2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Mal-va-mac-SN38

Mal-va-mac-SN38 is a drug-linker conjugate for ADC. Mal-va-mac-SN38 contains a ADC cytotoxin SN-38 (HY-13704) and a linker (HY-126364). Mal-va-mac-SN38 can rapidly and covalently bind with endogenous albumin in vivo, resulting in the formation of HSA-va-mac-SN38. Mal-va-mac-SN38 demonstrates exceptional stability in human plasma, and has anti-tumor and anti-metastasis effect.

For research use only. We do not sell to patients.

Mal-va-mac-SN38 Chemical Structure

Mal-va-mac-SN38 Chemical Structure

CAS No. : 2778229-31-3

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Based on 1 publication(s) in Google Scholar

Mal-va-mac-SN38 Related Antibodies

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View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Description

Mal-va-mac-SN38 is a drug-linker conjugate for ADC. Mal-va-mac-SN38 contains a ADC cytotoxin SN-38 (HY-13704) and a linker (HY-126364). Mal-va-mac-SN38 can rapidly and covalently bind with endogenous albumin in vivo, resulting in the formation of HSA-va-mac-SN38. Mal-va-mac-SN38 demonstrates exceptional stability in human plasma, and has anti-tumor and anti-metastasis effect[1].

Molecular Weight

1040.14

Formula

C52H61N7O14S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N(COC1=CC=C(N=C(C(N2C3)=CC([C@@](O)(CC)C(OC4)=O)=C4C2=O)C3=C5CC)C5=C1)CCS(=O)(C)=O)OCC6=CC=C(NC([C@@H](NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)C)=O)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (96.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9614 mL 4.8070 mL 9.6141 mL
5 mM 0.1923 mL 0.9614 mL 1.9228 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9614 mL 4.8070 mL 9.6141 mL 24.0352 mL
5 mM 0.1923 mL 0.9614 mL 1.9228 mL 4.8070 mL
10 mM 0.0961 mL 0.4807 mL 0.9614 mL 2.4035 mL
15 mM 0.0641 mL 0.3205 mL 0.6409 mL 1.6023 mL
20 mM 0.0481 mL 0.2404 mL 0.4807 mL 1.2018 mL
25 mM 0.0385 mL 0.1923 mL 0.3846 mL 0.9614 mL
30 mM 0.0320 mL 0.1602 mL 0.3205 mL 0.8012 mL
40 mM 0.0240 mL 0.1202 mL 0.2404 mL 0.6009 mL
50 mM 0.0192 mL 0.0961 mL 0.1923 mL 0.4807 mL
60 mM 0.0160 mL 0.0801 mL 0.1602 mL 0.4006 mL
80 mM 0.0120 mL 0.0601 mL 0.1202 mL 0.3004 mL
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Mal-va-mac-SN38 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-va-mac-SN382778229-31-3Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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