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Cyclen is a macrocyclic tetraamine. Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates. Cyclen is employed as a structural regulator through interfacial polymerization of polyethleneimine (PEI) and trimesoyl chloride (TMC) to develop polyamide NF membrane with efficient Li+/Mg2+ separation performance. Cyclen has specific cavity structure and exhibits selective coordination properties for Li+ ions.

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Cyclen Chemical Structure

Cyclen Chemical Structure

CAS No. : 294-90-6

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Description

Cyclen is a macrocyclic tetraamine. Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates. Cyclen is employed as a structural regulator through interfacial polymerization of polyethleneimine (PEI) and trimesoyl chloride (TMC) to develop polyamide NF membrane with efficient Li+/Mg2+ separation performance. Cyclen has specific cavity structure and exhibits selective coordination properties for Li+ ions[1][2].

Clinical Trial
Molecular Weight

172.28

Formula

C8H20N4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1CNCCNCCNCCN1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (290.23 mM; Need ultrasonic)

DMSO : 1.85 mg/mL (10.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8045 mL 29.0225 mL 58.0450 mL
5 mM 1.1609 mL 5.8045 mL 11.6090 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.94%

SDS (786 KB)

COA (249 KB) HNMR (109 KB) GC (108 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.8045 mL 29.0225 mL 58.0450 mL 145.1126 mL
5 mM 1.1609 mL 5.8045 mL 11.6090 mL 29.0225 mL
10 mM 0.5805 mL 2.9023 mL 5.8045 mL 14.5113 mL
H2O 15 mM 0.3870 mL 1.9348 mL 3.8697 mL 9.6742 mL
20 mM 0.2902 mL 1.4511 mL 2.9023 mL 7.2556 mL
25 mM 0.2322 mL 1.1609 mL 2.3218 mL 5.8045 mL
30 mM 0.1935 mL 0.9674 mL 1.9348 mL 4.8371 mL
40 mM 0.1451 mL 0.7256 mL 1.4511 mL 3.6278 mL
50 mM 0.1161 mL 0.5805 mL 1.1609 mL 2.9023 mL
60 mM 0.0967 mL 0.4837 mL 0.9674 mL 2.4185 mL
80 mM 0.0726 mL 0.3628 mL 0.7256 mL 1.8139 mL
100 mM 0.0580 mL 0.2902 mL 0.5805 mL 1.4511 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclen294-90-6OthersInhibitorinhibitorinhibit

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