is a block copolymer based on polylactic acid derivatives that can self-assemble in water. PLLA10000-PEG3000-NH2 can be used in drug delivery research .
PLLA10000-PEG2000-NH2 is a block copolymer based on polylactic acid derivatives that can self-assemble in water. PLLA10000-PEG2000-NH2 can be used in drug delivery research .
PLLA10000-PEG5000-NH2 is a block copolymer based on polylactic acid derivatives that can self-assemble in water. PLLA10000-PEG5000-NH2 can be used in drug delivery research .
PLLA10000-PEG1000-NH2 is a block copolymer based on polylactic acid derivatives that can self-assemble in water. PLLA10000-PEG1000-NH2 can be used in drug delivery research .
mPEG-SCM (MW 10000) is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
6-Arm-PEG-FA (MW 10000) (6-Arm-PEG-Folate (MW 10000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folate receptors and can be used for cell membrane receptors for targeted drug delivery .
mPEG-N3 (MW 10000) can be used to modify proteins, peptides, and other materials. The azide group can react with alkynes in aqueous solution catalyzed by copper. It can also be easily reduced to an amine group. PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins. mPEG-N3 (MW 10000) can also inhibit the nonspecific binding of charged molecules to the modified surface .
DBCO-PEG-Biotin (MW 10000) is a click chemistry biotinylation that can enable copper-free click chemistry with azide molecules to form a stable triazole linkage .
Poly(L-lactide) (MW 10000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
mPEG-NPC (MW 10000) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
HO-PEG-SCM (MW 10000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 10000 (ammonium) can be converted into aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
Cholesterol-PEG-Mal (MW 10000) is a PEG derivative composed of Cholesterol, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
8-Arm-PEG-CHO (MW 10000) is a polyethylene glycol derivative with multiple active aldehyde groups, which can be used to construct drug delivery carriers .
TPP-PEG-Mal (MW 10000) is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
mPEG-Alkyne (MW 10000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
DSPE-PEG-NHS (ammonium) (MW 10000) is one of the most commonly used reactive phospholipids for coupling antibodies, proteins, peptides or other substrates to the surface of liposomes and other lipid PEG nanoparticles .
Alkyne-PEG-COOH (MW 10000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
mPEG-CHO (MW 10000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
6-Arm-PEG-DA (MW 10000) is a polymer consisting of a four-arm PEG core structure with acrylate groups attached to the ends of each PEG chain by chemical reaction, which can be used for drug delivery .
4-Arm-PEG-Silane (MW 10000) is a silane-modified PEG derivative that can be used to modify glass, silicon or other surfaces by reacting hydroxyl groups with ethoxy (methoxy) silane. PEG can inhibit nonspecific surface binding .
6-Arm-PEG-Silane (MW 10000) is a silane-modified PEG derivative that can be used to modify glass, silicon or other surfaces by reacting hydroxyl groups with ethoxy (methoxy) silane. PEG can inhibit nonspecific surface binding .
Poloxamer 403 P123 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 5750. Poloxamer 403 P123 exhibits muscular toxicity .
4-Arm PEG-alkyne (MW 10000) is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 2000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn1000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 5000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 3400) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
m-PEG-OH (MW 10000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.
6-Arm-PEG-Mal (MW 10000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
mPEG-pALD (MW 10000) is an important unilaterally active PEG derivative whose reactive groups can react with amines, peptides and the N-termini of proteins to form imines containing C=N double bonds, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can be used for reversible PEGylation by reacting with hydrazine or hydrazine to form hydrolyzed acylhydrazone bonds .
Alkyne-PEG-NH2 (MW 10000) is an alkyne-functionalized bifunctional PEG derivative that can be used to modify proteins, peptides, and other materials. The alkyne group reacts with azides in aqueous solution in a copper-catalyzed manner. PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins .
Poloxamer 182 (L62) can be used as an excipient, such as Emulsifier, solubilizer, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
Poloxamer 105 L35 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1900 Da. Poloxamer 105 L35 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Polyvinyl alcohol (Mw 9000-10000, 80% hydrolyzed) also known as PVA, is a vinyl water-soluble polymer that can be used as a non-ionic surfactant. Polyvinyl alcohol (Mw 9000-10000, 80% hydrolyzed) can be used as a biodegradable polymer and can be used in adhesives, coatings, textiles, ceramics, and cosmetics. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A) .
Poloxamer 338 F108 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 14600. Poloxamer 338 F108 reduces the aggregation of red blood cells, inhibits proliferation of human lymphocyte cell IIBR1. Poloxamer 338 F108 exhibits short-term and subchronic toxicity in rats .
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8 AM and Quest Rhod-4 AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .
Polyoxyethylene(10) oleyl ether, also known as POE(10) monooleate, is a nonionic surfactant consisting of a polyethylene glycol chain with 10 ethylene oxide units and an oleic acid residue. It has excellent emulsifying, wetting and dispersing properties, making it suitable for a variety of applications including personal care products and pharmaceutical formulations. POE(10) monooleate is commonly used as a solubilizer to improve the solubility and bioavailability of poorly soluble drugs. Furthermore, it is biodegradable and has low toxicity, making it an environmentally friendly ingredient suitable for various industrial applications.
Pullulan (Pullulan standard 5800) (Mw 362-480 kDa; Mn 100-200 kDa) is a class of orally active and water-soluble linear glucosic polysaccharide. Pullulan can be isolated from the polymorphic fungus Aureobasidium pullulans. Pullulan is composed of maltotriose repeating units linked by α-1,6 linkages and is an amorphous slime matter. Pullulan is widely used in food, environment, pharmaceutical, manufacturing, and electronics .
Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death. Concanavalin A can be used to induce acute hepatic injury .
Concanavalin A-HRP (Con A-HRP) is a HRP-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
Concanavalin A-AF488 (Con A-AF488) is an AF488-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
Concanavalin A-Cy5.5 (Con A-Cy5.5) is a Cy5.5 (HY-D0924)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
Poloxamer 101 L31 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1100. Poloxamer 101 L31 forms hydrogel, that is utilized as surfactants and emulsifying agents. Poloxamer 101 L31 induces slight alveolitis .
Dextran T200 (MW 200,000) is a polymer of anhydroglucose with the average molecular weight of 200000. Dextran T200 (MW 200,000) exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Acrylate-PEG-acrylate (MW 1000) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Acrylate-PEG-acrylate (MW 3400) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Acrylate-PEG-acrylate (MW 2000) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Acrylate-PEG-acrylate (MW 5000) is a linear polymer formed by connecting acrylate groups at both ends of a PEG molecule and can be used for drug delivery .
Poloxamer 334 P104 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 5900. Poloxamer 334 P104 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 185 P65 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 3400. Poloxamer 185 P65 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 125 L45 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2400. Poloxamer 125 L45 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 234 P84 is is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4200. Poloxamer 234 P84 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 123 L43 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1850. Poloxamer 123 L43 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 215 P75 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4150. Poloxamer 215 P75 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 212 L72 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2750. Poloxamer 212 L72 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Silk Fibroin Methacryloyl (FibMA) is methacrylated silk fibroin with excellent biocompatibility, stable mechanical properties and good processing properties, and was selected as the substrate for multifunctional microneedle (MN) patches. . MN patches made of Silk Fibroin Methacryloyl exhibit excellent biocompatibility, sustained drug release, pro-angiogenic, antioxidant and antibacterial properties depending on the specific drug encapsulated . Silk Fibroin Methacryloyl needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Biotin-PEG-Biotin (MW 40000) can be used for crosslinking PEGylation by binding to two streptavidin and avidin. Biotin is conjugated to a linear PEG through a stable amide linker .
N3-PEG-SCM (MW 20000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 20000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 3400) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 3400)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 2000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 2000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 1000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 1000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 5000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 5000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
N3-PEG-SCM (MW 40000) (Azide PEG Succinimidyl Carboxymethyl Ester (MW 40000)) is a linear heteroterminal bifunctional PEG product with succinimidyl carbonate and azide groups.
Poloxamer 402 L122 (PEG-PPG-PEG, 5000 Averag) is a synthetic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO). Poloxamer 402 L122 forms thermoreversible gel, which remains fluid at room temperature but becomes more viscous gel at body temperature. Poloxamer 402 L122 is utilized in drug delivery, tissue regeneration and generation of micellar system .
Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD50 of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral LD50 of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .
mPEG-LA (MW 3400) is a linear block copolymer consisting of methoxy polyethylene glycol (mPEG) capped at one end and Lactic Acid (LA). mPEG-LA (MW 3400) can be used for drug delivery .
mPEG-LA (MW 2000) is a linear block copolymer consisting of methoxy polyethylene glycol (mPEG) capped at one end and Lactic Acid (LA). mPEG-LA (MW 2000) can be used for drug delivery .
mPEG-LA (MW 5000) is a linear block copolymer consisting of methoxy polyethylene glycol (mPEG) capped at one end and Lactic Acid (LA). mPEG-LA (MW 5000) can be used for drug delivery .
mPEG-LA (MW 1000) is a linear block copolymer consisting of methoxy polyethylene glycol (mPEG) capped at one end and Lactic Acid (LA). mPEG-LA (MW 1000) can be used for drug delivery .
Dextran T150 MW 150,000 (Dextran D150; Dextran T150 MW 130000-170000) is a polymer of anhydroglucose with the average molecular weight of 150000. Dextran T150 MW 150,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T200 MW 200,000 (Dextran D200; Dextran T200 MW 180000-220000) is a polymer of anhydroglucose with the average molecular weight of 1000. Dextran T1 MW 1,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
HPMC (Hypromellose) (Type I, Viscosity: 4000mPa.s) is a primary sodium alginate and controlled release hydrophilic polymer with an average viscosity of 4000mPa.s. The viscosity of HPMC may change due to concentration, pH, temperature or the presence of metal ions. When the pH is above 10, the viscosity decreases .
Dextran T7 MW 7,000 (Dextran 7; Dextran D7; Dextran T7 MW 5600-8400) is a polymer of anhydroglucose with the average molecular weight of 7000. Dextran T7 MW 7,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T1 MW 1,000 (Dextran 1; Dextran D1; Dextran T1 MW 800-1200) is a polymer of anhydroglucose with the average molecular weight of 1000. Dextran T1 MW 1,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
OHC-PEG-COOH (MW 40000) (OHC-PEG-carboxyl (MW 40000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 40000) can be used for drug delivery .
OHC-PEG-COOH (MW 1000) (OHC-PEG-carboxyl (MW 1000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 1000) can be used for drug delivery .
OHC-PEG-COOH (MW 3400) (OHC-PEG-carboxyl (MW 3400)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 3400) can be used for drug delivery .
OHC-PEG-COOH (MW 2000) (OHC-PEG-carboxyl (MW 2000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 2000) can be used for drug delivery .
OHC-PEG-COOH (MW 20000) (OHC-PEG-carboxyl (MW 20000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 20000) can be used for drug delivery .
OHC-PEG-COOH (MW 5000) (OHC-PEG-carboxyl (MW 5000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 5000) can be used for drug delivery .
Boc-NH-PEG-COOH (MW 1000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 1000) is an important cross-linker with PEG chains .
Boc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 40000) is an important cross-linker with PEG chains .
Boc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 2000) is an important cross-linker with PEG chains .
Boc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 5000) is an important cross-linker with PEG chains .
Boc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 20000) is an important cross-linker with PEG chains .
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations .
Boc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 3400) is an important cross-linker with PEG chains .
Dextran T500 MW 500,000 (Dextran 500; Dextran D500; Dextran T500 MW 440000-560000) is a polymer of anhydroglucose with the average molecular weight of 500,000. Dextran T500 MW 500,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T800 MW 800,000 (Dextran 800; Dextran D800; Dextran T800 MW 750000-850000) is a polymer of anhydroglucose with the average molecular weight of 800,000. Dextran T800 MW 800,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T20 MW 20,000 (Dextran 20; Dextran D20; Dextran T20 MW 16000-24000) is a polymer of anhydroglucose with the average molecular weight of 20,000. Dextran T20 MW 20,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Dextran T60 MW 60,000 (Dextran 60; Dextran D60; Dextran T60 MW 54000-66000) is a polymer of anhydroglucose with the average molecular weight of 60,000. Dextran T60 MW 60,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
Mal-PEG-NH2 TFA (MW 5000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 40000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 2000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 3400) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 20000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Mal-PEG-NH2 TFA (MW 1000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
Poloxamer 183 L63 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2650. Poloxamer 183 L63 exhibits antimicrobial activity, that inihibits 83% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 183 L63 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 122 L42 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1630. Poloxamer 122 L42 exhibits antimicrobial activity, that inihibits 56% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 122 L42 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 181 L61 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2000. Poloxamer 181 L61 exhibits antimicrobial activity, that inihibits 91% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 181 L61 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Poloxamer 333 P103 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4950. Poloxamer 333 P103 exhibits antimicrobial activity, that inihibits 90% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 333 P103 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Azide-PEG-Silane, MW 10,000 enables surface modification of various substrate through reaction between hydroxyl and ethoxyl silane. The polymer can be used for click chemistry with alkyne containing molecule. Reagent grade, for research use only.
Fmoc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 2000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
Fmoc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 5000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
Fmoc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 40000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
DHT/KLH is a conjugate of DHT (dihydrotestosterone) and keyhole limpet hemocyanin (KLH). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt linear epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
Fmoc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 3400) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
Fmoc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 20000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
DSPE-PEG-OH, MW 5000 is a linear phospholipid PEG polymer. The lipid tails allow encapsulation of hdyrophobic therapeutics while the PEG chain maintains its hydrophilicity. The polymer can be used for drug nanocarrier, such as liposomal anti cancer drug or mRNA/DNA vaccine. Reagent grade, for research use only.
BOC-NH-PEG-NH2 (MW 1000) (Boc-NH-PEG-Amine (MW 1000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 1000) is an important cross-linker with PEG chains .
BOC-NH-PEG-NH2 (MW 20000) (Boc-NH-PEG-Amine (MW 20000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 20000) is an important cross-linker with PEG chains .
Biotin-PEG-COOH (MW 20000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 20000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
BOC-NH-PEG-NH2 (MW 40000) (Boc-NH-PEG-Amine (MW 40000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 40000) is an important cross-linker with PEG chains .
Biotin-PEG-COOH (MW 40000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 401000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
BOC-NH-PEG-NH2 (MW 3400) (Boc-NH-PEG-Amine (MW 3400)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 3400) is an important cross-linker with PEG chains .
BOC-NH-PEG-NH2 (MW 5000) (Boc-NH-PEG-Amine (MW 5000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 5000) is an important cross-linker with PEG chains .
Biotin-PEG-COOH (MW 1000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 1000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Biotin-PEG-COOH (MW 2000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 2000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Biotin-PEG-COOH (MW 3400) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 3400) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
Biotin-PEG-COOH (MW 5000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 5000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
BOC-NH-PEG-NH2 (MW 2000) (Boc-NH-PEG-Amine (MW 2000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 2000) is an important cross-linker with PEG chains .
Poloxamer 335 P105 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 6500. Poloxamer 335 P105 exhibits antimicrobial activity, that inihibits 86% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 334 P104 exhibits muscular toxicity. Poloxamer 334 P104 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Biotin-PEG-maleimide (MW 3400) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 3400) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Biotin-PEG-maleimide (MW 5000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 5000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Phospholipid-PEG-Biotin (MW 3400) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
Biotin-PEG-maleimide (MW 1000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 1000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Biotin-PEG-maleimide (MW 2000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 2000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Phospholipid-PEG-Biotin (MW 20000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
Phospholipid-PEG-Biotin (MW 1000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
HPMC (Hypromellose) (Type I, Viscosity: 400mPa.s) is a first-grade sodium alginate with an average viscosity of 400 mPa.s. Typically, a 1% w/v HPMC aqueous solution has a viscosity of 20-400mPa.s (20-400cp) at 20°C. The viscosity of HPMC may vary depending on concentration, pH, temperature, or the presence of metal ions. Viscosity decreases at pH values above 10 .
Poloxamer 184 L64 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2900. Poloxamer 184 L64 exhibts short-term dermal toxicity characterized by slight erythema and intradermal inflammatory response. Poloxamer 184 L64 exhibits antimicrobial activity, that inihibits 60% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 184 L64 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
Cross-linked dextran G 50, medium is a gel filtration medium. Cross-linked dextran G 50, medium can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, medium are microspheres with an average particle size of D50 = 220-250 μm .
Cross-linked dextran G 50, fine is a gel filtration medium. Cross-linked dextran G 50, fine can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, fineThe average particle size is D50=110-130 μmof microspheres .
Mal-PEG-SCM (MW 3400) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 3400) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 2000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 2000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 40000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 40000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 5000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 5000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 20000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 20000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
Mal-PEG-SCM (MW 1000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 1000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
H2N-PEG-SH (MW 3400) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 3400) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
H2N-PEG-SH (MW 2000) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 2000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
H2N-PEG-SH (MW 5000) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 5000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
Mal-PEG-OH (MW 20000) (Maleimide-PEG-Hydroxy (MW 20000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 20000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .
Mal-PEG-OH (MW 40000) (Maleimide-PEG-Hydroxy (MW 40000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 40000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .
Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.
Mal-PEG-OH (MW 3400) (Maleimide-PEG-Hydroxy (MW 3400)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 3400) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .
DSPE-PEG-CHO ammonium (MW 3400) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 3400) can be used for drug delivery .
DSPE-PEG-CHO ammonium (MW 5000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 5000) can be used for drug delivery .
H2N-PEG-SH (MW 1000) (Amine-PEG-Thiol (MW 1000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 1000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
H2N-PEG-SH (MW 20000) (Amine-PEG-Thiol (MW 20000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 20000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
DSPE-PEG-CHO ammonium (MW 1000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 1000) can be used for drug delivery .
H2N-PEG-SH (MW 40000) (Amine-PEG-Thiol (MW 40000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 40000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
DSPE-PEG-CHO ammonium (MW 20000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 20000) can be used for drug delivery .
DSPE-PEG-CHO ammonium (MW 40000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 40000) can be used for drug delivery .
DSPE-PEG-CHO ammonium (MW 2000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 2000) can be used for drug delivery .
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion .
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
Bac2A TFA is an antimicrobial and immunomodulatory peptide. Bac2A TFA is a linear variant of bactenecin and is very effective against fungal pathogens.
Acetyl-octreotide is a reduced linear peptide. Acetyl-octreotide can synthesize Re(V)-cyclized peptides in aqueous methanol solutions with low Sst receptor binding affinities .
Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. Cecropin A TFA exhibits anti-bacterial, anti-inflammatory and anti-cancer activity .
Mast Cell Degranulating Peptide HR-2, a 14-membered linear peptide isolated from the venom of the giant hornet Vespa orientalis, is capable of degranulating mast cells and thus initiating histamine release .
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .
Delicious peptide is a small linear octapeptide with delicious taste, can be isolated from the gravy of beef meat. Delicious peptide has savory flavor, is also described as beefy meaty peptide and a beef flavor enhancer .
CooP is a linear glioblastoma-targeting nonapeptide. CooP binds to the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) in the glioblastoma cells and its associated vasculature. CooP is used for the targeted delivery of chemotherapy and different nanoparticles .
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .
Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 is a linear peptide from laminin B1 chain that interferes with tumor cell attachment and invasion into basement membrane and has anti-angiogenic effects .
Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .
H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH (EM7) acetate is a linear mesenchymal stem cell (MSC) specific peptide. H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH acetate can be used to prepare Gd-DOTA-peptide complexes.
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity .
Bulevirtide (Myrcludex B) is a NTCP inhibitor, a linear lipopeptide of 47 amino acids. Bulevirtide inhibits HBV and HDV entry into liver cells, blocks HBV infection in hepatocytes, and participates in HBV transcriptional suppression. Bulevirtide can be used in HDV infection and compensated cirrhosis research .
H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH (EM7) is a linear mesenchymal stem cells (MSC)-specific peptide. H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH can be used to prepare Gd-DOTA-peptide complexes .
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .
LDV-FITC TFA, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC TFA binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC TFA can be used to detect α4β1 integrin affinity .
Heart-homing peptide is a peptide, CRPPR. CRPPR is a linear peptide containing arginine that has been identified as a heart-homing peptide owing to its ability to specifically bind to heart endothelium, and cysteine-rich protein-2 (CRIP-2) has been proposed as the receptor. Heart-homing peptide can be used for conjugating liposomes .
Heart-homing peptide TFA is a Pentapeptide, CRPPR. CRPPR is a linear peptide containing arginine that has been identified as a heart-homing peptide owing to its ability to specifically bind to heart endothelium, and cysteine-rich protein-2 (CRIP-2) has been proposed as the receptor. Heart-homing peptide TFA can be used for conjugating liposomes .
HCV Core Protein (107-114) is a least immunogenic residue of the major linearHCV core regions. HCV Core Protein (107-114) is identified as the binding site within the region 101-118, which contains two residues differing between genotypes Ⅰ/Ⅱ and Ⅲ/Ⅵ. HCV Core Protein (107-114) might be a potential site for dissemination of HCV serotypes .
[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells .
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .
C5aR1 antagonist peptide is a biological active peptide. (This linear peptide is derived from the C-terminus of the chemokine, complement fragment 5 anaphylatoxin (C5a). This peptide functions to inhibit C5a binding and function at human and rat C5a receptors. C5a is crucial to triggering cellular immune responses and its overexpression is involved in arthritis, Alzheimer’s disease, cystic fibrosis, systemic lupus erythematosus, and other immunoinflammatory diseases.)
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively .
[Arg14,Lys15]Nociceptin TFA is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin TFA displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively .
Spike Glycoprotein (1147-1162) is a linear and broadly neutralizing peptide in the S2 protein of SARS-CoV-2. Spike Glycoprotein (1147-1162) is conserved across SARS-CoV, BatCoV RaTG13, SARS-CoV-2, and SARS-CoV-2 variants. Spike Glycoprotein (1147-1162)-targeting mAbs can neutralize both SARS-CoV-2 and SARS-CoV by preventing fusion between the virus and cell membrane. Spike Glycoprotein (1147-1162) can be used for universal vaccines against SARS-CoV-2 mutants research .
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .
GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects .
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
RNase R is a magnesium ion-dependent 3'-5' exoribonuclease that can increase the abundance of circular RNA by degrading linear RNA in mixed RNA, thereby enriching circular RNA.
MCE Red Nucleic Acid Gel Stain (10,000×) is a nucleic acid stain that can be used as a safer alternative to the traditional ethidium bromide (EB) stain for detecting nucleic acids in agarose gels or polyacrylamide gels.
0.5 mL Storage Tube, Three-Code Tube, External Thread with Screw Cap, Compatible with SBS- 96-Well Racks. This product is made from high-quality PP material, suitable for ultra-low temperature storage, with excellent weather resistance. Free from DNase and RNase, and can be sterilized by irradiation. The bottom of the tube features a unique QR code, while the side wall has a 1D linear barcode and directly readable numeric code, all three codes are identical and unique. The codes are laser-etched, scratch-resistant, not easy to fall off, and have high contrast for easy reading. The accompanying tube rack (HY-E0225) is made of the same material as the tube, effectively preventing uneven expansion issues during freeze-thaw cycles.
Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1MN, HIV-1SF2 and HIV-189.6 with IC50 values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection .
Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8 .
Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
Lemalesomab (IMMU-MN3) is a mouse IgG1 Anti-NCA-90 monoclonal antibody and a Fab'fragment. Lemalesomab can be used for the research of inflammation, infectious lesions and infection imaging .
Sulesomab (IMMU-MN3) is a murine monoclonal antibody fragment of the IgG1 class that binds to Normal Cross-Reactive Antigen-90 present on leukocytes. Sulesomab is cleared into infection nonspecifically through increased capillary membrane permeability .
Sacituzumab (powder) is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab (powder) demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab (powder) can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
(±)-Marmesin is a good precursor of the linear furanocoumarins. (±)-Marmesin derivatives have high degree of acetylcholinesterase inhibitory property .
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
Manganese peroxidase is a heme protein that oxidizes Mn2+ to Mn3+. Manganese peroxidase catalyzes plant lignin de-polymerization. Manganese peroxidase can be used for the biodegradation of hazardous environmental contaminants, and especially for dye wastewater decolorization .
Hirudonucleodisulfide B is a heterocyclic compound that can be found in Whitmania pigra. Hirudonucleodisulfide B shows moderately anti-anoxic activity .
Corynoxine B is an alkaloid-based autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances α-synuclein (α-syn) clearance in Parkinson's disease mice .
Marmesinin ((-)-Marmesinin), a natural coumarin, is a biosynthetic precursor of psoralen and linear furanocoumarins. Marmesinin exhibits significant neuroprotective activities against glutamate-induced toxicity .
Caffeoyl alcohol is a monomer constituting Catechyl lignin. Catechyl lignin is a linear homopolymer of caffeyl alcohol, a natural source of carbon fiber and high-value chemicals .
Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. Cecropin A TFA exhibits anti-bacterial, anti-inflammatory and anti-cancer activity .
Nostosin G is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal. Nostosin G has potent trypsin inhibitory property with an IC50 value of 0.1 μM .
L-Diguluronic acid is a linear polysaccharide copolymer composed of two L-guluronic acid (G) and can be used to from Alginate . Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of antifungal agents delivery carries .
Corynoxine B Standard is an analytical standard for Corynoxine B. This product is intended for research and analytical applications. Corynoxine B is an alkaloid-type autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances the clearance of α-synuclein (α-syn) in Parkinson's disease mice .
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC50: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC50: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC50: 50 nM) .
Tasiamide B is a Cathepsin D inhibitor, which is a linear peptide found in the marine cyanobacteria Symploca sp.. Tasiamide B is proved as a good template for the development of aspartic proteases inhibitors. Tasiamide B is effective against skin cancer by strongly interacting with the target protein HSP90 .
Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis .
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .
5-Methyl-2-thiophenecarboxaldehyde (Standard) is the analytical standard of 5-Methyl-2-thiophenecarboxaldehyde. This product is intended for research and analytical applications. 5-Methyl-2-thiophenecarboxaldehyde acts as a candidate to microscopic third order non-linear optical (NLO) material[1].
(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6 . (Z)-Ligustilide is orally active, it inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) . (Z)-Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer .
Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC50s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch .
SOD2/Mn-SOD protein is a key enzyme in cellular defense that neutralizes superoxide anion radicals and protects cells from oxidative stress. SOD2, as a manganese-containing superoxide dismutase, plays a key role in breaking down these free radicals and is essential for maintaining cellular homeostasis and protecting biological systems from potential damage caused by the accumulation of reactive oxygen species. SOD2/Mn-SOD Protein, Human (HEK293, His) is the recombinant human-derived SOD2/Mn-SOD protein, expressed by HEK293 , with C-6*His labeled tag.
The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Human (HEK293, Fc) is the recombinant human-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-hFc labeled tag.
The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Canine (HEK293, His) is the recombinant canine-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-His labeled tag.
The envelope glycoprotein gp120 protein facilitates viral capture and dissemination by dendritic cells and endothelial cells by attaching the virus to host lymphocytes through binding to the CD4 receptor.HIV exploits the migratory properties of dendritic cells to access CD4+ T cells, leading to infection.envelope glycoprotein gp120 Protein, HIV-1 (AAC31819, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-His labeled tag.
SOD2/Mn-SOD protein is a key enzyme in cellular defense that neutralizes superoxide anion radicals and protects cells from oxidative stress. SOD2, as a manganese-containing superoxide dismutase, plays a key role in breaking down these free radicals and is essential for maintaining cellular homeostasis and protecting biological systems from potential damage caused by the accumulation of reactive oxygen species. SOD2/Mn-SOD Protein, Human is the recombinant human-derived SOD2/Mn-SOD protein, expressed by E. coli , with tag free.
Carbonic Anhydrase 9 Protein catalyzes the reversible hydration of carbon dioxide, essential for converting it to bicarbonate ions and protons, and vice versa. This enzymatic activity is crucial in physiological processes like acid-base balance regulation, respiration, and cellular pH homeostasis. Carbonic Anhydrase 9 Protein is vital for carbon dioxide transport and metabolism, contributing to overall regulation of its levels in the body. Carbonic Anhydrase 9 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Carbonic Anhydrase 9 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is 361 a.a., with molecular weight of 50-55 kDa.
The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Canine (HEK293, hFc) is the recombinant canine-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-hFc labeled tag.
The Carbonic Anhydrase 9 protein is responsible for catalyzing the interconversion between carbon dioxide and water, as well as facilitating the conversion of carbonic acid into its dissociated ions, namely bicarbonate and hydrogen ions. Carbonic Anhydrase 9 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-His labeled tag.
The GYPA/CD235a protein is an important component of the ankyrin-1 complex, which is critical for the stability and shape of the red blood cell membrane. GYPA/CD235a Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived GYPA/CD235a protein, expressed by HEK293 , with C-His labeled tag.
Carbonic Anhydrase 9 Protein catalyzes the reversible hydration of carbon dioxide, essential for converting it to bicarbonate ions and protons, and vice versa. This enzymatic activity is crucial in physiological processes like acid-base balance regulation, respiration, and cellular pH homeostasis. Carbonic Anhydrase 9 Protein is vital for carbon dioxide transport and metabolism, contributing to overall regulation of its levels in the body. Carbonic Anhydrase 9 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-His labeled tag.
The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Human (HEK293, His) is the recombinant human-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-6*His labeled tag.
The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). FITC-Labeled Carbonic Anhydrase 9 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled Carbonic Anhydrase 9 protein, expressed by HEK293, with C-His labeled tag.
The GYPA/CD235a protein is an important component of the ankyrin 1 complex, which maintains the stability and shape of the red blood cell membrane. As a major intrinsic membrane protein, GYPA ensures the structural integrity and function of these blood cells. GYPA/CD235a Protein, Mouse (HEK293, His) is the recombinant mouse-derived GYPA/CD235a protein, expressed by HEK293 , with C-His labeled tag.
The GYPA/CD235a protein is an important component of the ankyrin 1 complex, which maintains the stability and shape of the red blood cell membrane. As a major intrinsic membrane protein, GYPA ensures the structural integrity and function of these blood cells. GYPA/CD235a Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GYPA/CD235a protein, expressed by HEK293 , with C-hFc labeled tag.
Edoxaban-d6 is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment .
Alogliptin-d3 is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes .
Melperone-d4 hydrochloride is the deuterium labeled Melperone hydrochloride (HY-103109) . Melperone hydrochloride is a butyrophenone with atypical antipsychotic properties. Melperone hydrochloride is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone hydrochloride has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone hydrochloride can be used for the study of schizophrenia, and agitation in the elderly .
Ibudilast-d7-1 is the deuterium labeled Ibudilast . Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
Ibudilast-d7 is the deuterium labeled Ibudilast. Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
Bexarotene- 13C6 (LGD1069- 13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
Bexarotene- 13C4 (LGD1069- 13C4) is the 13C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4, with EC50s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .
CA9 Antibody (YA4317) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CA9. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.
SOD2 Antibody (YA670) is a non-conjugated and Mouse origined monoclonal antibody about 25 kDa, targeting to SOD2 (4C4). It can be used for WB assays with tag free, in the background of Human.
CA9 Antibody (YA1368) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1368), targeting CA9. CA9 Antibody (YA1368) can be used for FC, ELISA experiment in human background.
SOD2 Antibody (YA5501) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SOD2. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse, rat.
SOD2 Antibody (YA6193) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOD2. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.
SOD2 Antibody (YA3635) is a mouse-derived and non-conjugated IgG1 antibody, targeting to SOD2. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.
Glycophorin A Antibody (YA5608) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glycophorin A. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.
Glycophorin A Antibody (YA1151) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1151), targeting Glycophorin A. Glycophorin A Antibody (YA1151) can be used for IHC-P experiment in human background.
CA9 Antibody (YA5697) is a mouse-derived and non-conjugated IgG monoclonal antibody, targeting to CA IX. It can be applicated for IHC-P, ELISA assays, in the background of human.
CA9 Antibody (YA6279) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Carbonic Anhydrase 9. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.
Carbonic Anhydrase 9Rabbit mAb Antibody (YA2443) is a mouse-derived non-conjugated IgG antibody (Clone NO.: YA2443), targeting Carbonic Anhydrase 9. Carbonic Anhydrase 9 Antibody (YA2443) can be used for WB,IHC-P,FC experiment in human background.
CA9 Antibody (YA5355) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CA IX. It can be applicated for ICC/IF, WB, IHC-P, IP assays, in the background of human.
SOD-1 Antibody (YA3541) is an unconjugated, approximately 17 kDa, rabbit-derived, anti-SOD1 monoclonal antibody. SOD1 Antibody can be used for: WB, IF-Cell, IF-Tissue, IHC-P, FC expriments in human, mouse, rat background without labeling.
Azide-PEG-azide (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG-azide (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
RB-PEG-N3 (MW 10000) (Rhodamine B-PEG-N3 (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
PLLA10000-PEG3000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG3000-N3 can be used in drug delivery research .
PLLA10000-PEG5000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG5000-N3 can be used in drug delivery research .
PLLA10000-PEG2000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG2000-N3 can be used in drug delivery research .
PLLA10000-PEG1000-N3 is a polylactic acid derivative used for encapsulating hydrophobic drugs. PLLA10000-PEG1000-N3 can be used in drug delivery research .
m-PEG-azide (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG-azide (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
mPEG-N3 (MW 10000) can be used to modify proteins, peptides, and other materials. The azide group can react with alkynes in aqueous solution catalyzed by copper. It can also be easily reduced to an amine group. PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins. mPEG-N3 (MW 10000) can also inhibit the nonspecific binding of charged molecules to the modified surface .
Biotin-PEG-Alk (MW 10000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; Alk (Alkyne), acyclic (branched or unbranched) aliphatic hydrocarbon, can react with azido, which improve the efficiency of biotin binding targets. Biotin-PEG-Alk (MW 10000) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
FITC-PEG-N3 (MW 10000) is an azide fluorescent dye containing polyethylene glycol (PEG) and FITC (HY-66019). FITC-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
mPEG-Alkyne (MW 10000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
AF 555 azide is a fluorescent dye and is the azide of AF 555. It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with averageEC50 values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models .
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery .
Poloxamer 182 (L62) can be used as an excipient, such as Emulsifier, solubilizer, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8 AM and Quest Rhod-4 AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .
Phospholipid-PEG-Biotin (MW 10000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
MN1 Human Pre-designed siRNA Set A contains three designed siRNAs for MN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mn1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mn1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 10000 (ammonium) can be converted into aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
mPEG-CHO (MW 10000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
Pak6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pak6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
AFP aptamer sodium is an aptamer that specifically targets the liver cancer biomarker alpha-fetoprotein (AFP). AFP aptamer sodium can be used as a recognition molecule for AFP, with a linear detection range of 12.5-800 ng/mL .
Dimethicone is an orally active biochemical assay reagents consisting of a fully methylated linear siloxane polymer whose ends are blocked by trimethylsiloxane units. Dimethicone can lubricate hair and physically block the respiratory system of lice to remove lice. Dimethicone has potential applications in cosmetics and daily cleaning products .
Phospholipid-PEG-Biotin (MW 3400) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
Phospholipid-PEG-Biotin (MW 20000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
Phospholipid-PEG-Biotin (MW 1000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
ODN INH-18 sodium is a linear 24-mer class B INH-ODN in which the 5' INH-ODN 4084-F sequence was followed by a random stretch of 12 nucleotides lacking the ability to form significant secondary structures. ODN INH-18 sodium showes inhibitory potency for TLR9 ligand-induced IFN-α production.
ODN INH-18 is a linear 24-mer class B INH-ODN in which the 5' INH-ODN 4084-F sequence was followed by a random stretch of 12 nucleotides lacking the ability to form significant secondary structures. ODN INH-18 showes inhibitory potency for TLR9 ligand-induced IFN-α production.
ODN INH-18 triethylamine is a linear 24-mer class B INH-ODN in which the 5' INH-ODN 4084-F sequence was followed by a random stretch of 12 nucleotides lacking the ability to form significant secondary structures. ODN INH-18 triethylamine showes inhibitory potency for TLR9 ligand-induced IFN-α production.
S2.2 aptamer sodium is a nucleic acid aptamer targeting the mucin MUC1 and can be used for targeted imaging of MCF-7 cancer cells. S2.2 aptamer sodium was labeled with Cy5, and when fluorescent silicon nanodots (SiND) were present, the fluorescence was quenched; when MUC1 was also present, the fluorescence was restored. S2.2 aptamer sodium detects MUC1 with a linear range of 3.33-250 nM .
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
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