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Results for "

AMPK activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (85) Acetyl-CoA Carboxylase (4) Akt (16) Amyloid-β (2) Androgen Receptor (1) Apoptosis (35) Atg8/LC3 (1) Aurora Kinase (3) Autophagy (27) Bacterial (17) Bcl-2 Family (4) Beta-secretase (2) Calcium Channel (3) CaMK (2) Caspase (6) Cholinesterase (ChE) (5) Cytochrome P450 (1) EGFR (2) Endogenous Metabolite (6) ERK (4) Fungal (3) GSK-3 (2) HDAC (2) HSP (1) Insecticide (3) Interleukin Related (7) Isotope-Labeled Compounds (12) JAK (1) JNK (2) Keap1-Nrf2 (6) Kinesin (1) MDM-2/p53 (4) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) Mitophagy (1) MMP (3) mTOR (8) NAMPT (2) NF-κB (12) NO Synthase (3) NOD-like Receptor (NLR) (3) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (2) Oxidative Phosphorylation (2) p38 MAPK (3) Parasite (17) PARP (5) PDGFR (1) PERK (1) Phosphatase (1) PI3K (6) Pim (1) PKA (2) PKC (2) PPAR (15) Pyroptosis (4) Ras (1) Reactive Oxygen Species (ROS) (13) Reference Standards (14) SARS-CoV (2) Sirtuin (5) SOD (5) STAT (1) Survivin (1) TNF Receptor (4) TRP Channel (1) Tyrosinase (3) ULK (1) VEGFR (1) YAP (1) β-catenin (1)
By Research Areas:	Cancer (58) Cardiovascular Disease (16) Endocrinology (2) Infection (27) Inflammation/Immunology (30) Metabolic Disease (44) Neurological Disease (27)

By Targets:

AMPK (85)

Acetyl-CoA Carboxylase (4)

Akt (16)

Amyloid-β (2)

Androgen Receptor (1)

Apoptosis (35)

Atg8/LC3 (1)

Aurora Kinase (3)

Autophagy (27)

Bacterial (17)

Bcl-2 Family (4)

Beta-secretase (2)

Calcium Channel (3)

CaMK (2)

Caspase (6)

Cholinesterase (ChE) (5)

Cytochrome P450 (1)

EGFR (2)

Endogenous Metabolite (6)

ERK (4)

Fungal (3)

GSK-3 (2)

HDAC (2)

HSP (1)

Insecticide (3)

Interleukin Related (7)

Isotope-Labeled Compounds (12)

JAK (1)

JNK (2)

Keap1-Nrf2 (6)

Kinesin (1)

MDM-2/p53 (4)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (1)

Mitophagy (1)

MMP (3)

mTOR (8)

NAMPT (2)

NF-κB (12)

NO Synthase (3)

NOD-like Receptor (NLR) (3)

Nuclear Factor of activated T Cells (NFAT) (1)

Nucleoside Antimetabolite/Analog (2)

Oxidative Phosphorylation (2)

p38 MAPK (3)

Parasite (17)

PARP (5)

PDGFR (1)

PERK (1)

Phosphatase (1)

PI3K (6)

Pim (1)

PKA (2)

PKC (2)

PPAR (15)

Pyroptosis (4)

Ras (1)

Reactive Oxygen Species (ROS) (13)

Reference Standards (14)

SARS-CoV (2)

Sirtuin (5)

SOD (5)

STAT (1)

Survivin (1)

TNF Receptor (4)

TRP Channel (1)

Tyrosinase (3)

ULK (1)

VEGFR (1)

YAP (1)

β-catenin (1)

By Research Areas:

Cancer (58)

Cardiovascular Disease (16)

Endocrinology (2)

Infection (27)

Inflammation/Immunology (30)

Metabolic Disease (44)

Neurological Disease (27)

108

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: AMPK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16397A

Phenformin hydrochloride 5+ Cited Publications Phenethylbiguanide hydrochloride	AMPK Autophagy	Cancer
Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate *AMPK* activity.

HY-13417

AICAR Maximum Cited Publications 190 Publications Verification Acadesine; AICA Riboside	AMPK Autophagy YAP Mitophagy Endogenous Metabolite	Cancer
AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .

HY-N6971

Cimiracemoside C Cimicifugoside M	AMPK	Metabolic Disease
Cimiracemoside C is an active component of Cimicifuga racemosa, activates *AMPK, has the potential activity* against diabetes .

HY-112233

O-304 4 Publications Verification	AMPK	Cardiovascular Disease Metabolic Disease
O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications .

HY-172094

AMPK-IN-6	AMPK Apoptosis Autophagy	Cardiovascular Disease
AMPK-IN-6 (compound 13a) is potent *AMPK* inhibitor with an IC₅₀ value of 0.093 µM. AMPK-IN-6 induces apoptosis and inhibits autophagy. AMPK-IN-6 shows antiproliferative activity. AMPK-IN-6 has the potential for the research of pulmonary arterial hypertension .

HY-172901

AMPK activator 17	AMPK	Cardiovascular Disease Metabolic Disease
AMPK activator 17 (Compound 10g) is an orally active *AMPK* activator. AMPK activator 17 has significant anti-adipogenic (IC₅₀: 3.4 μM) and dyslipidemia-modifying activities. AMPK activator 17 inhibits the early stages of adipocyte differentiation (mitotic clonal expansion) by activating the AMPK pathway. AMPK activator 17 can enhance mitochondrial function and fatty acid oxidation in mature adipocytes. AMPK activator 17 improves dyslipidemia by promoting reverse cholesterol transport. AMPK activator 17 can be used in the study of obesity and related metabolic diseases (such as type 2 diabetes and cardiovascular disease) .

HY-154973

AMPK activator 11	Oxidative Phosphorylation Mitochondrial Metabolism AMPK	Metabolic Disease Cancer
AMPK activator 11 is an AMP-activated protein kinase (AMPK) activator with nanomolelevel antiproliferation activities against several CRCs. AMPK activator 11 selectively inhibits the RKO xenograft growth along by activating AMPK and upregulating oxidative phosphorylation (OXPHOS) ( mitochondrial metabolism ) and can be used for anti-tumor and metabolic disease research .

HY-170931

AMPK activator 16	AMPK Acetyl-CoA Carboxylase	Neurological Disease Metabolic Disease
AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells .

HY-168652

4-PivO-NMT chloride	AMPK	Neurological Disease Inflammation/Immunology
4-PivO-NMT chloride is an indole-derived *AMPK* signaling pathway modulator that regulates neurogenesis or neurite outgrowth by modulating *AMPK* activity. 4-PivO-NMT chloride holds promise for research in the fields of neurological disorders, pain, and inflammation .

HY-W017212R

Methyl cinnamate (Standard)	Tyrosinase Bacterial AMPK	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Tyrosinase Bacterial AMPK	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

HY-124822

COH-SR4 2 Publications Verification	AMPK	Metabolic Disease Cancer
COH-SR4 is an *AMPK* activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders .

HY-16397AS

Phenformin-d5 hydrochloride Phenethylbiguanide-d₅ hydrochloride	Isotope-Labeled Compounds AMPK Autophagy	Cancer
Phenformin-d₅ (hydrochloride) is the deuterium labeled Phenformin hydrochloride. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity .

HY-16397AR

Phenformin hydrochloride (Standard) Phenethylbiguanide hydrochloride (Standard)	Reference Standards AMPK Autophagy	Cancer
Phenformin (hydrochloride) (Standard) is the analytical standard of Phenformin (hydrochloride). This product is intended for research and analytical applications. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.

HY-N10093

Chamaejasmine Chamaejasmin	Apoptosis AMPK Autophagy Reactive Oxygen Species (ROS)	Cancer
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of *AMPK/mTOR* signal pathway .

HY-N4176

Ginkgolide K	Autophagy	Neurological Disease
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity .

HY-136447

ASP4132 1 Publications Verification	AMPK	Cancer
ASP4132 is an orally active, potent *AMPK* activator with an EC₅₀ of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models .

HY-B1104

Indoprofen (±)-Indoprofe	Akt AMPK NF-κB p38 MAPK	Inflammation/Immunology
Indoprofen ((±)-Indoprofe) activates *AKT-AMPK* signaling pathway, inhibits NF-κB/MAPK signaling pathway. Indoprofen exhibits anti-inflammatory and immunomodulatory activities. Indoprofen is orally active .

HY-W017212S

Methyl cinnamate-d7 Methyl 3-phenylpropenoate-d₇	AMPK Tyrosinase Bacterial Isotope-Labeled Compounds	Infection
Methyl cinnamate-d₇ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N7459

Sakurasosaponin	AMPK Autophagy Fungal	Cancer
Sakurasosaponin is a saponin with potential anticancer activity that can be extracted from the root of Primula sieboldii. Sakurasosaponin can activate the AMPK pathway to induce cell autophagy and exert anti-NSCLC cell proliferation activity. Sakurasosaponin also has antifungal activity and significantly inhibits the growth of anthrax.

HY-12808

STF-118804 2 Publications Verification	NAMPT AMPK mTOR	Cancer
STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates *AMPK* and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer .

HY-N6971R

Cimiracemoside C (Standard) Cimicifugoside M (Standard)	Reference Standards AMPK	Metabolic Disease
Cimiracemoside C (Standard) is the analytical standard of Cimiracemoside C. This product is intended for research and analytical applications. Cimiracemoside C is an active component of Cimicifuga racemosa, activates AMPK, has the potential activity against diabetes .

HY-N7394

Galbacin (3S)-Zuonin A	AMPK	Metabolic Disease Cancer
Galbacin ((3S)-Zuonin A), the epimer of (-)-Zuonin A (HY-N7394A), is a *AMPK* activator. Galbacin can be isolated from Myristica fragrans (nutmeg). Galbacin stimulates AMPK enzyme in differentiated C2C12 cells. Galbacin also has anticancer activity, and inhibits the proliferation of lymphocyte and tumor cells. Galbacin prevents weight gain in diet-induced mice model. Galbacin can be used for metabolic syndrome (including obesity and type-2 diabetes) and caners research .

HY-N6258

Kahweol 1 Publications Verification	AMPK Apoptosis	Metabolic Disease Cancer
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-N0671

Rhapontin 2 Publications Verification Rhaponiticin	Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and *AMPK* activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

HY-N5018

Nepodin Musizin	Parasite AMPK	Infection
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N0072

Brazilin 2 Publications Verification	Apoptosis Autophagy	Inflammation/Immunology Cancer
Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

HY-B1104R

Indoprofen (Standard) (±)-Indoprofe (Standard)	Akt AMPK Reference Standards NF-κB p38 MAPK	Inflammation/Immunology
Indoprofen (Standard) is the analytical standard of Indoprofen. This product is intended for research and analytical applications. Indoprofen activates *AKT-AMPK* signaling pathway, inhibits NF-κB/MAPK signaling pathway. Indoprofen exhibits anti-inflammatory and immunomodulatory activities. Indoprofen is orally active .

HY-N6904

Crocetin monomethyl ester	Amyloid-β	Neurological Disease Inflammation/Immunology
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated *AMPK* pathway .

HY-141543

YW2065	β-catenin	Cancer
YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and *AMPK* activation .

HY-163315

YPLP	Keap1-Nrf2 AMPK	Metabolic Disease
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .

HY-131611

6-Azuridine 6-Azauridine	Nucleoside Antimetabolite/Analog Autophagy Apoptosis AMPK MDM-2/p53 SARS-CoV	Infection Others Cancer
6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux, induces Apoptosis that depends on *AMPK* and p53. 6-Azuridine exhibit both antitumor and antiviral activities .

HY-N0059

D-Arabinose	Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0671R

Rhapontin (Standard) 2 Publications Verification Rhaponiticin (Standard)	Reference Standards Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Rhapontin (Standard) is the analytical standard of Rhapontin (HY-N0671). This product is intended for research and analytical applications. Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and *AMPK* activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

HY-B2099

Buformin 1-Butylbiguanide	AMPK	Metabolic Disease Cancer
Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .

HY-B2099A

Buformin hydrochloride 3 Publications Verification 1-Butylbiguanide hydrochloride	AMPK	Cancer
Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .

HY-163649

A17	AMPK	Metabolic Disease
A17 is a bile acid analog with anti-non-alcoholic steatohepatitis (NASH) and anti-inflammatory activities. A17 reduces fatty acid (FA) uptake and promotes FA oxidation though inhibiting fatty acid translocase (Cd36) expression and activating AMPKα. A17 can be used for NASH research .

HY-N6258R

Kahweol (Standard)	Reference Standards AMPK Apoptosis	Metabolic Disease
Kahweol (Standard) is the analytical standard of Kahweol. This product is intended for research and analytical applications. Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-N5018R

Nepodin (Standard) Musizin (Standard)	Reference Standards Parasite AMPK	Infection
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N0059S

D-Arabinose-13C	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose- ¹³C is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N7082

D-Arabinopyranose	Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S4

D-Arabinose-d2	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose-d₂ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S6

D-Arabinose-d6	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose-d₆ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059R

D-Arabinose (Standard)	Reference Standards Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose (Standard) is the analytical standard of D-Arabinose. This product is intended for research and analytical applications. D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S5

D-Arabinose-d5	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose-d₅ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-126307

Urolithin B 5+ Cited Publications	NF-κB JNK ERK Akt AMPK Endogenous Metabolite	Inflammation/Immunology
Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases *AMPK*'s oxidation. Urolithin B is also a quantitative change factor for bone and skin quality .

HY-N0072R

Brazilin (Standard)	Reference Standards Apoptosis Autophagy	Inflammation/Immunology Cancer
Brazilin (Standard) is the analytical standard of Brazilin. This product is intended for research and analytical applications. Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

HY-10971A

Alisertib sodium MLN 8237 sodium	Aurora Kinase Autophagy Apoptosis	Cancer
Alisertib (MLN 8237) sodium is an orally active and selective Aurora A kinase inhibitor (IC₅₀=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib sodium induces apoptosis and autophagy through targeting the *AKT/mTOR/AMPK/p38* pathway in leukemic cells. Antitumor activity .

HY-B2099S

Buformin-d9 hydrochloride 1-Butylbiguanide-d₉ hydrochloride	Isotope-Labeled Compounds AMPK	Metabolic Disease Cancer
Buformin-d₉ (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .

HY-N0385

Gomisin J 3 Publications Verification	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2	Cardiovascular Disease Inflammation/Immunology
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, *AMPK* (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the *AMPK* pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .

Cat. No.	Product Name	Type

HY-Y0319G

Magnesium acetate tetrahydrate

4 Publications Verification

Buffer Reagents

Magnesium acetate tetrahydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Magnesium acetate tetrahydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Magnesium acetate tetrahydrate regulates energy metabolism. Magnesium acetate tetrahydrate has anticancer activity against gastric cancer. Magnesium acetate tetrahydrate induces writhing reaction and ulcerative colitis. Magnesium acetate tetrahydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

Cat. No.	Product Name	Target	Research Area

HY-P1797A

Sakamototide substrate peptide TFA	Peptides	Others
Sakamototide substrate peptide TFA is a peptide substrate for members of the AMPK family of kinases, used in kinase activity assays .

HY-163315

YPLP	Keap1-Nrf2 AMPK	Metabolic Disease
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13417

AICAR Maximum Cited Publications 190 Publications Verification Acadesine; AICA Riboside	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .

HY-N6971

Cimiracemoside C Cimicifugoside M	Triterpenes Classification of Application Fields Terpenoids Ranunculaceae Source classification Metabolic Disease Cimicifuga foetida Linn. Plants Disease Research Fields	AMPK
Cimiracemoside C is an active component of Cimicifuga racemosa, activates *AMPK, has the potential activity* against diabetes .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Microorganisms Classification of Application Fields Simple Phenylpropanols Source classification Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC.	Tyrosinase Bacterial AMPK
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

HY-N10093

Chamaejasmine Chamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis AMPK Autophagy Reactive Oxygen Species (ROS)
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of *AMPK/mTOR* signal pathway .

HY-N4176

Ginkgolide K	Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Ginkgo biloba	Autophagy
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity .

HY-N6258

Kahweol 1 Publications Verification	other families Classification of Application Fields Terpenoids Source classification Rubiaceae Metabolic Disease Diterpenoids Plants Disease Research Fields Coffea arabica L.	AMPK Apoptosis
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-W017212R

Methyl cinnamate (Standard)	Simple Phenylpropanols Source classification Rutaceae Phenylpropanoids Plants Zanthoxylum armatum DC.	Tyrosinase Bacterial AMPK
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N7459

Sakurasosaponin	Polysaccharides Tapeinosperma clethroides Mez Source classification Plants Primulaceae Saccharides	AMPK Autophagy Fungal
Sakurasosaponin is a saponin with potential anticancer activity that can be extracted from the root of Primula sieboldii. Sakurasosaponin can activate the AMPK pathway to induce cell autophagy and exert anti-NSCLC cell proliferation activity. Sakurasosaponin also has antifungal activity and significantly inhibits the growth of anthrax.

HY-N6971R

Cimiracemoside C (Standard) Cimicifugoside M (Standard)	Triterpenes Terpenoids Ranunculaceae Source classification Cimicifuga foetida Linn. Plants	Reference Standards AMPK
Cimiracemoside C (Standard) is the analytical standard of Cimiracemoside C. This product is intended for research and analytical applications. Cimiracemoside C is an active component of Cimicifuga racemosa, activates AMPK, has the potential activity against diabetes .

HY-N7394

Galbacin (3S)-Zuonin A	Natural Products Virola surinamensis (Rol. ex Rottb.) Warb. Source classification Myristicaceae Plants	AMPK
Galbacin ((3S)-Zuonin A), the epimer of (-)-Zuonin A (HY-N7394A), is a *AMPK* activator. Galbacin can be isolated from Myristica fragrans (nutmeg). Galbacin stimulates AMPK enzyme in differentiated C2C12 cells. Galbacin also has anticancer activity, and inhibits the proliferation of lymphocyte and tumor cells. Galbacin prevents weight gain in diet-induced mice model. Galbacin can be used for metabolic syndrome (including obesity and type-2 diabetes) and caners research .

HY-N0671

Rhapontin 2 Publications Verification Rhaponiticin	Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and *AMPK* activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

HY-N5018

Nepodin Musizin	Rumex crispus Linn. Infection Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants Disease Research Fields	Parasite AMPK
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N0072

Brazilin 2 Publications Verification	Natural Products Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy
Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

HY-N6904

Crocetin monomethyl ester	Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Lridaceae Plants Crocus sativus L. Inflammation/Immunology Disease Research Fields	Amyloid-β
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated *AMPK* pathway .

HY-N0059

D-Arabinose	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Parasite Bacterial AMPK PPAR
D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0671R

Rhapontin (Standard) 2 Publications Verification Rhaponiticin (Standard)	Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Plants Disease Research Fields Cancer	Reference Standards Apoptosis
Rhapontin (Standard) is the analytical standard of Rhapontin (HY-N0671). This product is intended for research and analytical applications. Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and *AMPK* activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

HY-N6258R

Kahweol (Standard)	other families Terpenoids Source classification Rubiaceae Diterpenoids Plants Coffea arabica L.	Reference Standards AMPK Apoptosis
Kahweol (Standard) is the analytical standard of Kahweol. This product is intended for research and analytical applications. Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-N5018R

Nepodin (Standard) Musizin (Standard)	Rumex crispus Linn. Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants	Reference Standards Parasite AMPK
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N7082

D-Arabinopyranose	Infection Microorganisms Classification of Application Fields Source classification Disease Research Fields Saccharides Monosaccharides	Parasite Bacterial AMPK PPAR
D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059R

D-Arabinose (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Saccharides	Reference Standards Parasite Bacterial AMPK PPAR
D-Arabinose (Standard) is the analytical standard of D-Arabinose. This product is intended for research and analytical applications. D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-126307

Urolithin B 5+ Cited Publications	Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB JNK ERK Akt AMPK Endogenous Metabolite
Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases *AMPK*'s oxidation. Urolithin B is also a quantitative change factor for bone and skin quality .

HY-N0072R

Brazilin (Standard)	Natural Products Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants	Reference Standards Apoptosis Autophagy
Brazilin (Standard) is the analytical standard of Brazilin. This product is intended for research and analytical applications. Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

HY-N0385

Gomisin J 3 Publications Verification	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, *AMPK* (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the *AMPK* pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .

HY-N12386

SIRT1 activator 1	Microorganisms Ketones, Aldehydes, Acids Source classification Marine natural products Marine microorganism	Sirtuin
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing SIRT1 expression levels and balancing the AMPK/Akt signaling pathway .

HY-N6904R

Crocetin monomethyl ester (Standard)	Terpenoids Source classification Diterpenoids Lridaceae Plants Crocus sativus L.	Reference Standards Amyloid-β
Crocetin monomethyl ester (Standard) is the analytical standard of Crocetin monomethyl ester. This product is intended for research and analytical applications. Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants	Phosphatase Apoptosis Autophagy
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-N0806

Sweroside 2 Publications Verification	Filago spathulata Presl. Monophenols Classification of Application Fields Labiatae Phenols Metabolic Disease Plants Disease Research Fields	Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP
Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, *AMPK/mTOR* pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .

HY-N8307

Syringaresinol	Dracaena cambodiana Pierre ex Gagnep. Lignans Phenols Polyphenols Phenylpropanoids Agavaceae Plants	NO Synthase NF-κB Akt AMPK Calcium Channel
Syringaresinol is a lignan-type phytochemical with anti-inflammatory activities. Syringaresinol inhibits the NF-κB and AKT signaling pathway in IL-1β-activated mouse chondrocytes. Syringaresinol increases phosphorylation of *AMPK, eNOS, and intracellular Ca ²⁺* levels in HUVECs. Syringaresinol attenuates osteoarthritis progression in mice with Destabilization of the Medial Meniscus (DMM)-induced osteoarthritis. Syringaresinol can be used for the study of osteoarthritis (OA) .

HY-126307R

Urolithin B (Standard)	Monophenols Source classification Phenols Endogenous metabolite	NF-κB JNK ERK Akt AMPK Endogenous Metabolite
Urolithin B (Standard) is the analytical standard of Urolithin B. This product is intended for research and analytical applications. Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality .

HY-N16431

NFAT-133	Natural Products Microorganisms Source classification	AMPK Nuclear Factor of activated T Cells (NFAT) Interleukin Related Endogenous Metabolite
NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the *AMPK* pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056) .

HY-N12124

Monascuspiloin Monascinol	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Akt mTOR AMPK Androgen Receptor Apoptosis Autophagy
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC₅₀ of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC₅₀ of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation *AMPK* signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice .

HY-N0806R

Sweroside (Standard)	Filago spathulata Presl. Monophenols Labiatae Phenols Plants	Reference Standards Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP
Sweroside (Standard) is the analytical standard of Sweroside (HY-N0806). This product is intended for research and analytical applications. Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, *AMPK/mTOR* pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .

HY-N0930B

Galegine hydrochloride	Alkaloids Classification of Application Fields Leguminosae Other Alkaloids Source classification Metabolic Disease Plants Galega officinalis Linn. Disease Research Fields	AMPK Bacterial
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates *AMPK* in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .

HY-N2447

Amarogentin 2 Publications Verification	Gentiana scabra Bunge Iridoids Classification of Application Fields Terpenoids Source classification Gentianaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	AMPK Apoptosis
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating *AMPK* .

HY-N16066

Candidusin A CHNQD-0803	Monophenols Microorganisms Source classification Phenols	AMPK Apoptosis NF-κB TNF Receptor
Candidusin A (CHNQD-0803) (Compound 4) is a *AMPK* activator with a K_D of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells). Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research .

HY-N3005

Britannin 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy NOD-like Receptor (NLR) Pyroptosis
Britannin is an NLRP3 inhibitor with an IC₅₀ of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics .

HY-N2787

8-Prenylnaringenin 1 Publications Verification	Flavonoids Classification of Application Fields Humulus lupulus L. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	PI3K Akt AMPK Sirtuin Reactive Oxygen Species (ROS) SOD
8-Prenylnaringenin is an orally active prenyl flavonoid. 8-Prenylnaringenin can be isolated from the hop spike Humulus lupulus. 8-Prenylnaringenin activates the PI3K/Akt pathway and the *AMPK* pathway, upregulates OXPHOS complexes (II, III, and V) and Sirt1, and reduces ROS production and SOD activity. 8-Prenylnaringenin improves muscle atrophy and obesity and inhibits angiogenesis. 8-Prenylnaringenin exhibits anticancer activity against glioblastoma and colon cancer. 8-Prenylnaringenin also has LH/FSH regulatory activity. 8-prenylnaringenin may be used in bone health research .

HY-N0563

Alizarin 1 Publications Verification	Quinones Classification of Application Fields Anthraquinones Source classification Rubiaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L.	AMPK VEGFR PI3K Akt NF-κB Cytochrome P450
Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates *AMPK* and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings .

HY-N2447R

Amarogentin (Standard)	Gentiana scabra Bunge Iridoids Terpenoids Source classification Gentianaceae Phenols Polyphenols Plants	Reference Standards AMPK Apoptosis
Amarogentin (Standard) is the analytical standard of Amarogentin. This product is intended for research and analytical applications. Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .

HY-13755

Sulforaphane 60+ Cited Publications	Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

HY-N0853

Alisol A 5 Publications Verification	Triterpenes Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Source classification Other Diseases Alismataceae Plants Disease Research Fields	AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related
Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates *AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity* against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .

HY-134356

AICA-riboside, 5′-phosphate AICAR-5'-MP	Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
AICA-riboside, 5′-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity .

HY-N5027

Oxyberberine 2 Publications Verification Oxyberberin; Berlambine; 8-Oxoberberine	Infection Phellodendron amurense Rupr. Stilbenes Classification of Application Fields Source classification Rutaceae Plants Disease Research Fields	Others
Oxyberberine (Oxyberberin; Berlambine) is an orally effective heme oxygenase HO-1 agonist that can activate antioxidant mechanisms by regulating the PI3K/Akt/AMPK signaling pathway. Oxyberberine induces HO-1 expression, increases SOD and GSH-Px activity, inhibits NF-κB-mediated inflammatory responses, and improves insulin sensitivity and glucose metabolism. Oxyberberine has anti-diabetic, neuroprotective, anti-inflammatory and antioxidant effects, and can be used to study type 2 diabetes, traumatic brain injury (TBI) and inflammatory bowel disease .

HY-N6866

Gomisin N	Neurological Disease Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields Cancer	Apoptosis AMPK Akt PERK Keap1-Nrf2 Caspase PARP GSK-3 NO Synthase Interleukin Related
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates *AMPK, Akt, MAPK/ERK, Nrf2, caspase-3* and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease .

HY-N0226

Epiberberine	Alkaloids Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids	Cholinesterase (ChE) Beta-secretase
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease . Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberinecan be used for the research of diabetic disease .

HY-116330

Hyperforin	Anti-inflammation/Immunoregulatory Antibiotics Guttiferae Source classification Hyperlcurn perforatum L. Disease Research Plants Anticancer	Calcium Channel TRP Channel
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-N0853R

Alisol A (Standard)	Triterpenes Alisma plantago-aquatica Linn. Terpenoids Source classification Alismataceae Plants	Reference Standards AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related
Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853). This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates *AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity* against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .

HY-N0281

Daphnetin 5+ Cited Publications 7,8-Dihydroxycoumarin	Daphne Classification of Application Fields Thymelaeaceae Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N0226A

Epiberberine chloride 4 Publications Verification	Alkaloids Neurological Disease Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields	Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species (ROS)
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .

HY-N3225

Myricanol	Myrica ceriferaL. Source classification Phenols Polyphenols Plants Myricaceae	NAMPT Sirtuin Microtubule/Tubulin Apoptosis Autophagy PDGFR NF-κB AMPK
Myricanol is a diarylheptanoid and a Nampt activator. Myricanol exerts anti-inflammatory effects and alleviates glucocorticoid-induced muscle atrophy by increasing Sirtuin 1 (SIRT1) and PRDX5 activities while regulating inflammatory factors. Myricanol exhibits growth inhibition and induces apoptosis in human lung adenocarcinoma A549 cells. Myricanol promotes autophagy-mediated clearance of microtubule-associated protein tau to exert neuroprotective effects. Myricanol protects cardiovascular function by inhibiting PDGFRβ and NF-κB signaling pathways. Myricanol activates mitochondrial transcription factor A (TFAM) expression to exert anti-renal fibrosis effects. Myricanol improves insulin resistance through *AMPK* activation .

Cat. No.	Product Name	Chemical Structure

HY-16397AS

Phenformin-d5 hydrochloride
Phenformin-d₅ (hydrochloride) is the deuterium labeled Phenformin hydrochloride. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity .

HY-W017212S

Methyl cinnamate-d7

Methyl cinnamate-d₇ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N0059S

D-Arabinose-13C

D-Arabinose- ¹³C is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S4

D-Arabinose-d2

D-Arabinose-d₂ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S6

D-Arabinose-d6

D-Arabinose-d₆ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S5

D-Arabinose-d5

D-Arabinose-d₅ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-B2099S

Buformin-d9 hydrochloride
Buformin-d₉ (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .

HY-N0059S1

D-Arabinose-13C-1

D-Arabinose- ¹³C-1 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S2

D-arabinose-13C-2

D-Arabinose- ¹³C-2 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S3

D-Arabinose-13C-3

D-Arabinose- ¹³C-3 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N7082S

D-Arabinopyranose-13C5

D-Arabinopyranos- ¹³C₅ is ¹³C labeled D-Arabinopyranos (HY-N7082). D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-B1885S

Fenitrothion-d6

Fenitrothion-d₆ is the deuterium labeled Fenitrothion (HY-B1885). Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .

HY-W701218

Sulforaphane-d8

Sulforaphane-d₈ is the deuterium labeled Sulforaphane (HY-13755). Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

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