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Results for "

stromal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (9) Bacterial (1) Biochemical Assay Reagents (2) c-Fms (1) c-Kit (3) CRAC Channel (1) CXCR (3) Cytochrome P450 (2) Drug Derivative (1) Drug Metabolite (3) Endogenous Metabolite (6) Estrogen Receptor/ERR (6) FKBP (3) Fungal (1) Interleukin Related (3) Isotope-Labeled Compounds (4) Leukotriene Receptor (2) Mitosis (1) Molecular Glues (1) Myosin (2) Necroptosis (1) NF-κB (1) Nuclear Factor of activated T Cells (NFAT) (1) PDGFR (2) Phosphodiesterase (PDE) (6) PKA (2) Progesterone Receptor (3) Prostaglandin Receptor (2) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Smo (1) TGF-β Receptor (1) Toll-like Receptor (TLR) (1) TRP Channel (1) VEGFR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (28) Cardiovascular Disease (8) Endocrinology (9) Infection (2) Inflammation/Immunology (13) Metabolic Disease (4)
Oligonucleotides:	CpG ODNs (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99872

Ecleralimab CSJ-117; NVP-CSJ117	Interleukin Related	Others
Ecleralimab (CSJ-117; NVP-CSJ117) is a Fab-IgG1-λ2 antibody targeting the thymic stromal lymphopoietin TSLP. The expression system of Ecleralimab is usually CHO (Chinese Hamster Ovary) cells .

HY-N1403

Tigogenin	Others	Metabolic Disease
Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid agents. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells .

HY-P5832

BMP2-derived peptide	TGF-β Receptor	Others
BMP2-derived peptide is a functional motif from positions 73 to 92 of the amino acid sequence of BMP-2. BMP2-derived peptide promotes osteogenic differentiation of bone marrow stromal cells (BMSCs) and enhances bone regeneration .

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP	Endocrinology
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-162730

OPB-171775	Molecular Glues Phosphodiesterase (PDE)	Cancer
OPB-171775 is an orally active molecular glue. OPB-171775 forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway. OPB-171775 exhibits significant efficacy against gastrointestinal stromal tumor .

HY-N1403R

Tigogenin (Standard)	Reference Standards Others	Metabolic Disease
Tigogenin (Standard) is the analytical standard of Tigogenin. This product is intended for research and analytical applications. Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid agents. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells .

HY-P2450

Leucinostatin A Antibiotic P168	Fungal Antibiotic	Infection Cancer
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .

HY-106064A

Piriprost potassium U 60257B	Leukotriene Receptor	Inflammation/Immunology
Piriprost (U-60,257B) potassium is an inhibitor of leukotriene synthesis. Piriprost potassium inhibits the release of both leukotriene and histamine with an IC₅₀ of 0.11 μM from isolated porcine lung cells. Piriprost potassium increases alkaline phosphatase (ALP) activity in cultured endometrial stromal cells .

HY-B0652R

Etonogestrel (Standard) 3-Oxodesogestrel (Standard); 3-keto-Desogestrel (Standard)	Drug Metabolite Reference Standards Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP	Endocrinology
Etonogestrel (Standard) is the analytical standard of Etonogestrel. This product is intended for research and analytical applications. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-B0523B

Anagrelide hydrochloride monohydrate	Phosphodiesterase (PDE) Apoptosis	Cardiovascular Disease Cancer
Anagrelide hydrochloride monohydrate is a potent inhibitor of phosphodiesterase type III (PDE3) (IC₅₀=36 nM). Anagrelide hydrochloride monohydrate, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride monohydrate inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride monohydrate decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride monohydrate is a platelet-lowering agent and plays in the antithrombopoietic action .

HY-B0523A

Anagrelide hydrochloride 3 Publications Verification BL4162A	Phosphodiesterase (PDE) Apoptosis	Cardiovascular Disease Cancer
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC₅₀=36 nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action .

HY-B0523AR

Anagrelide hydrochloride (Standard) BL4162A (Standard)	Reference Standards Phosphodiesterase (PDE) Apoptosis	Cardiovascular Disease Cancer
Anagrelide (hydrochloride) (Standard) is the analytical standard of Anagrelide (hydrochloride). This product is intended for research and analytical applications. Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action .

HY-112802A

AZD3229 Tosylate	c-Kit	Cancer
AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

HY-125086

Leustroducsin B LSN-B	c-Fms	Cardiovascular Disease
Leustroducsin B is a colony-stimulating factor (CSF) inducer. Leustroducsin B induces CSF production in bone marrow stromal cells .

HY-160850

C18 Ceramide-1-phosphate (d18:1/18:0) ammonium salt	Endogenous Metabolite	Endocrinology
C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt) is a specific type of long-chain molecule found in murine skin . C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt) promotes migration of both mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells at concentrations between 0.5-5 µM. C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt)’s levels are higher in CFPAC-1 pancreatic ductal adenocarcinoma cells than in pancreatic cancer stem cells .

HY-128589

CHMFL-KIT-033	c-Kit	Cancer
CHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC₅₀ of 0.045 μM .

HY-112802

AZD3229	c-Kit	Cancer
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC₅₀ value of 223.3 nM .

HY-160856

TOP5300 TOP05300	Estrogen Receptor/ERR	Endocrinology
TOP5300 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5300 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats .

HY-160857

TOP5668	Estrogen Receptor/ERR	Endocrinology
TOP5668 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5668 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats .

HY-W341962

Halometasone	Leukotriene Receptor	Inflammation/Immunology
Halometasone is a corticosteroid compound that can reduce the expression of serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP). Halometasone can be used in research on psoriasis and eczematous skin diseases .

HY-114244

USL311 1 Publications Verification	CXCR	Endocrinology Cancer
USL311 is a potent and selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4 .

HY-W591818

Sunitinib carboxylic acid	Drug Derivative	Cancer
Sunitinib carboxylic acid is a carboxylic acid metabolite of Sunitinib (HY-10255A). Sunitinib is a multi-target tyrosine kinase inhibitor, mainly used to inhibit malignant tumors such as gastrointestinal stromal tumors, renal cell carcinoma, and pancreatic neuroendocrine tumors .

HY-P991162

Tilrekimig	Interleukin Related	Inflammation/Immunology
Tilrekimig is a monoclonal antibody targeting human interleukin 4 (IL-4), interleukin 13 (IL-13), and TSLP (thymic stromal lymphopoietin). Tilrekimig is promising for research of allergic and inflammatory diseases, such as asthma and atopic dermatitis .

HY-N0101

Neohesperidin 5+ Cited Publications Hesperetin 7-O-neohesperidoside	β-catenin Wnt	Inflammation/Immunology
Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the Wnt/β-catenin signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells .

HY-P991623

CM-326	Interleukin Related	Inflammation/Immunology
CM-326 is a humanized monoclonal antibody targeting thymic stromal lymphopoietin (TSLP). CM-326 can improve T_h2 inflammation. CM-326 can be studied in research for chronic rhinosinusitis with nasal polyps .

HY-162346

KN-17	Bacterial	Infection
KN-17 is a modified based on the structure of cecropin B (HY-P0092), can effectively interfere with bacterial growth and induce the migration of human bone marrow stromal cells (hBMSCs). KN-17 can significantly stimulate angiogenesis in vitro and in vivo .

HY-12306

8-Bromo-cAMP sodium salt Maximum Cited Publications 28 Publications Verification 8-Br-Camp sodium salt	PKA Apoptosis	Cancer
8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells .

HY-12306A

8-Bromo-cAMP Maximum Cited Publications 28 Publications Verification 8-Br-Camp	PKA Apoptosis	Cancer
8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells .

HY-B0652S1

Etonogestrel-d6 3-Oxodesogestrel-d₆; 3-keto-Desogestrel-d₆	Isotope-Labeled Compounds Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP	Endocrinology
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-103071

GSK-5503A	CRAC Channel	Inflammation/Immunology
GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker. GSK-5503A effectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. GSK-5503A can be used for the research of asthma and allergic disorders .

HY-P3612

CTCE-0214	CXCR	Inflammation/Immunology
CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research .

HY-135023

5-trans-PGE2 5-trans Prostaglandin E2	Cytochrome P450 Prostaglandin Receptor	Cancer
5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase). This process is involved in the growth and development of breast cancer .

HY-B0523

Anagrelide 3 Publications Verification	Phosphodiesterase (PDE) Apoptosis	Cardiovascular Disease Cancer
Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC₅₀=36 nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action .

HY-N13214

Maca Extract (10:1)	Others	Metabolic Disease
Maca Extract is a maca extract. Maca Extract has the potential to improve fertility and sexual function, and can improve non-obstructive azoospermia. The polysaccharide part is its active ingredient. Maca Extract can alleviate seminiferous tubule vacuolation and testicular lesions. It improves sperm quantity and quality by promoting the recovery of seminiferous epithelium, inhibiting stromal cell proliferation, and increasing serum testosterone levels. .

HY-100932

ML-9 4 Publications Verification	Myosin	Cancer
ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity . ML-9 inhibits inhibits MLCK, PKA and PKC activity with K_i values of 4, 32 and 54 μM, respectively . ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation .

HY-121261

Antineoplastic agent-1	Necroptosis Apoptosis	Cancer
Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research .

HY-100932A

ML-9 Free Base	Myosin	Cancer
ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity . ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with K_i values of 4, 32 and 54 μM, respectively . ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation .

HY-170911

KIT/PDGFRA-IN-1	PDGFR	Cancer
KIT/PDGFRA-IN-1 (compound 19) is a stem cell growth factor receptor (KIT) and platelet-derived growth factor receptor alpha (PDGFRA) inhibitor. KIT/PDGFRA-IN-1 inhibits KIT-wt, KIT-D816H, KIT-T670I, PDGFRA-wt, PDGFRA-D842V, PDGFRA-T674I and PDGFRA-G680R with IC₅₀s of 2.3, 12, 492, 0.8, 99.9, 42.3, and 4.3 μM, respectively. KIT/PDGFRA-IN-1 inhibits GIST-T1, T1-a-D842V and GIST-48B cells (PDGFR- and KIT-Mutant GIST cell Lines) with GR₅₀s of 12, 8900, ≥10 000 nM, respectively .

HY-B1514R

Allantoic acid (Standard)	Reference Standards Endogenous Metabolite	Others
Anagrelide (hydrochloride) (Standard) is the analytical standard of Anagrelide (hydrochloride). This product is intended for research and analytical applications. Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action .

HY-B0966S

Dioxybenzone-d3 Benzophenone-8-d₃; UV-24-d₃	Isotope-Labeled Compounds Biochemical Assay Reagents	Inflammation/Immunology Cancer
Dioxybenzone-d₃ is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study .

HY-B0966

Dioxybenzone Benzophenone-8; UV-24	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study .

HY-173275

PDGFRα kinase inhibitor 3	PDGFR	Cancer
PDGFRα kinase inhibitor 3 (Compound L7) is a highly potent inhibitor targeting the PDGFRα ^D842V kinase with IC₅₀s values of 23.8 nM and 2.1 nM in biochemical and cellular assays, respectively. PDGFRα kinase inhibitor 3 binds to the ATP-binding pocket of PDGFRα ^D842V to block its downstream signaling pathways and inhibit kinase activity. PDGFRα kinase inhibitor 3 can be used for gastrointestinal stromal tumors (GISTs) study .

HY-B0523S

Anagrelide-13C2,15N,d2	Apoptosis Phosphodiesterase (PDE) Isotope-Labeled Compounds	Cardiovascular Disease Cancer
Anagrelide- ¹³C₂, ¹⁵N,d₂ is ¹⁵N and deuterated labeled Anagrelide (HY-B0523). Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC₅₀=36 nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action .

HY-135023R

5-trans-PGE2 (Standard) 5-trans Prostaglandin E2 (Standard)	Cytochrome P450 Prostaglandin Receptor Reference Standards	Cancer
5-trans-PGE2 (Standard) is the analytical standard of 5-trans-PGE2. This product is intended for research and analytical applications. 5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase). This process is involved in the growth and development of breast cancer .

HY-177058

DSP30	Toll-like Receptor (TLR) Mitosis	Inflammation/Immunology
DSP30 is a phosphorothioate cpG-oligodeoxynucleotide and a TLR9 agonist. DSP30 can activate immune system cells, including B cells and dendritic cells, by inducing proliferation and cytokine production.DSP30 can enhance the immunosuppressive function of bone marrow-multipotent mesenchymal stromal cells (BM-MSC). DSP30 combined with interleukin 2 (IL2) is an effective mitotic stimulant in B-cell disorders. DSP30 can be used for the genetic characteristic research and analysis of chronic lymphocytic leukemia (CLL) .

HY-19408

Pyr10 3 Publications Verification	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca ²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca ²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .

HY-117253

PHA-782584	Drug Metabolite	Cancer
PHA-782584 is a metabolite of sunitinib. Sunitinib is an oral multitargeted tyrosine kinase inhibitor with antitumor activities .

HY-103454B

MPP hydrochloride 5+ Cited Publications	Estrogen Receptor/ERR Apoptosis	Endocrinology Cancer
MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo .

HY-19867A

Burixafor hydrobromide 2 Publications Verification TG-0054 hydrobromide	CXCR VEGFR	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Burixafor (TG-0054) hydrobromide is a selective, orally active CXCR4 antagonist that effectively blocks the interaction between CXCR4 and its ligand, stromal cell-derived factor SDF-1. Burixafor hydrobromide interferes with the SDF-1/CXCR4 signaling pathway, prompting the release of bone marrow stem cells into the peripheral circulation, exerting immunomodulatory and anti-inflammatory activities. Burixafor hydrobromide can be used in the study of cancer, Intraocular neovascular diseases (such as choroidal neovascularization), myocardial infarction and other diseases, with the potential to mobilize stem cells, improve cardiac function and reduce inflammatory responses .

HY-12316

20(S)-Hydroxycholesterol 2 Publications Verification 20α-Hydroxycholesterol	Smo Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC₅₀ of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .

Cat. No.	Product Name

HY-L173

Anti-Ovarian Cancer Compound Library

2,391 compounds

Ovarian cancer is the most common cause of death in female genital malignancies, with the highest mortality rate in female genital malignancies. It is characterized by difficulty in detection in the early stage of the disease, high recurrence rate and poor prognosis. In fact, ovarian cancer includes many pathologic types. It is usually divided into epithelial ovarian cancer, malignant germ cell tumors and sex cord stromal tumors, of which epithelial ovarian cancer is the most dominant form. Clinical treatment of ovarian cancer prioritizes surgery combined with paclitaxel chemotherapy. However, due to the spread and drug resistance of tumor cells, the recurrence of ovarian cancer is high. In this case, combined with traditional methods, the development of new therapeutic agents can help to improve the treatment effect of ovarian cancer.

MCE designs a unique collection of 2,391 compounds with definite or potential anti-ovarian cancer activity, which mainly targeting the main targets of ovarian cancer such as PARP, ATM/ATR, VEGFR and HIF/HIF Prolyl-Hydroxylase, etc. It is an essential tool for development and research of anti-ovarian compounds.

Cat. No.	Product Name	Target	Research Area

HY-P5832

BMP2-derived peptide	TGF-β Receptor	Others
BMP2-derived peptide is a functional motif from positions 73 to 92 of the amino acid sequence of BMP-2. BMP2-derived peptide promotes osteogenic differentiation of bone marrow stromal cells (BMSCs) and enhances bone regeneration .

HY-P3612

CTCE-0214	CXCR	Inflammation/Immunology
CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research .

HY-P2263

KLD-12	Peptides	Inflammation/Immunology
KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair .

HY-P2263A

KLD-12 TFA	Peptides	Inflammation/Immunology
KLD-12 TFA is the TFA salt form of KLD-12 (HY-P2263). KLD-12 TFA is a self a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 TFA combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 TFA hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair .

Cat. No.	Product Name	Target	Research Area

HY-P99872

Ecleralimab CSJ-117; NVP-CSJ117	Interleukin Related	Others
Ecleralimab (CSJ-117; NVP-CSJ117) is a Fab-IgG1-λ2 antibody targeting the thymic stromal lymphopoietin TSLP. The expression system of Ecleralimab is usually CHO (Chinese Hamster Ovary) cells .

HY-P991162

Tilrekimig	Interleukin Related	Inflammation/Immunology
Tilrekimig is a monoclonal antibody targeting human interleukin 4 (IL-4), interleukin 13 (IL-13), and TSLP (thymic stromal lymphopoietin). Tilrekimig is promising for research of allergic and inflammatory diseases, such as asthma and atopic dermatitis .

HY-P991623

CM-326	Interleukin Related	Inflammation/Immunology
CM-326 is a humanized monoclonal antibody targeting thymic stromal lymphopoietin (TSLP). CM-326 can improve T_h2 inflammation. CM-326 can be studied in research for chronic rhinosinusitis with nasal polyps .

Species:	Human (25) Rat (2) Mouse (12) Cynomolgus (5) Canine (1)
Tag:	His (30) Tag Free (6) Avi (6) Myc (2) GST (1) Fc (8)
Source:	HEK293 (30) Sf9 insect cells (2) E. coli (13)

Cat. No.	Compare	Product Name	Species	Source

HY-P70818

	TSLP Protein, Human (HEK293, His) Thymic stromal lymphopoietin; TSLP	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (HEK293, His) is the recombinant human-derived TSLP protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78046

	TSLP Protein, Cynomolgus (HEK293, His) thymic stromal lymphopoietin; TSLP	Cynomolgus	HEK293
	TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TSLP protein, expressed by HEK293 , with C-8*His labeled tag.

HY-P78532

	TSLP Protein, Human (HEK293, His-Avi) thymic stromal lymphopoietin; TSLP	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (HEK293, His-Avi) is the recombinant human-derived TSLP protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78224

	TSLP Protein, Human (Biotinylated, HEK293, His-Avi) thymic stromal lymphopoietin; TSLP	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TSLP protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P704947

	TSLP Protein, Human (HEK293, Fc) Thymic stromal lymphopoietin; Thymic stromal lymphopoietin protein TSLP; Tslp; TSLP protein; TSLP_HUMAN	Human	HEK293

HY-P700601

	TSLP Protein, Human (HEK293, His-Myc) Thymic stromal lymphopoietin; Thymic stromal lymphopoietin protein TSLP; Tslp; TSLP protein; TSLP_HUMAN	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (HEK293, His-Myc) is the recombinant human-derived TSLP protein, expressed by HEK293 , with N-Myc, N-6*His labeled tag.

HY-P78613

	TSLP Protein, Rat (HEK293, His) Thymic stromal lymphopoietin; TSLP	Rat	HEK293
	TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Rat (HEK293, His) is the recombinant rat-derived TSLP protein, expressed by HEK293 , with C-His labeled tag. The total length of TSLP Protein, Rat (HEK293, His) is 118 a.a., with molecular weight of 20-30 kDa.

HY-P704948

	TSLP Protein, Human (R127A, R130A, HEK293, Fc) Thymic stromal lymphopoietin; Thymic stromal lymphopoietin protein TSLP; Tslp; TSLP protein; TSLP_HUMAN	Human	HEK293

HY-P78047

	TSLP Protein, Cynomolgus (Biotinylated, HEK293, His) thymic stromal lymphopoietin; TSLP	Cynomolgus	HEK293
	TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Cynomolgus (Biotinylated, HEK293, His) is the recombinant cynomolgus-derived TSLP protein, expressed by HEK293 , with C-His labeled tag.

HY-P70703

	TSLP Protein, Cynomolgus (His) Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; TSLP	Cynomolgus	E. coli
	Thymic stromal lymphopoietin (TSLP) is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. TSLP mainly impacts myeloid cells and promotes T helper type 2 (TH2) cell responses associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. TSLP Protein, Cynomolgus (His) is the recombinant cynomolgus-derived TSLP protein, expressed by E. coli , with C-6*His labeled tag and Q37E mutation.

HY-P70626

	TSLP Protein, Mouse (HEK293, Fc) Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; Tslp	Mouse	HEK293
	TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TSLP protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704949

	TSLP Protein, Mouse (HEK293, His) Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; Tslp	Mouse	HEK293

HY-P74536

	STIM1 Protein, Human (HEK293, His) stromal interaction molecule 1; STIM1; GOK	Human	HEK293
	STIM1 (stromal interacting molecule 1) coordinates store-operated Ca(2+) entry (SOCE) and acts as a Ca(2+) sensor in the endoplasmic reticulum. Upon Ca(2+) depletion, STIM1 translocates to the plasma membrane and activates the Ca(2+)-releasing activated Ca(2+) (CRAC) channel subunit ORAI1. STIM1 Protein, Human (HEK293, His) is the recombinant human-derived STIM1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76054

	SDF-2 Protein, Human (sf9, His) stromal cell-derived factor 2; SDF2	Human	Sf9 insect cells
	SDF-2 Protein is part of the family of proteins involved in the activation of ER stress/UPR. SDF2 protein is believed to be a secretory protein. SDF-2 Protein, Human (sf9, His) is the recombinant human-derived SDF-2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P76636

	SDF-2 Protein, Mouse (sf9, His) stromal cell-derived factor 2; SDF-2	Mouse	Sf9 insect cells
	SDF-2 protein is ubiquitously expressed, with its highest concentrations observed in liver and kidney tissues.SDF-2 Protein, Mouse (sf9, His) is the recombinant mouse-derived SDF-2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P78565

	TSLP Protein, Cynomolgus (R127A, R130S, HEK293, His) Thymic stromal lymphopoietin; TSLP	Cynomolgus	HEK293
	TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Cynomolgus (R127A, R130S, HEK293, His) is the recombinant cynomolgus-derived TSLP protein, expressed by HEK293 , with C-His labeled tag.

HY-P78789

	TSLP Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; TSLP	Cynomolgus	HEK293
	TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived TSLP protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of TSLP Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is 131 a.a., with molecular weight of ~12 kDa.

HY-P78790

	TSLP Protein, Mouse (Biotinylated, HEK293, His-Avi) Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; TSLP	Mouse	HEK293
	TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived TSLP protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of TSLP Protein, Mouse (Biotinylated, HEK293, His-Avi) is 121 a.a., with molecular weight of 25-33 kDa.

HY-P78533

	TSLP Protein, Human (R127A, R130A, HEK293, His-Avi) thymic stromal lymphopoietin; TSLP	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (R127A, R130A, HEK293, His-Avi) is the recombinant human-derived TSLP protein, expressed by HEK293 , with C-Avi, C-His labeled tag and R127A, R130A mutation.

HY-P78225

	TSLP Protein, Human (Biotinylated, R127A, R130A, HEK293, His-Avi) Thymic stromal lymphopoietin; TSLP	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (Biotinylated, R127A, R130A, HEK293, His-Avi) is the recombinant human-derived TSLP protein, expressed by HEK293 , with C-Avi, C-His labeled tag and R127A, R130A mutation.

HY-P7673

	BST2 Protein, Human (HEK293, His) rHuBST2, His; Bone Marrow stromal Antigen 2; BST-2	Human	HEK293
	BST2 Protein, Human (HEK293, His) is a recombinant human bone marrow stromal antigen 2 produced in HEK293 cells. Bone marrow stromal antigen 2 (BST-2; also known as tetherin or CD317) is an IFN-inducible gene that functions to block the release of a range of nascent enveloped virions from infected host cells.

HY-P70823

	TSLPR Protein, Mouse (HEK293, Fc) CRL2; CRLF2; CRL2 cytokine receptor; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; Thymic stromal-derived lymphopoietin receptor; TSLP receptor; TSLPR	Mouse	HEK293
	Cytokine receptor-like factor 2 (Crlf2), also known as thymic stromal lymphopoietin (TSLP) receptor, is a receptor for TSLP. Crlf2 can forms a functional complex with TSLP and IL7RA, and overexpression of Crlf2 stimulates cell proliferation through activation of the JAK-STAT pathway. The expression of Crlf2 usually upregulates and mutated in populations of B-progenitor acute lymphoblastic leukemia (B-ALL). TSLPR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TSLPR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74569

	SDF-1 Protein, Canine stromal Cell-Derived Factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1	Canine	E. coli
	SDF-1 (stromal cell-derived factor-1) is a homeostatic chemokine that binds CXCR4 and CXCR7 receptors and physiologically functions in hematopoiesis, leucocyte trafficking, cardiogenesis, and neurogenesis. SDF-1 is constitutively expressed in several organs including lung, liver, skeletal muscle, brain, kidney, heart, skin, and bone marrow. SDF-1 has an essential role in neural and vascular development, hematopoiesis, cancer and in immunity. SDF-1 Protein, Canine is produced in E. coli, and consists of 72 amino acids (K22-M93).

HY-P78658

	TSLP Protein, Human (R127A, R130A, HEK293, His) Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; TSLP	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (R127A, R130A, HEK293, His) is the recombinant human-derived TSLP protein, expressed by HEK293 , with C-His labeled tag and R127A, R130A, , , mutation.

HY-P78659

	TSLP Protein, Human (R127A, R130A, HEK293, mFc) Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; TSLP	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (R127A, R130A, HEK293, mFc) is the recombinant human-derived TSLP protein, expressed by HEK293 , with C-mFc labeled tag and R127A, R130A mutation.

HY-P75468

	BST2 Protein, Mouse (HEK293, His) Bone marrow stromal antigen 2; BST-2; HM1.24 antigen; Bst2	Mouse	HEK293
	The BST2 protein is an IFN-induced antiviral factor that inhibits mammalian enveloped viruses by tethering viral particles to infected cell membranes. BST2 acts as a physical tether connecting virions, limiting their release and spread. BST2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BST2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P75469

	BST2 Protein, Mouse (HEK293, hFc) Bone marrow stromal antigen 2; BST-2; HM1.24 antigen; Bst2	Mouse	HEK293
	The BST2 protein is an IFN-induced antiviral factor that inhibits mammalian enveloped viruses by tethering viral particles to infected cell membranes. BST2 acts as a physical tether connecting virions, limiting their release and spread. BST2 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived BST2 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P70989

	TSLP R Protein, Mouse (HEK293, His) CRL2; CRLF2; CRL2 cytokine receptor; Cytokine receptor-like 2; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; Thymic stromal-derived lymphopoietin receptor; TSLP receptor; TSLPR	Mouse	HEK293
	Cytokine receptor-like factor 2 (Crlf2), also known as thymic stromal lymphopoietin (TSLP) receptor, is a receptor for TSLP. Crlf2 can forms a functional complex with TSLP and IL7RA, and overexpression of Crlf2 stimulates cell proliferation through activation of the JAK-STAT pathway. The expression of Crlf2 usually upregulates and mutated in populations of B-progenitor acute lymphoblastic leukemia (B-ALL). TSLP R Protein, Mouse (HEK293, His) is the recombinant mouse-derived TSLP R protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70584

	Serpin F1 Protein, Mouse (375a.a) Pigment epithelium-derived factor; Pedf; Sdf3; Caspin; Serpin F1; stromal cell-derived factor 3.	Mouse	E. coli
	Serpin F1 is a neurotrophin that significantly induces extensive neuronal differentiation of retinoblastoma cells and exhibits potent anti-angiogenic effects.Its unique conformation lacks the S (stress) to R (relaxation) transition typical of active serpins, resulting in a lack of serpin activity.Serpin F1 Protein, Mouse is the recombinant mouse-derived Serpin F1 protein, expressed by E.coli , with tag free.

HY-P71153

	Neuroplastin Protein, Human (192a.a, HEK293, His) Neuroplastin; stromal Cell-Derived Receptor 1; SDR-1; NPTN; SDFR1; SDR1	Human	HEK293
	Neuroplastin protein is a possible cell adhesion molecule that plays a crucial role in the long-term potentiation of hippocampal synapses and regulates neurite growth through the p38MAPK and FGFR1 pathways.It acts as a chaperone of ATP2B1, stabilizing and enhancing its ATPase activity, affecting cellular calcium homeostasis.Neuroplastin Protein, Human (HEK293, His) is the recombinant human-derived Neuroplastin protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73661

	SDF-1 alpha/CXCL12 Protein, Human (His) stromal Cell-Derived Factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1	Human	E. coli
	SDF-1 alpha (Stromal Cell-Derived Factor-1α, SDF-1α) is a member of the chemokine α subfamily that lack the ELR domain. SDF-1α works as a chemoattractant for T- and B-lymphocytes and monocytes. SDF-1α is a ligand for CXCR4. The SDF-1α/CXCR4 signaling mediates many physiological processes including cell trafficking, angiogenesis, embryogenesis, tumor invasion and metastatic. It also controls the chemotaxis of hematopoietic stem cells homing to the bone marrow. SDF-1 alpha/CXCL12 Protein, Human (His) is produced in E. coli with a N-Terminal His-tag. It consists of 68 amino acids (K22-K89).

HY-P70581

	MYDGF Protein, Human (His) UPF0556 protein C19orf10; stromal cell-derived growth factor SF20; C19orf10; Myeloid-derived growth factor; MYDGF	Human	E. coli
	The MYDGF protein is derived from bone marrow mononuclear cells and significantly promotes cardioprotection and post-myocardial infarction (MI) repair. Its functions include promoting cardiomyocyte survival and promoting adaptive angiogenesis. MYDGF Protein, Human (His) is the recombinant human-derived MYDGF protein, expressed by E. coli , with N-6*His labeled tag.

HY-P73411

	SDF-1 beta/CXCL12 Protein, Human (HEK293, Fc) stromal Cell-Derived Factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1	Human	HEK293
	SDF-1 beta (Stromal-derived factor-1β, SDF-1β) is a stromal derived CXC chemokine that signal through the CXCR4 receptor. SDF-1β has chemotactic activity on B and T cells. SDF-1 beta/CXCL12 Protein, Human (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 72 amino acids (K22-M93).

HY-P700043AF

	Animal-Free SDF-1 alpha/CXCL12 Protein, Human (His) stromal Cell-Derived Factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1	Human	E. coli
	The SDF-1 alpha/CXCL12 protein is a chemoattractant for immune cells. Animal-Free SDF-1 Beta/CXCL12 Protein, Human (His) is the recombinant human-derived animal-FreeSDF-1 Beta/CXCL12 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P72781

	SDF-1 beta/CXCL12 Protein, Rat C-X-C motif chemokine 12; stromal cell-derived factor 1; CXCL12; SDF-1β	Rat	E. coli
	SDF-1 beta (Stromal-derived factor-1β, SDF-1β) is a stromal derived CXC chemokine that signal through the CXCR4 receptor. SDF-1β has chemotactic activity on B and T cells. SDF-1 beta/CXCL12 Protein, Rat is produced in E. coli.

HY-P72782

	SDF-1 beta/CXCL12 Protein, Mouse 2 Publications Verification C-X-C motif chemokine 12; stromal cell-derived factor 1; CXCL12; SDF-1β	Mouse	E. coli
	SDF-1 beta (Stromal-derived factor-1β, SDF-1β) is a stromal derived CXC chemokine that signal through the CXCR4 receptor. SDF-1β has chemotactic activity on B and T cells. SDF-1 beta/CXCL12 Protein, Mouse is produced in E. coli, and consists of 72 amino acids (K22-M93).

HY-P703366

	KIF18A Protein, Human Kinesin-like protein KIF18A; Marrow stromal KIF18A; MS-KIF18A; KIF18A; Homo sapiens; Human; MS-KIF18A; Motor protein	Human	E. coli
	KIF18A Protein, Human is the recombinant human-derived KIF18A, expressed by E. coli , with tag Free labeled tag. ,

HY-P7792

	CD157 Protein, Human (HEK293, Fc) ADP-ribosyl cyclase; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST1; Cyclic ADP-ribose hydrolase 2; CD157	Human	HEK293
	CD157 Protein, Human (HEK293, Fc) is a recombinant human CD157 expressed in HEK 293 cells with a C-Fc tag at the C-terminus. CD157 Protein is a cell surface receptor and an immunoregulatory molecule.

HY-P7791

	CD157 Protein, Human (HEK293, His) rHuCD157, His; ADP-ribosyl cyclase; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST1; Cyclic ADP-ribose hydrolase 2; CD157	Human	HEK293
	CD157 Protein, Human (HEK293, His) is a recombinant human CD157 expressed in HEK 293 cells with a His tag at the N-terminus. CD157 Protein is a cell surface receptor and an immunoregulatory molecule.

HY-P7793

	CD157 Protein, Mouse (HEK293, His) rMuCD157, His; ADP-ribosyl cyclase; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST1; Cyclic ADP-ribose hydrolase 2; CD157	Mouse	HEK293
	CD157 Protein, Mouse (HEK293, His) is a recombinant mouse CD157 expressed in HEK 293 cells with a His tag at the N-terminus. CD157 Protein is a cell surface receptor and an immunoregulatory molecule.

HY-P70469

	SDF-1 alpha/CXCL12 Protein, Human 1 Publications Verification stromal Cell-Derived Factor 1; SDF-1; hSDF-1; C-X-C Motif Chemokine 12; Intercrine Reduced in Hepatomas; IRH; hIRH; Pre-B Cell Growth-Stimulating Factor; PBSF; CXCL12; SDF1; SDF1A; SDF1B	Human	E. coli
	SDF-1 alpha (CXCL12α) belongs to the CXC chemokine family and is encoded by the CXCL12 gene. SDF-1 alpha mediates cell chemotaxis and tissue repair through CXCR4/CXCR7, activates AMPK to inhibit NLRP3 inflammasome and pyroptosis; SDF-1 alpha promotes autophagy through the PI3K-mTOR pathway, is induced by upstream inflammatory factors such as TNF-α, and recruits integrins downstream to promote cell adhesion. SDF-1 alpha/CXCL12 Protein, Human is the recombinant human-derived SDF-1 alpha/CXCL12 protein, expressed by E. coli, with tag free.

HY-P700219AF

	Animal-Free SDF-1 alpha/CXCL12 Protein, Mouse (His) 1 Publications Verification CXCL12; stromal cell-derived factor 1; SDF-1; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; TPAR1; C-X-C motif chemokine 12; Pre-B cell growth-stimulating factor; PBSF; Thymic lymphoma cell-stimulating factor; TLSF; Sdf1	Mouse	E. coli
	The SDF-1 α/CXCL12 protein acts as a chemoattractant with specific activity on T lymphocytes and monocytes (excluding neutrophils).It activates the CXC chemokine receptor CXCR4, inducing a rapid and transient rise in intracellular calcium ions and promoting chemotaxis.Animal-Free SDF-1 alpha/CXCL12 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeSDF-1 alpha/CXCL12 protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

HY-P702258

	CXCR4-VLP Protein, Human (HEK293, His) CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184	Human	HEK293
	CXCR4-VLP Protein, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P72160

	CXCR4 Protein, Human (GST) C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain receptor; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y receptor Y3; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; Probable G protein coupled receptor lcr1 homolog; SDF 1 receptor; SDF-1 receptor; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR; stromal cell derived factor 1 receptor; stromal cell-derived factor 1 receptor; WHIM; WHIMS	Human	E. coli
	The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (GST) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-GST labeled tag.

HY-P700616

	ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc) anoctamin 1, calcium activated chloride channel; oral cancer overexpressed 2, ORAOV2, TMEM16A, transmembrane protein 16A; anoctamin-1; DOG1; FLJ10261; TAOS2; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains); ORAOV2; TMEM16A	Human	E. coli
	ANO1/Anoctamin-1 protein, a calcium-activated chloride channel (CaCC), is involved in ion transport, smooth muscle contraction, and mucus secretion. ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc) is the recombinant human-derived ANO1/Anoctamin-1 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0652S1

Etonogestrel-d6
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-B0966S

Dioxybenzone-d3

Dioxybenzone-d₃ is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study .

HY-B0523S

Anagrelide-13C2,15N,d2

Anagrelide- ¹³C₂, ¹⁵N,d₂ is ¹⁵N and deuterated labeled Anagrelide (HY-B0523). Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC₅₀=36 nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action .

HY-152021S

C18 Ceramide-1-phosphate (d18:1/18:0)-d3

C18 Ceramide-1-phosphate (d18:1/18:0)-d₃ is the deuterium labeled C18 Ceramide-1-phosphate (d18:1/18:0) (HY-160850). C18 Ceramide-1-phosphate (d18:1/18:0) is a specific type of long-chain molecule found in murine skin. C18 Ceramide-1-phosphate (d18:1/18:0) promotes migration of both mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells at concentrations between 0.5-5 μM. C18 Ceramide-1-phosphate (d18:1/18:0)’s levels are higher in CFPAC-1 pancreatic ductal adenocarcinoma cells than in pancreatic cancer stem cells .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83612

	BST2 Antibody (YA3357) Bone marrow stromal antigen 2; BST2; CD317; HM1.24 antigen; NPC A 7; Tetherin	WB, IHC-P, FC	Human
	BST2 Antibody (YA3357) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3357), targeting BST2, with a predicted molecular weight of 20 kDa (observed band size: 28-40 kDa). BST2 Antibody (YA3357) can be used for WB, IHC-P, FC experiment in human background.

HY-P81089

	CXCR4 Antibody C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; stromal cell-derived factor 1 receptor; SDF-1 receptor; Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; CD184 antigen; CXCR4_HUMAN.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
	CXCR4 Antibody is an unconjugated, approximately 40 kDa, rabbit-derived, anti-CXCR4 polyclonal antibody. CXCR4 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: cow, rabbit background without labeling.

HY-P83443

	SDF1 Antibody (YA3188) CXCL12; SDF1; SDF1A; SDF1B; stromal cell-derived factor 1; SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF	WB, ICC/IF	Human
	SDF1 Antibody (YA3188) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3188), targeting SDF1, with a predicted molecular weight of 11 kDa (observed band size: 11 kDa). SDF1 Antibody (YA3188) can be used for WB, ICC/IF experiment in human background.

HY-P86530

	Stromal Interaction Molecule 1 Antibody (YA6222) stromal interaction molecule 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Stromal Interaction Molecule 1 Antibody (YA6222) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Stromal Interaction Molecule 1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P82347

	Stromal Interaction Molecule 1 Antibody (YA2092) GOK; TAM; TAM1; IMD10; STRMK; D11S4896E	WB	Human, Mouse, Rat
	Stromal Interaction Molecule 1 Antibody (YA2092) is a non-conjugated IgG antibody, targeting Stromal Interaction Molecule 1, with a predicted molecular weight of 77 kDa (observed band size: 77 kDa). Stromal Interaction Molecule 1 Antibody (YA2092) can be used for WB experiment in human, mouse, rat background.

HY-P81402

	SA2 Antibody (YA1147) SA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; stag2; stromal antigen 2	IHC-P	Human
	SA2 Antibody (YA1147) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1147), targeting SA2. SA2 Antibody (YA1147) can be used for IHC-P experiment in human background.

HY-P84972

	CD184 Antibody (YA4664) CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E; C-X-C chemokine receptor type 4 antibody; CD184 antibody; CD184 antigen antibody; Chemokine; C X C motif; receptor 4 antibody; Chemokine CXC Motif Receptor 4 antibody; CXC-R4 antibody; CXCR-4 antibody; CXCR4 antibody; CXCR4_HUMAN antibody; D2S201E antibody; FB22 antibody; Fusin antibody; HM89 antibody; HSY3RR antibody; LAP 3 antibody; LAP3 antibody; LCR1 antibody; LESTR antibody; Leukocyte derived seven transmembrane domain receptor antibody; Leukocyte-derived seven transmembrane domain receptor antibody; Lipopolysaccharide associated protein 3 antibody; Neuropeptide Y receptor Y3 antibody; NPY3R antibody; NPYR antibody; NPYRL antibody; NPYY3 antibody; NPYY3R antibody; Probable G protein coupled receptor lcr1 homolog antibody; SDF 1 receptor antibody; SDF-1 receptor antibody; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody; stromal cell derived factor 1 receptor antibody; stromal cell-derived factor 1 receptor antibody; WHIM antibody; WHIMS antibody
	CD184 Antibody (YA4664) is a non-conjugated antibody, targeting to CD184.