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Results for "

HSC/HPCs

" in MedChemExpress (MCE) Product Catalog:

74

Inhibitors & Agonists

2

Fluorescent Dye

10

Biochemical Assay Reagents

3

Peptides

2

Inhibitory Antibodies

9

Natural
Products

3

Recombinant Proteins

1

Isotope-Labeled Compounds

5

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155786
    3,7-DMF

    		TGF-beta/Smad Others
    3,7-DMF is an orally active inhibitor of TGF-β1-induced activation of HSCs. 3,7-DMF induces antioxidant genes and quenches ROS away, which can be used to study liver fibrosis .
    3,7-DMF
  • HY-N3619
    Conophylline
    1 Publications Verification

    		 Apoptosis Neurological Disease Endocrinology
    Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis .
    Conophylline
  • HY-D1613
    BODIPY FL C5-HPC

    		Fluorescent Dye Others
    BODIPY FL C5-HPC is a lipophilic green fluorescent dye (Ex/Em: 500/510 nm) .
    BODIPY FL C5-HPC
  • HY-106420
    16,16-Dimethyl prostaglandin E2

    16,16-dimethyl PGE2

    		 Wnt Prostaglandin Receptor Inflammation/Immunology
    16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway .
    16,16-Dimethyl prostaglandin E2
  • HY-134258
    MEISi-1

    		HOXA Cardiovascular Disease Others Cancer
    MEISi-1 is a homeodomain inhibitor of small molecule MEIS1 protein. MEISi-1 significantly inhibited the activity of luciferase reporter genes containing MEIS binding sites (TGACAG) and induced self-renewal of mouse and human HSCS in vitro and in vivo. MEISi-1 can be used for research in blood diseases, heart regeneration and cancer .
    MEISi-1
  • HY-119582
    Safironil

    		MMP Inflammation/Immunology
    Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation .
    Safironil
  • HY-175496
    Acid Ceramidase-IN-3

    		Ceramidase Inflammation/Immunology
    Acid Ceramidase-IN-3 is a acid ceramidase (aCDase) inhibitor. Acid Ceramidase-IN-3 inhibits the enzymatic activity of aCDase with a pIC 50 of 8.5 in enzymatic assays and 6.8 in A375 melanoma cellular assays. Acid Ceramidase-IN-3 promotes HSC inactivation, as measured by a dose-dependent reduction in COL1A1 and ACTA2. Acid Ceramidase-IN-3 inhibits aCDase activity in HSCs, promotes HSC inactivation and suppresses YAP/TAZ nuclear localization. Acid Ceramidase-IN-3 increases Dynein/Kinesin (NDE1, NDEL1. KIF3B, KIF15) while decreases several proteins involved with signaling pathway (SARM1, RGAP1, PDGF-D,PDGFR-B). Acid Ceramidase-IN-3 can be used for the study of fibrotic diseases .
    Acid Ceramidase-IN-3
  • HY-15001A
    Stemregenin 1 hydrochloride

    SR1 hydrochloride

    		 Aryl Hydrocarbon Receptor Others
    Stemregenin 1 hydrochloride is a purine derivative that antagonizes aryl hydrocarbon receptor signaling in CD34+ cells. IC50 The value is 127 nM. Stemregenin 1 hydrochloride can be used to expand the pluripotency of hematopoietic stem cells (HSC) in stem cell studies .
    Stemregenin 1 hydrochloride
  • HY-172087
    VDR agonist 3

    		VD/VDR Inflammation/Immunology
    VDR agonist 3 (Compound E15) is a potent vitamin D receptor (VDR) agonist. VDR agonist 3 can effectively inhibit HSC activation through VDR. VDR agonist 3 significantly reduces liver fibrosis without causing hypercalcemia in a CCl4-induced mouse liver fibrosis model .
    VDR agonist 3
  • HY-149899
    VDR agonist 2

    		VD/VDR Others
    VDR agonist 2 (compound 16i) is a VDR (vitamin D receptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC). VDR agonist 2 has significant anti-hepatic fibrosis effects both in vitro and in vivo .
    VDR agonist 2
  • HY-129453
    BOP sodium

    		Integrin Inflammation/Immunology
    BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins .
    BOP sodium
  • HY-100557B
    HPC, Viscosity(1%):150-400mPa.s

    Hydroxypropyl Cellulose, Viscosity(1%):150-400mPa.s

    		 Biochemical Assay Reagents Others
    HPC, Viscosity (1%):150-400mPa.s (Hydroxypropyl Cellulose, Viscosity (1%):150-400mPa.s) is a thickening agent. HPC, Viscosity(1%):150-400mPa.s is a kind of biological materials or organic compounds that are widely used in life science research .
    HPC, Viscosity(1%):150-400mPa.s
  • HY-100557H
    HPC, Viscosity(2%):95000-105000mPa.s

    Hydroxypropyl Cellulose, Viscosity(2%):95000-105000mPa.s

    		 Biochemical Assay Reagents Others
    HPC, Viscosity (2%):95000-105000mPa.s (Hydroxypropyl Cellulose, Viscosity (2%):95000-105000mPa.s) is a thickening agent. HPC, Viscosity(2%):95000-105000mPa.s is a kind of biological materials or organic compounds that are widely used in life science research .
    HPC, Viscosity(2%):95000-105000mPa.s
  • HY-100557E
    HPC, Viscosity(1%):1275-3500mPa.s

    Hydroxypropyl Cellulose, Viscosity(1%):1275-3500mPa.s

    		 Biochemical Assay Reagents Others
    HPC, Viscosity (1%):1275-3500mPa.s (Hydroxypropyl Cellulose, Viscosity (1%):1275-3500mPa.s) is a thickening agent. HPC, Viscosity(1%):1275-3500mPa.s is a kind of biological materials or organic compounds that are widely used in life science research .
    HPC, Viscosity(1%):1275-3500mPa.s
  • HY-100557C
    HPC, Viscosity(1%):4000-6500mPa.s

    Hydroxypropyl Cellulose, Viscosity(1%):4000-6500mPa.s

    		 Biochemical Assay Reagents Others
    HPC, Viscosity (1%):4000-6500mPa.s (Hydroxypropyl Cellulose, Viscosity (1%):4000-6500mPa.s) is a thickening agent. HPC, Viscosity(1%):4000-6500mPa.s is a kind of biological materials or organic compounds that are widely used in life science research .
    HPC, Viscosity(1%):4000-6500mPa.s
  • HY-100557D
    HPC, Viscosity(5%):75-150mPa.s

    Hydroxypropyl Cellulose, Viscosity(5%):75-150mPa.s, MW 100000

    		 Biochemical Assay Reagents Others
    HPC, Viscosity (5%):75-150mPa.s (Hydroxypropyl Cellulose, Viscosity (5%):75-150mPa.s, MW 100000) is a thickening agent. HPC, Viscosity(5%):75-150mPa.s is a kind of biological materials or organic compounds that are widely used in life science research .
    HPC, Viscosity(5%):75-150mPa.s
  • HY-178328
    VDR agonist 4

    		VD/VDR Collagen TGF-beta/Smad MMP JAK Metabolic Disease Inflammation/Immunology Endocrinology
    VDR agonist 4 is an orally active potent VDR agonist. VDR agonist 4 exerts VDR-dependent antifibrotic activity by regulating multiple fibrosis-related genes to suppress α-SMA and collagen I production, thereby inhibiting hepatic stellate cell (HSC) activation. VDR agonist 4 improves CCl4 (HY-RS16594)-induced hepatic fibrosis in mice. VDR agonist 4 can be used for liver fibrosis research .
    VDR agonist 4
  • HY-100557
    Hydroxypropyl Cellulose

    		Biochemical Assay Reagents Interleukin Related Metabolic Disease Inflammation/Immunology
    Hydroxypropyl Cellulose is an orally active cellulose ether and surfactant. Hydroxypropyl cellulose is divided into high-substituted HPC (HHPC) and low-substituted HPC (LHPC). Hydroxypropyl Cellulose reduces inflammatory mediators (IL-6, IL-1β). Hydroxypropyl Cellulose improves colitis and obesity. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier .
    Hydroxypropyl Cellulose
  • HY-P99488
    Briquilimab

    JSP-191; AMG-191

    		 c-Kit Inflammation/Immunology Cancer
    Briquilimab (JSP-191 or AMG-191) is a humanized IgG1 monoclonal antibody that binds human CD117 (c-Kit). Briquilimab blocks the interaction between CD117 receptor and stem cell factor on various CD117 expressing tissues. Briquilimab can lead to inhibition of SCF/c-Kit signaling and MC apoptosis. Briquilimab is a non-toxic approach to target and deplete HSC, enabling blood and immune reconstitution with minimal toxicity with the other agents being used for transient immune suppression to prevent immunologic rejection. Briquilimab can be used in various disease research such as severe combined immunodeficiency (SCID), myelodyplastic syndromes (MDS), acute myeloid leukemia (AML), chronic spontaneous urticarial (CSU), chronic inducible urticarial (CIndU) and asthema .
    Briquilimab
  • HY-115893A
    P18IN005 hydrochloride

    		CDK Cancer
    P18IN005 hydrochloride is a novel inhibitor of p18, exhibiting potent activity in negatively regulating haematopoietic stem cell (HSC) self-renewal. P18IN005 hydrochloride has been shown to be more effective than p27 in inhibiting HSC self-renewal in mouse models. P18IN005 hydrochloride promotes the expansion of functional HSCs in short-term cultures. P18IN005 hydrochloride serves as a valuable tool for dissecting the signaling pathways involved in stem cell self-renewal.
    P18IN005 hydrochloride
  • HY-138993
    NNMT-IN-6

    		Amine N-methyltransferase Cancer
    NNMT-IN-6 (compound 78) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.41 μM and a Kd of 5.6 μM. NNMT-IN-6 shows an inhibitory effect on the cell proliferation of the HSC-2 human oral cancer cell line .
    NNMT-IN-6
  • HY-138993A
    NNMT-IN-6 hydrochloride

    		Amine N-methyltransferase Cancer
    NNMT-IN-6 hydrochloride (compound 78) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.41 μM and a Kd of 5.6 μM. NNMT-IN-6 hydrochloride shows an inhibitory effect on the cell proliferation of the HSC-2 human oral cancer cell line .
    NNMT-IN-6 hydrochloride
  • HY-127106
    VU0810464
    1 Publications Verification

    		 Potassium Channel Neurological Disease
    VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC50=165 nM) and GIRK1/4 (EC50=720 nM) channels with improved brain penetration .
    VU0810464
  • HY-116664
    DPQZ

    		Apoptosis Ras Raf Caspase Cancer
    DPQZ is an anti-tubulin agent that inhibits cell separation and induces cell cycle arrest at the G2/M phase. In addition, DPQZ induces caspase-dependent apoptosis of HSC-3 cells by inhibiting Ras/Raf and activating MAP kinase. DPQZ can be used in the study of oral cancer .
    DPQZ
  • HY-108420
    INK4C-IN-2
    1 Publications Verification

    		 CDK Cancer
    INK4C-IN-2 (Compound 40) is the inhibitor for INK4C (also known as p18) and the activator for CDK4/6. INK4C-IN-2 increases the number and expansion capacity of mouse and human hematopoietic stem cells (HSCs) with EC50 of 5.21 nM, promotes the self-renewal and multilineage differentiation of HSCs. INK4C-IN-2 improves the expansion and long-term hematopoietic reconstruction ability of HSCs in mouse bone marrow transplantation model .
    INK4C-IN-2
  • HY-177267
    Camptothecin derivative-3

    		Drug Derivative ADC Payload Cancer
    Camptothecin derivative-3 (Compound 11) is a derivative of Camptothecin (HY-16560) and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC50 values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research .
    Camptothecin derivative-3
  • HY-111244
    DCB-3503

    		CDK HSP Others
    DCB-3503 is an allosteric modulator of heat shock cognate protein HSC70 and an inhibitor of Cyclin D1. DCB-3503 inhibits Cyclin D1 translation by allosterically modulating the ATPase and chaperone activities of HSC70. DCB-3503 may inhibit malignancies such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1 .
    DCB-3503
  • HY-133387
    HS-C6-PEG9-acid

    		PROTAC Linkers Cancer
    HS-C6-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    HS-C6-PEG9-acid
  • HY-15098
    Apoptozole
    10+ Cited Publications

    Apoptosis Activator VII

    		 HSP Apoptosis Cancer
    Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
    Apoptozole
  • HY-100791
    NSC23005 sodium
    1 Publications Verification

    		 Others Cancer
    NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.
    NSC23005 sodium
  • HY-N11644
    Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid

    		Others Cancer
    Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid, also known as ganoderic acid 24. Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid shows high cytotoxicity against cancer cells, such as human lung cancer cells CH27, melanoma cells M21, and oral cancer cells HSC-3 .
    Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid
  • HY-120942
    XIE18-6

    		CDK Cancer
    XIE18-6 is a potent INK4C (p18) inhibitor. XIE18-6 shows potent bioactivity in hematopoietic stem cells (HSCs) expansion with an ED50 of 105.5 nM .
    XIE18-6
  • HY-134259
    MEISi-2

    		HOXA Cancer
    MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer .
    MEISi-2
  • HY-113806
    (±)-Trolline

    (±)-Oleracein E

    		 Bacterial Influenza Virus Apoptosis Infection Inflammation/Immunology
    (±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis .
    (±)-Trolline
  • HY-10941
    VER-155008
    30+ Cited Publications

    		 HSP Autophagy Neurological Disease Cancer
    VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
    VER-155008
  • HY-N13117
    Pinocembrin 7-O-[4′′,6′′-(S)-HHDP]-β-D-glucoside

    		Others Cancer
    Pinocembrin 7-O-[4′′,6′′-(S)-HHDP]-β-D-glucoside (compound 3) is a polyphenol that has weak antiproliferative activity in PDGF-induced HSC-T6 cells (IC50: 200 μM) .
    Pinocembrin 7-O-[4′′,6′′-(S)-HHDP]-β-D-glucoside
  • HY-123535
    P18IN003

    		CDK Inflammation/Immunology
    P18IN003 is a potent p18(INK4C) inhibitor andspecifically block the activity of p18 protein. P18IN003 has the potential to be aneffective chemical agent for therapeutic expansion of HSC .
    P18IN003
  • HY-N3523
    3-O-Beta-D-Glucopyranosylplatycodigenin

    		Others Cancer
    3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC50 of 13.36 μM .
    3-O-Beta-D-Glucopyranosylplatycodigenin
  • HY-10046
    Plerixafor
    Maximum Cited Publications
    90 Publications Verification

    AMD 3100; JM3100; SID791

    		 CXCR HIV Infection Inflammation/Immunology Endocrinology Cancer
    Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM .
    Plerixafor
  • HY-172275A
    DSPE-PEG2000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)

    		Liposome Inflammation/Immunology
    DSPE-PEG2000-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG2000-pPB can be used for drug delivery .
    DSPE-PEG2000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)
  • HY-172275
    DSPE-PEG1000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)

    		Liposome Inflammation/Immunology
    DSPE-PEG1000-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG1000-pPB can be used for drug delivery .
    DSPE-PEG1000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)
  • HY-172275B
    DSPE-PEG5000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)

    		Liposome Inflammation/Immunology
    DSPE-PEG5000-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG5000-pPB can be used for drug delivery .
    DSPE-PEG5000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)
  • HY-172275C
    DSPE-PEG3400-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)

    		Liposome Inflammation/Immunology
    DSPE-PEG3400-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG3400-pPB can be used for drug delivery .
    DSPE-PEG3400-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)
  • HY-W107409
    Meridianin C

    		Others Cancer
    Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation .
    Meridianin C
  • HY-W024604
    4,4-Dimethyl-2-cyclopenten-1-one

    4,4-Dimethylcyclopent-2-enone

    		 Others Cancer
    4,4-Dimethyl-2-cyclopenten-1-one, a natural compound from Apocyniveneti Folium, displays higher tumor-specific cytotoxicity .
    4,4-Dimethyl-2-cyclopenten-1-one
  • HY-162605
    CYD0682

    		STAT HSP Cancer
    CYD0682 is an analog of Oridonin (HY-N0004). CYD0682 attenuates STAT3 activation and ECM production via an HSP90 pathway in hepatic stellate cells .
    CYD0682
  • HY-155801
    CRX 527

    		Toll-like Receptor (TLR) Inflammation/Immunology Cancer
    CRX 527 is a ligand of TLR4 and also serves as an adjuvant for peptide-based cancer vaccines, showing potential to enhance anti-tumor immune responses. CRX 527 can also induce HSC differentiation, increase the proportion and quantity of LSK cells, and promote their differentiation into macrophages, activating immune defense and protecting intestinal epithelium from radiation damage .
    CRX 527
  • HY-10046S
    Plerixafor-d4

    		Isotope-Labeled Compounds CXCR HIV Infection Inflammation/Immunology Endocrinology Cancer
    Plerixafor-d4 is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM .
    Plerixafor-d4
  • HY-131831A
    6-Bn-ADP sodium

    N6-benzyl ADP sodium

    		 ATP Synthase Cancer
    6-Bn-ADP (N6-benzyl ADP) sodium is a derivative of Adenosine 5'-diphosphate (ADP) (HY-W010918) that inhibits ATP hydrolysis. 6-Bn-ADP sodium inhibits the ATPase activities of Mortalin, Hsc70, and Hsp70 protein with Kis of 86.51 μM, 294.5 μM, and 1612 μM, respectively .
    6-Bn-ADP sodium
  • HY-10046R
    Plerixafor (Standard)

    AMD 3100 (Standard); JM3100 (Standard); SID791 (Standard)

    		 Reference Standards CXCR HIV Infection Inflammation/Immunology Endocrinology Cancer
    Plerixafor (Standard) is the analytical standard of Plerixafor. This product is intended for research and analytical applications. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM .
    Plerixafor (Standard)

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