Search Result

Results for "

IKK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IKK (89) Akt (7) Angiotensin-converting Enzyme (ACE) (1) Annexin A (2) Antibiotic (4) Apoptosis (26) Autophagy (11) Bacterial (8) Bcl-2 Family (1) Biochemical Assay Reagents (1) Calcium Channel (1) CaMK (1) Caspase (5) COX (6) Cytochrome P450 (2) Ferroptosis (1) Fungal (5) HIF/HIF Prolyl-Hydroxylase (1) IAP (1) Integrin (2) Interleukin Related (4) IRAK (1) Isotope-Labeled Compounds (4) JAK (3) Keap1-Nrf2 (5) Lipoxygenase (2) LRRK2 (3) MAPKAPK2 (MK2) (2) Mitophagy (5) Monoamine Oxidase (2) Na+/H+ Exchanger (NHE) (1) NF-κB (29) NO Synthase (5) NOD-like Receptor (NLR) (1) P-glycoprotein (3) p38 MAPK (2) PDK-1 (1) Phosphatase (1) Phosphodiesterase (PDE) (4) PI3K (1) PKC (1) PKD (3) PPAR (1) PROTACs (2) Reactive Oxygen Species (ROS) (3) Reference Standards (10) Ser/Thr Protease (1) Sirtuin (6) Sodium Channel (3) SphK (1) STAT (4) TNF Receptor (7) ULK (3)
By Research Areas:	Cancer (60) Cardiovascular Disease (7) Infection (9) Inflammation/Immunology (81) Metabolic Disease (4) Neurological Disease (8)

By Targets:

IKK (89)

Akt (7)

Angiotensin-converting Enzyme (ACE) (1)

Annexin A (2)

Antibiotic (4)

Apoptosis (26)

Autophagy (11)

Bacterial (8)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Calcium Channel (1)

CaMK (1)

Caspase (5)

COX (6)

Cytochrome P450 (2)

Ferroptosis (1)

Fungal (5)

HIF/HIF Prolyl-Hydroxylase (1)

IAP (1)

Integrin (2)

Interleukin Related (4)

IRAK (1)

Isotope-Labeled Compounds (4)

JAK (3)

Keap1-Nrf2 (5)

Lipoxygenase (2)

LRRK2 (3)

MAPKAPK2 (MK2) (2)

Mitophagy (5)

Monoamine Oxidase (2)

Na+/H+ Exchanger (NHE) (1)

NF-κB (29)

NO Synthase (5)

NOD-like Receptor (NLR) (1)

P-glycoprotein (3)

p38 MAPK (2)

PDK-1 (1)

Phosphatase (1)

Phosphodiesterase (PDE) (4)

PI3K (1)

PKC (1)

PKD (3)

PPAR (1)

PROTACs (2)

Reactive Oxygen Species (ROS) (3)

Reference Standards (10)

Ser/Thr Protease (1)

Sirtuin (6)

Sodium Channel (3)

SphK (1)

STAT (4)

TNF Receptor (7)

ULK (3)

By Research Areas:

Cancer (60)

Cardiovascular Disease (7)

Infection (9)

Inflammation/Immunology (81)

Metabolic Disease (4)

Neurological Disease (8)

117

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: IKK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13687A

IKK 16 hydrochloride 15+ Cited Publications	IKK LRRK2 P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
IKK 16 hydrochloride is an orally active *IKK* inhibitor. IKK 16 hydrochloride shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for *IKK2, IKK* complex, *IKK1, and LRRK 2, respectively. IKK* 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway .

HY-13687

IKK 16 15+ Cited Publications	IKK LRRK2 P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
IKK 16 is an orally active IKK inhibitor. IKK 16 shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway .

HY-112456

IKK2-IN-4	IKK	Inflammation/Immunology
IKK2-IN-4 (compound 4) is a potent *IKK-2* inhibitor, with an IC₅₀ of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs .

HY-111135

IKK2-IN-3	IKK	Inflammation/Immunology Cancer
IKK2-IN-3 (Compound 8) is a potent *IKK2* inhibitor with an IC₅₀ of 0.075 μM .

HY-13873

IKK-IN-1 1 Publications Verification	IKK	Inflammation/Immunology
IKK-IN-1 is an inhibitor of *IKK* extracted from patent WO2002024679A1, compound example 18-13.

HY-13060

ACHP Hydrochloride 5+ Cited Publications IKK-2 Inhibitor VIII	IKK	Inflammation/Immunology
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective *IKK-β* inhibitor with an IC₅₀ of 8.5 nM.

HY-10172

IMD-0354 15+ Cited Publications IKK2 Inhibitor V	IKK	Cancer
IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC₅₀ of 1.2 uM .

HY-13687R

IKK 16 (Standard)	IKK LRRK2 Reference Standards P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Inflammation/Immunology
IKK 16 (Standard) is the analytical standard of IKK 16. This product is intended for research and analytical applications. IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway.

HY-136392

IKK-IN-3	IKK	Inflammation/Immunology
IKK-IN-3 is a potent and selective IkappaB kinase 2 (IKK2 or IKKβ) inhibitor, with IC₅₀s of 19 and 400 nM for IKK2 and IKK1 (or IKKα), respectively .

HY-136393

IKK-IN-4	IKK	Inflammation/Immunology
IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC₅₀s of 45 and 650 nM for IKKβ and IKKα, respectively .

HY-10172R

IMD-0354 (Standard) IKK2 Inhibitor V (Standard)	Reference Standards IKK	Cancer
IMD-0354 (Standard) is the analytical standard of IMD-0354. This product is intended for research and analytical applications. IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-163412

IKKβ-IN-3	IKK	Inflammation/Immunology
IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC₅₀ value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis .

HY-W028127

IKKβ-IN-4	IKK	Inflammation/Immunology
IKKβ-IN-4 (compound 14) is an IkappaB kinase-β ( IKKβ ) inhibitor with IC₅₀ value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases .

HY-146723

IKKβ-IN-1	IKK	Inflammation/Immunology
IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC₅₀ of 0.20 μM. IKKβ-IN-1 can reduce PGE₂ and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality .

HY-169053

SU1261	IKK NF-κB	Cancer
SU1261 is an *IKK* inhibitor with K_i values of 10 nM and 680 nM for IKKα and IKKβ, respectively. SU1261 can inhibit non-canonical NF-κB signaling in U2OS osteosarcoma cells .

HY-123936

SR12343	NF-κB IKK	Neurological Disease Inflammation/Immunology
SR12343, an *IKK/NF-κB* inhibitor, is a NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic. SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO, with an IC₅₀ of 37.02 μM for TNF-α-mediated NF-κB activation. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 can be used for research of inflammatory and degenerative diseases .

HY-P10966

Tat-IKIP (46-60)	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-138537

NF-κB-IN-1 3 Publications Verification	IKK	Cancer
NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits *IKK* to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	p38 MAPK	Neurological Disease Inflammation/Immunology
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-10519

BMS-345541 25+ Cited Publications	IKK	Cancer
BMS-345541 is a selective inhibitor of the catalytic subunits of *IKK* (IKK-2 IC₅₀=0.3 μM, *IKK-1* IC₅₀=4 μM). BMS-345541 binds at an allosteric site of IKK.

HY-10518

BMS-345541 hydrochloride 25+ Cited Publications	IKK	Cancer
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of *IKK* (IKK-2 IC₅₀=0.3 μM, *IKK-1* IC₅₀=4 μM). BMS-345541 binds at an allosteric site of IKK.

HY-12453

TBK1/IKKε-IN-2 2 Publications Verification	IKK	Inflammation/Immunology
TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

HY-N0918

Desmethoxyyangonin Demethoxyyangonin; 5,6-Dehydrokavain	Monoamine Oxidase JAK IKK STAT NO Synthase Cytochrome P450	Neurological Disease Inflammation/Immunology
Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC₅₀: 0.123 µM). Desmethoxyyangonin exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin induces CYP3A23 expression and leads to skeletal muscle relaxation .

HY-138931

TBK1/IKKε-IN-6	IKK	Cancer
TBK1/IKKε-IN-6 (example 110) is a TBK1 and IKKε inhibitor, with IC₅₀ values of <100 nM for both TBK1 and IKKε .

HY-69047

6-Chloro-7-deazaguanine	IKK	Cancer
6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of *IKK* (lacking the critical 5-cyano group), targeting IKKα and IKKβ with K_i values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively .

HY-128679

TBK1/IKKε-IN-5	IKK	Cancer
TBK1/IKKε-IN-5 (compound 1) is an orally active TBK1 and IKKε dual inhibitor, with IC₅₀ values of 1 and 5.6 nM, respectively. TBK1/IKKε-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKε-IN-5 can be used in cancer research, especially in tumour immunity .

HY-13802

SC-514 5+ Cited Publications GK 01140	IKK	Cancer
SC-514 is a selective *IKK-2* inhibitor (IC₅₀=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

HY-124652

TBK1/IKKε-IN-4	IKK	Cancer
TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC₅₀ values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR .

HY-U00457

TBK1/IKKε-IN-1	IKK	Cancer
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC₅₀s of <100 nM.

HY-135366

HPN-01	IKK	Inflammation/Immunology
HPN-01 is a potent and selective *IKK* inhibitor, with pIC₅₀ values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2 .

HY-13802R

SC-514 (Standard)	IKK	Cancer
SC-514 (Standard) is the analytical standard of SC-514. This product is intended for research and analytical applications. SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

HY-14682

GSK319347A 1 Publications Verification	IKK	Inflammation/Immunology
GSK319347A is a dual inhibitor of TBK1 and IKKε with IC₅₀s of 93 nM and 469 nM, respectively. GSK319347A also inhibits *IKK2* with an IC₅₀ of 790 nM.

HY-10074

TPCA-1 35+ Cited Publications	IKK STAT Apoptosis	Inflammation/Immunology Cancer
TPCA-1 is a potent and selective inhibitor of *IKK-2* with IC₅₀ of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.

HY-107591A

(Rac)-PF-184 hydrate	IKK	Inflammation/Immunology
(Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC₅₀ of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects .

HY-107591

(Rac)-PF-184	IKK	Inflammation/Immunology
(Rac)-PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC₅₀ of 37 nM. (Rac)-PF-184 has anti-inflammatory effects .

HY-B0713

Amlexanox 15+ Cited Publications AA673; Amoxanox; CHX3673	IKK	Metabolic Disease
Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC₅₀ of approximately 1-2 μM.

HY-114454

INH14 5 Publications Verification	IKK	Inflammation/Immunology Cancer
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC₅₀s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity .

HY-19362

AZD3264 2 Publications Verification	IKK	Inflammation/Immunology
AZD3264 is a selective IkB-kinase *IKK2* inhibitor.

HY-50948

Bay 65-1942 hydrochloride 3 Publications Verification	IKK	Inflammation/Immunology
Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor.

HY-18008

PS-1145 4 Publications Verification	IKK Apoptosis	Cancer
PS-1145 is an IκB kinase (IKK) inhibitor with an IC₅₀ of 88 nM.

HY-14180

PHA 408 1 Publications Verification	IKK	Inflammation/Immunology
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation .

HY-19383

Ertiprotafib 2 Publications Verification PTP 112	Phosphatase IKK PPAR	Metabolic Disease
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC₅₀ of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC₅₀ of ~1 μM for PPARα/PPARβ.

HY-133117

BAY-985 2 Publications Verification	IKK	Cancer
BAY-985, a chemical probe, is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC₅₀s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy .

HY-50949

Bay 65-1942 free base	IKK	Inflammation/Immunology
Bay 65-1942 free base is an ATP-competitive and selective IKKβ inhibitor.

HY-107591B

PF-184	IKK	Inflammation/Immunology
PF-184 is a potent and selective *IKK-2* inhibitor (IC₅₀: 37 nM) over rhIKK-1, IKKi, and more than 30 tyrosine and serine/threonine kinases. PF-184 can be used in the research of inflammation, such as asthma and chronic obstructive pulmonary disease .

HY-B0713R

Amlexanox (Standard) AA673 (Standard); Amoxanox (Standard); CHX3673 (Standard)	Reference Standards IKK	Metabolic Disease
Amlexanox (Standard) is the analytical standard of Amlexanox. This product is intended for research and analytical applications. Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC₅₀ of approximately 1-2 μM.

HY-B0788A

LY2409881 trihydrochloride 3 Publications Verification	IKK Apoptosis	Cancer
LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

HY-B0788

LY2409881	IKK	Cancer
LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library

1,337 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 1,337 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Fluorescent Dye

Resveratrol (GMP) is Resveratrol (HY-16561) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name	Type

HY-W145521

β-1,3-Glucan

β Glucan

Carbohydrates

β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors .

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P1938

Cyclo(L-Pro-L-Val)	Bacterial	Infection Inflammation/Immunology
Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases .

HY-P1098

Ac2-26 Maximum Cited Publications 7 Publications Verification	Annexin A NF-κB	Inflammation/Immunology
Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .

HY-P1098A

Ac2-26 TFA Maximum Cited Publications 7 Publications Verification	Annexin A NF-κB	Inflammation/Immunology
Ac2-26 TFA is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .

HY-P1098B

Ac2-26 ammonium Maximum Cited Publications 7 Publications Verification	IKK	Inflammation/Immunology
Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .

HY-P1740

RGD peptide (GRGDNP) 5 Publications Verification	Integrin Apoptosis Caspase	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P10966

Tat-IKIP (46-60)	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-P10839

NBD peptide	NF-κB	Inflammation/Immunology
NBD peptide inhibits NF-κB signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT .

HY-P10469

NBD-2	NF-κB	Inflammation/Immunology Cancer
NBD-2 is an inhibitor of the *NEMO-IKKα/β* interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc .

HY-P1740A

RGD peptide (GRGDNP) (TFA) 5 Publications Verification	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0918

Desmethoxyyangonin Demethoxyyangonin; 5,6-Dehydrokavain	Structural Classification other families Classification of Application Fields Source classification Other Diseases Other Phenylpropanoids Phenylpropanoids Plants Disease Research Fields	Monoamine Oxidase JAK IKK STAT NO Synthase Cytochrome P450
Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC₅₀: 0.123 µM). Desmethoxyyangonin exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin induces CYP3A23 expression and leads to skeletal muscle relaxation .

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Apocynaceae Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct *IKK* inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N1949

Homoplantaginin 4 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	TNF Receptor NF-κB
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

HY-P1938

Cyclo(L-Pro-L-Val)	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases .

HY-W009338

H-Val-Tyr-OH 1 Publications Verification Val-Tyr	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	IKK NF-κB
H-Val-Tyr-OH (Val-Tyr) is a dipeptide formed by the connection of valine and tyrosine via a peptide bond. H-Val-Tyr-OH is a potential IKKα inhibitor and can be used in the research of cancer and inflammatory diseases .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	Structural Classification Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants	p38 MAPK
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-N10768

1-Dehydro-[10]-gingerdione	Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-13295R

Vinpocetine (Standard) Ethyl apovincaminate (Standard)	Apocynaceae Alkaloids Piperidine Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Reference Standards Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct *IKK* inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N11085

Isophysalin A	Structural Classification Natural Products Source classification Plants Solanaceae Alkekengi officinarum Moench	NO Synthase IKK
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity .

HY-N1949R

Homoplantaginin (Standard)	Structural Classification Flavonoids Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants	Reference Standards TNF Receptor NF-κB
Homoplantaginin (Standard) is the analytical standard of Homoplantaginin. This product is intended for research and analytical applications. Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

HY-126232

Verproside	Plantaginaceae Infection Structural Classification Iridoids Veronica officinalis L. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	NF-κB TNF Receptor IKK
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) .

HY-13425

Deguelin 5+ Cited Publications (-)-Deguelin; (-)-cis-Deguelin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Isoflavanones Source classification Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Akt Autophagy Apoptosis
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N0551

Wedelolactone 20+ Cited Publications	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Structural Classification Flavonoids Leguminosae Source classification Plants Other Flavonoids Erythrina variegata Linn.	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase
1,3,5-Trihydroxy-4-prenylxanthone is a Na ⁺/H ⁺ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-N0918R

Desmethoxyyangonin (Standard) Demethoxyyangonin (Standard); 5,6-Dehydrokavain (Standard)	Structural Classification other families Source classification Other Phenylpropanoids Phenylpropanoids Plants	Reference Standards Monoamine Oxidase JAK STAT NO Synthase IKK Cytochrome P450
Desmethoxyyangonin (Standard) is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin (Standard) is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC₅₀: 0.123 µM). Desmethoxyyangonin (Standard) exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin (Standard) induces CYP3A23 expression and leads to skeletal muscle relaxation .

HY-N0551R

Wedelolactone (Standard)	Structural Classification Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae	Reference Standards Caspase Lipoxygenase Apoptosis
Wedelolactone (Standard) is the analytical standard of Wedelolactone. This product is intended for research and analytical applications. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-13425R

Deguelin (Standard)	Structural Classification Flavonoids Leguminosae Isoflavanones Source classification Derris trifoliata Lour. Plants	Akt Autophagy Apoptosis
Deguelin (Standard) is the analytical standard of Deguelin. This product is intended for research and analytical applications. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N1904

4′-Hydroxywogonin 8-Methoxyapigenin	Structural Classification Flavonoids Flavones Verbenaceae Verbena littoralis H.B.K. Plants	IKK NF-κB p38 MAPK PI3K Akt Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor Apoptosis Caspase Bcl-2 Family
4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis .

HY-N2435

[8]-Shogaol 3 Publications Verification	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Zingiberaceae Cancer	COX Apoptosis
[8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC₅₀=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC₅₀=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC₅₀=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA).

HY-16561

Resveratrol Maximum Cited Publications 131 Publications Verification trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Microorganisms Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561R

Resveratrol (Standard) Maximum Cited Publications 131 Publications Verification trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Source classification Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	Reference Standards IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N5063

Plantainoside D 1 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Scrophulariaceae Phenylpropanoids Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields	Angiotensin-converting Enzyme (ACE) IKK Calcium Channel PKC Reactive Oxygen Species (ROS) NF-κB Apoptosis Sirtuin NOD-like Receptor (NLR)
Plantainoside D, a phenylethanoid glycosides, is a *IKK-β* inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC₅₀ of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension .

HY-N2435R

[8]-Shogaol (Standard)	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	Reference Standards COX Apoptosis
-Shogaol (Standard) is the analytical standard of -Shogaol. This product is intended for research and analytical applications. -Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC₅₀=5 μM), anti-cancer and anti-inflammatory activity. -Shogaol inhibited COX-2 (IC₅₀=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC₅₀=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA) .

HY-N6871

Abietic acid 2 Publications Verification	Infection Structural Classification Colophony Classification of Application Fields Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Bacterial IKK Ferroptosis
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .

Species:	Human (5)
Tag:	His (2) Tag Free (1) Strep (1) GST (2)
Source:	Sf9 insect cells (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P701788

	IKKε Protein, Human (sf9, GST) IKKε; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	Human	Sf9 insect cells
	IKKε protein is a serine/threonine kinase that coordinates the inflammatory response to viral infection by activating type I IFN, NF-kappa-B, and STAT signaling pathways. Upon activation of the viral RNA sensor, IKKε binds to DDX3X and phosphorylates IRF3, IRF7, and DDX3X, resulting in IRF3 nuclear translocation. IKKε Protein, Human (sf9, GST) is the recombinant human-derived IKKε protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701786

	IKKβ Protein, Human (sf9, GST) IKBKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB	Human	Sf9 insect cells
	IKKβ protein is a serine kinase that is critical in the NF-kappa-B signaling pathway and can respond to various stimuli such as cytokines or cellular stress. As part of the classical IKK complex, IKKβ activates NF-kappa-B through phosphorylation inhibitors, leading to its degradation and release of NF-kappa-B for gene transcription. IKKβ Protein, Human (sf9, GST) is the recombinant human-derived IKKβ protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701489

	UB2V1 Protein, Human (sf9) UBE2V1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A	Human	Sf9 insect cells
	The UBE2V1 protein does not have intrinsic ubiquitin ligase activity and can cooperate with UBE2N to synthesize non-canonical polyubiquitin chains linked through Lys-63. This type of polyubiquitination activates IKK and mediates NF-kappa-B activation, thereby affecting transcriptional activation, cell cycle progression, and DNA repair. UB2V1 Protein, Human (sf9) is the recombinant human-derived UB2V1 protein, expressed by sf9 insect cells , with tag free.

HY-P701501

	UB2V1 Protein, Human (sf9, His, StrepⅡ) UBE2V1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A	Human	Sf9 insect cells
	The UBE2V1 protein does not have intrinsic ubiquitin ligase activity and can cooperate with UBE2N to synthesize non-canonical polyubiquitin chains linked through Lys-63. This type of polyubiquitination activates IKK and mediates NF-kappa-B activation, thereby affecting transcriptional activation, cell cycle progression, and DNA repair. UB2V1 Protein, Human (sf9, His, Strep) is the recombinant human-derived UB2V1 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P71410

	UBE2V1 Protein, Human (His) Ubiquitin-Conjugating Enzyme E2 Variant 1; UEV-1; CROC-1; TRAF6-Regulated IKK Activator 1 Beta Uev1A; UBE2V1; CROC1; UBE2V; UEV1; P/OKcl.19	Human	E. coli
	The UBE2V1 protein does not have intrinsic ubiquitin ligase activity and can cooperate with UBE2N to synthesize non-canonical polyubiquitin chains linked through Lys-63. This type of polyubiquitination activates IKK and mediates NF-kappa-B activation, thereby affecting transcriptional activation, cell cycle progression, and DNA repair. UBE2V1 Protein, Human (His) is the recombinant human-derived UBE2V1 protein, expressed by E. coli , with C-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-W709448

Oxaprozin-d10

Oxaprozin-d₁₀ (Oxaprozinum-d₁₀; Wy21743-d₁₀) is the deuterium labeled Oxaprozin (HY-B0808). Oxaprozin is an orally active and potent COX inhibitor, with IC₅₀ values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80414

	IKK alpha + IKK beta Antibody (YA349)	WB, ICC/IF, IP	Human, Mouse
	IKK alpha + IKK beta Antibody (YA349) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha + IKK beta.

HY-P80413

	IKK alpha Antibody (YA348)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
	IKK alpha Antibody (YA348) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha.

HY-P80415

	IKK gamma Antibody (YA346)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	IKK gamma Antibody (YA346) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK gamma.

HY-P80719

	IKK beta Antibody (YA347) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ICC/IF	Human, Mouse, Rat
	IKK beta Antibody (YA347) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK beta.

HY-P82126

	IKK alpha/beta Antibody (YA1871) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, ICC/IF, IP	Human, Mouse, Rat
	IKK alpha/beta Antibody (YA1871) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha/beta.

HY-P81866

	IKK epsilon Antibody (YA1611) IKBKE; IKKE; IKKI; KIAA0151; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	WB, IHC-P, ICC/IF, FC	Human
	IKK epsilon Antibody (YA1611) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK epsilon.

HY-P85218

	IKK epsilon Antibody (YA4910) IKBKE; IKKE; IKKI; KIAA0151; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	WB, ELISA	Human
	IKK epsilon Antibody (YA4910) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK epsilon.

HY-P85217

	IKK beta Antibody (YA4909) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, IHC-P, ICC/IF, ELISA	Human
	IKK beta Antibody (YA4909) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P85216

	IKK alpha Antibody (YA4908) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, ICC/IF, FC, ELISA	Human
	IKK alpha Antibody (YA4908) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK alpha.

HY-P86384

	IKK alpha Antibody (YA6076) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	IKK alpha Antibody (YA6076) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha.

HY-P86459

	IKK alpha/beta Antibody (YA6151) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	IKK alpha/beta Antibody (YA6151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha/beta.

HY-P85530

	IKK beta Antibody (YA5222) I kappa B kinase 2; I kappa B kinase beta; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK 2; IKK B; IKK beta; IKK-B; IKK-beta; IKK2; IKKB; IKKB_HUMAN; IMD15; Inhibitor of kappa light chain gene enhancer in B cells; Inhibitor of kappa light polypeptide gene enhancer in B cells; Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta; Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta; Inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa B kinase subunit beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF kappa B inhibitor kinase beta; Nuclear factor NF-kappa-B inhibitor kinase beta; Nuclear factor of kappa light chain gene enhancer in B cells inhibitor.	WB	Human, Rat
	IKK beta Antibody (YA5222) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P83823

	CHUK Antibody (YA3520) IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha; CHUK	WB, ICC/IF, FC, ELISA	Human
	CHUK Antibody (YA3520) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHUK.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

IKK

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products