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Results for "

FGF-R2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibody-Drug Conjugates (ADCs) (1) Apoptosis (15) Aurora Kinase (2) c-Fms (2) CDK (1) Cytochrome P450 (2) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) E3 Ligase Ligand-Linker Conjugates (1) EGFR (2) Endogenous Metabolite (4) ERK (2) FAK (1) FGFR (97) FLT3 (3) GSK-3 (1) HDAC (1) Isotope-Labeled Compounds (2) JAK (1) Microtubule/Tubulin (1) mRNA (1) p38 MAPK (1) PDGFR (6) PROTAC Linkers (1) PROTACs (3) Reactive Oxygen Species (ROS) (1) Reference Standards (5) SHP2 (1) Small Interfering RNA (siRNA) (3) Src (6) VEGFR (11)
By Research Areas:	Cancer (99) Cardiovascular Disease (4) Endocrinology (1) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) mRNA (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

106

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS04916

Fgfr2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgfr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgfr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgfr2 Mouse Pre-designed siRNA Set A Fgfr2 Mouse Pre-designed siRNA Set A

HY-162626

FGFR2 degrader 1	PROTACs FGFR	Cancer
FGFR2 degrader 1 (compound 28E) is a selectively PROTACS degrader of *FGFR2, with the DC₅₀* of 0.645 nM. FGFR2 plays an important role in cancer research (Pink: ligand of target protein; (HY-13304) black: linker; blue: ligand of E3 ligase) .

HY-E70827

FGFR2 V564L Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 V564L is a mutant of FGFR3. FGFR2 V564L Recombinant Human Active Protein Kinase is a recombinant FGFR2 V564L protein that can be used to study FGFR2 V564L-related functions .

HY-E70818

FGFR2 K659M Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 K659M is a mutant of FGFR3. FGFR2 K659M Recombinant Human Active Protein Kinase is a recombinant FGFR2 K659M protein that can be used to study FGFR2 K659M-related functions .

HY-E70815

FGFR2 K526E Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 K526E is a mutant of FGFR3. FGFR2 K526E Recombinant Human Active Protein Kinase is a recombinant FGFR2 K526E protein that can be used to study FGFR2 K526E-related functions .

HY-E70825

FGFR2 V564F Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 V564F is a mutant of FGFR3. FGFR2 V564F Recombinant Human Active Protein Kinase is a recombinant FGFR2 V564F protein that can be used to study FGFR2 V564F-related functions .

HY-E70826

FGFR2 V564I Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 V564I is a mutant of FGFR3. FGFR2 V564I Recombinant Human Active Protein Kinase is a recombinant FGFR2 V564I protein that can be used to study FGFR2 V564I-related functions .

HY-E70814

FGFR2 C491S Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 C491S is a mutant of FGFR3. FGFR2 C491S Recombinant Human Active Protein Kinase is a recombinant FGFR2 C491S protein that can be used to study FGFR2 C491S-related functions .

HY-E70817

FGFR2 K641R Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 K641R is a mutant of FGFR3. FGFR2 K641R Recombinant Human Active Protein Kinase is a recombinant FGFR2 K641R protein that can be used to study FGFR2 K641R-related functions .

HY-E70820

FGFR2 L617V Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 L617V is a mutant of FGFR3. FGFR2 L617V Recombinant Human Active Protein Kinase is a recombinant FGFR2 L617V protein that can be used to study FGFR2 L617V-related functions .

HY-E70821

FGFR2 M537I Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 M537I is a mutant of FGFR3. FGFR2 M537I Recombinant Human Active Protein Kinase is a recombinant FGFR2 M537I protein that can be used to study FGFR2 M537I-related functions .

HY-E70824

FGFR2 R612T Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 R612T is a mutant of FGFR3. FGFR2 R612T Recombinant Human Active Protein Kinase is a recombinant FGFR2 R612T protein that can be used to study FGFR2 R612T-related functions .

HY-E70819

FGFR2 K659N Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 K659N is a mutant of FGFR3. FGFR2 K659N Recombinant Human Active Protein Kinase is a recombinant FGFR2 K659N protein that can be used to study FGFR2 K659N-related functions .

HY-E70816

FGFR2 K641N Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 K641N is a mutant of FGFR3. FGFR2 K641N Recombinant Human Active Protein Kinase is a recombinant FGFR2 K641N protein that can be used to study FGFR2 K641N-related functions .

HY-RS04915

FGFR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) FGFR	Others
FGFR2 Human Pre-designed siRNA Set A contains three designed siRNAs for FGFR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FGFR2 Human Pre-designed siRNA Set A FGFR2 Human Pre-designed siRNA Set A

HY-RS04917

Fgfr2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgfr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgfr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgfr2 Rat Pre-designed siRNA Set A Fgfr2 Rat Pre-designed siRNA Set A

HY-E70823

FGFR2 N549K Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 N549K is a mutant of FGFR3. FGFR2 N549K Recombinant Human Active Protein Kinase is a recombinant FGFR4 N535K protein that can be used to study FGFR4 N535K-related functions .

HY-E70822

FGFR2 N549H Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR2 is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. FGFR2 N549H is a mutant of FGFR3. FGFR2 N549H Recombinant Human Active Protein Kinase is a recombinant FGFR4 N535H protein that can be used to study FGFR4 N535H-related functions .

HY-162865

FGFR2-IN-3	FGFR	Cancer
FGFR2-IN-3 is an inhibitor of fibroblast growth factor receptor 2 (FGFR2). FGFR2-IN-3 has good binding properties, forming key interactions and inducing conformational changes in FGFR2. FGFR2-IN-3 can be used for research on tumors .

HY-145230

FGFR2-IN-1	FGFR	Others
FGFR2-IN-1 is a selective *FGFR2* inhibitor with an IC₅₀ of 140 nM.

HY-145231

FGFR2-IN-2	FGFR	Cancer
FGFR2-IN-2 (Compound 38) is a selective *FGFR2* inhibitor with IC₅₀s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively .

HY-170919

FGFR2/3-IN-2	FGFR	Cancer
FGFR2/3-IN-2 (compound 10) is an orally active *FGFR2* and *FGFR3* inhibitor. FGFR2/3-IN-2 inhibits *FGFR2* and *FGFR3* with IC₅₀s of 3.7 nM and 31.2 nM (preincubation time 1 h), respectively. FGFR2/3-IN-2 spares *FGFR1/4* and other kinases without causing diarrhea and serum phosphate elevation in vivo. FGFR2/3-IN-2 induces tumor stasis or regression in the SNU-16 gastric cancer model .

HY-176547

FGFR2/3-IN-3	FGFR Cytochrome P450	Endocrinology
FGFR2/3-IN-3 is a dual-target *FGFR2/3* inhibitor with IC₅₀s of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), respectively. FGFR2/3-IN-3 has effective activity against both wild-type and mutant *FGFR3. FGFR2/3-IN-3 has low CYP3A4* inhibitory effect and hERG toxicity. FGFR2/3-IN-3 improves the imbalance between chondrocyte proliferation and differentiation and promotes bone growth by inhibiting the signaling pathway mediated by mutant *FGFR3. FGFR2*/3-IN-3 shows a growth-promoting effect in a dwarfism mouse model and has the potential to study bone development disorder-related diseases such as achondroplasia (ACH) .

HY-151903S

FGFR2/3-IN-1	FGFR	Cancer
FGFR2/3-IN-1 is a potent and selective FGFR2 and FGFR3 (FGFR) inhibitor with IC₅₀s of 1 nM and 0.5 nM, respectively. FGFR2/3-IN-1 displays >40-fold selectivity over FGFR1/FGFR4 and other kinome. FGFR2/3-IN-1 also inhibits FGFR3 V555L and V555M mutants with IC₅₀s of 2.7 nM and 6.1 nM, respectively .

HY-174689

*Human FGFR2* mRNA**	mRNA	Cancer
Human FGFR2 mRNA encodes the human fibroblast growth factor receptor 2 (FGFR2) protein, a member of the fibroblast growth factor receptor (FGFR) family. The extracellular portion of FGFR2 protein can interact with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

HY-163985

*PROTAC FGFR2* degrader 1**	PROTACs FGFR Apoptosis	Cancer
PROTAC FGFR2 degrader 1 (compound N5) is a PROTAC that effectively targets FGFR2 with DC₅₀ of 6.46 nM, the *FGFR2* IC₅₀ is 0.08 nM. PROTAC FGFR2 degrader 1 has anti-proliferative activity and highly selective, induces G0/G1 arrest of KATOIII and SNU16 cell cycle and inhibits apoptosis by reducing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. PROTAC FGFR2 degrader 1 inhibits gastric cancer cells remained above 50% at a concentration of 0.17 nM. PROTAC FGFR2 degrader 1 potently inhibits the growth of SNU16 xenograft tumors in mouse model (Structure Note: Pink, FGFR2 activator: HY-18708; Blue, E3 ligase ligand: HY--10984; Black, linker: HY-163989; E3 ligase ligand + linker：HY-163986) .

HY-141685

3-Methylthienyl-carbonyl-JNJ-7706621	CDK GSK-3 VEGFR FGFR	Cancer
3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective inhibitor of cyclin-dependent kinase (CDK), with IC₅₀s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. 3-Methylthienyl-carbonyl-JNJ-7706621 also shows potent inhibition of GSK-3 (IC₅₀=0.041 μM) and modest potency against CDK4, *VEGF-R2, and FGF-R2* (IC₅₀=0.11, 0.13, 0.22 μM, respectively). 3-Methylthienyl-carbonyl-JNJ-7706621 can be used for the research of cancer .

HY-P99007

Aprutumab BAY 1179470	FGFR	Cancer
Aprutumab (BAY 1179470) is a fully human *FGFR2* monoclonal antibody, which binds to the FGFR2 isoforms FGFR2-IIIb and FGFR2-IIIc. Aprutumab has the potential for solid tumors research .

HY-163620

LHQ490	FGFR Apoptosis	Cancer
LHQ490 is a selective *FGFR2* inhibitor, with an IC₅₀ of 5.2 nM. LHQ490 efficiently inhibits the proliferation of BaF3-FGFR2 cells with an IC₅₀ value of 1.4 nM. LHQ490 inhibits FGFR2-driven cancer cell proliferation and induces apoptosis of FGFR2-driven cancer cells .

HY-174974

ISM7594	FGFR	Cancer
ISM7594 is an orally active *FGFR2/3* inhibitor. ISM7594 shows broad-spectrum antiproliferative potency in *FGFR2- or FGFR3*-altered cancer cell panels, including *FGFR2/3* amplification, fusion, and mutation (BaF3-TEL-FGFR2-V564F (IC₅₀ = 0.067 nM), BaF3-TEL-FGFR2-V564I (IC₅₀ = 2 nM)) types. ISM7594 inhibits tumor growth in a dose-dependent manner. ISM7594 can be used for the study of advanced solid tumors with FGFR2/3 aberrations .

HY-170934

BW710	FGFR	Cancer
BW710 is an orally active fibroblast growth factor receptor 2 (FGFR2) inhibitor. BW710 inhibits the proliferation of BaF3-FGFR2 cells with an IC₅₀ of 2.8 nM. BW710 abolishes *FGFR2* enzymatic activity and is selective against other 75 tyrosine kinases including *FGFR1, FGFR3, and FGFR4* at 1 μM. BW710 suppresses the *FGFR2* signaling and selectively inhibits *FGFR2*-driven cancer cell proliferation. BW710 displays reasonable pharmacokinetic properties with an oral bioavailability of 29 % in mice .

HY-149843

LC-MB12	FGFR PROTACs	Cancer
LC-MB12 is an orally active PROTAC compound targets *FGFR2* degradation with a DC₅₀ of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits *FGFR2* signaling in gastric cancer cells and has anti-tumor activity .

HY-172923

FGFR-IN-20	FGFR	Cancer
Glu-IN-1 (compound AF1) is a covalent and selective *FGFR2* inhibitor with an IC₅₀ of 1.6 μM. Glu-IN-1 covalently modifies Glu489 in FGFR2 .

HY-175743

TYRA-200	FGFR	Cancer
TYRA-200 is an orally active *FGFR1/2/3* inhibitor. TYRA-200 shows dose-dependent tumor regression in both wild-type FGFR2 and FGFR2 mutant mice model. TYRA-200 can be used for advanced or metastatic intrahepatic cholangiocarcinoma and other FGFR2-driven solid tumors research .

HY-147250A

Lirafugratinib hydrochloride 1 Publications Verification RLY-4008 hydrochloride	FGFR	Cancer
Lirafugratinib (RLY-4008) hydrochloride is an orally active, irreversible and highly selective *FGFR2* inhibitor with an IC₅₀ of 3 nM. Lirafugratinib hydrochloride covalently binds to Cys491. Lirafugratinib hydrochloride targets FGFR2 primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs .

HY-147250

Lirafugratinib 1 Publications Verification RLY-4008	FGFR	Cancer
Lirafugratinib (RLY-4008) is an orally active, irreversible and highly selective *FGFR2* inhibitor with an IC₅₀ of 3 nM. Lirafugratinib covalently binds to Cys491. Lirafugratinib targets FGFR2 primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs .

HY-141600

Aprutumab ixadotin BAY 1187982	Antibody-Drug Conjugates (ADCs) FGFR Microtubule/Tubulin Apoptosis	Cancer
Aprutumab ixadotin (BAY 1187982) is the first antibody-drug conjugate (ADC) to target *FGFR2* and the first to use Auristatin-based payload. Aprutumab ixadotin contains a fully human anti-FGFR2 monoclonal antibody (Aprutumab) (HY-P99007) conjugated by lysine side chains to a non-cleavable linker and via this an innovative Auristatin W derivative. Aprutumab ixadotin can be used for the study of advanced solid tumors, such as FGFR2-positive gastric cancer and triple-negative breast cancer ^[2].

HY-P991583

GP369	FGFR ERK	Cancer
GP369 is a humanized *FGFR2-IIIb*-specific antibody. GP369 significantly inhibits the proliferation of tumor cells. GP369 can significantly inhibit phosphorylation of FGFR2 and downstream signaling pathways. GP369 can be used for research on cancer such as gastric cancer and breast cancer .

HY-N0183

Formononetin 15+ Cited Publications Biochanin B; Flavosil; Formononetol	FGFR Apoptosis	Cardiovascular Disease Cancer
Formononetin is a potent *FGFR2* inhibitor with an IC₅₀ of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth .

HY-163989

N-Ethylheptanamide	PROTAC Linkers	Cancer
N-Ethylheptanamide is a PROTAC linker. N-Ethylheptanamide can be used in synthesis PROTAC FGFR2 degrader 1 (HY-163985) .

HY-17601

Alofanib 4 Publications Verification RPT835	FGFR Apoptosis	Cardiovascular Disease Cancer
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity ^[2].

HY-117595

PHM16	FAK FGFR Apoptosis	Cancer
PHM16 is an ATP competitive inhibitor of FAK and *FGFR2* (IC₅₀: 0.4 μM and 0.37 μM, respectively), with direct potent anti-angiogenic activity .

HY-18602

FIIN-2	FGFR	Cancer
FIIN-2 is an irreversible inhibitor of *FGFR* with an IC₅₀ of 3.1, 4.3, 27, and 45 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.

HY-145043

FGFR-IN-1	FGFR	Cancer
FGFR-IN-1 is a potent *FGFR* inhibitor with an IC₅₀ of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219) .

HY-N0060

Ferulic acid 10+ Cited Publications Coniferic acid	FGFR Endogenous Metabolite	Cancer
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-N0060A

Ferulic acid sodium 10+ Cited Publications Coniferic acid sodium	FGFR Endogenous Metabolite Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-18603

FIIN-3	EGFR FGFR	Cancer
FIIN-3 is an irreversible inhibitor of *FGFR* with an IC₅₀ of 13.1, 21, 31.4, and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.

HY-101544

ARQ 069	FGFR	Cancer
ARQ 069, an analog of ARQ 523, inhibits *FGFR* in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases (IC₅₀s of 0.84 μM and 1.23 μM, respectively). ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC₅₀s of 2.8 and 1.9 μM, respectively) through a mechanism in a non-ATP competitive dependent manner .

HY-162577

FGFR-IN-14	FGFR	Cancer
FGFR-IN-14 (compound 10h) is a *pan-FGFR* inhibitor. FGFR-IN-14 inhibits FGFR1, FGFR2, FGFR3 and FGFR2 V564F gatekeeper mutant with IC₅₀s of 46, 41, 99, and 62 nM, respectively. FGFR-IN-14 strongly suppresses NCI-H520 lung cancer cells, SNU-16 and KATO III gastric cancer cells proliferation with IC₅₀s of 19, 59, and 73 nM, respectively .

HY-13304

LY2874455 3 Publications Verification	FGFR	Cancer
LY2874455 is a *pan-FGFR* inhibitor with IC₅₀s of 2.8, 2.6, 6.4, 6 nM for *FGFR1, FGFR2, FGFR3, FGFR4*, respectively.

Cat. No.	Product Name	Target	Research Area

HY-P99007

Aprutumab BAY 1179470	FGFR	Cancer
Aprutumab (BAY 1179470) is a fully human *FGFR2* monoclonal antibody, which binds to the FGFR2 isoforms FGFR2-IIIb and FGFR2-IIIc. Aprutumab has the potential for solid tumors research .

HY-141600

Aprutumab ixadotin BAY 1187982	Antibody-Drug Conjugates (ADCs) FGFR Microtubule/Tubulin Apoptosis	Cancer
Aprutumab ixadotin (BAY 1187982) is the first antibody-drug conjugate (ADC) to target *FGFR2* and the first to use Auristatin-based payload. Aprutumab ixadotin contains a fully human anti-FGFR2 monoclonal antibody (Aprutumab) (HY-P99007) conjugated by lysine side chains to a non-cleavable linker and via this an innovative Auristatin W derivative. Aprutumab ixadotin can be used for the study of advanced solid tumors, such as FGFR2-positive gastric cancer and triple-negative breast cancer ^[2].

HY-P991583

GP369	FGFR ERK	Cancer
GP369 is a humanized *FGFR2-IIIb*-specific antibody. GP369 significantly inhibits the proliferation of tumor cells. GP369 can significantly inhibit phosphorylation of FGFR2 and downstream signaling pathways. GP369 can be used for research on cancer such as gastric cancer and breast cancer .

HY-P991584

HuGAL-FR21	FGFR	Cancer
HuGAL-FR21 is a humanized antiFGFR2IIIb IgG1 monoclonal antibody. HuGAL-FR21 can block the binding of *FGF2, FGF7, and FGF10* to FGFR2IIIb and inhibit FGF-induced phosphorylation of FGFR2IIIb. HuGAL-FR21 can downregulate the expression of *FGFR2* in SNU-16 cells. HuGAL-FR21 shows the significant anti-tumor activity in athymic nude mice bearing gastric cancer xenograft models. HuGAL-FR21 can be used for research on cancer such as gastric cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0183

Formononetin Maximum Cited Publications 18 Publications Verification Biochanin B; Flavosil; Formononetol	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Flavonoids other families Leguminosae Sunscreen Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones	FGFR Apoptosis
Formononetin is a potent *FGFR2* inhibitor with an IC₅₀ of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth .

HY-N0060

Ferulic acid 10+ Cited Publications Coniferic acid	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols other families Simple Phenylpropanols Sunscreen Phenols Phenylpropanoids Cosmetic Research Disease Research Fields Cancer	FGFR Endogenous Metabolite
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-N0060A

Ferulic acid sodium 10+ Cited Publications Coniferic acid sodium	Structural Classification Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Endogenous metabolite Disease Research Fields Cancer	FGFR Endogenous Metabolite Reactive Oxygen Species (ROS)
Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-N0183R

Formononetin (Standard) Biochanin B (Standard); Flavosil (Standard); Formononetol (Standard)	Structural Classification Flavonoids other families Leguminosae Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Glycyrrhiza uralensis Fisch. Isoflavones	Reference Standards FGFR Apoptosis
Formononetin (Standard) is the analytical standard of Formononetin. This product is intended for research and analytical applications. Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth .

HY-N0060R

Ferulic acid (Standard) Coniferic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols other families Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Endogenous metabolite	Reference Standards FGFR Endogenous Metabolite
Ferulic acid (Standard) is the analytical standard of Ferulic acid. This product is intended for research and analytical applications. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

HY-N7715

Ferulic acid acyl-β-D-glucoside Ferulic acid glucoside	Structural Classification Monophenols Classification of Application Fields Simple Phenylpropanols Source classification Rosaceae Other Diseases Phenols Phenylpropanoids Plants Aruncus sylvester Kostel. Disease Research Fields	Drug Metabolite
Ferulic acid acyl-β-D-glucoside (Ferulic acid glucoside) is a metabolite of Ferulic Acid (HY-N0060). Ferulic acid acyl-β-D-glucoside can be isolated from flaxseed extract. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀ values of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively ^[2] .

HY-N9507

Picrasidine Q	Alkaloids Structural Classification other families Classification of Application Fields Source classification Quinoline Alkaloids Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis FGFR
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits *FGFR2* kinase activity .

Recombinant Proteins Recommended:

Species:	Human (19) Mouse (3) Cynomolgus (1)
Tag:	His (15) Avi (6) GST (1) Fc (7)
Source:	HEK293 (21) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P72645

	FGFR-2 alpha (IIIc) Protein, Human (HEK293, Fc) BEK, FGFR2IIIc; CD332; FGF R2b; FGFR2 beta; FGFR2; FGFR2b; Fibroblast growth factor receptor 2 (IIIc)	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72646

	FGFR-2 beta (IIIb) Protein, Human (HEK293, His) BFR-1; FGFR2IIIb; KGFR; CD332; FGF R2b; FGFR2 beta; FGFR2; FGFR2b; Fibroblast growth factor receptor 2 (IIIb)	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 beta IIIb protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78125

	FGFR-2 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) FGF R2a; FGFR2 alpha; KGFR; CD332; BBDS; BEK; BFR-1; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; FLJ98662	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78131

	FGFR-2 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) FGF R2a; FGFR2 alpha; KGFR; CD332; BBDS; BEK; BFR-1; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; FLJ98662	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P76340

	FGFR-2 Protein, Mouse (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Mouse	HEK293
	FGFR-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-2, expressed by HEK293 , with C-6*His labeled tag.

HY-P76336

	FGFR-2 alpha (IIIb) Protein, Human (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIb) Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-His labeled tag.

HY-P72647

	FGFR-2 beta (IIIc) Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIc) Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 beta IIIc protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76339

	FGFR-2 Protein, Mouse (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Mouse	HEK293
	FGFR2, also known as CD332 (differentiated cluster 332), is a receptor for fibroblast growth factor. FGFR2 is involved in activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR2 up-regulates PAI-1 via JAK2/STAT3 signaling and induces M2 polarization in colorectal cancer macrophages. FGFR-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76333

	FGFR-2 Protein, Human (sf9, His-GST) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	Sf9 insect cells
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 Protein, Human (sf9, His-GST) is the recombinant human-derived FGFR-2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P76334

	FGFR-2 alpha (IIIb) Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIb) Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76337

	FGFR-2 alpha (IIIc) Protein, Human (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His labeled tag.

HY-P76338

	FGFR-2 alpha (IIIc) Protein, Human (HEK293, His-Fc) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (HEK293, His-Fc) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P76335

	FGFR-2 beta (IIIc) Protein, Human (267a.a, HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 beta IIIc protein is part of the fibroblast growth factor receptor family and has a conserved sequence. Its full-length structure includes an extracellular immunoglobulin-like domain, a transmembrane segment, and a tyrosine kinase domain. FGFR-2 beta (IIIc) Protein, Human (267a.a, HEK293, His) is the recombinant human-derived FGFR-2 beta IIIc protein, expressed by HEK293 , with C-His labeled tag.

HY-P702759

	FGFR-2 Protein, Human (Biotinylated, sf9, Avi) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	Sf9 insect cells
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived FGFR-2, expressed by Sf9 insect cells , with Avi labeled tag.

HY-P704610

	FGFR-2 alpha (IIIc) Protein, Human (205a.a, HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (205a.a, HEK293, His) is the recombinant human-derived FGFR-2 alpha (IIIc) protein, expressed by HEK293, with C-His labeled tag.

HY-P77653

	FGFR-2 beta (IIIb) Protein, Cynomolgus (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KGFR; K-sam; Keratinocyte growth factor receptor; CD332; BEK; KSAM	Cynomolgus	HEK293
	FGFR-2 beta is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factor and is critical for cell regulation, proliferation, differentiation, migration, and apoptosis. It plays important roles in embryonic development, trophoblast function, limb buds, lungs, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived FGFR-2 beta, expressed by HEK293 , with C-His labeled tag.

HY-P77661

	FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KGFR; K-sam; Keratinocyte growth factor receptor; CD332; BEK; KSAM	Mouse	HEK293
	FGFR-2 beta is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factor and is critical for cell regulation, proliferation, differentiation, migration, and apoptosis. It plays important roles in embryonic development, trophoblast function, limb buds, lungs, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-2 beta, expressed by HEK293 , with C-His labeled tag.

HY-P700986

	FGFR-2 beta (IIIb) Protein, Human (HEK293, Avi) Fibroblast growth factor receptor 2; FGFR-2; KGFR; K-sam; Keratinocyte growth factor receptor; CD332; BEK; KSAM	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Human (HEK293, Avi) is the recombinant human-derived FGFR-2 beta IIIb protein, expressed by HEK293 , with C-Avi labeled tag.

HY-P704611

	FGFR-2 beta (IIIb) Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; KGFR; K-sam; Keratinocyte growth factor receptor; CD332; BEK; KSAM	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 beta (IIIb) protein, expressed by HEK293, with C-hFc labeled tag.

HY-P78129

	FGFR-2 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) Fibroblast growth factor receptor 2; FGFR-2; KGFR; K-sam; Keratinocyte growth factor receptor; CD332; BEK; KSAM	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 beta IIIb protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78130

	FGFR-2 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) Fibroblast growth factor receptor 2; FGFR-2; KGFR; K-sam; Keratinocyte growth factor receptor; CD332; BEK; KSAM	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 beta IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P75763

	FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha	Human	HEK293
	FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293 , with C-hFc labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc), has molecular weight of ~113.3 kDa.

HY-P75764

	FGFR-1 alpha (IIIb) Protein, Human (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha	Human	HEK293
	FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293 , with C-His, C-10*His labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His), has molecular weight of 60-90 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-13311S

Infigratinib-d3
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the *FGFR* family, with IC₅₀ values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for *FGFR1, FGFR2, FGFR3, and FGFR4*, respectively .

HY-N0060S1

Ferulic acid-13C3
Ferulic acid- ¹³C₃ is the ¹³C-labeled Ferulic acid. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

HY-151903S

FGFR2/3-IN-1
FGFR2/3-IN-1 is a potent and selective FGFR2 and FGFR3 (FGFR) inhibitor with IC₅₀s of 1 nM and 0.5 nM, respectively. FGFR2/3-IN-1 displays >40-fold selectivity over FGFR1/FGFR4 and other kinome. FGFR2/3-IN-1 also inhibits FGFR3 V555L and V555M mutants with IC₅₀s of 2.7 nM and 6.1 nM, respectively .

HY-W754878

Pemigatinib-d6
Pemigatinib-d₆ (INCB054828-d₆) is deuterium labeled Pemigatinib. Pemigatinib (INCB054828) is an orally active, selective *FGFR* inhibitor with IC₅₀s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma ^[2] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80397

	FGFR2 Antibody (YA439)	WB, IP	Human
	FGFR2 Antibody (YA439) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FGFR2.

HY-P80398

	FGFR2 Antibody (YA764)	WB, ICC/IF, IHC-P	Human, Mouse
	FGFR2 Antibody (YA764) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FGFR2.