2. Apoptosis
  3. Apoptosis
  4. Tigogenin

Tigogenin is a steroidal sapogenins. Tigogenin can inhibit adipocytic differentiation and induce osteoblastic differentiation in mouse bone marrow stromal cells. Tigogenin can inhibit cells proliferation and induce apoptosis. Tigogenin can be used for the researches of cancer, inflammation, immunology, metabolic and cardiovascular disease, such as mammary gland carcinoma, rheumatoid arthritis, osteoporosis and atherosclerosis.

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Tigogenin

Tigogenin Chemical Structure

CAS No. : 77-60-1

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Based on 1 publication(s) in Google Scholar

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Tigogenin Related Antibodies

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Description

Tigogenin is a steroidal sapogenins. Tigogenin can inhibit adipocytic differentiation and induce osteoblastic differentiation in mouse bone marrow stromal cells. Tigogenin can inhibit cells proliferation and induce apoptosis. Tigogenin can be used for the researches of cancer, inflammation, immunology, metabolic and cardiovascular disease, such as mammary gland carcinoma, rheumatoid arthritis, osteoporosis and atherosclerosis[1][2][3][4].

In Vitro

Tigogenin (10-90 μM, 3 days) promotes bone marrow stromal cells (BMSCs) proliferation in a dose-dependent manner[1].
Tigogenin (10-90 μM, 18 days) decreases lipid accumulation and visfatin secretions in BMSCs[1].
Tigogenin (10-90 μM, 5-18 days) reduces PPAR mRNA and ap2 levels in BMSCs[1].
Tigogenin (10-90 μM, 5 days) increases levels of mRNA for Cbfa1, COL I, OCN and ALP activity in BMSCs[1].
Tigogenin (30 μM, 5-40 mins) activates the phosphorylation of p38 kinase in BMSCs[1].
Tigogenin (40 μM, 24-96 h) inhibits proliferation in rheumatoid arthritis (RA) synoviocytes[2].
Tigogenin (40 μM, 6-24 h) induces apoptosis in RA synoviocytes[2].
Tigogenin (40 μM, 1-24 h) increases P38, COX-2 and PEG2 levels in RA synoviocytes[2].
Tigogenin (20 μM, 24 h) reduces FXR, SHP, and BSEP levels companied with CDCA (HY-76847) in HepG2 cells[3].
Tigogenin (L–serine derivative of Tigogenin) (48 h) inhibits MCF-7 and MDA-MB-231 cells proliferation with IC50 values of 1.5 and 10.5 μM[4].
Tigogenin (L–serine derivative of Tigogenin) (2.8-7 μM, 18 h) induces apoptosis and increases caspase 3/7 activity in MCF-7 cells[4].
Tigogenin (L–serine derivative of Tigogenin) (5 μM, 6 h) reduces TNF-α, IL-1, IL-12, IL-10 and IL-4 levels in THP–1 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tigogenin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: BMSCs
Concentration: 10, 30 and 90 μM
Incubation Time: 3 days
Result: Promoted proliferation in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: BMSCs
Concentration: 10, 30 and 90 μM
Incubation Time: 5 or 18 days
Result: Reduced PPAR mRNA and ap2 levels.

Apoptosis Analysis[2]

Cell Line: RA synoviocytes
Concentration: 40 μM
Incubation Time: 6 and 24 h
Result: Induced cell shrinkage, cytoplasm condensation and formation of cytoplasmic filaments.
Increased caspase-3, caspase-8 and caspase-9 activities.
Showed DNA fragmentation.
Molecular Weight

416.64

Formula

C27H44O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 14.29 mg/mL (34.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4002 mL 12.0008 mL 24.0015 mL
5 mM 0.4800 mL 2.4002 mL 4.8003 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.4002 mL 12.0008 mL 24.0015 mL 60.0038 mL
5 mM 0.4800 mL 2.4002 mL 4.8003 mL 12.0008 mL
10 mM 0.2400 mL 1.2001 mL 2.4002 mL 6.0004 mL
15 mM 0.1600 mL 0.8001 mL 1.6001 mL 4.0003 mL
20 mM 0.1200 mL 0.6000 mL 1.2001 mL 3.0002 mL
25 mM 0.0960 mL 0.4800 mL 0.9601 mL 2.4002 mL
30 mM 0.0800 mL 0.4000 mL 0.8001 mL 2.0001 mL
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Tigogenin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tigogenin77-60-1ApoptosisSteroidal sapogeninsMammary gland carcinomaRheumatoid arthritisOsteoporosisAtherosclerosisInhibitorinhibitorinhibit

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