1. Gene
  2. Mal - myelin and lymphocyte protein, T cell differentiation protein Gene

Mal - myelin and lymphocyte protein, T cell differentiation protein Gene

Mus musculus

Also known as Mpv17; Vip17

Gene ID: 17153 | Gene type: protein coding

About Mal

Summary

This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Mal Products(2)

mRNA Protein Name
NM_001171187.1 NP_001164658.1 myelin and lymphocyte protein isoform 2
NM_010762.5 NP_034892.1 myelin and lymphocyte protein isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of central nervous system myelination IMP
IMP: Inferred from mutant phenotype
15337780 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
11032882 MGI
involved in protein insertion into plasma membrane IMP
IMP: Inferred from mutant phenotype
22323295 MGI
involved in protein localization to paranode region of axon IMP
IMP: Inferred from mutant phenotype
15337780 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in apical plasma membrane IDA
IDA: Inferred from direct assay
11032882 MGI
is active in hinge region between urothelial plaques of apical plasma membrane IMP
IMP: Inferred from mutant phenotype
22323295 MGI
is active in membrane raft IDA
IDA: Inferred from direct assay
22323295 MGI
is active in plasma membrane raft IMP
IMP: Inferred from mutant phenotype
15337780 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin and lymphocyte protein

T-lymphocyte maturation-associated protein

Orthologs Information

Species Symbol Source ID
Homo sapiens Mal NCBI NCBI:4118
Canis familiaris Mal NCBI NCBI:403933
Macaca fascicularis Mal NCBI NCBI:101926035
Susscrofa domestica Mal NCBI
Rattus norvegicus Mal NCBI NCBI:25263
Macaca mulatta Mal NCBI NCBI:703532