2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Tipepidine

Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect.

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Tipepidine Chemical Structure

Tipepidine Chemical Structure

CAS No. : 5169-78-8

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Tipepidine Related Antibodies

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Description

Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2].

IC50 & Target

IC50: 7.0 μM (dopamine D2 receptor)[1]
In Vivo

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2]
Dosage: 10, 20 and 40 mg/kg.
Administration: I.p.; 0.5, 5, 23 hours.
Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.
Clinical Trial
Molecular Weight

275.43

Formula

C15H17NS2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tipepidine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tipepidine5169-78-8Potassium ChannelKcsAantidepressant-likenon-narcotic antitussivedopamineGIRKInhibitorinhibitorinhibit

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