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Results for "

ACVR2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Small Interfering RNA (siRNA) (6) TGF-beta/Smad (1) TGF-β Receptor (7)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99818

Ramatercept ACE-031	TGF-β Receptor	Metabolic Disease
Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy ^[2] .

HY-RS00245

ACVR2A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACVR2A Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACVR2A Human Pre-designed siRNA Set A ACVR2A Human Pre-designed siRNA Set A

HY-RS00246

Acvr2a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acvr2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acvr2a Mouse Pre-designed siRNA Set A Acvr2a Mouse Pre-designed siRNA Set A

HY-RS00247

Acvr2a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acvr2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acvr2a Rat Pre-designed siRNA Set A Acvr2a Rat Pre-designed siRNA Set A

HY-RS00248

ACVR2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACVR2B Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACVR2B Human Pre-designed siRNA Set A ACVR2B Human Pre-designed siRNA Set A

HY-RS00249

Acvr2b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acvr2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acvr2b Mouse Pre-designed siRNA Set A Acvr2b Mouse Pre-designed siRNA Set A

HY-RS00250

Acvr2b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acvr2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acvr2b Rat Pre-designed siRNA Set A Acvr2b Rat Pre-designed siRNA Set A

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Endocrinology Cancer
LAE-102, a monoclonal antibody, is an activin receptor type II-A (ACTRIIA/ACVR2) antagonist. LAE-102 is promising for research of endocrine and metabolic diseases, tumors, and respiratory system diseases .

HY-P990327

*Anti-ACVR2B Antibody*	TGF-β Receptor	Inflammation/Immunology
The Anti-ACVR2B Antibody is a human antibody expressed in CHO cells, targeting *ACVR2B. The Anti-ACVR2B Antibody has huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 144.42 kDa. The isotype control for the Anti-ACVR2*B Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990326

*Anti-ACVR2A Antibody (Ab-14E1)* Ab-14E1	TGF-β Receptor	Inflammation/Immunology
Anti-ACVR2A Antibody (Ab-14E1) is a CHO-expressed human antibody that targets *ACVR2A. Anti-ACVR2A Antibody (Ab-14E1) features an IgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-ACVR2*A Antibody (Ab-14E1) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99355

Bimagrumab 1 Publications Verification Anti-ACVR2B Reference Antibody; BYM338	TGF-β Receptor	Metabolic Disease
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with K_Ds of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness ^[2].

HY-P991158

Rinvatercept	TGF-β Receptor	Neurological Disease
Rinvatercept, a fusion protein, is a glycyl (1)-chimeric N-terminal (1-108)-peptide (2-109) combined from the sequences of the extracellular domains of the human ACVR2A/B, and is fused via a G3 peptide linker (110-112) to an immunoglobulin G1 (IgG1) Fc fragment. Rinvatercept can be used for research of neuromuscular disease .

HY-P99590

Sotatercept ACE-011	TGF-β Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P99818

Ramatercept ACE-031	TGF-β Receptor	Metabolic Disease
Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy ^[2] .

HY-P99355

Bimagrumab 1 Publications Verification Anti-ACVR2B Reference Antibody; BYM338	TGF-β Receptor	Metabolic Disease
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with K_Ds of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness ^[2].

HY-P99590

Sotatercept ACE-011	TGF-β Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions ^[2] .

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Endocrinology Cancer
LAE-102, a monoclonal antibody, is an activin receptor type II-A (ACTRIIA/ACVR2) antagonist. LAE-102 is promising for research of endocrine and metabolic diseases, tumors, and respiratory system diseases .

HY-P990327

*Anti-ACVR2B Antibody*	TGF-β Receptor	Inflammation/Immunology
The Anti-ACVR2B Antibody is a human antibody expressed in CHO cells, targeting *ACVR2B. The Anti-ACVR2B Antibody has huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 144.42 kDa. The isotype control for the Anti-ACVR2*B Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990326

*Anti-ACVR2A Antibody (Ab-14E1)* Ab-14E1	TGF-β Receptor	Inflammation/Immunology
Anti-ACVR2A Antibody (Ab-14E1) is a CHO-expressed human antibody that targets *ACVR2A. Anti-ACVR2A Antibody (Ab-14E1) features an IgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-ACVR2*A Antibody (Ab-14E1) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991158

Rinvatercept	TGF-β Receptor	Neurological Disease
Rinvatercept, a fusion protein, is a glycyl (1)-chimeric N-terminal (1-108)-peptide (2-109) combined from the sequences of the extracellular domains of the human ACVR2A/B, and is fused via a G3 peptide linker (110-112) to an immunoglobulin G1 (IgG1) Fc fragment. Rinvatercept can be used for research of neuromuscular disease .

Species:	Human (13) Mouse (5) Rat (2) Cynomolgus (5)
Tag:	His (14) Tag Free (1) Avi (3) GST (1) Fc (9)
Source:	HEK293 (20) P. pastoris (1) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75537

	ACVR2A/Activin RIIA Protein, Human (HEK293, Fc) ACVR-2A; Activin receptor type 2A; ACTR-IIA; ACVR2	Human	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134 amino acids (M1-P134).

HY-P75563

	ACVR2A/Activin RIIA Protein, Mouse (HEK293, His) ACVR-2A; Activin receptor type 2A; ACTR-IIA; ACVR2	Mouse	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 134 amino acids (M1-P134).

HY-P7455

	ACVR2A/Activin RIIA Protein, Human (HEK293, His, solution) rHuActivin receptor type 2A, His; ACVR-2A; Activin receptor type 2A	Human	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 115 amino acids (A20-P134).

HY-P77290

	ACVR2B Protein, Cynomolgus (HEK293) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293) is produced in HEK293 cells,and consists of 116 amino acids (S28-M143).

HY-P7456

	ACVR2B Protein, Human (HEK293, His) rHuActivin receptor type 2B, His; ACVR-2B; Activin receptor type 2B	Human	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 116 amino acids (S19-T134).

HY-P72813

	ACVR2B Protein, Human (HEK293, Fc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Human	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134amino acids (M1-T134).

HY-P703977

	ACVR2A/Activin RIIA Protein, Human/Cynomolgus (Biotinylated, HEK293, His, Avi) ACTR-IIA; ACTRIIA; ACVR2A; ACVR2	Human	HEK293

HY-P703995

	ACVR2A/Activin RIIA Protein, Human/Cynomolgus (Biotinylated, HEK293, hFc, Avi) ACTR-IIA; ACTRIIA; ACVR2A; ACVR2	Human	HEK293

HY-P75562

	ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc) ACVR-2A; Activin receptor type 2A; ACTR-IIA; ACVR2	Mouse	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 134 amino acids (M1-P134).

HY-P703956

	ACVR2B Protein, Human/Cynomolgus (Biotinylated, HEK293, mFc) Activin receptor type-2B; ACVR2B; Activin RIIB	Human	HEK293

HY-P75536

	ACVR2B Protein, Mouse (HEK293, His) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Mouse	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 134 amino acids (M1-T134).

HY-P77291

	ACVR2B Protein, Cynomolgus (HEK293, Fc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 116 amino acids (S28-M143).

HY-P77292

	ACVR2B Protein, Cynomolgus (HEK293, His) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 116 amino acids (S28-M143).

HY-P75535

	ACVR2B Protein, Mouse (HEK293, His-hFc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Mouse	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His-hFc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 134 amino acids (M1-T134).

HY-P7455A

	ACVR2A/Activin RIIA Protein, Human (HEK293, C-His) rHuActivin receptor type 2A, His; ACVR-2A; Activin receptor type 2A	Human	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 115 amino acids (A20-P134).

HY-P700557

	ACVR2B Protein, Human (P. pastoris, N-His) Activin receptor type IIB; ACTR-IIB	Human	P. pastoris
	ACVR2B is a transmembrane kinase that forms the activin receptor complex and is essential for transducing activin signals. It regulates diverse processes including neuronal differentiation, hair follicle development, FSH production, wound healing, matrix production, immunosuppression, and carcinogenesis. ACVR2B Protein, Human (P. pastoris, N-His) is the recombinant human-derived ACVR2B protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P703526

	ACVR2B Protein, Human Activin receptor type-2B; ACTR-IIB; Activin receptor type IIB	Human	Sf9 insect cells

HY-P703909

	ACVR2B Protein, Mouse (134a.a, HEK293, His) activin A receptor; type IIB	Mouse	HEK293

HY-P704048

	ACVR2B Protein, Human (His, GST) Activin receptor type-2B; ACTR-IIB; Activin receptor type IIB	Human	Sf9 insect cells

HY-P703707

	*RIIB/ACVR2B Protein, Human/Cynomolgus (HEK293, mFc)*	Human;Cynomolgus	HEK293

HY-P703681

	*RIIB/ACVR2B Protein, Rat (HEK293, His)* Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2b; ACTR-IIB	Rat	HEK293

HY-P703683

	*RIIA/ACVR2A Protein, Rat (HEK293, His)* Activin receptor type-2A; Activin receptor type IIA; ACTR-IIA; ACVR2a; ACTR-IIA	Rat	HEK293

HY-P703706

	*RIIB/ACVR2B Protein, Human/Cynomolgus (HEK293, Avi-Fc)*	Human;Cynomolgus	HEK293

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83050

	Activin Receptor Type IIA Antibody (YA2795) ACTR2; ACTRII; ACTRIIA; ACVR2; ACVR2A	WB	Human, Mouse, Rat
	Activin Receptor Type IIA Antibody (YA2795) is a non-conjugated IgG antibody, targeting Activin Receptor Type IIA, with a predicted molecular weight of 58 kDa (observed band size: 85 kDa). Activin Receptor Type IIA Antibody (YA2795) can be used for WB experiment in human, mouse, rat background.

HY-P82600

	Activin Receptor Type IIB Antibody (YA2345) ActR IIB; ACVR 2B; HTX4	WB	Human, Mouse, Rat
	Activin Receptor Type IIB Antibody (YA2345) is a non-conjugated IgG antibody, targeting Activin Receptor Type IIB, with a predicted molecular weight of 58 kDa (observed band size: 65 kDa). Activin Receptor Type IIB Antibody (YA2345) can be used for WB experiment in human, mouse, rat background.