2. Search Result
Search Result
Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

cell growth and migration

" in MedChemExpress (MCE) Product Catalog:

147

Inhibitors & Agonists

1

Fluorescent Dye

3

Biochemical Assay Reagents

8

Peptides

4

Inhibitory Antibodies

23

Natural
Products

6

Isotope-Labeled Compounds

13

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156293
    FPR1 antagonist 1

    		Formyl Peptide Receptor (FPR) Apoptosis Cancer
    FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 25 nM. FPR1 antagonist 1 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis .
    FPR1 antagonist 1
  • HY-156294
    FPR1 antagonist 2

    		Formyl Peptide Receptor (FPR) Apoptosis Cancer
    FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 70 nM. FPR1 antagonist 2 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis .
    FPR1 antagonist 2
  • HY-174553
    Human PDGFA mRNA

    		mRNA Cancer
    Human PDGFA mRNA encodes the human platelet derived growth factor A (PDGFA) protein, a member of the platelet-derived growth factor family. PDGFA plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.
    Human PDGFA mRNA
  • HY-174552
    Human PDGFB mRNA

    		mRNA Cancer
    Human PDGFB mRNA encodes the human platelet derived growth factor B (PDGFB) protein, a member of the platelet-derived growth factor family. PDGFB plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.
    Human PDGFB mRNA
  • HY-174550
    Human PDGFD mRNA

    		mRNA Cancer
    Human PDGFD mRNA encodes the human platelet derived growth factor D (PDGFD) protein, a member of the platelet-derived growth factor family. PDGFD plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.
    Human PDGFD mRNA
  • HY-174551
    Human PDGFC mRNA

    		mRNA Cancer
    Human PDGFC mRNA encodes the human platelet derived growth factor C (PDGFC) protein, a member of the platelet-derived growth factor family. PDGFC plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.
    Human PDGFC mRNA
  • HY-174704
    Human FGF18 mRNA

    		mRNA Cancer
    Human FGF18 mRNA encodes the human fibroblast growth factor 18 (FGF18) protein, a member of the fibroblast growth factor (FGF) family. FGF18 probably plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. It is also required for normal ossification and bone development.
    Human FGF18 mRNA
  • HY-174510
    Human VEGFA mRNA

    		mRNA Cancer
    Human VEGFA mRNA encodes the human vascular endothelial growth factor A (VEGFA) protein, a member of the PDGF/VEGF growth factor family. VEGFA could induce proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis.
    Human VEGFA mRNA
  • HY-N14618
    Rhodomycin A

    		Src Cancer
    Rhodomycin A can suppress lung cancer cell progression via modulating Src-related pathways.?Rhodomycin A significantly suppressed cancer cell proliferation, migration, invasion, and clonogenicity in vitro and tumour growth in vivo .
    Rhodomycin A
  • HY-174652
    Human IGFBP1 mRNA

    		mRNA Metabolic Disease
    Human IGFBP1 mRNA encodes the human insulin like growth factor binding protein 1 (IGFBP1) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP1 is important in cell migration and metabolism.
    Human IGFBP1 mRNA
  • HY-174687
    Human FGFR4 mRNA

    		mRNA Cancer
    Human FGFR4 mRNA encodes the human fibroblast growth factor receptor 4 (FGFR4) protein, a tyrosine kinase and cell surface receptor for fibroblast growth factors. FGFR4 is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis.
    Human FGFR4 mRNA
  • HY-100498A
    GSK-2256098 hydrochloride
    5+ Cited Publications

    		 FAK Apoptosis Cancer
    GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival.
    GSK-2256098 hydrochloride
  • HY-115996
    Antitumor agent-51

    		Apoptosis Cancer
    Antitumor agent-51 possesses potent and selective inhibitory for osteosarcoma cell growth and migration with IC50 of 21.9 nM in MNNG/HOS cells. Antitumor agent-51 has a considerable bioavailability and a low toxicity .
    Antitumor agent-51
  • HY-174712
    Human FGF1 mRNA

    		mRNA Cancer
    Human FGF1 mRNA encodes the human Fibroblast growth factor 1 (FGF1) protein, a member of fibroblast growth factor (FGF) family. FGF1 functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It also acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis.
    Human FGF1 mRNA
  • HY-124632
    WJ460
    2 Publications Verification

    		 Ferroptosis Autophagy Cancer
    WJ460 is a potent inhibitor of myoferlin (MYOF) that interacts directly with MYOF. WJ460 inhibits the migration and growth, induces cell cycle arrest, mitochondrial autophagy, lipid peroxidation and ferroptosis in tumor cells. WJ460 has anti-tumor activity .
    WJ460
  • HY-115686
    8-Azaadenosine
    5 Publications Verification

    		 Adenosine Deaminase Inflammation/Immunology Cancer
    8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells .
    8-Azaadenosine
  • HY-P99196
    Ficlatuzumab

    		c-Met/HGFR Cancer
    Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion .
    Ficlatuzumab
  • HY-155362
    Tubulin polymerization-IN-56

    		Microtubule/Tubulin Apoptosis Cancer
    Tubulin polymerization-IN-56 (compound 8l), an indazole derivative, is a potent tubulin polymerization inhibitor through interacting with the colchicine site, resulting in cell cycle arrest and cellular apoptosis. polymerization-IN-56 reduces cell migration and leads to more potent inhibition of tumor growth in vivo .
    Tubulin polymerization-IN-56
  • HY-144707
    AK-778-XXMU

    		Apoptosis Cancer
    AK-778-XXMU is a potent inhibitor of DNA Binding 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and more importantly, slow down the tumor growth .
    AK-778-XXMU
  • HY-161400
    TGFβRII-IN-2

    		TGF-β Receptor Cancer
    TGFβRII-IN-2 (Compound 3n) is an inhibitor for transforming growth factor-β type II receptor (TGFβRII) with IC50 of 2.4 μM, which blocks endothelial-to-mesenchymal transition and cell migration in different cancer cell lines without perturbing the microtubule network .
    TGFβRII-IN-2
  • HY-114356
    BPI-9016M

    		c-Met/HGFR Cancer
    BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma .
    BPI-9016M
  • HY-16916
    NS1643
    1 Publications Verification

    		 Potassium Channel Autophagy Cancer
    NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K + channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells .
    NS1643
  • HY-149631
    HFY-4A

    		HDAC Cancer
    HFY-4A is a HDAC inhibitor. HFY-4A inhibits breast cancer cell proliferation, migration, and invasion, and induces cell apoptosis. HFY-4A induces immunogenic cell death (ICD). HFY-4A inhibits tumor growth in breast cancer xenograft mouse models .
    HFY-4A
  • HY-126410
    Petunidin chloride
    1 Publications Verification

    		 FAK Metabolic Disease
    Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.
    Petunidin chloride
  • HY-12616
    ACT-209905

    		LPL Receptor Cancer
    ACT-209905 is a S1P1 receptor agonist. ACT-209905 can inhibit glioblastoma (GBM) cell growth and migration. ACT-209905 also has immunomodulating activity, and can be used in research of autoimmune diseases .
    ACT-209905
  • HY-19536
    LLL12
    1 Publications Verification

    		 STAT Cancer
    LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin (HY-17394) and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth .
    LLL12
  • HY-173143
    BTK-IN-42

    		Btk Cancer
    BTK-IN-42 (Compound 11a) is a Btk inhibitor. BTK-IN-42 can effectively inhibit the growth and migration of tumor cells TMD8, with IC50 values of 2.61 and 5.34 μM for TMD8 and T9 cells respectively. It shows promise for research in the field of anti-cancer .
    BTK-IN-42
  • HY-N0416
    Cucurbitacin B
    5+ Cited Publications

    		 HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX Others Neurological Disease Inflammation/Immunology Cancer
    Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .
    Cucurbitacin B
  • HY-W159754
    Chavicol

    p-Hydroxyallylbenzene

    		 Cholinesterase (ChE) Cancer
    Chavicol (p-Hydroxyallylbenzene, compound 6) can inhibit acetylcholinesterase (Cholinesterase (ChE)), with an IC50 of 7.42 μM. Chavicol has anti-cancer activity and can suppress the growth, survival, migration, and invasion of cancer cells. Chavicol cytotoxic effect is significant, approximately 31 μg/mL in A-549 cells .
    Chavicol
  • HY-175202
    CIDD-8633

    		Discoidin Domain Receptor Apoptosis Caspase Interleukin Related PERK Cancer
    CIDD-8633 is a potent DDR2 inhibitor with an IC50 of 6.105 μM. CIDD-8633 inhibits cell migration and halts the cell cycle and induces apoptosis, significantly suppressing pancreatic ductal adenocarcinoma (PDAC) tumor growth. CIDD-8633 can be used for the study of pancreatic cancer such as PDAC .
    CIDD-8633
  • HY-174411
    Tubulin polymerization-IN-82

    		Microtubule/Tubulin MMP Bcl-2 Family Reactive Oxygen Species (ROS) Caspase Cancer
    Tubulin polymerization-IN-82 is a tubulin inhibitor. Tubulin polymerization-IN-82 inhibits cell migration and invasion, and triggers cell apoptosis through the mitochondria and ER stress mediated pathway. Tubulin polymerization-IN-82 exhibits antitumor activity against drug resistance cancer cells, and inhibits tumor growth, can be used for liver cancer research .
    Tubulin polymerization-IN-82
  • HY-147867
    MMP-2/9-IN-1

    		MMP Cancer
    MMP-2/9-IN-1 (Compound 4a) is a potent dual MMP-2 and MMP-9 inhibitor with IC50 values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation .
    MMP-2/9-IN-1
  • HY-162346
    KN-17

    		Bacterial Infection
    KN-17 is a modified based on the structure of cecropin B (HY-P0092), can effectively interfere with bacterial growth and induce the migration of human bone marrow stromal cells (hBMSCs). KN-17 can significantly stimulate angiogenesis in vitro and in vivo .
    KN-17
  • HY-N0410
    Daucosterol
    5 Publications Verification

    Eleutheroside A; β-Sitosterol β-D-glucoside

    		 Apoptosis Reactive Oxygen Species (ROS) Autophagy Inflammation/Immunology Cancer
    Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .
    Daucosterol
  • HY-175531
    EGFR-IN-169

    		EGFR Apoptosis Reactive Oxygen Species (ROS) CDK Bcl-2 Family Cancer
    EGFR-IN-169 is an epidermal growth factor (EGFR) (IC50 = 5.19 μM) inhibitor form panaxadiol. EGFR-IN-169 interferes with the migration and growth of colorectal cancer cells by inhibiting EGFR-mediated RalA/EMT pathway. EGFR-IN-169 shows an IC50 value of 4.46 μM and SI of 16.92 for HCT-116 cells. EGFR-IN-169 inhibits CDKs activity, induces G0/G1 cycle arrest and inhibits migration and invasion. EGFR-IN-169 reduces mitochondrial membrane potential and induces apoptosis and ROS production. EGFR-IN-169 can be used for the research of cancer, such as colorectal cancer .
    EGFR-IN-169
  • HY-169282
    RGS2–Galpha-q PPI-IN-1

    		Others Cancer
    RGS2–Galpha-q interaction-IN-1 (Compound AJ-3) is an inhibitor of the RGS2-Galpha-q interaction. RGS2–Galpha-q interaction-IN-1 can inhibit the growth of cancer cell lines expressing RGS2 and exhibits anti-cell migration properties .
    RGS2–Galpha-q PPI-IN-1
  • HY-116269
    AZA197

    		Ras Apoptosis PAK ERK Cancer
    AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts .
    AZA197
  • HY-W357818
    Glycinexylidide

    GX

    		 Sodium Channel ERK MEK NF-κB Drug Metabolite Cancer
    Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local agent that can suppress or relieve pain, that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease .
    Glycinexylidide
  • HY-164410
    MO-I-1100

    		Notch Cancer
    MO-I-1100 is an inhibitor of ASPH (Aspartyl-(Asparaginyl)-β-hydroxylase) enzymatic activity. MO-I-1100 suppresses HCC cell migration, invasion and anchorage independent growth. MO-I-1100 shows antitumor effects through inhibiting Notch signaling cascade in HCC .
    MO-I-1100
  • HY-129046E
    RNase A (DNase & Protease Free), Recombinant

    Ribonuclease A (DNase & Protease Free), Recombinant

    		 DNA/RNA Synthesis Others
    RNase A (DNase & Protease Free), Recombinant is an endonuclease, that can be found in bovine pancreas. RNase A (DNase & Protease Free), Recombinant purifies DNA by hydrolyzing cytosine or uracil residues in RNA. RNase A (DNase & Protease Free), Recombinant regulates cell growth, proliferation, differentiation, and migration, and exhibits antitumor efficacy .
    RNase A (DNase & Protease Free), Recombinant
  • HY-147187
    MNK8

    		STAT Apoptosis Bcl-2 Family Survivin Cancer
    MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells .
    MNK8
  • HY-12965B
    (Z)-S49076 hydrochloride

    		TAM Receptor Cancer
    (Z)-S49076 hydrochloride is an orally active inhibitor of MET and AXL that blocks the downstream signaling of these receptors both in vitro and in vivo, inhibiting the proliferation and migration of tumor cells and suppressing tumor growth in xenograft models. (Z)-S49076 hydrochloride is capable of overcoming the resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) due to MET amplification in Erlotinib (HY-50896)-resistant cell lines both in vitro and in vivo. (Z)-S49076 hydrochloride can be used for research in non-small cell lung cancer (NSCLC) .
    (Z)-S49076 hydrochloride
  • HY-P9933
    Dinutuximab

    APN-311

    		 Apoptosis PERK mTOR Cancer
    Dinutuximab (APN-311) is a chimeric human-mouse anti-GD2 monoclonal antibody. Dinutuximab can bind to GD2 on the cell surface, triggering antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, and promoting tumor regression. Dinutuximab can inhibit the growth, invasion, and migration and induce apoptosis of tumor cells. Dinutuximab can be used in the research of tumors such as neuroblastoma and breast cancer .
    Dinutuximab
  • HY-144873
    AVJ16

    		Insulin Receptor Apoptosis Cancer
    AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA binding protein IGF2BP1 with a good affinity of Kd of 1.4μM. AVJ16 interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation .
    AVJ16
  • HY-151429
    Antitumor agent-77

    		Apoptosis Ferroptosis Bcl-2 Family COX Cancer
    Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .
    Antitumor agent-77
  • HY-151428
    Antitumor agent-78

    		Ferroptosis Apoptosis Bcl-2 Family COX Cancer
    Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .
    Antitumor agent-78
  • HY-B0185
    Lidocaine
    Maximum Cited Publications
    17 Publications Verification

    Lignocaine

    		 Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .
    Lidocaine
  • HY-B0185B
    Lidocaine hydrochloride hydrate
    10+ Cited Publications

    Lignocaine hydrochloride hydrate

    		 Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia .
    Lidocaine hydrochloride hydrate
  • HY-126410R
    Petunidin chloride (Standard)

    		Reference Standards FAK Metabolic Disease
    Petunidin (chloride) (Standard) is the analytical standard of Petunidin (chloride). This product is intended for research and analytical applications. Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.
    Petunidin chloride (Standard)
  • HY-160053
    Gint4.T aptamer sodium

    		PDGFR Cancer
    Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .
    Gint4.T aptamer sodium

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: