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  4. Nitrilotriacetic acid

Nitrilotriacetic acid  (Synonyms: Triglycollamic acid)

Cat. No.: HY-W030778 Purity: ≥98.0%
SDS
COA
Handling Instructions Technical Support

Nitrilotriacetic acid is an orally active chelating agent for metal ions. Nitrilotriacetic acid is an aminotricarboxylic acid that can sequester metal ions as water soluble complexes. Nitrilotriacetic acid reacts with strong oxidizing agents such as hypochlorite, chlorine, ozone, or oxygen in the presence of palladium/carbon catalyst. Nitrilotriacetic acid interacts with solid phases such as cell membranes and bone matrices in the mammalian system. Nitrilotriacetic acid is classified as an epigenetic rodent carcinogen.

For research use only. We do not sell to patients.

Nitrilotriacetic acid Chemical Structure

Nitrilotriacetic acid Chemical Structure

CAS No. : 139-13-9

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Nitrilotriacetic acid:

Nitrilotriacetic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nitrilotriacetic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nitrilotriacetic acid is an orally active chelating agent for metal ions. Nitrilotriacetic acid is an aminotricarboxylic acid that can sequester metal ions as water soluble complexes. Nitrilotriacetic acid reacts with strong oxidizing agents such as hypochlorite, chlorine, ozone, or oxygen in the presence of palladium/carbon catalyst. Nitrilotriacetic acid interacts with solid phases such as cell membranes and bone matrices in the mammalian system. Nitrilotriacetic acid is classified as an epigenetic rodent carcinogen[1][2].

In Vitro

Nitrilotriacetic acid (Compound NTA) (0-1250 μg/mL, 24 h) induces a statistically significant increase in the number of micronucleated cells on L5178Y mouse lymphoma cells without S9[1].
Nitrilotriacetic acid (625-2500 μg/mL, 24-44 h) induces a statistically significant increase in the number of micronuclei in bot CTLL-2 and CTLL-2 bcl2 cells without S9, whilst not associated with an increase in the percentage of apoptotic cells[1].
Nitrilotriacetic acid (0-500 μg/mL, 24 h) significantly increases the NTA-induced mutation frequency[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nitrilotriacetic acid Related Antibodies
In Vivo

Nitrilotriacetic acid (Compound NTA) (0-2000 mg/kg, p.o., single dose) induces a strong and statistically significant increase in DNA damage in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

191.14

Formula

C6H9NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CN(CC(O)=O)CC(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (130.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

0.1 M NaOH : ≥ 19.11 mg/mL (99.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2318 mL 26.1588 mL 52.3177 mL
5 mM 1.0464 mL 5.2318 mL 10.4635 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (557 KB)

COA (250 KB) HNMR (239 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M NaOH / DMSO 1 mM 5.2318 mL 26.1588 mL 52.3177 mL 130.7942 mL
5 mM 1.0464 mL 5.2318 mL 10.4635 mL 26.1588 mL
10 mM 0.5232 mL 2.6159 mL 5.2318 mL 13.0794 mL
15 mM 0.3488 mL 1.7439 mL 3.4878 mL 8.7196 mL
20 mM 0.2616 mL 1.3079 mL 2.6159 mL 6.5397 mL
25 mM 0.2093 mL 1.0464 mL 2.0927 mL 5.2318 mL
30 mM 0.1744 mL 0.8720 mL 1.7439 mL 4.3598 mL
40 mM 0.1308 mL 0.6540 mL 1.3079 mL 3.2699 mL
50 mM 0.1046 mL 0.5232 mL 1.0464 mL 2.6159 mL
60 mM 0.0872 mL 0.4360 mL 0.8720 mL 2.1799 mL
80 mM 0.0654 mL 0.3270 mL 0.6540 mL 1.6349 mL
DMSO 100 mM 0.0523 mL 0.2616 mL 0.5232 mL 1.3079 mL
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Nitrilotriacetic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitrilotriacetic acid139-13-9Triglycollamic acidBiochemical Assay ReagentsChelatingmetal ionscarcinogenInhibitorinhibitorinhibit

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