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Results for "

antitussive

" in MedChemExpress (MCE) Product Catalog:

76

Inhibitors & Agonists

2

Biochemical Assay Reagents

22

Natural
Products

5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1895
    Levodropropizine

    (S)-(-)-Dropropizine; DF-526

    		 Histamine Receptor Neurological Disease Inflammation/Immunology Endocrinology
    Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent .
    Levodropropizine
  • HY-B2090
    Pipazethate

    SKF 70230A; SQ 15874; Pipazetate

    		 GABA Receptor Others
    Pipazethate (SKF 70230A), a pyridobenzothiazine derivative, is a potent GABA antagonist. Pipazethate has antitussive activity. Pipazethate can be used in research in cough supressant .
    Pipazethate
  • HY-N10620
    Melitidin

    		Others Inflammation/Immunology
    Melitidin is a flavanone glycoside, that can be isolated from Citrus grandis 'Tomentosa'. Melitidin shows a good antitussive effect on cough induced by citric acid in Guinea pig .
    Melitidin
  • HY-N7600
    Zhebeirine

    25-Epieduardine; Puqiedinone

    		 Others Others
    Zhebeirine (Puqiedinone), a steroidal alkaloid, is isolated from the bulbs of Fritillaria puqiensis. Zhebeirine exhibits antitussive and expectorant properties .
    Zhebeirine
  • HY-106495
    Vadocaine

    OR K-242

    		 Adrenergic Receptor Neurological Disease
    Vadocaine (OR K-242), an orally active antitussive compound, is a local agent that can suppress or relieve pain .
    Vadocaine
  • HY-121644
    Viminol

    		Opioid Receptor Neurological Disease
    Viminol is a centrally acting analgesic agent. Viminol also shows antitussive activity .
    Viminol
  • HY-134006
    Stemoninine

    		Cholinesterase (ChE) Neurological Disease Inflammation/Immunology
    Stemoninine is a lycoris alkaloid that can be used as an antitussive. Stemoninine has significant inhibitory activity against human acetylcholinesterase (AChE) (IC50=5.52 μM) .
    Stemoninine
  • HY-W725190A
    Piperidylthiambutene

    		Opioid Receptor Neurological Disease
    Piperidylthiambutene is a potent µ-opioid receptor (MOR) agonist with a Ki of 2.75 nM. Piperidylthiambutene exhibits analgesic and antitussive properties and can be utilized in relevant research .
    Piperidylthiambutene
  • HY-B1895R
    Levodropropizine (Standard)

    		Histamine Receptor Neurological Disease Inflammation/Immunology Endocrinology
    Levodropropizine (Standard) is the analytical standard of Levodropropizine. This product is intended for research and analytical applications. Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent .
    Levodropropizine (Standard)
  • HY-A0161
    Chlophedianol

    Clofedanol; Calmotusin; NSC 113595

    		 Others Infection
    Chlophedianol (Clofedanol) is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
    Chlophedianol
  • HY-N3197
    Neostenine

    (+)-Neostenine

    		 P-glycoprotein Cancer
    Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .
    Neostenine
  • HY-121685
    Tipepidine

    		Potassium Channel Neurological Disease
    Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron . Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect .
    Tipepidine
  • HY-B1032
    Dropropizine

    (±)-Dropropizine; UCB-196

    		 Others Neurological Disease
    Dropropizine ((±)-Dropropizine; UCB-196) is an orally effective, peripherally selective antitussive that inhibits the activity of peripheral receptors and afferent nerves in the respiratory tract. Dropropizine acts on the cough reflex pathway, does not pass the blood-brain barrier, and has no central nervous system side effects. Dropropizine mainly regulates the level of sensory neuropeptides and inhibits the afferent signal transmission of the cough reflex, thereby alleviating the symptoms of dry cough, and has both mild local anesthetic and antihistamine activity. Dropropizine is mainly used for symptomatic research on dry cough caused by respiratory diseases .
    Dropropizine
  • HY-A0161A
    Chlophedianol hydrochloride

    Clofedanol hydrochloride; Calmotusin hydrochloride; NSC 113595 hydrochloride

    		 Others Infection
    Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
    Chlophedianol hydrochloride
  • HY-B1551
    Benzonatate

    Benzononatine

    		 Sodium Channel Neurological Disease
    Benzonatate (Benzononatine) is an orally active and non-narcotic peripheral antitussive agent. Benzonatate is a reversible voltage-gated Na + channels inhibitor. Benzonatate dampens the activity of cough stretch receptors .
    Benzonatate
  • HY-13716
    Noscapine
    1 Publications Verification

    (S,R)-Noscapine

    		 Opioid Receptor Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
    Noscapine
  • HY-13716A
    Noscapine hydrochloride
    1 Publications Verification

    (S,R)-Noscapine hydrochloride

    		 Opioid Receptor Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Noscapine ((S,R)-Noscapine) hydrochloride is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine hydrochloride exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine hydrochloride disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine hydrochloride possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier .
    Noscapine hydrochloride
  • HY-13716R
    Noscapine (Standard)

    (S,R)-Noscapine (Standard)

    		 Reference Standards Opioid Receptor Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .
    Noscapine (Standard)
  • HY-B1551R
    Benzonatate (Standard)

    Benzononatine (Standard)

    		 Reference Standards Sodium Channel Neurological Disease
    Benzonatate (Standard) (Benzononatine (Standard)) is the analytical standard of Benzonatate (HY-B155). This product is intended for research and analytical applications. Benzonatate (Benzononatine) is an orally active and non-narcotic peripheral antitussive agent. Benzonatate is a reversible voltage-gated Na + channels inhibitor. Benzonatate dampens the activity of cough stretch receptors.
    Benzonatate (Standard)
  • HY-B2078A
    Eprazinone dihydrochloride

    		Neurokinin Receptor Inflammation/Immunology
    Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen .
    Eprazinone dihydrochloride
  • HY-124959
    Spiradoline mesylate

    U-62066 mesylate

    		 Opioid Receptor Neurological Disease
    Spiradoline mesylate (U-62066 mesylate), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline mesylate for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline mesylate has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier .
    Spiradoline mesylate
  • HY-106756
    Spiradoline

    U-62066

    		 Opioid Receptor Neurological Disease
    Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier .
    Spiradoline
  • HY-170918
    BKCa activator-1

    		Potassium Channel Others
    BKCa activator-1 (Compound 51b) is the orally active activator for the calcium-activated potassium channel BKCa with an EC50 of 2.82 μM. BKCa activator-1 increases K+ efflux, leads to cell membrane hyperpolarization, thereby inhibiting smooth muscle contraction. BKCa activator-1 alleviates urinary incontinence in spontaneously hypertensive rat (SHR) model, exhibits antitussive effect in puinea pig cough model .
    BKCa activator-1
  • HY-114723
    NPD9948

    		DNA/RNA Synthesis Others
    NPD9948 is an antitussive agent with antitussive activity in a guinea pig antitussive test. Its half antitussive dose (AtD50) is 14.5 mg/kg and 22.6 mg/kg when injected intraperitoneally and orally, respectively.
    NPD9948
  • HY-101828
    Guaiapate

    Klamar; Mg 5454

    		 Others Inflammation/Immunology
    Guaiapate is an antitussive agent.
    Guaiapate
  • HY-N3945R
    Glaucine (Standard)

    		Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus Infection Inflammation/Immunology
    Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .
    Glaucine (Standard)
  • HY-B2215
    Dimemorfan phosphate
    2 Publications Verification

    		 Sigma Receptor Neurological Disease Inflammation/Immunology
    Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
    Dimemorfan phosphate
  • HY-N3163
    Obtucarbamate A

    		Others Inflammation/Immunology Cancer
    Obtucarbamate A isolated from Disporum cantoniense has antitussive activity .
    Obtucarbamate A
  • HY-106372A
    Carcainium chloride

    QX 572; RSD 931

    		 Histamine Receptor Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Carcainium chloride (QX 572) is a quaternary derivative of Lidocaine. Antitussive effect .
    Carcainium chloride
  • HY-B0505
    Moguisteine
    1 Publications Verification

    BBR-2173

    		 Opioid Receptor Neurological Disease Cancer
    Moguisteine???(BBR-2173) is an antitussive compound but has no significant affinity for opiate receptors.
    Moguisteine
  • HY-N8197
    Epigambogic acid

    		Others Cancer
    Epigambogic acid is a natural anti-tumor, antitussive, expectorant and anti-inflammatory compound .
    Epigambogic acid
  • HY-134004
    Pentoxyverine

    Carbetapentane

    		 Sigma Receptor mAChR Neurological Disease Inflammation/Immunology
    Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
    Pentoxyverine
  • HY-B1055
    Pentoxyverine citrate

    Carbetapentane citrate

    		 Sigma Receptor mAChR Neurological Disease Inflammation/Immunology
    Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
    Pentoxyverine citrate
  • HY-134004R
    Pentoxyverine (Standard)

    		Sigma Receptor mAChR Neurological Disease Inflammation/Immunology
    Pentoxyverine (Standard) is the analytical standard of Pentoxyverine. This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
    Pentoxyverine (Standard)
  • HY-106873A
    Nepinalone hydrochloride

    		Drug Derivative Others
    Nepinalone hydrochloride, an alchilaminate derivative of β-tetralone and an orally active cough suppressant, possesses a non-opioid antitussive activity .
    Nepinalone hydrochloride
  • HY-106873
    Nepinalone

    		Drug Derivative Others
    Nepinalone, an alchilaminate derivative of β-tetralone and an orally active cough suppressant, possesses a non-opioid antitussive activity .
    Nepinalone
  • HY-B1055R
    Pentoxyverine (citrate) (Standard)

    		Sigma Receptor mAChR Neurological Disease Inflammation/Immunology
    Pentoxyverine (citrate) (Standard) is the analytical standard of Pentoxyverine (citrate). This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance [4].
    Pentoxyverine (citrate) (Standard)
  • HY-128418
    Benzonatate (PEGn)

    		Sodium Channel Neurological Disease Inflammation/Immunology
    Benzonatate (PEGn) is a unique non-narcotic antitussive agent that has sodium channel-blocking properties and anesthetic effects on the respiratory stretch receptors .
    Benzonatate (PEGn)
  • HY-N3196
    Neotuberostemonine

    		Bacterial Infection Inflammation/Immunology
    Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages .
    Neotuberostemonine
  • HY-W742300
    Pipazethate hydrochloride

    SKF 70230A hydrochloride; SQ 15874 hydrochloride; Pipazetate hydrochloride

    		 GABA Receptor Inflammation/Immunology
    Pipazethate (SKF 70230A; SQ 15874) hydrochloride is a potent GABA antagonist. Pipazethate hydrochloride shows antitussive activity and can be used in research in cough suppressant .
    Pipazethate hydrochloride
  • HY-148144
    Clobutinol

    		Potassium Channel Cardiovascular Disease Inflammation/Immunology
    Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research .
    Clobutinol
  • HY-148144A
    Clobutinol hydrochloride

    		Potassium Channel Cardiovascular Disease Inflammation/Immunology
    Clobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research .
    Clobutinol hydrochloride
  • HY-N1471R
    Liquiritin apioside (Standard)

    		Others Inflammation/Immunology
    Liquiritin apioside (Standard) is the analytical standard of Liquiritin apioside. This product is intended for research and analytical applications. Liquiritin apioside, a main flavonoid component of licorice, possesses antitussive effects .
    Liquiritin apioside (Standard)
  • HY-B1895S
    Levodropropizine-d8

    (S)-(-)-Dropropizine-d8; DF-526-d8

    		 Isotope-Labeled Compounds Histamine Receptor Inflammation/Immunology Endocrinology
    Levodropropizine-d8 is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.
    Levodropropizine-d8
  • HY-13716S
    Noscapine-13C,d3

    		Isotope-Labeled Compounds Apoptosis Opioid Receptor Cancer
    Noscapine- 13C,d3 is a 13C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
    Noscapine-13C,d3
  • HY-W354753
    Homatropine hydrochloride

    		mAChR Others
    Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .
    Homatropine hydrochloride
  • HY-N0808
    Camphor
    2 Publications Verification

    (±)-Camphor

    		 TRP Channel Influenza Virus Infection Inflammation/Immunology Cancer
    Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
    Camphor
  • HY-121388
    Ledol

    (+)-Ledol

    		 Fungal Infection
    Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting .
    Ledol
  • HY-B1038
    L-Cysteine methyl ester hydrochloride

    		Endogenous Metabolite Inflammation/Immunology
    L-Cysteine methyl ester hydrochloride is an antitussive, phlegmolytic agent used to relieve breathing difficulties caused by large amounts of phlegm. L-Cysteine methyl ester hydrochloride is a copper corrosion inhibitor used in various industrial studies .
    L-Cysteine methyl ester hydrochloride
  • HY-B1032R
    Dropropizine (Standard)

    (±)-Dropropizine (Standard); UCB-196 (Standard)

    		 Others Neurological Disease
    Dropropizine (Standard) is the analytical standard of Dropropizine. This product is intended for research and analytical applications. Dropropizine ((±)-Dropropizine) is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .
    Dropropizine (Standard)

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