Activin Receptor Type IIB Antibody (YA6947)

Activin Receptor Type IIB Antibody (YA6947) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin Receptor Type IIB.

Activin Receptor Type IIB (ACVR2B) is a transmembrane serine/threonine kinase that forms an activin receptor complex with type I receptors (ACVR1, ACVR1B or ACVR1C). Functioning as the primary receptor for activin-A/INHBA, activin-B/INHBB and inhibin-A/INHA-INHBA, it regulates diverse processes including neuronal differentiation/survival, hair follicle cycling, pituitary FSH production, wound healing, extracellular matrix formation, immunosuppression and carcinogenesis (by similar: potential paracrine/autocrine roles in ovarian folliculogenesis). Upon activation, ACVR2B phosphorylates type I receptors to initiate SMAD2/SMAD3-SMAD4-mediated transcriptional regulation. Its signaling can be inhibited by SMAD7 (recruited via FKBP1A) or inhibin-B (bound through IGSF1 coreceptor).

Q13705

Predicted band size: 58 kDa; Observed band size: 65 kDa

Affinity Purified

Non-conjugated

Unmodified

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

WB: 1:1000-1:5000; IP: 1:20-1:50

WB, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

A synthetic peptide of human Activin Receptor Type IIB/ACVR2B aa1-100.