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PS

" in MedChemExpress (MCE) Product Catalog:

121

Inhibitors & Agonists

3

Fluorescent Dye

8

Biochemical Assay Reagents

2

Peptides

3

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2

Inhibitory Antibodies

8

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14

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15

Isotope-Labeled Compounds

10

Antibodies

11

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13851

    PDK-1 Others
    PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48 .
    PS47
  • HY-18008
    PS-1145
    4 Publications Verification

    IKK Apoptosis Cancer
    PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
    PS-1145
  • HY-103053

    VD/VDR Apoptosis Cancer
    PS121912 is a selective vitamin D receptor (VDR)-coregulator inhibitor. PS121912 has acceptable metabolic stability in vivo. PS121912 can be used for the research of cancer .
    PS121912
  • HY-124060

    PDK-1 Cancer
    PS423 is a prodrug of PS210, acting as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K. PS210 is a potent and selective PDK1 activator targeting the PIF binding pocket of PDK1 .
    PS423
  • HY-121629

    PDK-1 Cancer
    PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K .
    PS210
  • HY-18008R

    IKK Apoptosis Cancer
    PS-1145 (Standard) is the analytical standard of PS-1145. This product is intended for research and analytical applications. PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
    PS-1145 (Standard)
  • HY-136898

    Thrombin Others
    PS-915 dihydrochloride is a peptide substrate used in a colorimetric assay for plasma antithrombin III (ATIII). PS-915 dihydrochloride is highly specific for thrombin. By enzyme hydrolysis, PS-915 dihydrochloride liberates 3-carboxy-4-hydroxyaniline (CHA), which turns blue in color due to the complex formation with added alkaline-pentacyanoammine ferroate .
    PS-915 dihydrochloride
  • HY-107593

    IKK Inflammation/Immunology
    PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats .
    PS-1145 dihydrochloride
  • HY-167877

    p38 MAPK Inflammation/Immunology
    PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC50 of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay .
    PS-166276
  • HY-124308

    PKC Cancer
    PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity .
    PS315
  • HY-111149A
    PS372424 hydrochloride
    1 Publications Verification

    CXCR Inflammation/Immunology
    PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation .
    PS372424 hydrochloride
  • HY-111149

    CXCR Inflammation/Immunology
    PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation .
    PS372424
  • HY-121744
    PS10
    3 Publications Verification

    PDHK Inflammation/Immunology
    PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM) . PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy .PDK: pyruvate dehydrogenase kinase
    PS10
  • HY-15967
    PS48
    5 Publications Verification

    PDK-1 Cancer
    PS48 is an activator of PDK1 with an AC50 of 8 μM.
    PS48
  • HY-117366

    PKC Cancer
    PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models .
    PS432
  • HY-174248

    PROTACs PAK Cancer
    PS21M is a negative control of CPS-021 (HY-174247). PS21M cannot effectively degrade PAK4 in MDA-MB-231 cells. (Pink: Target Protein Ligand (HY-174822); Black: Linker; Blue: E3 Ligase Ligand (HY-W586822)) .
    PS21M
  • HY-D2418

    Fluorescent Dye Metabolic Disease
    PS-SCOTfluor-12 (compound 10) is a fluorescent probe for imaging Lactic acid (HY-B2227) metabolism in live cells. λex/λem= 485/605 nm .
    PS-SCOTfluor-12
  • HY-10227G

    PS-341; LDP-341; NSC 681239

    Proteasome NF-κB Apoptosis Autophagy Cancer
    Bortezomib (GMP) (PS-341 (GMP)) is Bortezomib (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .
    Bortezomib
  • HY-10227
    Bortezomib
    Maximum Cited Publications
    187 Publications Verification

    PS-341; LDP-341; NSC 681239

    Proteasome NF-κB Apoptosis Autophagy Cancer
    Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .
    Bortezomib
  • HY-10227R

    PS-341 (Standard); LDP-341 (Standard); NSC 681239 (Standard)

    Reference Standards Proteasome NF-κB Apoptosis Autophagy Cancer
    Bortezomib (Standard) is the analytical standard of Bortezomib. This product is intended for research and analytical applications. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .
    Bortezomib (Standard)
  • HY-107412

    PS-IX; AM114

    Proteasome Cancer
    Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53 +/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity .
    Proteasome inhibitor IX
  • HY-10227S

    PS-341-d8; LDP-341-d8; NSC 681239-d8

    Proteasome NF-κB Apoptosis Autophagy Cancer
    Bortezomib-d8 is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .
    Bortezomib-d8
  • HY-122285

    PS 2747

    Antibiotic Neurological Disease
    A-25794 is an antibiotic with antidepressant properties .
    A-25794
  • HY-144314

    Estrogen Receptor/ERR Cancer
    PSDalpha is an ERα degrader conjugating photosensitizer (PS), triphenylamine benzothiadiazole (TB) and 17β-estradiol via an acetylene bond. PSDalpha shows excellent anti-proliferation performance on MCF-7 cells. The maximum absorption wavelength of PSDalpha in the visible region is located at 465 nm .
    PSDalpha
  • HY-W013758

    TMBZ-PS sodium

    Biochemical Assay Reagents Cancer
    TMB-PS (TMBZ-PS) sodium is a chromogenic substrate for the detection and quantification of peroxidase activity .
    TMB-PS sodium
  • HY-157620

    Endogenous Metabolite
    18:0 Lyso PS sodium is a bioactive molecule with the activity of promoting cell signaling. 18:0 Lyso PS sodium plays an important role in regulating the fluidity and integrity of cell membranes. 18:0 Lyso PS sodium is widely used in lipidomics research to analyze lipid metabolism in cells.
    18:0 Lyso PS sodium
  • HY-145539

    Liposome Others
    12-Dipalmitoyl-sn-glycero-3-PS sodium salt is an anionic diacyl phospholipid, a lipid component in cell membrane. 12-Dipalmitoyl-sn-glycero-3-PS sodium salt can be use in the preparation of catanionic vesicles and liposome .
    12-Dipalmitoyl-sn-glycero-3-PS sodium salt
  • HY-13856

    PDK-1 Cancer
    (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment .
    (R)-PS210
  • HY-Y1422K

    Biochemical Assay Reagents Lipase Others
    Lipase PS-IM is an immobilized lipase derived from Burkholderiacepacia .
    Lipase PS-IM
  • HY-145539S

    Isotope-Labeled Compounds Others
    12-Dipalmitoyl-sn-glycero-3-PS-d62 (sodium) is deuterium labeled 12-Dipalmitoyl-sn-glycero-3-PS.
    12-Dipalmitoyl-sn-glycero-3-PS-d62 sodium salt
  • HY-Y1422J

    Biochemical Assay Reagents Lipase Others
    Lipase PS-SD comes from Burkholderiacepacia and can be used for catalytic reaction .
    Lipase PS-SD
  • HY-146885S
    16:0-18:1 PS-d31 sodium
    1 Publications Verification

    Isotope-Labeled Compounds Others
    16:0-18:1 PS-d31 (sodium) is deuterium labeled 16:0-18:1 PS (sodium).
    16:0-18:1 PS-d31 sodium
  • HY-15931

    TMBZ-PS

    Fluorescent Dye Others
    TMB-PS(102062-36-2) is N-(3-sulfopropyl)-3,3',5,5'-tetramenthylbenzidine sodium salt; White - pale yellow crystalline powder, soluble in water, can be used under neutral, acidic and alkaline conditions.
    TMB-PS
  • HY-168797

    Biochemical Assay Reagents Metabolic Disease
    1,2-Dihexanoyl-sn-glycero-3-PS sodium is a phospholipid containing Hexanoic acid (HY-N4078) at the sn-1 and sn-2 positions.
    1,2-Dihexanoyl-sn-glycero-3-PS sodium
  • HY-143675S

    Isotope-Labeled Compounds Others
    1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9 is the deuterium labeled 1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS .
    1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9
  • HY-P990144

    Integrin Inflammation/Immunology Cancer
    Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) is an anti-mouse/human VLA-4/CD49d IgG2b monoclonal antibody. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can reduce VLA-4 positive cells. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can inhibit the migration of Tc1 cells to tumors. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) inhibits the retention of leukemia cells in the spleen and bone marrow by blocking VLA-4. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can be used for research on inflammation conditions and cancer such as experimental autoimmune encephalomyelitis (EAE), melanoma and leukemia .
    Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2)
  • HY-148978

    Endogenous Metabolite Metabolic Disease
    18:0,18:1 PS sodium is a lipid component of synaptic vesicles and cholesterol, which can be used for metabolic research .
    18:0,18:1 PS sodium
  • HY-148977

    Endogenous Metabolite Metabolic Disease
    18:0,22:6 PS sodium is a lipid component of synaptic vesicles and cholesterol, which can be used for metabolic research .
    18:0,22:6 PS sodium
  • HY-165084

    Soy PS sodium

    Biochemical Assay Reagents Inflammation/Immunology
    L-a-Phosphatidylserine sodium is an antigen targeting phosphatidylserine (PS) and can induce the production of polyclonal antibodies. L-a-Phosphatidylserine can trigger complement-dependent immune damage by binding to PS on the cell membrane surface. After L-a-Phosphatidylserine is recognized by antibodies, it activates the complement system, causing liposome membrane damage and content release, and then participates in the regulation of immune response and cell apoptosis signaling. L-a-Phosphatidylserine can be used in immunological research, such as antibody specificity analysis and complement activation mechanism research .
    L-a-Phosphatidylserine sodium
  • HY-173090S

    Isotope-Labeled Compounds Others
    VAVVR(pT)PPK(pS)PSSAK-(Lys- 13C6, 15N2) TFA is the 13C- and 15N-labeled VAVVR(pT)PPK(pS)PSSAK-(Lys) TFA.
    VAVVR(pT)PPK(pS)PSSAK-(Lys-13C6,15N2) TFA
  • HY-126213

    18:1 Lyso-PS

    NADPH Oxidase Inflammation/Immunology
    Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following activation of the NADPH oxidase and lyso-PS signaling. Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium through the macrophage G2A functions to enhance existing receptor/ligand systems for resolution of neutrophilic inflammation .
    1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium
  • HY-172378

    Biochemical Assay Reagents Others
    Poly(styrene)-block-poly(acrylic acid) (PS:PAA 30000:2000) is a diblock copolymer used to prepare polymer micelles or vesicles and other encapsulation applications .
    Poly(styrene)-block-poly(acrylic acid) (PS:PAA 30000:2000)
  • HY-157692

    1,2-Didecanoyl-sn-glycero-3-phospho-L-serine sodium

    Biochemical Assay Reagents
    10:0 PS (1,2-Didecanoyl-sn-glycero-3-phospho-L-serine (sodium)) is a kind of biochemical reagent.
    10:0 PS
  • HY-12885C

    ADU-S100 enantiomer ammonium salt; MIW815 enantiomer ammonium salt; ML RR-S2 CDA enantiomer ammonium salt

    IFNAR Inflammation/Immunology
    2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (ADU-S100 enantiomer ammonium salt) is the less active enantiomer of 2’3’-c-di-AM(PS)2 (Rp,Rp). 2’3’-c-di-AM(PS)2 (Rp,Rp) is an activator of stimulator of interferon genes (STING) .
    2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt
  • HY-167592S

    1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(-d5)-3-phospho- L-serine sodium

    Isotope-Labeled Compounds Others
    17:0-20:3 PS-d5 (1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phospho- L-serine (sodium)) is deuterium labeled 17:0-20:3 PS .
    17:0-20:3 PS-d5
  • HY-157623

    1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium

    Biochemical Assay Reagents
    16:0 Lyso PS (1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine (sodium)) is a kind of biochemical reagent.
    16:0 Lyso PS
  • HY-172378A

    Biochemical Assay Reagents Others
    Poly(styrene)-block-poly(acrylic acid) (PS:PAA 3,000:5,000,DDMAT terminated) is a diblock copolymer used to prepare polymer micelles or vesicles and other encapsulation applications .
    Poly(styrene)-block-poly(acrylic acid) (PS:PAA 3,000:5,000,DDMAT terminated)
  • HY-P10943

    Ser/Thr Kinase Inflammation/Immunology Cancer
    APO-15 is a fluorogenic imaging agent targeting phosphatidylserine (PS) exposed on the cell membrane of apoptotic cells. APO-15 can selectively bind to apoptotic cells, enabling staining and imaging of apoptotic cells in a calcium-independent and wash-free manner. APO-15 is promising for research of inflammatory diseases and cancers .
    APO-15
  • HY-12885
    2’3’-c-di-AM(PS)2 (Rp,Rp)
    60+ Cited Publications

    ADU-S100; MIW815; ML RR-S2 CDA

    STING Inflammation/Immunology Cancer
    2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .
    2’3’-c-di-AM(PS)2 (Rp,Rp)
  • HY-12885A

    ADU-S100 disodium salt; MIW815 disodium salt; ML RR-S2 CDA disodium salt

    STING Inflammation/Immunology Cancer
    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).
    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt

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