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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Activin Receptor Type IIB Antibody (YA2345)

Activin Receptor Type IIB Antibody (YA2345)

Cat. No.: HY-P82600
User Guide for Antibodies Technical Support

Activin Receptor Type IIB Antibody (YA2345) is a non-conjugated IgG antibody, targeting Activin Receptor Type IIB, with a predicted molecular weight of 58 kDa (observed band size: 65 kDa). Activin Receptor Type IIB Antibody (YA2345) can be used for WB experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Activin Receptor Type IIB Antibody (YA2345) is a non-conjugated IgG antibody, targeting Activin Receptor Type IIB, with a predicted molecular weight of 58 kDa (observed band size: 65 kDa). Activin Receptor Type IIB Antibody (YA2345) can be used for WB experiment in human, mouse, rat background.
Background

Activin Receptor Type IIB (ACVR2B) is a transmembrane serine/threonine kinase that forms an activin receptor complex with type I receptors (ACVR1, ACVR1B or ACVR1C). Functioning as the primary receptor for activin-A/INHBA, activin-B/INHBB and inhibin-A/INHA-INHBA, it regulates diverse processes including neuronal differentiation/survival, hair follicle cycling, pituitary FSH production, wound healing, extracellular matrix formation, immunosuppression and carcinogenesis (by similar: potential paracrine/autocrine roles in ovarian folliculogenesis). Upon activation, ACVR2B phosphorylates type I receptors to initiate SMAD2/SMAD3-SMAD4-mediated transcriptional regulation. Its signaling can be inhibited by SMAD7 (recruited via FKBP1A) or inhibin-B (bound through IGSF1 coreceptor).
Gene ID
SwissProt ID
Synonyms
ActR IIB; ACVR 2B; HTX4
Molecular Weight

Predicted band size: 58 kDa; Observed band size: 65 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000
Application

WB
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human Activin Receptor Type IIB
Database

Entrez Gene: 93 Human ; 11481 Mouse ; 25366 Rat

SwissProt: Q13705 Human ; P27040 Mouse ; Q66T47Pig

OMIM: 613751 Human

Documentation
User Guide for Antibodies (1077 KB)

Activin Receptor Type IIB Antibody (YA2345) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Activin Receptor Type IIB Antibody (YA2345)
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