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Results for "

chelating

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Akt (2) Amino Acid Derivatives (3) Amyloid-β (8) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (5) Apoptosis (13) Autophagy (2) Bacterial (18) Biochemical Assay Reagents (93) Btk (1) Carbonic Anhydrase (1) Cholinesterase (ChE) (12) COX (2) Cuproptosis (2) DNA-PK (1) DNA/RNA Synthesis (1) Dopamine β-hydroxylase (3) Drug Derivative (2) Drug Intermediate (4) Drug Metabolite (3) EGFR (1) Endogenous Metabolite (22) FAP (3) Ferroptosis (10) Fluorescent Dye (13) Fungal (8) G-quadruplex (1) GSK-3 (1) HCV (3) HDAC (1) Histamine Receptor (1) HIV (2) HIV Integrase (1) iGluR (1) Isotope-Labeled Compounds (7) Lipoxygenase (1) MCHR1 (GPR24) (2) Mitochondrial Metabolism (5) MMP (6) Monoamine Oxidase (4) mTOR (2) NF-κB (2) NOD-like Receptor (NLR) (2) Oxidative Phosphorylation (1) Parasite (2) PI3K (2) PSMA (2) Radionuclide-Drug Conjugates (RDCs) (12) Reactive Oxygen Species (ROS) (9) Reference Standards (27) Reverse Transcriptase (2) ROS Kinase (1) SARS-CoV (2) SOD (9) Tau Protein (1) TGF-beta/Smad (2) Wnt (2) Xanthine Oxidase (3)
By Research Areas:	Cancer (72) Cardiovascular Disease (20) Endocrinology (6) Infection (26) Inflammation/Immunology (24) Metabolic Disease (16) Neurological Disease (45)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Antioxidants (1) Cosolvents (1) Chelating Agents (1) pH Modifiers (1)

234

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

D-Gluconic acid potassium	Endogenous Metabolite Fungal	Infection Cancer
D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties .

Benzo-15-crown-5-ether B15C5	Biochemical Assay Reagents	Others
Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .

p-SCN-Bn-DOTA 1 Publications Verification	Radionuclide-Drug Conjugates (RDCs)	Cancer
p-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunoresearch of tumor .

1-(2-Pyridylazo)-2-naphthol 1-Pyridylazo-2-naphthol	Biochemical Assay Reagents	Others
1-(2-Pyridylazo)-2-naphthol (1-Pyridylazo-2-naphthol) is an azo compound. 1-(2-Pyridylazo)-2-naphthol can be used as a chelating precipitant, flocculant, auxiliary complexing agent, and as a ligand for anchoring on other supports with the purpose of introducing chelating property .

BAPTA-TMFM	Fluorescent Dye	Cancer
BAPTA-TMFM is a fluorescent chelating indicator used to study the role of cytosolic free calcium.

PSMA-BCH NOTA-PSMA	Radionuclide-Drug Conjugates (RDCs)	Cancer
PSMA-BCH (NOTA-PSMA) is a NOTA-conjugated precursor. NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools .

Sodium tripolyphosphate (STPP), 98% Sodium triphosphate pentabasic, 98%	Biochemical Assay Reagents	Others
Sodium tripolyphosphate (STPP), 98% is a biochemical reagent that can be used as pH adjustment, chelating agent, and detergent additive .

D-Gluconic acid potassium (Standard)	Reference Standards Endogenous Metabolite Fungal	Infection Cancer
D-Gluconic acid (potassium) (Standard) is the analytical standard of D-Gluconic acid (potassium). This product is intended for research and analytical applications. D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties .

p-SCN-Bn-HOPO	Biochemical Assay Reagents	Others
p-SCN-Bn-HOPO is a bifunctional chelating agent. p-SCN-Bn-HOPO is used to bind to the radioactive isotope zirconium-89 (^89Zr) for use in ImmunoPET .

DOPE-DOTA sodium 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N- tetraazacyclododecane-N-tetraacetic acid, sodium salt	Biochemical Assay Reagents	Inflammation/Immunology Cancer
DOPE-DOTA sodium is a chelated lipid that serves as a key contrast agent in magnetic resonance imaging (MRI). DOPE-DOTA sodium can be used for cancer, blood-brain barrier disruption, abnormalities such as aneurysms or plaque buildup, inflammation in arthritis, and liver function and lesions study

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

p-SCN-Bn-DOTA (Standard)	Others	Cancer
p-SCN-Bn-DOTA (Standard) is the analytical standard of p-SCN-Bn-DOTA. This product is intended for research and analytical applications. p-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunoresearch of tumor .

Sodium tripolyphosphate (STPP), 85% Sodium triphosphate pentabasic, 85%	Biochemical Assay Reagents	Others
Sodium tripolyphosphate (STPP), 85% (Sodium triphosphate pentabasic, 85%) is a biochemical reagent that can be used as pH adjustment, chelating agent, and detergent additive .

Licam-C	Biochemical Assay Reagents	Others
Licam-C is a promising radiological decontaminant agent. Acting as a chelating agent, LICAM-C forms stable complexes with radioactive elements such as Plutonium (Pu) and Americium (Am). Licam-C is employed in research addressing the remediation of radioactive nucleotide contamination .

(R)-DOTAGA2	Biochemical Assay Reagents	Others
(R)-DOTAGA2 (Compound 7) is a metal chelate ligand. (R)-DOTAGA2 can be used to evaluate blood volume changes in the heart and brain .

8-Quinolinesulfonic acid	Drug Intermediate	Others
8-Quinolinesulfonic acid is an organic compound that can be used as chelating agents. 8-Quinolinesulfonic acid is also employed in the synthesis of pharmaceuticals and agrochemicals .

Antitumor agent-31	Fluorescent Dye	Cancer
Antitumor agent-31 is a nanosized chelates of anchoring bisazo dye. Antitumor agent-31 can be used for an antioxidant and antitumor agent .

8-Hydroxyquinoline hemisulfate (Standard) 8-Quinolinol hemisulfate (Standard)	Reference Standards Bacterial Antibiotic	Infection
8-Hydroxyquinoline (hemisulfate) (Standard) is the analytical standard of 8-Hydroxyquinoline (hemisulfate). This product is intended for research and analytical applications. 8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

Magnesium glycinate 1 Publications Verification Magnesium bisglycinate; Magnesium diglycinate	Biochemical Assay Reagents	Cancer
Magnesium glycinate (Magnesium bisglycinate), the magnesium salt of glycine, is a nutrient supplement. Magnesium glycinate has satisfactory physico-chemical properties and bioactivities. Metal glycinate chelates are formed by glycine and metal compounds through chemical reactions. Magnesium is an essential mineral that plays a critical role in the human body. Magnesium takes part in the process of energy metabolism and assists the maintenance of normal muscle function .

Nitrilotriacetic acid 1 Publications Verification Triglycollamic acid	Biochemical Assay Reagents	Others
Nitrilotriacetic acid is an orally active *chelating* agent for metal ions. Nitrilotriacetic acid is an aminotricarboxylic acid that can sequester metal ions as water soluble complexes. Nitrilotriacetic acid reacts with strong oxidizing agents such as hypochlorite, chlorine, ozone, or oxygen in the presence of palladium/carbon catalyst. Nitrilotriacetic acid interacts with solid phases such as cell membranes and bone matrices in the mammalian system. Nitrilotriacetic acid is classified as an epigenetic rodent carcinogen .

MAO-B-IN-22	Monoamine Oxidase	Neurological Disease
MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC₅₀ of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect .

Alizarin complexone	Reverse Transcriptase	Infection
Alizarin complexone is a calcium-tracer and a chelating agent. Alizarin complexone is Rous-associated virus 2 reverse transcriptase (RAV-2 RT) inhibitor .

Lactobionic acid	Bacterial	Infection
Lactobionic acid is a bionic acid naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties .

DL-Penicillamine (±)-Penicillamine	Biochemical Assay Reagents	Others
DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response .

2,2'-Bipyridine 1 Publications Verification	Biochemical Assay Reagents	Infection Endocrinology
2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .

DL-Penicillamine (Standard) (±)-Penicillamine (Standard)	Biochemical Assay Reagents Reference Standards	Others
DL-Penicillamine (Standard) is the analytical standard of DL-Penicillamine. This product is intended for research and analytical applications. DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response .

Alizarin complexone (Standard)	Reverse Transcriptase	Infection
Alizarin complexone (Standard) is the analytical standard of Alizarin complexone. This product is intended for research and analytical applications. Alizarin complexone is a calcium-tracer and a chelating agent. Alizarin complexone is Rous-associated virus 2 reverse transcriptase (RAV-2 RT) inhibitor .

NH2-UAMC1110 TFA	FAP Drug Intermediate Drug Derivative	Cancer
NH2-UAMC1110 TFA is a UAMC1110 (HY-100684) derivative that can be used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activation protein (FAP) inhibitor. FAPI-QS is a chelating agent that can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors .

2,2'-Bipyridine (Standard)	Biochemical Assay Reagents Reference Standards	Infection Endocrinology
2,2'-Bipyridine (Standard) is the analytical standard of 2,2'-Bipyridine. This product is intended for research and analytical applications. 2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .

Dexrazoxane 10+ Cited Publications ICRF-187; ADR-529; NSC-169780	Ferroptosis Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .

NOTA	Radionuclide-Drug Conjugates (RDCs)	Cardiovascular Disease Cancer
NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research .

NLRP3-IN-33	Reactive Oxygen Species (ROS) Cholinesterase (ChE)	Cancer
NLRP3-IN-33 (Compound 12o) is a blood-brain barrier permeable inhibitor of AChE and BChE, with IC₅₀ values of 1.02 μM and 7.03 μM against hAChE and hBChE respectively. NLRP3-IN-33 possesses antioxidant, anti-inflammatory, and metal chelating activities, making it a potential candidate for research in Alzheimer's disease (AD) .

Rilopirox HOE 351	Fungal	Infection
Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research .

NOTA (Standard)	Radionuclide-Drug Conjugates (RDCs)	Cardiovascular Disease Cancer
NOTA (Standard) is the analytical standard of NOTA. This product is intended for research and analytical applications. NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research .

hAChE-IN-10	Cholinesterase (ChE) Amyloid-β	Neurological Disease
hAChE-IN-10 (Compound ET11) is the inhibitor for human acetylcholinesterase (AChE) with an IC₅₀ of 6.34 nM. hAChE-IN-10 scavenges free radicals, and exhibits antioxidant activity. hAChE-IN-10 exhibits metal chelating activity, inhibits Cu ²⁺-induced Aβ1-42 aggregation, reduces the formation of amyloid plaques, and exhibits neuroprotective activity. hAChE-IN-10 ameliorates the Scopolamine (HY-N0296)-induced cognitive impairment in mouse models .

PF-00356231 hydrochloride 1 Publications Verification	MMP	Inflammation/Immunology
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively .

Succinic acid 5+ Cited Publications Wormwood acid	Endogenous Metabolite	Neurological Disease
Succinic acid is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid is an important platform chemical. Succinic acid can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

*Deferasirox (Fe3+ chelate)*	Ferroptosis Bacterial	Others
Deferasirox Fe3+ Chelate is an iron chelating agent extracted from patent WO2003053986 .

Disodium succinate 5+ Cited Publications	Endogenous Metabolite	Inflammation/Immunology
Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

5',5-Difluoro BAPTA tetrapotassium	Biochemical Assay Reagents	Others
5,5'-Difluoro BAPTA tetrapotassium is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA tetrapotassium shows large ¹⁹F NMR chemical shifts upon chelating divalent cations. 5,5'-Difluoro BAPTA tetrapotassium has high selectivity for Ca ²⁺. 5,5'-Difluoro BAPTA tetrapotassium can inhibit the growth of pollen tube .

Magnesium D-gluconate hydrate, 98%	Biochemical Assay Reagents	Others
Magnesium D-gluconate hydrate, 98% is a strong chelating agent that chelates calcium, iron, aluminum, copper, and other heavy metal anions.

Neuroinflammatory-IN-2	Monoamine Oxidase Amyloid-β	Neurological Disease Inflammation/Immunology
Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC₅₀ value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ_1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H₂O₂-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease .

Succinic acid (Standard) 3 Publications Verification Wormwood acid (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease
Succinic acid (Standard) is the analytical standard of Succinic acid. This product is intended for research and analytical applications. Succinic acid is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid is an important platform chemical. Succinic acid can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

Disodium succinate (Standard)	Reference Standards Endogenous Metabolite	Inflammation/Immunology
Disodium succinate (Standard) is the analytical standard of Disodium succinate. This product is intended for research and analytical applications. Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

Sodium glycolate, 98% Sodium hydroxyacetate, 98%	Biochemical Assay Reagents	Others
Sodium glycolate, 98% is a metal chelating agent.

Ethylenediaminetetraacetic acid 10+ Cited Publications EDTA	Biochemical Assay Reagents Bacterial SOD	Cardiovascular Disease Neurological Disease Cancer
Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .

Cat. No.	Product Name	Type

HY-W351339

BAPTA-TMFM	Fluorescent Dyes/Probes
BAPTA-TMFM is a fluorescent chelating indicator used to study the role of cytosolic free calcium.

HY-D1895A

3,5-DiBr-PAESA sodium	Fluorescent Dyes/Probes
3,5-DiBr-PAESA (sodium) is an ultrasensitive chelating agent used for the determination of silver (I) in water in the absence of interfering ions. It can also be used for the determination of copper (II) .

HY-D0156

ZnAF-1	Fluorescent Dyes/Probes
ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection . ZnAF-1 can bind Zn(II) with a 1 : 1 stoichiometry .

HY-D2730

N14G-Fe	Fluorescent Dyes/Probes
N14G-Fe, the Fe ³⁺-chelated form of N14G, identifies Mtb in sputum samples with tuberculosis, exhibiting exceptional fluorescence. N14G-Fe can effectively traverse the cell wall and inner membrane region where IrtAB is located .

HY-D1895

3,5-DiBr-PAESA	Fluorescent Dyes/Probes
3,5-DiBr-PAESA is a supersensitive chelating agent that can be used for silver (I) determination in water in the case of absence of other interfering ions. 3,5-DiBr-PAESA can also be used for copper (II) determination .

HY-D0038

BTBCT	Dyes
BTBCT is mainly used as a label in time-resolved fluorescence immunoassays (TRFIA). The lower limit of detection for TSH TR-IFMA is 0.011 mIU/L in a 10 μl sample volume. The high fluorescence intensity and stability of BTBCT improves the sensitivity of the assay .

HY-W591393

Biotin Azide Plus	Fluorescent Dyes/Probes
Biotin Azide Plus is a biotinylation reagent used for labeing glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Biotin Azide Plus is a complete copper-chelating system that acts simultaneously as both reactant and catalyst in CuAAC reactions. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W800769

BP Fluor 532 azide plus	Fluorescent Dyes/Probes
BP Fluor 532 Azide Plus is a fluroescent agent with a terminal azide group. The fluroescent compound has a max absorption at 532 nm and emission at 554 nm. The BP Fluor 532 Azide Plus was designed with a copper-chelating system within its structure, enabling the formation of strong, active copper complexes that act as both reactant and catalyst in CuAAC reactions.

HY-136894

Rhod-5N	Fluorescent Dyes/Probes
Rhod-5N is a calcium-binding fluorescent dye composed of a BAPTA chelating group and a rhodamine fluorophore. Rhod-5N is often added to MOPS buffer to complex and indicate cation content. The selectivity of Rhod-5N for Cd ²⁺ is higher than other interfering cations ((Na+, K+, Mg ²⁺, Ca ²⁺, Zn ²⁺) except Pb ²⁺), and the detection limit is 3.1 μg/L .

HY-D1536

Glycine cresol red	Fluorescent Dyes/Probes
Glycine cresol red is a complexometric indicator. Glycine cresol red forms coloured complexes with Al ³⁺, Ga ³⁺ and In ³⁺ ions in aqueous solutions. Glycine cresol red can been used for the spectrophotometric determination of inorganic ions. Glycine cresol red can be used as a stain in neurohistology .

HY-W800697

BP Fluor 430 picolyl azide

Fluorescent Dyes/Probes

BP Fluor 430 Picolyl Azide is an advanced fluorescent probe that incorporatess a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. The rate of the CuAAC reaction depends on the concentrations of all reagents, including copper, therefore raising the effective copper concentration at the reaction site will dramatically increase the rate of CuAAC reaction without the need to increase concentration of azide reagent or copper. In addition, the use of BP Fluor 430 Picolyl Azide instead of conventional BP Fluor 430 Azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling. In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. This is of special value for the detection of low abundance targets or where significant increase in signal intensity is desired.

HY-W800693

BP Fluor 405 picolyl azide

Fluorescent Dyes/Probes

BP Fluor 405 Picolyl Azide is an advanced fluorescent probe that incorporatess a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. The rate of the CuAAC reaction depends on the concentrations of all reagents, including copper, therefore raising the effective copper concentration at the reaction site dramatically increases the rate of CuAAC reaction without increasing the concentrations of azide reagent or copper. In addition, the use of picolyl azide instead of conventional azides allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling. In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. This is of special value for the detection of low abundance targets or where significant increase in signal intensity is desired.

Cat. No.	Product Name	Type

HY-W008585

Benzo-15-crown-5-ether B15C5	Chelators
Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .

HY-D0223

1-(2-Pyridylazo)-2-naphthol 1-Pyridylazo-2-naphthol	Biochemical Assay Reagents
1-(2-Pyridylazo)-2-naphthol (1-Pyridylazo-2-naphthol) is an azo compound. 1-(2-Pyridylazo)-2-naphthol can be used as a chelating precipitant, flocculant, auxiliary complexing agent, and as a ligand for anchoring on other supports with the purpose of introducing chelating property .

HY-W019885A

Sodium tripolyphosphate (STPP), 98% Sodium triphosphate pentabasic, 98%	Buffer Reagents
Sodium tripolyphosphate (STPP), 98% is a biochemical reagent that can be used as pH adjustment, chelating agent, and detergent additive .

HY-W019885

Sodium tripolyphosphate (STPP), 85% Sodium triphosphate pentabasic, 85%	Buffer Reagents
Sodium tripolyphosphate (STPP), 85% (Sodium triphosphate pentabasic, 85%) is a biochemical reagent that can be used as pH adjustment, chelating agent, and detergent additive .

HY-W088011B

Sodium glycolate, 98% Sodium hydroxyacetate, 98%	Chelators
Sodium glycolate, 98% is a metal chelating agent.

HY-Y0682

Ethylenediaminetetraacetic acid

Maximum Cited Publications

14 Publications Verification

EDTA

Chelators

Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .

HY-W105700

Ethylenediaminetetraacetic acid sodium hydrate

10+ Cited Publications

EDTA sodium hydrate

Chelators

Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research .

HY-W018746

EDTA disodium

10+ Cited Publications

Ethylenediaminetetraacetic acid disodium

Chelators

EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.

HY-173383

DOPE-DOTA sodium 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N- tetraazacyclododecane-N-tetraacetic acid, sodium salt	Drug Delivery
DOPE-DOTA sodium is a chelated lipid that serves as a key contrast agent in magnetic resonance imaging (MRI). DOPE-DOTA sodium can be used for cancer, blood-brain barrier disruption, abnormalities such as aneurysms or plaque buildup, inflammation in arthritis, and liver function and lesions study

HY-Y0569H

Magnesium D-gluconate hydrate, 98%	Chelators
Magnesium D-gluconate hydrate, 98% is a strong chelating agent that chelates calcium, iron, aluminum, copper, and other heavy metal anions.

HY-W127819

Phenyleneethylenetriamine pentaacetic acid	Biochemical Assay Reagents
Phenyleneethylenetriamine Pentaacetic Acid is a precursor of a dual functional chelating agent .

HY-Y0682R

Ethylenediaminetetraacetic acid (Standard)

EDTA (Standard)

Chelators

Ethylenediaminetetraacetic acid (Standard) is the analytical standard of Ethylenediaminetetraacetic acid. This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research [4] .

HY-Y0682A

Ethylenediaminetetraacetic acid disodium dihydrate

10+ Cited Publications

EDTA disodium dihydrate

Chelators

Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .

HY-W018746R

EDTA disodium (Standard)

Ethylenediaminetetraacetic acid disodium (Standard)

Chelators

EDTA (disodium) (Standard) is the analytical standard of EDTA (disodium). This product is intended for research and analytical applications. EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.

HY-B0658A

Zinc (acetate dihydrate), ACS, 98% Zinc(II) acetate dihydrate, ACS, 98%	Chelators
Zinc (acetate dihydrate), ACS, 98% is a metal chelating agent, also used in protein experiments.

HY-W013851

EDTA-OH	Chelators
EDTA-OH is a chelating agent, which forms thermodynamically stable chelates with metal ions like calcium, magnesium, iron, zinc and copper . EDTA-OH exhibits ability of phytoremediation in heavy-metal-contaminated soils . EDTA-OH is able to cross brain-blood barrier .

HY-Y0682AR

Ethylenediaminetetraacetic acid disodium dihydrate (Standard)

EDTA disodium dihydrate (Standard)

Chelators

Ethylenediaminetetraacetic acid (disodium dihydrate) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (disodium dihydrate). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research [4] .

HY-Y0998

Potassium hexacyanoferrate(III), 99.5% Red prussiate, 99.5%	Cell Assay Reagents
Potassium hexacyanoferrate(III), 99.5% (Red prussiate, 99.5%) is a chelating agent for metals such as iron and copper.

HY-W102590

DOTMP	Chelators
DOTMP is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .

HY-W691498

Sodiumα-glucoheptonate，97%	Chelators
Sodiumα-glucoheptonate, 97% is a multifunctional chelating agent capable of forming stable complexes with various metal ions.

HY-W111522

Sodium phosphite dibasic pentahydrate, 98% di-Sodium hydrogen phosphite, 98%	Chelators
Sodium phosphite dibasic pentahydrate, 98% is a metal chelating agent used to remove copper ions from water supplies.

HY-W423191

Maltobionic acid 4-O-α-D-Glucopyranosyl-D-gluconic acid	Carbohydrates
Maltobionic acid is a naturally-derived polyhydroxy bionic acid. Maltobionic acid shows iron chelating ability, antibacterial potential and cytoprotection .

HY-W031536

2-Imidazolidone, 96% 2-Oxoimidazolidine, 96%	Chelators
2-Imidazolidone, 96% is a chelating agent that forms complexes with metal ions, enabling its use in catalytic processes.

HY-Y1175A

Calcium acetate monohydrate，ACS, 99%	Buffer Reagents
Calcium acetate monohydrate, ACS, 99% is a monohydrate form of calcium acetate used to precipitate oxalates in solution; it also serves as a stabilizer, buffer, and chelating agent.

HY-W749867

Ca(II)-EDTA disodium dihydrate Calcium disodium EDTA dihydrate	Chelators
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .

HY-W004649

Tris-BOC-cyclen	Chelators
Tris-BOC-cyclen is a bifunctional chelator. Bifunctional chelating agentscan be used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .

HY-W108801

α-D-Glucoheptonic acid sodium	Chelators
α-D-Glucoheptonic acid sodium is a compound that modulates the immune system, has chelating activity, and can be used in the preparation of cleaning agents.

HY-W402032

Bis-Cbz-cyclen	Chelators
Bis-Cbz-cyclen is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .

HY-W013178

DCTA monohydrate

Indicators

DCTA monohydrate is an organic acid. DCTA refers to N,N,N',N' -tetraacetic acid, which has a strong chelating ability. DCTA monohydrate can be used as a chelating agent and coordination reagent for metal ions. DCTA monohydrate, for example, forms stable complexes with many metal ions, including calcium, magnesium and zinc. DCTA modified with ethylene glycol is selective to calcium ions in the presence of magnesium ions .

HY-W127801

Ethylenediaminetetraacetic acid trisodium hydrate

EDTA trisodium hydrate

Biochemical Assay Reagents

Ethylenediaminetetraacetic acid (trisodium hydrate) is a class of organic compounds containing carboxylic acid functional groups. It is commonly used as a chelating agent in various industrial and medical applications, especially in the food and pharmaceutical industries. Ethylenediaminetetraacetic acid (trisodium hydrate) has strong metal ion binding properties and can be used to chelate trace metals that may affect product quality or stability. In addition, it is used as an anticoagulant in blood collection tubes and as a stabilizer in some cosmetic and personal care products.

HY-W673626

Etidronic acid,60% in water monohydrate Etidronate monohydrate; HEDPA monohydrate; HEDP monohydrate	Cell Assay Reagents
Etidronic acid,60% in water (Etidronate) monohydrate is a strong complexing agent that can be used as a chelating agent to remove heavy metals from water .

HY-Y0308E

Sodium phosphate dibasic, for cell culture Disodium hydrogen phosphate, for cell culture	Buffer Reagents
Sodium phosphate dibasic (Disodium hydrogen phosphate), for cell culture is a buffer and chelating agent. Sodium phosphate dibasic is used to adjust the pH of liquids. Sodium phosphate dibasic can be used in cell culture .

HY-W133934A

EDTA magnesium disodium,99%	Chelators
EDTA magnesium disodium, 99% is a chelating agent with the ability to effectively bind metal ions (including calcium, magnesium, and iron) and remove them from solution.

HY-W127789

Ethylenediaminetetraacetic acid diammonium

EDTA diammonium

Biochemical Assay Reagents

Ethylenediaminetetraacetic acid diammonium is a class of organic compounds containing both ammonium and carboxylic acid functional groups. It is commonly used as a chelating agent in various industrial and medical applications, especially in the food and pharmaceutical industries. Ethylenediaminetetraacetic acid diammonium has strong metal ion binding properties and can be used to chelate trace metals that may affect product quality or stability. In addition, it is used as an anticoagulant in blood collection tubes and as a clarifying agent in cosmetic and personal care products.

HY-W099337

N-Ethyl-D-glucamine	Carbohydrates
N-Ethyl-D-glucamine is a glucose derivative with biological activity as a buffer and chelating agent. Therefore, it is widely used in biochemical research to regulate pH and bind metal ions.

HY-W009722A

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0%

Ditiocarb sodium trihydrate, ACS, 99.0%

Chelators

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu ²⁺ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .

HY-D0973

EGTA-AM 5+ Cited Publications EGTA Acetoxymethyl ester	Chelators
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca ²⁺ chelator with slow chelating dynamics.

HY-W140537

EDTA diammonium salt hydrate, 97%	Chelators
EDTA diammonium salt hydrate, 97% is a derivative of ethylenediaminetetraacetic acid (EDTA), commonly used as a chelating agent in various applications due to its ability to bind with various metal ions and form stable complexes.

HY-N7059A

Lactobionic acid calcium dihydrate	Cell Assay Reagents
Lactobionic acid calcium dihydrate is a biomimetic acid found in Caspian yogurt, chemically composed of gluconic acid bonded to galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant and humectant properties .

HY-D0330

Mordant black 17 Sunchromine blue black R	Indicators
Mordant black 17 (Sunchromine blue black R) is a versatile chelating agent, demonstrating significant adsorptive properties through its interaction with metal ions, enhancing the efficiency of polymeric materials in various applications.

HY-W031536R

2-Imidazolidone, 96% (Standard) 2-Oxoimidazolidine, 96% (Standard)	Chelators
2-Imidazolidone, 96% (Standard) is the analytical standard of 2-Imidazolidone, 96%. This product is intended for research and analytical applications. 2-Imidazolidone, 96% is a chelating agent that forms complexes with metal ions, enabling its use in catalytic processes.

HY-W127847

Nitrilotriacetic acid trisodium salt 1 Publications Verification Triglycollamic acid trisodium salt	Biochemical Assay Reagents
Nitrilotriacetic acid (Triglycollamic acid) trisodium salt is a chelating agent commonly used in various industrial processes, especially in the production of detergents, cleaners and metal plating solutions. Nitrilotriacetic acid trisodium salt has unique chemical properties that bind to metal ions, preventing them from reacting or precipitating out of solution.

HY-107921

EDTA Calcium disodium,98% EDTA calcium disodium salt,98%; Adsorbonac,98%	Chelators
EDTA Calcium disodium, 98% (EDTA calcium disodium salt, 98%; Adsorbonac, 98%) is a chelating agent for calcium and other metal ions, preventing them from participating in chemical reactions. It can effectively remove metal ions from solutions, preventing them from interfering with experimental processes.

HY-Y1841

o-Phenanthroline monohydrate 3 Publications Verification 1,10-Phenanthroline monohydrate	Biochemical Assay Reagents
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor .

HY-173384

DSPE-DOTA sodium 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- tetraazacyclododecane-N-tetraacetic acid, sodium salt	Drug Delivery
DSPE-DOTA sodium (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- tetraazacyclododecane-N-tetraacetic acid, sodium salt) is a chelating lipid used as a key contrast agent in magnetic resonance imaging (MRI). DSPE-DOTA sodium can be used for imaging detection of tumors, neurological and inflammatory diseases .

HY-W004544

o-Phenanthroline 3 Publications Verification 1,10-Phenanthroline	Chelators
o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .

HY-Y1885

Tetrasodium pyrophosphate	Buffer Reagents
Tetrasodium pyrophosphate is a chelating that can bind calcium and help improve olfaction. Tetrasodium pyrophosphate is an antimicrobial agent that can reduce microbial colonization. Tetrasodium pyrophosphate is a biological material that is widely used in life science research. Tetrasodium pyrophosphate can be studied in research for alleviating symptoms post COVID-19 .

HY-W034576

Hexacyclen hexahydrochloride

Hexaaza-18-crown-6 hexahydrochloride; 1,4,7,10,13,16-Hexaazacyclooctadecane hexahydrochloride

Biochemical Assay Reagents

Hexacyclen (Cycloalkene) is an organic compound with a unique macrocyclic structure composed of six nitrogen-containing rings. Hexacyclen is commonly used as a chelating agent in chemistry and biochemistry due to its ability to bind metal ions, and is often used to selectively bind metal ions in proteins or enzymes to study their structure and function. Hexacyclen also acts as an inhibitor of cancer .

HY-W034674

Silver diethyldithiocarbamate

Silver(1+) diethyldithiocarbamate

Indicators

Silver diethyldithiocarbamate (SDDC) is an organic compound consisting of silver ions complexed with the ligand diethyldithiocarbamate. SDDC is mainly used as a reagent in analytical chemistry to detect the presence of copper, iron and other heavy metals in various materials. It acts as a chelating agent, binding to metal ions and forming stable complexes that can be easily analyzed using techniques such as UV-Vis spectroscopy.

HY-157926

Nitroso-PSAP	Chelators
Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe ²⁺), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe ²⁺) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >) .

Cat. No.	Product Name	Target	Research Area

HY-P3320

Phytochelatin 3 PC 3	Biochemical Assay Reagents	Others
Phytochelatin 3 (PC 3) is the small metal chelating peptide that can be used for chelating heavy metals. Phytochelatin 3 is a short metal detoxification peptide made from the sulfur-rich molecule glutathione. Phytochelatin 3 can be found in different sources including plant, fungal, algal, and bacterial species, as a detoxification mechanism in response to heavy metal exposure. Phytochelatin 3 plays an important metabolic role in plants .

HY-116073

L-Penicillamine	Biochemical Assay Reagents	Metabolic Disease
L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .

HY-W046355

Fmoc-D-Dap(Boc)-OH	Radionuclide-Drug Conjugates (RDCs) Amino Acid Derivatives	Others
Fmoc-D-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as DOTA-modified peptides and their metal chelates with cancer diagnostic effects .

HY-P2512A

Phytochelatin 2 (PC2) (TFA)	Peptides	Others
Phytochelatin 2 (PC2) TFA is a phytochelatin, an important heavy metal-binding peptide. Phytochelatin 2 (PC2) TFA can chelate metals, prevent metal toxicity, and maintain metal stability in the internal environment .

HY-W048718

Fmoc-D-Tle-OH Fmoc-D-α-t-butylglycine	Amino Acid Derivatives	Others
Fmoc-D-Tle-OH (Fmoc-D-α-t-butylglycine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize chelating agents that can form a single stereoisomer-enriched form after coordination with metal centers .

HY-N9413

γ-Glutamyl-S-allylcysteine L-γ-Glutamyl-(S)-Allyl-Cysteine	Peptides	Metabolic Disease
γ-Glutamyl-S-allylcysteine (L-γ-Glutamyl-(S)-Allyl-Cysteine) is a naturally occurring organosulfur compound found in garlic. γ-Glutamyl-S-allylcysteine has antiglycative effect and shows radical-scavenging and metal-chelating capacities .

HY-P2512

Phytochelatin 2 (PC2)	Peptides	Others
Phytochelatin 2, a short phytochelatin, is a key plant peptide binding heavy metals. Phytochelatins are a diverse set of plant compounds that chelate metals, protect against metal toxicity and function in metal homeostasis .

HY-P3320A

Phytochelatin 3 TFA PC 3 TFA	Peptides	Others
Phytochelatin 3 (PC 3) TFA is the small metal chelating peptide that can be used for chelating heavy metals .

HY-P10254

Iso-phytochelatin 2 (Glu)	Fungal	Others
Iso-phytochelatin 2 Glu is chelating peptide with general structure (γ-Glu-Cys)n-Gly, which is induced by heavy metals in high plants and fungi .

HY-P10012

Pendetide GYK-DTPA	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Cancer
Pendetide is a chelating agent, can be conjugated with Indium (111In) Capromab for further diagnostic use. Capromab pendetide is a FDA-approved imaging agent for the detection of soft tissue metastases in prostate carcinoma . Pendetide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P10369

Betiatide	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Cardiovascular Disease Inflammation/Immunology
Betiatide, as a chelating agent for Technetium-99m ( ^99mTc), is used to prepare ^99mTc-MAG3 (mercaptoacetyltriglycine), a radiopharmaceutical for renal function imaging. Betiatide is used for the diagnosis of congenital and acquired abnormalities, renal failure, urinary tract obstructions, and calculi . Betiatide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P1204A

[Ala17]-MCH TFA	MCHR1 (GPR24)	Metabolic Disease
[Ala17]-MCH TFA, a MCH analogue (HY-P1525A), is a selective ligand for MCHR₁ (K_i=0.16 nM) over MCHR₂ (K_i=34 nM). [Eu ³⁺ chelate-labeled [Ala17]-MCH shows high affnity for MCHR₁ (K_d=0.37 nM) while has little demonstrable binding affnity for MCHR₂ .

HY-P1204

[Ala17]-MCH	MCHR1 (GPR24)	Metabolic Disease
[Ala17]-MCH, a MCH analogue (HY-P1525A), is a selective ligand for MCHR₁ (K_i=0.16 nM) over MCHR₂ (K_i=34 nM). [Eu ³⁺ chelate-labeled [Ala17]-MCH shows high affnity for MCHR₁ (K_d=0.37 nM) while has little demonstrable binding affnity for MCHR₂ .

HY-W006064

(S)-2-Aminopent-4-ynoic acid	Amino Acid Derivatives	Others
(S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes . (S)-2-Aminopent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P10761

DPI-4452	Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase	Cancer
DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC₅₀ for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-W013494R

L-Carnosine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Cancer
L-Carnosine (Standard) is the analytical standard of L-Carnosine. This product is intended for research and analytical applications. L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging. In Vitro: L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging . L-Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of L-Carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability .

HY-P10792

HER2-targeted peptide H6F	EGFR	Cancer
HER2-targeted peptide H6F is a HER2 targeting peptide that binds to HER2 to target breast cancer cells, with the amino acid sequence YLFFVFER. The HER2-targeted peptide H6F can be conjugated with the bifunctional chelating agent hydrazinonicotinamide (HYNIC) for radiolabeling with 99mTc. Single-photon emission computed tomography (SPECT) imaging shows that the labeled HER2-targeted peptide H6F specifically accumulates in HER2-positive MDA-MBA-453 tumor-bearing mice models. The HER2-targeted peptide H6F can be used for tumor molecular imaging studies .

Cat. No.	Product Name

HY-K0256

Chelating Agarose (IDA) 6FF
MCE Chelating Agarose (IDA) 6FF allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

Cat. No.	Product Name	Chemical Structure

HY-B0568S

Deferiprone-d3
Deferiprone-d₃ is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating agent to be used therapeutically in conditions of transfusional iron overload .

HY-B0300S

Penicillamine-d3
Penicillamine-d₃ is the deuterium labeled Penicillamine. Penicillamine (D-(-)-Penicillamine) is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.

HY-W030778S

Nitrilotriacetic acid-d9
Nitrilotriacetic acid-d₉ is the deuterium labeled Nitrilotriacetic acid . Nitrilotriacetic acid is an aminotricarboxylic acid. Nitrilotriacetic acid can be used as a chelating agent, forming coordination compounds with metal ions .

HY-B1159S

Nitroxoline-d4
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe ²⁺ and Zn ²⁺ ions from the biofilm matrix .

HY-W745771

D-Penicillamine-d6
D-Penicillamine-d₆ is the deuterium labeled L-Penicillamine (HY-116073). L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .

HY-I0301S

D-(+)-Glucono-1,5-lactone-1-13C
D-(+)-Glucono-1,5-lactone-1- ¹³C is the ¹³C labeled D-(+)-Glucono-1,5-lactone. D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activ .

HY-W768262

D-(+)-Glucono-1,5-lactone-13C6
D-(+)-Glucono-1,5-lactone- ¹³C₆ (Gluconic acid lactone- ¹³C₆) is the ¹³C-labeled D-(+)-Glucono-1,5-lactone (HY-I0301). D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

HY-W004544S

o-Phenanthroline-d8
o-Phenanthroline-d₈ is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .

HY-W777365

Ethylenediaminetetraacetic acid-13C4

Ethylenediaminetetraacetic acid- ¹³C₄ (EDTA- ¹³C₄) is the ¹³C-labeled Ethylenediaminetetraacetic acid (HY-Y0682). Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .

Cat. No.	Product Name		Classification

HY-W006064

(S)-2-Aminopent-4-ynoic acid		Alkynes
(S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes . (S)-2-Aminopent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-N0420

Succinic acid 5+ Cited Publications Wormwood acid		Cosolvents pH Modifiers
Succinic acid is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid is an important platform chemical. Succinic acid can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

HY-Y0682A

Ethylenediaminetetraacetic acid disodium dihydrate 10+ Cited Publications EDTA disodium dihydrate		Antioxidants Chelating Agents
Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .

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