2. NF-κB
  3. IKK
  4. 6-Chloro-7-deazaguanine

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively.

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6-Chloro-7-deazaguanine Chemical Structure

6-Chloro-7-deazaguanine Chemical Structure

CAS No. : 84955-31-7

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6-Chloro-7-deazaguanine Related Antibodies

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Description

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively[1].

Molecular Weight

168.58

Formula

C6H5ClN4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=NC(Cl)=C2C(NC=C2)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 2.5 mg/mL (14.83 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9319 mL 29.6595 mL 59.3190 mL
5 mM 1.1864 mL 5.9319 mL 11.8638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Purity & Documentation

Purity: 99.83%

COA (245 KB) HNMR (112 KB) RP-HPLC (229 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.9319 mL 29.6595 mL 59.3190 mL 148.2975 mL
5 mM 1.1864 mL 5.9319 mL 11.8638 mL 29.6595 mL
10 mM 0.5932 mL 2.9660 mL 5.9319 mL 14.8298 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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6-Chloro-7-deazaguanine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Chloro-7-deazaguanine84955-31-7IKKIκB kinaseI kappa B kinaseInhibitorinhibitorinhibit

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