PSG9 Protein, Human (HEK293, His)

PSG9 Protein, Human (HEK293, His) is the recombinant human-derived PSG9 protein, expressed by HEK293, with C-6*His labeled tag.

Pregnant-specific beta-1-glycoprotein 9 is a member of the Pregnancy-specific glycoprotein family and is secreted by placental syncytial trophoblastic cells from the formation of the blastocyst syncytium to term. PSG9 stimulates the increase of FoxP3⁺ regulatory T cells through the TGF-β1 pathway. PSG is considered to be a pro-angiogenic factor that induces endodermal duct formation and VEGFA secretion in different cell types, promotes angiogenesis by stimulating VEGFA production, and is associated with poor prognosis in hepatocellular carcinoma. PSG9 is involved in Wnt signaling and is dysregulated during colorectal cancer development^[1][2][3].

Human

HEK293

C-6*His

AAH20759.1 (E35-S426)

5678  [NCBI]

Partial

EVTIEAQPPKVSEGKDVLLLVHNLPQNLPGYFWYKGEMTDLYHYIISYIVDGKIIIYGPAYSGRETVYSNASLLIQNVTRKDAGTYTLHIIKRGDETREEIRHFTFTLYLETPKPYISSSNLNPREAMEAVRLICDPETLDASYLWWMNGQSLPVTHRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVSASRSDPVTLNLLPKLPIPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLNGQSLPVSPGVKRPIENRILILPSVTRNETGPYQCEIQDRYGGLRSNPVILNVLYGPDLPRIYPSFTYYRSGENLDLSCFTESNPPAEYFWTINGKFQQSGQKLFIPQITRNHSGLYACSVHNSATGKEISKSMTVKVSGPCHGDLTESQS

Approximately 65.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.