Remdesivir maleate  (Synonyms: GS-5734 maleate)

Remdesivir maleate (GS-5734 maleate) is a nucleoside analogue with effective antiviral activity. Remdesivir maleate can inhibit the synthesis of viral DNA or RNA. Remdesivir maleate can be used for the research of infection, such as SARS-CoV and MHV infection^[1][2][3].

Remdesivir maleate inhibits MHV replication with an IC₅₀ of 1.1 μM in infected delayed brain tumor (DBT) cells with MHV^[1].
Remdesivir maleate (2 μM, 2 h preinfection and 2 h postinfection) shows maximal inhibition in infected cells with MHV^[1].
Remdesivir maleate (1-10 μM, 24-72 h) decreases SARS-CoV and MERS-CoV viral titer in HAE cells^[1].
Remdesivir maleate inhibits 2019-nCoV with an EC₅₀ of 0.77 μM and CC₅₀ >100 μM^[2].
Remdesivir maleate shows antiviral activity with EC₅₀ values of 3.3 μM, 4.7 μM, 32 μM, 3.7 μM and 9.2 μM for SARS-CoV-2 and its variants alpha, beta, gamma and delta, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Remdesivir maleate (0.01-100 μM) reduces lung viral titers in mice models of WT and F480L + V557L SARS-CoV^[1].
Remdesivir maleate (10 mg/kg, i.v.) shows 100% protection against Ebola virus infection in nonhuman primate (NHP) models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

718.65

C₃₁H₃₉N₆O₁₂P

2250110-53-1

OC(/C=C\C(O)=O)=O.N#C[C@@]1(C2=CC=C3N2N=CN=C3N)O[C@@H]([C@H]([C@H]1O)O)COP(OC4=CC=CC=C4)(N[C@@H](C)C(OCC(CC)CC)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.  [Content Brief]

  [2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.  [Content Brief]

  [3]. Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 22;65(18):12044-12054.  [Content Brief]