ACVR2A/Activin RIIA Protein, Human/Cynomolgus (Biotinylated, HEK293, His, Avi)

ACVR2A/Activin RIIA Protein, Human/Cynomolgus (Biotinylated, HEK293, His, Avi) is the recombinant human-derived ACVR2A/Activin RIIA protein, expressed by HEK293, with C-Avi & C-His tag.

Activin Receptor Type IIA (ACVR2A) is a transmembrane serine/threonine kinase that forms a heterotetrameric receptor complex with type I receptors upon ligand binding. Functioning as a receptor for activin A, activin B and inhibin A, it initiates SMAD-mediated transcriptional regulation by phosphorylating and activating type I receptors (by similar: mediates GDF6-induced adipogenesis).

Human

HEK293

C-Avi;C-8*His

P27037-1 (A20-P135)

92

Extracellular Domain

Approximately 30-45 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.