Mal-PEG2-Val-Cit-PABA-PNP

Name: Mal-PEG2-Val-Cit-PABA-PNP
Brand: MedChemExpress
SKU: HY-131156
Rating: 4.5 (1 reviews)

Cat. No.: HY-131156 Purity: 96.82%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

Mal-PEG2-Val-Cit-PABA-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mal-PEG2-Val-Cit-PABA-PNP Chemical Structure

CAS No. : 1345681-52-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-PEG2-Val-Cit-PABA-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

755.73

Formula

C₃₄H₄₁N₇O₁₃

CAS No.

1345681-52-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1=CC=C(C=C1)[N+]([O-])=O)OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OCCOCCN3C(C=CC3=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (132.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3232 mL	6.6161 mL	13.2322 mL
5 mM	0.2646 mL	1.3232 mL	2.6464 mL
10 mM	0.1323 mL	0.6616 mL	1.3232 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.82%

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Data Sheet (272 KB) SDS (252 KB)

COA (251 KB) HNMR (285 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3232 mL	6.6161 mL	13.2322 mL	33.0806 mL
	5 mM	0.2646 mL	1.3232 mL	2.6464 mL	6.6161 mL
	10 mM	0.1323 mL	0.6616 mL	1.3232 mL	3.3081 mL
	15 mM	0.0882 mL	0.4411 mL	0.8821 mL	2.2054 mL
	20 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6540 mL
	25 mM	0.0529 mL	0.2646 mL	0.5293 mL	1.3232 mL
	30 mM	0.0441 mL	0.2205 mL	0.4411 mL	1.1027 mL
	40 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.8270 mL
	50 mM	0.0265 mL	0.1323 mL	0.2646 mL	0.6616 mL
	60 mM	0.0221 mL	0.1103 mL	0.2205 mL	0.5513 mL
	80 mM	0.0165 mL	0.0827 mL	0.1654 mL	0.4135 mL
	100 mM	0.0132 mL	0.0662 mL	0.1323 mL	0.3308 mL