Search Result

Pathways Recommended:	Anti-infection

Results for "

Antiviral infections

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (2) AAK1 (1) Amyloid-β (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (19) Apoptosis (22) Autophagy (7) Bacterial (34) Biochemical Assay Reagents (3) Calcium Channel (2) Caspase (1) CaSR (1) Cathepsin (1) CCR (1) CDK (2) CHIKV (1) CMV (13) COX (2) Cyclic GMP-AMP Synthase (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (1) Dengue Virus (5) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (21) Drug Derivative (1) Drug Intermediate (2) Drug Isomer (1) Drug Metabolite (3) EBV (1) Endogenous Metabolite (11) Endonuclease (1) Enterovirus (13) Ephrin Receptor (1) ERK (1) Filovirus (1) Flavivirus (6) Fungal (2) Gap Junction Protein (2) HBV (16) HCV (15) HCV Protease (5) Histamine Receptor (1) Histone Demethylase (1) HIV (41) HPV (2) HSP (1) HSV (38) IFNAR (2) Influenza Virus (23) Insecticide (1) Interleukin Related (3) Isotope-Labeled Compounds (15) JNK (1) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (1) MMP (1) MyD88 (1) Necroptosis (1) NF-κB (9) NO Synthase (1) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (8) Orthopoxvirus (6) P2X Receptor (1) p38 MAPK (1) Parasite (3) Phosphodiesterase (PDE) (1) PKC (1) PPAR (1) Proton Pump (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (6) Reference Standards (17) Reverse Transcriptase (9) RSV (8) SARS-CoV (53) Ser/Thr Protease (1) STING (2) Tau Protein (1) Thymidylate Synthase (3) TMV (2) Toll-like Receptor (TLR) (2) Virus Protease (11) VSV (3) YB-1 (1)
By Research Areas:	Cancer (43) Cardiovascular Disease (9) Endocrinology (1) Infection (228) Inflammation/Immunology (37) Metabolic Disease (13) Neurological Disease (12)
Click Chemistry:	Azide (3) Alkynes (1)
Oligonucleotides:	Guanosine (1) Nucleoside Analogs (2) CpG ODNs (1) Cytidine (1)

241

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163773

JNJ-7950	RSV	Infection
JNJ-7950 (compound 5c) exhibits antiviral activity against RSV with an EC₅₀ value of 0.78 nM. JNJ-7950 can be used in the study of respiratory tract infections .

HY-19840

Voxilaprevir GS-9857	HCV Protease	Infection Cancer
Voxilaprevir (GS-9857) is a noncovalent, reversible inhibitor of HCV NS3/4A protease inhibitor (PI) with pangenotypic antiviral activity . Voxilaprevir inhibits genotype 1b and 3a wild-type NS3 proteases with K_i values of 0.038 nM and 0.066 nM, respectively . Voxilaprevir is an orally active direct-acting antiviral agent (DAA) and can be used for HCV infection research .

HY-175796

Antiviral agent 70	Influenza Virus	Infection
Antiviral agent 70 (Compound 12b) is an antiviral agent. Antiviral agent 70 has a superior binding capacity to to NeuraminidaseAntiviral agent 70 has potent antiviral activity against influenza A/H1N1 virus with an IC₅₀ of 2.9  μM. Antiviral agent 70 can be used for influenza virus infections research .

HY-153062

6-Chloro-7-deazapurine-2F-β-D-arabinofuranose	HCV	Infection
6-Chloro-7-deazapurine-2F-β-D-arabinofuranose is a nucleoside derivative. 6-Chloro-7-deazapurine-2F-β-D-arabinofuranose can be used for synthesis of antiviral agent against hepatitis C virus infection .

HY-P5550

Urumin	Influenza Virus	Infection
Urumin has antiviral activity against the human influenza A virus. Urumin inhibits the growth of PR8 influenza virus (IC₅₀: 3.8 μM). Urumin targets the conserved stalk of H1 hemagglutini, and is effective at neutralizing drug-resistant H1 influenza viruses. Urumin protects naive mice from lethal influenza infection .

HY-P991690

Glarivibart	RSV	Infection
Glarivibart is a humanized IgG1κ monoclonal antibody inhibitor targeting Respiratory syncytial virus (RSV) fusion F protein (RSV-F). Glarivibart has significant antiviral activity. Glarivibart can be used for RSV infections research .

HY-154990

RdRP-IN-7	SARS-CoV	Infection
RdRP-IN-7 is a RNA-dependent RNA polymerase (RdRp) inhibitor that shows the inhibition of SARS-CoV-2 infection with an IC₅₀ of 8.2 μM, an IC₉₀ of 14.1 μM and an CC₉₀ of 79.1 μM. RdRP-IN-7 can be used for antiviral research .

HY-105232

AZT-P-ddI IVX-E-59	HIV	Infection
AZT-P-ddI is an antiviral heterodimer composed of Zidovudine (AZT) (HY-17413) and Didanosine (ddI) (HY-B0249). AZT-P-ddI shows inhibitory effect against HIV-1 with an EC₅₀ of 0.14 nM. AZT-P-ddI can be used for the research of infection .

HY-175683

EBV-IN-1	EBV HIV	Infection
EBV-IN-1 (Compound 15) is an antiviral agent. EBV-IN-1 has a potent antiviral activity against EBV with a EC₅₀ of 0.17  μM. EBV-IN-1 also shows inhibitory effects on HIV (EC₅₀: 20.8 μM). EBV-IN-1 can be used for EBV and HIV infections research .

HY-168015

5-Oxo leukotriene B4	Drug Isomer	Infection
5-Oxo leukotriene B4 is a byproduct in the synthesis of 12-oxo LTB4 (HY-130497) with antiviral activity. 5-Oxo leukotriene B4 is promising for research of viral infections caused by human and animal enveloped RNA viruses .

HY-174258

ATPase-IN-6	Proton Pump HIV SARS-CoV	Infection
ATPase-IN-6 is a H ⁺/K ⁺- ATPase inhibitor and a prazole derivative. ATPase-IN-6 has significant antiviral activity against multiple viruses, such as HIV-1 and SARS-COV2. ATPase-IN-6 can be used for antiviral infections research .

HY-14532

Brincidofovir 3 Publications Verification CMX001; HDP-CDV	CMV HSV Orthopoxvirus	Infection
Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo .

HY-175740

Antiviral agent 71	Enterovirus	Infection
Antiviral agent 71 (Compound 26) is an antiviral agent. Antiviral agent 71 has a broad-spectrum enterovirus antiviral activity, such as EV-D68, Echo-11 and HRV-14 with EC₅₀s of 0.017-4.1 μM. EV-D68-IN-1 can be used for non-polio enteroviruses (NPEV) infections research .

HY-17426

Famciclovir 1 Publications Verification BRL 42810	HSV HBV	Infection
Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection .

HY-162074

Nipamovir	HIV	Infection
Nipamovir is a nitroimidazole prodrug. Nipamovir shows comparable *antiviral* activity to SAMT-247 (HY-102077) and NS-1040 in both cellular assays and a human ex vivo model of HIV infection, along with low toxicity. Nipamovir has EC₅₀ values of 3.64±3.28 and 3.23±2.81 μM for CEM-SS/HIV-1RF and hPBMC/HIV-192HT599, respectively .

HY-144833

SARS-CoV-2 3CLpro-IN-1	SARS-CoV	Infection
SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a potent inhibitor of SARS-CoV-2 3CL ^pro. 3CL ^pro (main coronaviruses cysteine-protease) has been identified as a promising target for the development of antiviral agents. SARS-CoV-2 3CLpro-IN-1 has the potential for the research of infection diseases .

HY-178156

DHODH-IN-31	Dihydroorotate Dehydrogenase SARS-CoV	Infection
DHODH-IN-31 is a human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 0.59 μM. DHODH-IN-31 exhibits antiviral activity. DHODH-IN-31 can be used for the research of infection, such as SARS-CoV-2 .

HY-14532S

Brincidofovir-d6 CMX001-d₆; HDP-CDV-d₆	Isotope-Labeled Compounds HSV CMV Orthopoxvirus	Infection
Brincidofovir-d₆ (CMX001-d₆) is the deuterium labeled Brincidofovir (HY-14532). Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo. .

HY-128382

Brilliant Black BN E 151	Enterovirus	Infection
Brilliant black BN (E151) is an azo dye and a food colorant . Brilliant black BN is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease .

HY-17426R

Famciclovir (Standard) BRL 42810 (Standard)	Reference Standards HSV HBV	Infection
Famciclovir (Standard) is the analytical standard of Famciclovir. This product is intended for research and analytical applications. Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection .

HY-N8188

Dehydrojuncusol	HCV HCV Protease	Infection
Dehydrojuncusol, a potent HCV inhibitor, targets HCV NS5A and is able to inhibit RNA replication of replicons harboring resistance mutations to anti-NS5A direct-acting antivirals. Dehydrojuncusol significantly inhibits HCV infection when added after virus inoculation of HCV genotype 2a (EC₅₀=1.35?μM) .

HY-175368

DENV-IN-13	Dengue Virus	Infection
DENV-IN-13 (Compound 30) is a DENV2 protease inhibitor with an EC₅₀ of 9.8  μM for DENV2 protease in HeLa cells. DENV-IN-13 has potent antiviral activity with negligible cytotoxicity and no inhibition of the off-targets thrombin and trypsin. DENV-IN-13 can be used for flaviviral infections research .

HY-128423A

Tylvalosin 2 Publications Verification Acetylisovaleryltylosin	Antibiotic Bacterial NF-κB Apoptosis	Infection Inflammation/Immunology Cancer
Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation .

HY-P2317A

Cecropin P1, porcine acetate	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows *antiviral* activity and inhibits PRRSV infection .

HY-N16441

Pulvic acid	Endogenous Metabolite Influenza Virus	Infection
Pulvic acid (Compound 3), a butenolide, is a microbial secondary metabolite. Pulvic acid can be isolated from the marine-derived fungus Aspergillus terreus Gwq-48. Pulvic acid has significant antiviral activity with an IC₅₀ of 29.1 μg/mL for influenza A H1N1 virus. Pulvic acid can be used for influenza virus infections research .

HY-N7934

Trachelogenin (-)-Trachelogenin	HCV	Infection Neurological Disease Inflammation/Immunology
Trachelogenin ((-)-Trachelogenin) is an HCV entry inhibitor without genotype specificity, and with low cytotoxicity. Trachelogenin inhibits HCVcc infection and HCVpp cell entry in a dose-dependent manner with an IC₅₀ of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively. Trachelogenin exhibits effective antiviral, anti-inflammatory and analgesic effects .

HY-107401

Ancriviroc SCH-351125	HIV CCR	Infection
Ancriviroc (SCH-351125) is an orally active CCR5 antagonist. Ancriviroc has a broad-spectrum antiviral activity against HIV-1 isolates using CCR5 as their entry coreceptor (such as ASM 80, 92US715 and YU-2) with IC₅₀s of 0.4-9 nM. Ancriviroc strongly inhibits the replication of R5-using HIV-1 isolates in SCID-hu Thy/Liv mice model of HIV-1 infection. Ancriviroc can be used for HIV infection research .

HY-P11032

Mp-4D7-pF2	SARS-CoV Virus Protease	Infection
Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC₅₀ of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .

HY-P991674

Brelovitug BJT-778	HBV	Infection Inflammation/Immunology
Brelovitug (BJT-778) is a humanized IgG1 neutralizing monoclonal antibody targeting hepatitis B surface antigen (HBsAg). Brelovitug has significant antiviral activity, and neutralizes and removes HBV and HDV as well as depleting HBsAg-containing subviral particles. Brelovitug can be used for HDV and HBV infections, chronic hepatitis delta (CHD) and chronic hepatitis B (CHB) research .

HY-N2127

Pinostrobin 1 Publications Verification	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

HY-146345

Antiviral agent 18	Antibiotic	Infection
Antiviral agent 18 (Compound 5) is an anti-infection agent. Antiviral agent 18 results in good antiviral activity against murine norovirus. Antiviral agent 18 has the potential for the research of infectious and malignant diseases .

HY-146344

Antiviral agent 17	DNA/RNA Synthesis	Infection
Antiviral agent 17 is an anti-infection agent. Antiviral agent 17 retains its antiviral effect in a human replicon assay (EC₅₀ = 0.015 μM). Antiviral agent 17 results in good antiviral activity against murine norovirus with an EC₅₀ of 7 nM. . Antiviral agent 17 has the potential for the research of infectious and malignant diseases .

HY-150217A

CpG ODN 10101 sodium 1 Publications Verification ODN 10101 sodium	Toll-like Receptor (TLR)	Infection
CpG ODN 10101 sodium, a synthetic oligodeoxynucleotide (ODN), is a toll-like receptor 9 (TLR9) agonist. CpG ODN 10101 sodium is a potent inducer of cytokine/chemokine expression ex vivo when used in combination with HH2(VQLRIRVAVIRA-NH2). CpG ODN 10101 sodium induces IFN- secretion from dendritic cells (DCs) and stimulates B-cells.CpG ODN 10101 sodium has antiviral and immunomodulatory properties that can influence chronic infection with HCV .

HY-150217

CpG ODN 10101 1 Publications Verification ODN 10101	Toll-like Receptor (TLR) HCV	Infection Inflammation/Immunology
CpG ODN 10101, a synthetic oligodeoxynucleotide (ODN), is a toll-like receptor 9 (TLR9) agonist. CpG ODN 10101 is a potent inducer of cytokine/chemokine expression ex vivo when used in combination with HH2(VQLRIRVAVIRA-NH2). CpG ODN 10101 induces IFN- secretion from dendritic cells (DCs) and stimulates B-cells.CpG ODN 10101 has antiviral and immunomodulatory properties that can influence chronic infection with HCV .

HY-177303

AXT-914	CaSR SARS-CoV	Infection Metabolic Disease Endocrinology
AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research .

HY-146417

Antiviral agent 19	Flavivirus	Infection
Antiviral agent 19 (Compound 3) is a selective inhibitor against Zika virus infection with an EC₅₀ of 1.3 µM. Antiviral agent 19 has low cytotoxicity .

HY-151924

Antiviral agent 23	Enterovirus	Infection
Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC₅₀ value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection .

HY-146418

Antiviral agent 20	Flavivirus	Infection
Antiviral agent 20 (Compound 17b) is a selective inhibitor against Zika virus infection with an EC₅₀ of 4.5 µM. Antiviral agent 20 has low cytotoxicity .

HY-146344R

Antiviral agent 17 (Standard)	Reference Standards DNA/RNA Synthesis	Infection
Antiviral agent 17 (Standard) is the analytical standard of Antiviral agent 17 (HY-146344). This product is intended for research and analytical applications. Antiviral agent 17 is an anti-infection agent. Antiviral agent 17 retains its antiviral effect in a human replicon assay (EC₅₀ = 0.015 μM). Antiviral agent 17 results in good antiviral activity against murine norovirus with an EC₅₀ of 7 nM. . Antiviral agent 17 has the potential for the research of infectious and malignant diseases .

HY-177097

Lenacapavir pacfosacil	HIV	Infection
Lenacapavir pacfosacil (Example 44) is a viral capsid and nucleocapsid inhibitor. Lenacapavir pacfosacil has antiviral effects. Lenacapavir pacfosacil can be used for research of Retroviridae infection, including an HIV infection .

HY-104077

Remdesivir Maximum Cited Publications 199 Publications Verification GS-5734	DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .

HY-104077A

Remdesivir maleate GS-5734 maleate	DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir maleate (GS-5734 maleate) is a nucleoside analogue with effective antiviral activity. Remdesivir maleate can inhibit the synthesis of viral DNA or RNA. Remdesivir maleate can be used for the research of infection, such as SARS-CoV and MHV infection .

HY-17427

Emtricitabine 5+ Cited Publications BW1592	HIV Reverse Transcriptase Endogenous Metabolite	Infection
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-17422C

Acyclovir alaninate Aciclovir alaninate; Acycloguanosine alaninate	HSV	Infection
Acyclovir alaninate (Acyclovir alaninate) is a prodrug of Acyclovir (HY-17422) and can be used in antiviral (HSV) research .

HY-121513

Torcitabine 2'-Deoxy-L-cytidine; L-dC	HBV	Infection
Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment .

HY-159737

Rociclovir HOE 602	HCV CMV	Infection
Rociclovir (HOE 602) is an acyclic nucleoside derivative. Rociclovir protects mice against HSV and MCMV infections, but lacks antiviral activity in cell cultures .

HY-16957

LJ001	HCV HIV	Infection
LJ001 is a broad-spectrum and orally active antiviral agent. LJ001 exerts antiviral activities by binding to viral membranes. LJ001 inhibits TGEV and PDCoV infection. LJ001 decreases TGEV N and PDCoV N-protein expression .

HY-B0277AR

Vidarabine phosphate (Standard) ara-AMP (Standard); ara-A 5'-monophosphate (Standard)	Reference Standards HBV Antibiotic	Infection
Vidarabine phosphate (Standard) is the analytical standard of Vidarabine phosphate. This product is intended for research and analytical applications. Vidarabine phosphate (Ara-AMP), an antiviral agent, inhibits chronic HBV infection[1][2]. Vidarabine phosphate also against herpes simplex and varicella zoster viruses[3].

HY-104077R

Remdesivir (Standard) GS-5734 (Standard)	Reference Standards DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir (Standard) (GS-5734 (Standard)) is a nucleoside analogue with effective antiviral activity. Remdesivir (Standard) can inhibit the synthesis of viral DNA or RNA. Remdesivir (Standard) can be used for the research of infection, such as SARS-CoV and MHV infection .

HY-B0277A

Vidarabine phosphate ara-AMP; ara-A 5'-monophosphate	HBV Antibiotic	Infection
Vidarabine phosphate (Ara-AMP), an antiviral agent, inhibits chronic HBV infection . Vidarabine phosphate also against herpes simplex and varicella zoster viruses .

Cat. No.	Product Name

HY-L002

Anti-Infection Compound Library

3,706 compounds

An infection occurs when another organism enters a person’s body and causes disease. The organisms that cause infections are very diverse and can include things like viruses, bacteria, fungi, and parasites. The immune system is an effective barrier against infectious agents.

MCE provides a unique collection of 3,706 anti-infective compounds with anti-bacterial, anti-viral, anti-fungal and anti-parasite activities that can be used for drug screening and other research in anti-microbial area.

HY-L073

Anti-Hepatitis C Virus Compound Library

361 compounds

Hepatitis C virus (HCV) is a hepatotropic enveloped positive- strand RNA virus (family Flaviviridae) that infects the parenchymal cells of the liver. HCV infection is a significant public health burden. Globally, an estimated 71 million people have chronic hepatitis C virus infection. A significant number of those who are chronically infected will develop cirrhosis or liver cancer. To date, there is no vaccine against HCV, and combination pegylated alpha interferon (pIFN-) and ribavirin, the main standard-of-care treatment for HCV, is effective in only a subset of patients and is associated with a wide spectrum of toxic side effects and complications. More recently, new therapeutic approaches that target essential components of the HCV life cycle have been developed, including direct-acting antiviral (DAA) that specifically block a viral enzyme or functional protein and host-targeted agents (HTA) that block interactions between host proteins and viral components that are essential to the viral life cycle. However, the genetic diversity of HCV viruses and the stage of liver disease (i.e., cirrhosis) are revealing themselves as obstacles for effective, pan-genotypic treatments. There still exists a need for the discovery and development of new HCV inhibitors. In particular, since the future of HCV therapy will likely consist of a cocktail approach using multiple inhibitors that target different steps of infection, new antivirals targeting all steps of the viral infection cycle.

MCE offers a unique collection of 361 compounds with identified and potential anti-HCV activity. MCE Anti- Hepatitis C Virus Compound Library is a useful tool for discovery new anti-HCV drugs and other anti-infection research.

HY-L027

Antiviral Compound Library

1,465 compounds

Viruses are much simpler organisms than bacteria, and they are made from protein substances and nucleic acid. Despite the fact that the exact mechanism of infection is extremely specific to each type of virus, the general scheme of infection can be represented in the following manner: A virus is absorbed at the surface of a host cell and then permeates through the membrane, where it releases nucleic acid from its protein protection. Then the viral nucleic acid begins to replicate, and transcription of the viral genome takes place either in the cytoplasm, or in the nucleus of the host cell. As a result of these events, a large amount of viral nucleic acid and protein are made to make new generations of virions. Therefore, one mechanism of action of antiviral drugs is to interfere with the ability of a virus to get into a target cell. A second mechanism of action is to target the processes that synthesize virus components after a virus invades a cell, such as nucleotide or nucleoside analogs.

MCE designs a unique collection of 1,465 anti-virus compounds that target several viruses, including SARS-CoV, HBV, HCV, HIV, HSV and Influenza Virus. It’s an effective tool for anti-virus drug discovery.

Cat. No.	Product Name	Type

HY-128382

Brilliant Black BN E 151	Fluorescent Dye
Brilliant black BN (E151) is an azo dye and a food colorant . Brilliant black BN is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease .

HY-15233G

Letermovir (GMP) AIC246 (GMP); MK-8228 (GMP)	Fluorescent Dye
Letermovir (GMP) is the GMP grade of Letermovir (HY-15233). Letermovir (GMP) is an orally active CMV inhibitor. Letermovir (GMP) targets the CMV terminase complex rather than CMV DNA polymerase and exerts its antiviral activity. Letermovir (GMP) can be used in the study of CMV infection .

Cat. No.	Product Name	Type

HY-133172

Zanamivir amine	Biochemical Assay Reagents
Zanamivir amine is a neuraminidase inhibitor with antiviral activity. Zanamivir amine can effectively inhibit the proliferation of influenza virus. Zanamivir amine is clinically used to inhibit influenza infection. Zanamivir amine reduces viral load by interfering with the viral replication process.

HY-15233G

Letermovir (GMP) AIC246 (GMP); MK-8228 (GMP)	Biochemical Assay Reagents
Letermovir (GMP) is the GMP grade of Letermovir (HY-15233). Letermovir (GMP) is an orally active CMV inhibitor. Letermovir (GMP) targets the CMV terminase complex rather than CMV DNA polymerase and exerts its antiviral activity. Letermovir (GMP) can be used in the study of CMV infection .

Cat. No.	Product Name	Target	Research Area

HY-N6689

Destruxin A 1 Publications Verification	Insecticide Bacterial	Infection Inflammation/Immunology Cancer
Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections .

HY-106268A

Larazotide acetate 4 Publications Verification	Gap Junction Protein	Inflammation/Immunology
Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.

HY-P2317

Cecropin P1, porcine	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows *antiviral* activity and inhibits PRRSV infection .

HY-106268

Larazotide 4 Publications Verification	Gap Junction Protein	Infection Inflammation/Immunology
Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection .

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-W141881

N-Lauroylsarcosine	Biochemical Assay Reagents HSV	Infection
N-lauroylsarcosine is an anionic surfactant. N-lauroylsarcosine has *antiviral* activity against HSV-2 strain 333 and HSV-1 strain F. N-lauroylsarcosine synergistically increases skin permeability with 25-50% ethanol. N-lauroylsarcosine can be used to study HSV-2 infection .

HY-P5550

Urumin	Influenza Virus	Infection
Urumin has antiviral activity against the human influenza A virus. Urumin inhibits the growth of PR8 influenza virus (IC₅₀: 3.8 μM). Urumin targets the conserved stalk of H1 hemagglutini, and is effective at neutralizing drug-resistant H1 influenza viruses. Urumin protects naive mice from lethal influenza infection .

HY-P2317A

Cecropin P1, porcine acetate	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows *antiviral* activity and inhibits PRRSV infection .

HY-P11032

Mp-4D7-pF2	SARS-CoV Virus Protease	Infection
Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC₅₀ of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .

HY-P2015

Diacetylsplenopentine BCH 069	HIV	Infection Inflammation/Immunology
Diacetylsplenopentine (BCH 069) is an antiviral agent, and protects guinea pigs from foot-and-mouth disease (FMD) infection. Berlopentin has immunostimulatory properties .

HY-P11160

GF-17	HSV	Infection
GF-17 is a polypeptide containing 17 amino acids. is the precursor peptide of GF19. GF-17 exhibits significant *antiviral* activity at concentrations of 35-45 μM in HCECs. GF-17 has good biocompatibility. GF-17 can be used for research on viral infections such as HSV-1 virus .

HY-P10056

HEP-1 Human ezrin peptide (324-337)	HIV HCV HPV Influenza Virus Interleukin Related	Infection Inflammation/Immunology
HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .

HY-P5567

GLR-19	HIV HSV	Infection
GLR-19 is an anti-HIV peptide. GLR-19 also has antiviral activity against HSV-2 .

HY-P10855

S1b3inL1	SARS-CoV	Infection
S1b3inL1 is a SARS-CoV-2 spike protein macrocyclic peptide inhibitor. S1b3inL1 can bind the conserved site of spike protein with high affinity and inhibit the infection of various SARS-CoV-2 variant strains. S1b3inL1 has antiviral activity .

HY-P10975

P9R	SARS-CoV Influenza Virus Enterovirus	Infection
P9R is an antiviral peptide. P9R has broad-spectrum antiviral activities against the coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), A(H1N1)pdm09, A(H7N9) virus, and rhinovirus. P9R directly binds to viruses and inhibits virus-host endosomal acidification. P9R significantly protects mice from A(H1N1)pdm09 infection without generating drug-resistant virus. P9R can be used for pH-dependent respiratory viruses research .

HY-P5694

Human α-defensin 5	HPV Parasite	Infection
Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC₅₀: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity .

HY-P1633

Protegrin-1 PG1	Bacterial ERK COX NF-κB Apoptosis NO Synthase Dengue Virus	Infection Inflammation/Immunology
Protegrin-1 is an orally active antibacterial peptide. Protegrin-1 activates ERK, COX2, NFκB, inhibits Apoptosis, and NO production. Protegrin-1 has antibacterial activity against S. aureus, E. faecium, E. coli, P. aeruginosa and K. Pneumoniae, with MBC values between 10 and 20 µM. Protegrin-1 has *antiviral* activity against dengue NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in the study of inflammatory diseases and infections .

HY-16050R

Plitidepsin (Standard) Aplidine (Standard); PM90001 (Standard)	Reference Standards DNA/RNA Synthesis SARS-CoV	Infection Cancer
Plitidepsin (Standard) is the analytical standard of Plitidepsin. This product is intended for research and analytical applications. Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-16050

Plitidepsin 3 Publications Verification Aplidine; PM90001	DNA/RNA Synthesis SARS-CoV	Infection Cancer
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-144334

CHIKV-IN-3	CHIKV DNA/RNA Synthesis	Infection
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC₅₀ values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC₅₀>100 μM). Prophylactic effect .

Cat. No.	Product Name	Target	Research Area

HY-P99608

Exbivirumab	HBV	Infection
Exbivirumab is a monoclonal antibody directed against highly conserved HBsAg epitopes. Exbivirumab enhances the antiviral activity of hepatitis B immunoglobulin (HBIG). Exbivirumab combined with Libivirumab (HY-P99703) decreases circulating HBsAg and hepatitis B virus (HBV) DNA levels in a chronically infected chimpanzee. Exbivirumab can be used for HBV re-infection in liver transplant .

HY-P99136

Anti-Mouse IFN gamma Antibody (H22)	IFNAR	Infection Inflammation/Immunology
Anti-Mouse IFN gamma Antibody (H22) is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IFN gamma Antibody (H22) abrogates specific binding of ^I25II-rIFN-γ to macrophages. Anti-Mouse IFN gamma Antibody (H22) inhibits macrophage-activating factor (MAF) (ID₅₀ = 56 ng). Anti-Mouse IFN gamma Antibody (H22) inhibits IFN-gamma dependent antiviral activity (ID₅₀ = 2 ng). Anti-Mouse IFN gamma Antibody (H22) neutralizes IFNγ in mice. Anti-Mouse IFN gamma Antibody (H22) can be used for the researches of inflammation and infection, such as arthritis .

HY-P991690

Glarivibart	RSV	Infection
Glarivibart is a humanized IgG1κ monoclonal antibody inhibitor targeting Respiratory syncytial virus (RSV) fusion F protein (RSV-F). Glarivibart has significant antiviral activity. Glarivibart can be used for RSV infections research .

HY-P991674

Brelovitug BJT-778	HBV	Infection Inflammation/Immunology
Brelovitug (BJT-778) is a humanized IgG1 neutralizing monoclonal antibody targeting hepatitis B surface antigen (HBsAg). Brelovitug has significant antiviral activity, and neutralizes and removes HBV and HDV as well as depleting HBsAg-containing subviral particles. Brelovitug can be used for HDV and HBV infections, chronic hepatitis delta (CHD) and chronic hepatitis B (CHB) research .

HY-P991491

VIR-7229	SARS-CoV Influenza Virus	Infection
VIR-7229 is a human IgG1 monoclonal antibody (mAb) targeting Receptor-Binding Domain, RBD, Spike glycoprotein. VIR-7229 exerts antiviral activity by competing with ACE2 for binding and inducing S1 protein shedding. VIR-7229 can be used in SARS-CoV-2 infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7934

Trachelogenin (-)-Trachelogenin	Infection Monophenols Classification of Application Fields Source classification Lignans Phenols Rhaponticum carthamoides (Willd.) Iljin Phenylpropanoids Plants Compositae Disease Research Fields Inflammation/Immunology	HCV
Trachelogenin ((-)-Trachelogenin) is an HCV entry inhibitor without genotype specificity, and with low cytotoxicity. Trachelogenin inhibits HCVcc infection and HCVpp cell entry in a dose-dependent manner with an IC₅₀ of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively. Trachelogenin exhibits effective antiviral, anti-inflammatory and analgesic effects .

HY-N2127

Pinostrobin 1 Publications Verification	Monophenols Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

HY-17427

Emtricitabine 5+ Cited Publications BW1592	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	HIV Reverse Transcriptase Endogenous Metabolite
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-B0957

Erythromycin Ethylsuccinate Erythromycin ethyl succinate; EES	Infection Microorganisms Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial HIV Autophagy Antibiotic
Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.

HY-17427R

Emtricitabine (Standard) BW1592 (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards HIV Reverse Transcriptase Endogenous Metabolite
Emtricitabine (Standard) is the analytical standard of Emtricitabine. This product is intended for research and analytical applications. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-N6689

Destruxin A 1 Publications Verification	Infection Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields Biological Pesticide Research Agricultural Research	Insecticide Bacterial
Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections .

HY-N8188

Dehydrojuncusol	Infection other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	HCV HCV Protease
Dehydrojuncusol, a potent HCV inhibitor, targets HCV NS5A and is able to inhibit RNA replication of replicons harboring resistance mutations to anti-NS5A direct-acting antivirals. Dehydrojuncusol significantly inhibits HCV infection when added after virus inoculation of HCV genotype 2a (EC₅₀=1.35?μM) .

HY-N16441

Pulvic acid	Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite Influenza Virus
Pulvic acid (Compound 3), a butenolide, is a microbial secondary metabolite. Pulvic acid can be isolated from the marine-derived fungus Aspergillus terreus Gwq-48. Pulvic acid has significant antiviral activity with an IC₅₀ of 29.1 μg/mL for influenza A H1N1 virus. Pulvic acid can be used for influenza virus infections research .

HY-111243

Ganoderone A	Triterpenes Microorganisms Terpenoids Source classification	HSV
Ganoderone A is a triterpene compound that can be isolated from the fruiting body of Ganoderma pfeifferi and Ganoderma calidophilum. Ganoderone A has antiviral activity against HSV with IC₅₀ value of 0.3 µg/mL. Ganoderone A has potential applications in viral infections and tumors .

HY-B0957R

Erythromycin Ethylsuccinate (Standard) Erythromycin ethyl succinate (Standard); EES (Standard)	Microorganisms Antibiotics Source classification Antiviral Antibacterial Disease Research Other Antibiotics	Reference Standards Bacterial HIV Autophagy Antibiotic
Erythromycin Ethylsuccinate (Standard) is the analytical standard of Erythromycin Ethylsuccinate. This product is intended for research and analytical applications. Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.

HY-120104

Nitidanin (±)-Nitidanin	Buxaceae Source classification Lignans Phenylpropanoids Plants Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.	Parasite HCV
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection .

HY-N15344

Euryachin E	Triterpenes Terpenoids Source classification Eurya chinensis R. Brown Pentaphylacaceae Plants	Antibiotic Bacterial SARS-CoV
Euryachin E is an antimicrobial and antiviral agent found in Eurya chinensis. It exhibits a MIC of 6.25 μg/mL against B. cereus and 0.78 μg/mL against S. aureus. Its IC₅₀ against COVID-19 is 6.41 μM. Euryachin E can be utilized for research in the fields of infection and inflammation .

HY-N0224

Epigoitrin	Alkaloids Classification of Application Fields Other Alkaloids Cruciferae Source classification Isatis tinctoria L. Plants Disease Research Fields Cancer	Influenza Virus
Epigoitrin is a natural alkaloid that provides protection against influenza infection by reducing the host’s susceptibility to influenza virus under stress. Epigoitrin exerts antiviral activity against influenza A1 virus FM1 via inhibiting virus attachment and multiplication in vitro. Epigoitrin also has lipid-lowering effects .

HY-B1150

Clofoctol 1 Publications Verification	Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Antiviral Anticancer Disease Research Fields	Bacterial SARS-CoV Antibiotic
Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has *antiviral* potency .

HY-A0097

Teicoplanin 1 Publications Verification Antibiotic MDL-507; MDL-507	Infection Microorganisms Source classification Polyphenols Disease Research Fields	Bacterial Antibiotic
Teicoplanin is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-A0097A

Teicoplanin sodium Antibiotic MDL-507 sodium; MDL-507 sodium	Source classification Phenols Polyphenols Endogenous metabolite	Antibiotic HIV SARS-CoV
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-Y0136

3-Indoleacetonitrile 1 Publications Verification	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Influenza Virus HSV VSV
3-Indoleacetonitrile is an indole derivative with *anti-influenza* activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .

HY-N2562

Norwogonin 1 Publications Verification 5,7,8-Trihydroxyflavone	Infection Flavonoids Classification of Application Fields Flavones Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields Medicago truncatula Gaertn.	Enterovirus
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC₅₀ of 31.83 μg/ml

HY-N0224R

Epigoitrin (Standard)	Alkaloids Other Alkaloids Cruciferae Source classification Isatis tinctoria L. Plants	Influenza Virus
Epigoitrin (Standard) is the analytical standard of Epigoitrin. This product is intended for research and analytical applications. Epigoitrin is a natural alkaloid that provides protection against influenza infection by reducing the host’s susceptibility to influenza virus under stress. Epigoitrin exerts antiviral activity against influenza A1 virus FM1 via inhibiting virus attachment and multiplication in vitro. Epigoitrin also has lipid-lowering effects .

HY-B1150R

Clofoctol (Standard)	Monophenols Microorganisms Antibiotics Source classification Phenols Antiviral Antibacterial Disease Research Anticancer Other Antibiotics	Reference Standards Bacterial SARS-CoV Antibiotic
Clofoctol (Standard) is the analytical standard of Clofoctol. This product is intended for research and analytical applications. Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has *antiviral* potency .

HY-N3187

Nimbin	Other Terpenoids Infection other families Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Flavivirus Dengue Virus Fungal Bacterial Histamine Receptor
Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections .

HY-122920

Soyasaponin II	Triterpenes Classification of Application Fields Leguminosae Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc.	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-N14351

Ferrocin A	Natural Products Microorganisms Source classification	SARS-CoV Bacterial Antibiotic
Ferrocin A is a lipopeptide compound that targets the SARS-CoV-2 RNA-dependent RNA polymerase (nsp12). Ferrocin A can stably bind to nsp12, and as an iron-chelating peptide, it reduces the concentration of free iron in the environment via complexation, thereby inhibiting bacterial growth by repressing the acquisition of essential metal cations. As an iron-chelating antiviral molecule, Ferrocin A may be used in studies related to COVID-19 and bacterial infections .

HY-N2925

β-Amyrone 1 Publications Verification β-Amyron	Triterpenes Caprifoliaceae Source classification Plants Sambucus adnata Wall. ex DC.	Fungal COX PPAR
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity .

HY-N0570

Hydroxytyrosol 5+ Cited Publications DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol	Infection Canarium album (Lour.) Rauesch. Classification of Application Fields Source classification Phenols Polyphenols Plants Endogenous metabolite Burseraceae Inflammation/Immunology Disease Research Fields	Apoptosis Reactive Oxygen Species (ROS) Bacterial SARS-CoV
Hydroxytyrosol (DOPET) is a phenol found in the olive oil. Hydroxytyrosol can alleviate oxidative stress and improve mitochondrial function, thereby exerting neuroprotective effects. Hydroxytyrosol can induce cancer cells apoptosis via inducing ROS production. Hydroxytyrosol shows antibacterial and antiviral effect. Hydroxytyrosol can be used for the researches of cancer, infection, inflammation, immunology, metabolic, neurological and cardiovascular disease, such as colon cancer, diabetes, Alzheimer's Disease and atherosclerosis .

HY-Y0136R

3-Indoleacetonitrile (Standard)	Natural Products Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite Influenza Virus HSV VSV
3-Indoleacetonitrile (Standard) is the analytical standard of 3-Indoleacetonitrile. This product is intended for research and analytical applications. 3-Indoleacetonitrile is an indole derivative with *anti-influenza* activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .

HY-N14780

Pochonin D (+)-Pochonin D	Natural Products Microorganisms Source classification	HSP Interleukin Related Enterovirus
Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affecting the homeostasis, folding, and assembly processes of viral proteins, reducing the replication ability of the virus. Pochonin D reduces the infiltration of inflammatory cells and the secretion of inflammatory cytokines such as TNF-α and IL-1β, alleviating the inflammatory response. Pochonin D is promising for research of Human rhinoviruses (HRV) infections and cancers .

HY-N0570R

Hydroxytyrosol (Standard) DOPET (Standard); 3,4-Dihydroxyphenethyl alcohol (Standard); 3-Hydroxytyrosol (Standard)	Canarium album (Lour.) Rauesch. Source classification Phenols Polyphenols Plants Endogenous metabolite Burseraceae	Reference Standards Apoptosis Reactive Oxygen Species (ROS) Bacterial SARS-CoV
Hydroxytyrosol (Standard) (DOPET (Standard)) is the analytical standard of Hydroxytyrosol (HY-N0570). Hydroxytyrosol is a phenol found in the olive oil. Hydroxytyrosol can alleviate oxidative stress and improve mitochondrial function, thereby exerting neuroprotective effects. Hydroxytyrosol can induce cancer cells apoptosis via inducing ROS production. Hydroxytyrosol shows antibacterial and antiviral effect. Hydroxytyrosol can be used for the researches of cancer, infection, inflammation, immunology, metabolic, neurological and cardiovascular disease, such as colon cancer, diabetes, Alzheimer's Disease and atherosclerosis .

HY-N6043

Hydroxytyrosol acetate	Canarium album (Lour.) Rauesch. Classification of Application Fields Source classification Phenols Polyphenols Plants Burseraceae Inflammation/Immunology Disease Research Fields	Apoptosis Reactive Oxygen Species (ROS) Bacterial SARS-CoV
Hydroxytyrosol acetate is a prodrug of Hydroxytyrosol (HY-N0570). Hydroxytyrosol acetate is converted into the active form of Hydroxytyrosol in vivo. Hydroxytyrosol is a phenol found in the olive oil. Hydroxytyrosol can alleviate oxidative stress and improve mitochondrial function, thereby exerting neuroprotective effects. Hydroxytyrosol can induce cancer cells apoptosis via inducing ROS production. Hydroxytyrosol shows antibacterial and antiviral effect. Hydroxytyrosol can be used for the researches of cancer, infection, inflammation, immunology, metabolic, neurological and cardiovascular disease, such as colon cancer, diabetes, Alzheimer's Disease and atherosclerosis .

HY-N6043R

Hydroxytyrosol acetate (Standard)	Canarium album (Lour.) Rauesch. Source classification Phenols Polyphenols Plants Burseraceae	Reference Standards Apoptosis Reactive Oxygen Species (ROS) Bacterial SARS-CoV
Hydroxytyrosol acetate (Standard) is a prodrug of Hydroxytyrosol (HY-N0570). Hydroxytyrosol acetate (Standard) is converted into the active form of Hydroxytyrosol in vivo. Hydroxytyrosol is a phenol found in the olive oil. Hydroxytyrosol can alleviate oxidative stress and improve mitochondrial function, thereby exerting neuroprotective effects. Hydroxytyrosol can induce cancer cells apoptosis via inducing ROS production. Hydroxytyrosol shows antibacterial and antiviral effect. Hydroxytyrosol can be used for the researches of cancer, infection, inflammation, immunology, metabolic, neurological and cardiovascular disease, such as colon cancer, diabetes, Alzheimer's Disease and atherosclerosis .

HY-N0763

Angelicin Maximum Cited Publications 10 Publications Verification Isopsoralen	Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

HY-16050R

Plitidepsin (Standard) Aplidine (Standard); PM90001 (Standard)	Microorganisms Marine natural products Source classification Other marine organisms	Reference Standards DNA/RNA Synthesis SARS-CoV
Plitidepsin (Standard) is the analytical standard of Plitidepsin. This product is intended for research and analytical applications. Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-16050

Plitidepsin 3 Publications Verification Aplidine; PM90001	Microorganisms Marine natural products Source classification Other marine organisms	DNA/RNA Synthesis SARS-CoV
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

Cat. No.	Product Name	Chemical Structure

HY-104077S

Remdesivir-d5 2 Publications Verification
Remdesivir-d₅ (GS-5734-d₅) is a deuterium labeled Remdesivir (HY-104077). Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .

HY-17427S

Emtricitabine-15N,d2
Emtricitabine- ¹⁵N,d₂ is a ¹⁵N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-14532S

Brincidofovir-d6

Brincidofovir-d₆ (CMX001-d₆) is the deuterium labeled Brincidofovir (HY-14532). Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo. .

HY-17426S

Famciclovir-d4
Famciclovir-d₄ is the deuterium labeled Famciclovir. Famciclovir (BRL 42810) is a guanine analogue antiviral agent used for the treatment of various herpesvirus infections .

HY-104077S2

Remdesivir impurity 9-d4
Remdesivir impurity 9-d₄ is deuterium labeled Remdesivir (HY-104077). Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .

HY-A0032S

Valganciclovir-d5 TFA
Valganciclovir-d₅ (TFA) is the deuterium labeled Valganciclovir TFA . Valganciclovir, the L-valyl ester of ganciclovir, is actually a proagent for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections .

HY-104077S1

Remdesivir-d4
Remdesivir-d₄ (GS-5734-d₄) is deuterium labeled Remdesivir (HY-104077). Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .

HY-17427S4

Emtricitabine-d2
Emtricitabine-d₂ (BW1592-d₂) is deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-17426S1

Famciclovir-d6
Famciclovir-d₆ (BRL 42810-d₆) is deuterium labeled Famciclovir. Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection .

HY-B0957S

Erythromycin ethylsuccinate-13C,d3
Erythromycin ethylsuccinate- ¹³C,d₃ is the ¹³C- and deuterium labeled Erythromycin Ethylsuccinate. Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.

HY-17427S2

Emtricitabine-13C,15N2
Emtricitabine- ¹³C, ¹⁵N₂ (BW1592- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity .

HY-104074S

Pocapavir-d3
Pocapavir-d₃ (SCH-48973-d₃; V-073-d₃) is the deuterium labeled Pocapavir (HY-104074) . Pocapavir (SCH-48973) is an orally active capsid inhibitor. Pocapavir prevents virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections .

HY-15303S

Pritelivir-d4-1
Pritelivir-d₄-1 (AIC316-d₄-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-N0570S1

Hydroxytyrosol-d5

Hydroxytyrosol-d₅ (DOPET-d5) is the deuterium labeled Hydroxytyrosol (HY-N0570). Hydroxytyrosol is a phenol found in the olive oil. Hydroxytyrosol can alleviate oxidative stress and improve mitochondrial function, thereby exerting neuroprotective effects. Hydroxytyrosol can induce cancer cells apoptosis via inducing ROS production. Hydroxytyrosol shows antibacterial and antiviral effect. Hydroxytyrosol can be used for the researches of cancer, infection, inflammation, immunology, metabolic, neurological and cardiovascular disease, such as colon cancer, diabetes, Alzheimer's Disease and atherosclerosis .

HY-N0570S

Hydroxytyrosol-d4

Hydroxytyrosol-d₄ (DOPET-d4) is the deuterium labeled Hydroxytyrosol (HY-N0570). Hydroxytyrosol is a phenol found in the olive oil. Hydroxytyrosol can alleviate oxidative stress and improve mitochondrial function, thereby exerting neuroprotective effects. Hydroxytyrosol can induce cancer cells apoptosis via inducing ROS production. Hydroxytyrosol shows antibacterial and antiviral effect. Hydroxytyrosol can be used for the researches of cancer, infection, inflammation, immunology, metabolic, neurological and cardiovascular disease, such as colon cancer, diabetes, Alzheimer's Disease and atherosclerosis .

HY-W766548

Floxuridine-13C,15N2

Floxuridine- ¹³C, ¹⁵N₂ (5-Fluorouracil 2'-deoxyriboside- ¹³C, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled labeled Floxuridine (HY-B0097). Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .

HY-B1588S

Carbenoxolone-d4

Carbenoxolone-d₄ is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties . Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease . Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD . Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop .Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself .

Cat. No.	Product Name		Classification

HY-19476

AG-7404		Alkynes
AG-7404 is an orally active, irreversible inhibitor of the picornavirus 3C protease. AG-7404 blocks the processing of viral polyproteins, thereby inhibiting viral replication. AG-7404 has synergistic antiviral activity with capsid inhibitors such as V-073 (HY-104074) or BTA798 (HY-106254) and is effective against V-073-resistant variants. AG-7404 is used in the study of enterovirus infections such as poliovirus .

HY-149058

Neuraminidase-IN-13		Azide
Neuraminidase-IN-13 (Compound 10) is a neuraminidase inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells . Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159174

EPHA2/A4/GAK-IN-1		Azide
EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of EPHA2/EPHA4 and GAK with K_D values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. EPHA2/GAK-IN-1 shows an extrapolated half-life time of 4.6 h in a microsomal stability assay. EPHA2/GAK-IN-1 shows antiviral activity and prevents dengue virus infection of Huh7 liver cells .

HY-149057

Neuraminidase-IN-12		Azide
NDV-IN-1 is an antiviral agent with high neuraminidase inhibitory activity. NDV-IN-1 exhibits in vitro inhibitory activity against Newcastle disease virus (NDV). NDV-IN-1 significantly inhibits NDV infection of Vero cells by preventing the release of virus particles from infected cells . Neuraminidase-IN-12 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification