2. Apoptosis Anti-infection
  3. HSV Apoptosis Antibiotic Bacterial
  4. Acyclovir sodium

Acyclovir sodium  (Synonyms: Aciclovir sodium; Acycloguanosine sodium)

Cat. No.: HY-17422A
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Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia.

For research use only. We do not sell to patients.

Acyclovir sodium

Acyclovir sodium Chemical Structure

CAS No. : 69657-51-8

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Based on 15 publication(s) in Google Scholar

Other Forms of Acyclovir sodium:

Acyclovir sodium Related Antibodies

Top Publications Citing Use of Products

    Acyclovir sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Jun:162:114595.  [Abstract]

    Acyclovir (ACV; 2.5 μM; 48 h) significantly inhibits the expression of gD in HSV-2-infected HeLa, Vero, Beas-2B and HaCaT cells.

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    Description

    Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].

    IC50 & Target[2]

    HSV-1

    0.85 μM (IC50)

    HSV-2

    0.86 μM (IC50)

    In Vitro

    Acyclovir (Aciclovir) sodium (3-100 µM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent[1].
    Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner[1].
    Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Acyclovir sodium Related Antibodies

    Cell Viability Assay[1]

    Cell Line: Jurkat, U937 and K562 leukemia cells
    Concentration: 3, 10, 30 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Showed a dose- and time-dependent reduction of cell viability.

    Apoptosis Analysis[1]

    Cell Line: Jurkat cells
    Concentration: 10 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Increased of caspase-3 activity and cleavaged the internucleosomal DNA.

    Cell Cycle Analysis[1]

    Cell Line: Jurkat cells
    Concentration: 10 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Revealed a dose-dependent accumulation of cells in S phase after 24 and 48 h. Showed a dose-dependent increase of the sub-G1 hypodiploid peak after 72 h.
    In Vivo

    Acyclovir (Aciclovir) sodium (20 mg/kg; p.o.; three times daily; for 10 d; BALB/c mice) suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production[3]

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1[3]
    Dosage: 20 mg/kg
    Administration: Oral administration; three times daily; for 10 days
    Result: Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
    Clinical Trial
    Molecular Weight

    248.19

    Formula

    C8H11N5NaO3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1N=C(N)NC2=C1N=CN2COCCO.[Na]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 6.25 mg/mL (25.18 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.0292 mL 20.1459 mL 40.2917 mL
    5 mM 0.8058 mL 4.0292 mL 8.0583 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.0292 mL 20.1459 mL 40.2917 mL 100.7293 mL
    5 mM 0.8058 mL 4.0292 mL 8.0583 mL 20.1459 mL
    10 mM 0.4029 mL 2.0146 mL 4.0292 mL 10.0729 mL
    15 mM 0.2686 mL 1.3431 mL 2.6861 mL 6.7153 mL
    20 mM 0.2015 mL 1.0073 mL 2.0146 mL 5.0365 mL
    25 mM 0.1612 mL 0.8058 mL 1.6117 mL 4.0292 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Acyclovir sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Acyclovir69657-51-8AciclovirAcycloguanosineHSVApoptosisAntibioticBacterialHerpes simplex virusimmunosuppressionantibodythymidinekinaseDNApolymerasetriphosphateanti-herpeticInhibitorinhibitorinhibit

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