2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. TRK-851

RK-851 is a highly selective and orally active δ-opioid receptor antagonist, with a negative logarithm of the antagonist concentration (pA2) of 8.84. TRK-851 exhibits the selectivity for the δ receptor of more than 100 times higher than that for the μ or κ receptors. TRK-851 exhibits a potent antitussive effect in a rat model of capsaicin-induced cough. TRK-851 can be used for research on antitussive effects.

For research use only. We do not sell to patients.

TRK-851

TRK-851 Chemical Structure

CAS No. : 189015-24-5

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TRK-851 Related Antibodies

Top Publications Citing Use of Products

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

RK-851 is a highly selective and orally active δ-opioid receptor antagonist, with a negative logarithm of the antagonist concentration (pA2) of 8.84. TRK-851 exhibits the selectivity for the δ receptor of more than 100 times higher than that for the μ or κ receptors. TRK-851 exhibits a potent antitussive effect in a rat model of capsaicin-induced cough. TRK-851 can be used for research on antitussive effects[1].

IC50 & Target[1]

δ Opioid Receptor/DOR

8.84 (pA2)

Molecular Weight

472.55

Formula

C29H29FN2O3
CAS No.
SMILES

OC1=CC=C2C3=C1O[C@](C4=C(C5=CC(F)=CC6=C5N4CCC6)C7)([H])[C@@]3(CC8)[C@@]7(O)[C@]([H])(N8CC9CC9)C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRK-851 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRK-851189015-24-5TRK851TRK 851Opioid Receptorδ opioid receptor antagonistsNaltrindoleAntitussiveMetabolismStructure-activity relationshipPharmacokineticsDrug designInhibitorinhibitorinhibit

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