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Pathways Recommended:	Vitamin D Related/Nuclear Receptor PI3K/Akt/mTOR

Results for "

vitamin K

" in MedChemExpress (MCE) Product Catalog:

By Targets:	VD/VDR (11) VKOR (6) Akt (1) APC (1) Apoptosis (6) Bacterial (4) c-Myc (1) Cytochrome P450 (3) Dihydroorotate Dehydrogenase (2) DNA/RNA Synthesis (2) Drug Derivative (2) Drug Metabolite (2) Endogenous Metabolite (27) ERK (1) Factor Xa (1) Fungal (3) Glucocorticoid Receptor (2) GSK-3 (1) Isotope-Labeled Compounds (14) JNK (1) MMP (2) NF-κB (3) NO Synthase (1) p38 MAPK (1) Parasite (3) Phosphatase (1) PKA (1) Pyruvate Kinase (3) Reactive Oxygen Species (ROS) (2) Reference Standards (1) SARS-CoV (1) Ser/Thr Protease (1) TrxR (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (27) Infection (8) Inflammation/Immunology (7) Metabolic Disease (8) Neurological Disease (1)

By Targets:

VD/VDR (11)

VKOR (6)

Akt (1)

APC (1)

Apoptosis (6)

Bacterial (4)

c-Myc (1)

Cytochrome P450 (3)

Dihydroorotate Dehydrogenase (2)

DNA/RNA Synthesis (2)

Drug Derivative (2)

Drug Metabolite (2)

Endogenous Metabolite (27)

ERK (1)

Factor Xa (1)

Fungal (3)

Glucocorticoid Receptor (2)

GSK-3 (1)

Isotope-Labeled Compounds (14)

JNK (1)

MMP (2)

NF-κB (3)

NO Synthase (1)

p38 MAPK (1)

Parasite (3)

Phosphatase (1)

PKA (1)

Pyruvate Kinase (3)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

SARS-CoV (1)

Ser/Thr Protease (1)

TrxR (1)

By Research Areas:

Cancer (25)

Cardiovascular Disease (27)

Infection (8)

Inflammation/Immunology (7)

Metabolic Disease (8)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: VD/VDR VKOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B2172

Vitamin K	Endogenous Metabolite	Cardiovascular Disease Cancer
Vitamin K, the blood-clotting vitamin, is important for the function of numerous proteins within the body, such as the coagulation factors, osteocalcin and matrix-Gla protein.

HY-B1508

Vitamin K4 Acetomenaphthone	Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .

HY-N0684S

Vitamin K1-d7	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1-d₇ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism .

HY-N2552

Vitamin K5 hydrochloride	Pyruvate Kinase Bacterial Fungal Apoptosis	Infection Cancer
Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC₅₀ values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages .

HY-132389S

Vitamin K3-d8	Isotope-Labeled Compounds	Others
Vitamin K3-d₈ is the deuterium labeled Vitamin K3 .

HY-113164

Vitamin K1 2,3-epoxide	Endogenous Metabolite	Others
Vitamin K1 2,3-epoxide is an inactive metabolite form of Vitamin K1 (HY-N0684), which is reduced to active vitamin by microsomal epoxide reductase in the vitamin K epoxide cycle. Vitamin K1 2,3-epoxide is involved in blood clotting .

HY-B1508R

Vitamin K4 (Standard)	Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Vitamin K4 (Standard) is the analytical standard of Vitamin K4. This product is intended for research and analytical applications. Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .

HY-N0684R

Vitamin K1 (Standard)	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1 (Standard) is the analytical standard of Vitamin K1. This product is intended for research and analytical applications. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-N2552R

Vitamin K5 hydrochloride (Standard)	Pyruvate Kinase Bacterial Fungal Apoptosis	Infection Cancer
Vitamin K5 (hydrochloride) (Standard) is the analytical standard of Vitamin K5 (hydrochloride). This product is intended for research and analytical applications. Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3].

HY-109569

Vitamin K2	Endogenous Metabolite	Metabolic Disease
Vitamin K2 is an endogenous metabolite.

HY-N0684

Vitamin K1 4 Publications Verification Phylloquinone; Phytomenadione	Endogenous Metabolite	Cardiovascular Disease Cancer
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-112499

Menaquinone-7 1 Publications Verification vitamin K2-7; vitamin K2(35); vitamin MK-7	Others	Cardiovascular Disease
Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .

HY-B1814

Vitamin K5 Synkamin; Synkamin base	Pyruvate Kinase Bacterial Fungal Apoptosis	Infection Cancer
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC₅₀ values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages .

HY-112499S

Menaquinone-7-d7 vitamin K2-7-d₇; vitamin K2(35)-d₇; vitamin MK-7-d₇	Isotope-Labeled Compounds	Cardiovascular Disease
Menaquinone-7-d₇ is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .

HY-B0332

Menadione Maximum Cited Publications 21 Publications Verification vitamin K3	Endogenous Metabolite	Cancer
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .

HY-113164S

Vitamin K1 2,3-epoxide-d7	Isotope-Labeled Compounds	Others
Vitamin K1 2,3-epoxide-d₇ is the deuterium labeled Vitamin K1 2,3-epoxide .

HY-112499R

Menaquinone-7 (Standard) vitamin K2-7(Standard); vitamin K2(35)(Standard); vitamin MK-7 (Standard)	Endogenous Metabolite	Cardiovascular Disease
Menaquinone-7 (Standard) is the analytical standard of Menaquinone-7. This product is intended for research and analytical applications. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .

HY-N0684S1

Vitamin K1-d4 Phylloquinone-d₄; Phytomenadione-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism .

HY-B2156

Menaquinone-4 4 Publications Verification vitamin K2(MK-4); Menaquinone K4	Endogenous Metabolite	Cancer
Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-112499S1

Menaquinone-7-13C6 vitamin K2-7-¹³C₆; vitamin K2(35)-¹³C₆; vitamin MK-7-¹³C₆	Isotope-Labeled Compounds	Cardiovascular Disease
Menaquinone-7- ¹³C₆ is the ¹³C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .

HY-N0684S4

Vitamin K1-d3 Phylloquinone-d₃; Phytomenadione-d₃	Endogenous Metabolite Isotope-Labeled Compounds	Cardiovascular Disease
Vitamin K1-d₃ (Phylloquinone-d₃; Phytomenadione-d₃) is deuterium-labeled Vitamin K1 (HY-N0684) .

HY-N0684S3

Vitamin K1-13C6 Phylloquinone-¹³C₆; Phytomenadione-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-B2156S

Menaquinone-4-d7 vitamin K2(MK-4)-d₇; Menaquinone K4-d₇	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
Menaquinone-4-d₇ (Vitamin K2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-B0332S

Menadione-d3 vitamin K3-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Others
Menadione-d₃ is the deuterium labeled Menadione. Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

HY-B2156S1

Menaquinone-4-13C6 vitamin K2(MK-4)-¹³C₆; Menaquinone K4-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
Menaquinone-4- ¹³C₆ is the ¹³C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-B1897A

Menadione bisulfite sodium Menadione sodium bisulfite; vitamin K3 sodium bisulfite	Endogenous Metabolite	Others
Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.

HY-N0684AS

*cis-Vitamin* K1-d7**	Endogenous Metabolite Isotope-Labeled Compounds	Others
cis-Vitamin K1-d₇ is the deuterium labeled cis-Vitamin K1, is an endogenous metabolite of Vitamin K .

HY-N0684A

*cis-Vitamin* K1** cis-Phylloquinone; cis-Phytomenadione	Endogenous Metabolite	Cardiovascular Disease
Cis-Vitamin K1 is an endogenous metabolite of Vitamin K .

HY-106561

Tioclomarol	VD/VDR	Cardiovascular Disease
Tioclomarol, a coumarin anticoagulant, is a vitamin K antagonist .

HY-121556

Rufigallol	Reactive Oxygen Species (ROS) Parasite	Infection
Rufigallol is one of the earliest systems reported to form columnar mesophases. Rufigallol is also an oxidant agent. Rufigallol acts in a pro-oxidant fashion to produce oxygen radicals inside parasitized erythrocytes. Rufigallol has vitamin K activity and antimalarial activity .

HY-116601

6-Hydroxywarfarin	Cytochrome P450	Others
6-Hydroxywarfarin is a metabolite of (+) -warfarin. 6-Hydroxywarfarin is a weaker vitamin K antagonist. 6-Hydroxywarfarin is metabolized by the cytochrome P450 isomer 2C9 (CYP2C9) .

HY-W017464

NAPQI N-Acetyl-4-benzoquinone Imine	Drug Metabolite Endogenous Metabolite	Metabolic Disease
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-111186

Flocoumafen WL 108366	Glucocorticoid Receptor MMP VKOR	Others
Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects .

HY-113958

Difethialone LM-2219	VD/VDR	Others
Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

HY-134999

10-Hydroxywarfarin	Drug Metabolite Cytochrome P450 VKOR	Metabolic Disease
10-Hydroxywarfarin, a metabolite of (R)-(+)-Warfarin (HY-W015998 ), is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC₅₀s of 1.6 µM and 80 ng/mL, respectively .

HY-111186R

Flocoumafen (Standard)	VKOR Glucocorticoid Receptor MMP	Others
Flocoumafen (Standard) is the analytical standard of Flocoumafen. This product is intended for research and analytical applications. Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects .

HY-113958R

Difethialone (Standard)	TrxR	Others
Difethialone (Standard) is the analytical standard of Difethialone. This product is intended for research and analytical applications. Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

HY-N6961

Lapachol 2 Publications Verification	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-N6961R

Lapachol (Standard)	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Lapachol (Standard) is the analytical standard of Lapachol. This product is intended for research and analytical applications. Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-U00017

Coumetarol Dicumoxane; Ph 137	VD/VDR	Metabolic Disease
Coumetarol (Dicumoxane) is a vitamin K antagonist.

HY-16516

Vitamin CK3	Others	Cancer
Vitamin CK3 is the combination of Vitamin C and vitamin K3 (100:1 ratio) and has been shown to inhibit tumor growth and lung metastasis.

HY-121244

Coumafuryl	Factor Xa	Cardiovascular Disease
Coumafuryl is a kind of coumarin rodenticide. Coumafuryl inhibits the metabolic cycle of vitamin K that causes the interference with protein biosynthesis of vitamin K-dependent coagulant factors (II, VII, IX, and X factors) in the liver .

HY-B0325

Phenindione Rectadione	VD/VDR	Cardiovascular Disease
Phenindione is an anticoagulant and can act as a vitamin K antagonist.

HY-16516R

Vitamin CK3 (Standard)	Reactive Oxygen Species (ROS) Endogenous Metabolite	Cancer
Vitamin CK3 (Standard) is the analytical standard of Vitamin CK3. This product is intended for research and analytical applications. Vitamin CK3 is the combination of Vitamin C and vitamin K3 (100:1 ratio) and has been shown to inhibit tumor growth and lung metastasis.

HY-14854

Tecarfarin ATI-5923	VKOR	Cardiovascular Disease
Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X . Tecarfarin has the antithrombotic activity .

HY-14854A

Tecarfarin sodium ATI-5923 sodium	VKOR	Metabolic Disease
Tecarfarin sodium (ATI-5923 sodium) is a novel orally active non-competitive vitamin K epoxide reductase (VKOR) antagonist, impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X . Tecarfarin sodium has the antithrombotic activity .

HY-W024644

Hydroxyethylthio Vitamine K3	Phosphatase	Cancer
Hydroxyethylthio Vitamin K3 is a Cdc25 phosphatase inhibitor, with IC₅₀ values of 4.56 μM and 23.63 μM for Cdc25A and Cdc25B, respectively. Hydroxyethylthio Vitamin K3 can be used in tumor research .

HY-N2853R

D-α-Tocopherylquinone (Standard)	Others	Cancer
DCIP (sodium) (Standard) is the analytical standard of DCIP (sodium). This product is intended for research and analytical applications. DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.

HY-N2853

D-α-Tocopherylquinone α-Tocopherylquinone	Others	Cancer
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant .

HY-B0918

Chlorindione Chlophenadione; Indaliton; G-25766	VD/VDR	Cardiovascular Disease
Chlorindione (Chlophenadione) is a potent anticoagulant. Chlorindione also is a vitamin K1 antagonist .

Cat. No.	Product Name	Target	Research Area

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	Ser/Thr Protease	Cardiovascular Disease
Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-P2588

Osteocalcin (human)	Endogenous Metabolite	Inflammation/Immunology Cancer
Osteocalcin (human) is a vitamin K-dependent bone specific protein. Osteocalcin (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces .

HY-P1918A

Activated Protein C (390-404), human TFA	APC	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-P4557

H-Phe-Leu-Glu-Glu-Leu-OH	Peptides	Others
H-Phe-Leu-Glu-Glu-Leu-OH is a synthetic pentapeptide, which can be used as the substrate of vitamin K dependent carboxylase, and a glutamyl residue in the generated product is carboxylated .

HY-P10126

Osteocalcin, bovine	Endogenous Metabolite	Others
Osteocalcin, bovine is a vitamin K-dependent bone specific protein. Osteocalcin, bovine is also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP). Osteocalcin, bovine is a small (49-amino-acid) noncollagenous protein hormone .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2172

Vitamin K	Cardiovascular Disease Structural Classification Natural Products Microorganisms other families Animals Classification of Application Fields Source classification Plants Disease Research Fields	Endogenous Metabolite
Vitamin K, the blood-clotting vitamin, is important for the function of numerous proteins within the body, such as the coagulation factors, osteocalcin and matrix-Gla protein.

HY-B1508

Vitamin K4 Acetomenaphthone	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .

HY-N0684

Vitamin K1 4 Publications Verification Phylloquinone; Phytomenadione	Cardiovascular Disease Quinones Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Classification of Application Fields Source classification Plants Endogenous metabolite Naphthalene Quinones Disease Research Fields	Endogenous Metabolite
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-B0332

Menadione Maximum Cited Publications 21 Publications Verification vitamin K3	Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Naphthalene Quinones Disease Research Fields	Endogenous Metabolite
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .

HY-B2156

Menaquinone-4 4 Publications Verification vitamin K2(MK-4); Menaquinone K4	Quinones Structural Classification Microorganisms other families Classification of Application Fields Source classification Plants Endogenous metabolite Naphthalene Quinones Disease Research Fields Cancer	Endogenous Metabolite
Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-N0684A

*cis-Vitamin* K1** cis-Phylloquinone; cis-Phytomenadione	Cardiovascular Disease Quinones Structural Classification Classification of Application Fields Source classification Endogenous metabolite Naphthalene Quinones Disease Research Fields	Endogenous Metabolite
Cis-Vitamin K1 is an endogenous metabolite of Vitamin K .

HY-W017464

NAPQI N-Acetyl-4-benzoquinone Imine	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Drug Metabolite Endogenous Metabolite
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-B1508R

Vitamin K4 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Apoptosis
Vitamin K4 (Standard) is the analytical standard of Vitamin K4. This product is intended for research and analytical applications. Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .

HY-N0684R

Vitamin K1 (Standard)	Quinones Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Source classification Plants Endogenous metabolite Naphthalene Quinones	Endogenous Metabolite
Vitamin K1 (Standard) is the analytical standard of Vitamin K1. This product is intended for research and analytical applications. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-109569

Vitamin K2	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Vitamin K2 is an endogenous metabolite.

HY-N6961

Lapachol 2 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Tabebuia avellanedae Bignoniaceae Plants Naphthalene Quinones Inflammation/Immunology Disease Research Fields	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-N6961R

Lapachol (Standard)	Quinones Structural Classification Tabebuia avellanedae Bignoniaceae Plants Naphthalene Quinones	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite
Lapachol (Standard) is the analytical standard of Lapachol. This product is intended for research and analytical applications. Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-121244

Coumafuryl	Structural Classification Animals Source classification Coumarins Phenylpropanoids	Factor Xa
Coumafuryl is a kind of coumarin rodenticide. Coumafuryl inhibits the metabolic cycle of vitamin K that causes the interference with protein biosynthesis of vitamin K-dependent coagulant factors (II, VII, IX, and X factors) in the liver .

HY-N2853R

D-α-Tocopherylquinone (Standard)	Quinones Microorganisms Source classification Benzene Quinones	Others
DCIP (sodium) (Standard) is the analytical standard of DCIP (sodium). This product is intended for research and analytical applications. DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.

HY-N2853

D-α-Tocopherylquinone α-Tocopherylquinone	Quinones Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields Cancer	Others
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant .

HY-W107616

3,7,11,15-Tetramethyl-2-hexadecen-1-ol	Structural Classification Natural Products Rudbeckia laciniata L. Source classification Plants Compositae	Endogenous Metabolite
3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

HY-B0332R

Menadione (Standard)	Quinones Structural Classification Microorganisms Source classification Endogenous metabolite Naphthalene Quinones	Endogenous Metabolite
Menadione (Standard) is the analytical standard of Menadione. This product is intended for research and analytical applications. Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .

HY-B2156R

Menaquinone-4 (Standard)	Quinones Structural Classification Microorganisms other families Source classification Plants Endogenous metabolite Naphthalene Quinones	Endogenous Metabolite
Menaquinone-4 (Standard) is the analytical standard of Menaquinone-4. This product is intended for research and analytical applications. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-169843

Cotylenin A	Structural Classification Microorganisms Antibiotics Source classification	c-Myc
Cotylenin A is a type of phenanthraquinone compound that works alongside vitamin K2 to induce the differentiation of monocytes and halt their growth, while also inhibiting the expression of c-Myc and inducing the expression of cyclin G2 in human leukemia HL-60 cells. Cotylenin A can be used in studies on acute myeloid leukemia .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

Species:	Human (4) Mouse (1)
Tag:	GFP (1) His (4) Flag (1)
Source:	HEK293 (4) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74614

	Protein S/PROS1 Protein, Human (HEK293, His) vitamin K-dependent protein S; PROS1; PROS	Human	HEK293
	Protein S/PROS1 Proteinas are potent antagonists of BMP4 and inhibit BMP4 by binding to BMP4 and preventing receptor interaction. This change redirects neural stem cells from gliogenesis to neurogenesis, thereby promoting the differentiation of neurons in the brain. Protein S/PROS1 Protein, Human (HEK293, His) is the recombinant human-derived protein S/PROS1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74236

	Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) vitamin K-dependent protein C; APC; Protein C; PROC	Mouse	HEK293
	Factor XIV/PROC protein (or protein C) is an important vitamin K-dependent serine protease that regulates blood clotting.Protein C plays a crucial role in inactivating factors Va and VIIIa and regulating the coagulation cascade in the presence of calcium ions and phospholipids.Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) is the recombinant mouse-derived Coagulation Factor XIV/PROC protein, expressed by HEK293 , with C-His labeled tag.

HY-P74237

	Coagulation Factor XIV/PROC Protein, Human (HEK293, His) vitamin K-dependent protein C; APC; Protein C; PROC	Human	HEK293
	Coagulation Factor XIV/PROC is a vital vitamin K-dependent serine protease regulating blood coagulation. Active Protein C inactivates factors Va and VIIIa in the presence of calcium ions and phospholipids, maintaining the intricate balance of coagulation pathways. Its protective effect on endothelial cell barrier function underscores a broader impact on vascular integrity. Coagulation Factor XIV/PROC Protein, Human (HEK293, His) is the recombinant human-derived Coagulation Factor XIV/PROC protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor XIV/PROC Protein, Human (HEK293, His) is 443 a.a., with molecular weight of 56-64 & 45 kDa, respectively.

HY-P701835

	VKOR1 Protein, Human (HEK293, GFP, His) VKORC1; vitamin K epoxide reductase complex subunit 1; vitamin K1 2; 3-epoxide reductase subunit 1	Human	HEK293
	As the catalytic subunit of the VKOR complex, the VKOR1 protein is crucial in vitamin K metabolism and is essential for the reduction of inactive vitamin K 2,3-epoxide to the active form. This process is critical for γ-carboxylation of proteins and is particularly important for blood coagulation and the synthesis of coagulation factors. VKOR1 Protein, Human (HEK293, GFP, His) is the recombinant human-derived VKOR1 protein, expressed by HEK293 , with C-10*His, GFP labeled tag.

HY-P701838

	P371 Protein, Human (L573F, sf9, FLAG) GGCX; vitamin K-dependent gamma-carboxylase; Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; vitamin K gamma glutamyl carboxylase	Human	Sf9 insect cells
	The P371 protein is critical in cellular processes and mediates vitamin K-dependent carboxylation of glutamate residues to form calcium-binding γ-carboxyglutamic acid (Gla) residues. At the same time, it converts the reduced hydroquinone form of vitamin K into vitamin K epoxide. P371 Protein, Human (L573F, sf9, FLAG) is the recombinant human-derived P371 protein, expressed by sf9 insect cells , with C-Flag labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-N0684S

Vitamin K1-d7
Vitamin K1-d₇ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism .

HY-132389S

Vitamin K3-d8
Vitamin K3-d₈ is the deuterium labeled Vitamin K3 .

HY-N0684S1

Vitamin K1-d4
Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism .

HY-112499S1

Menaquinone-7-13C6

Menaquinone-7- ¹³C₆ is the ¹³C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .

HY-N0684S3

Vitamin K1-13C6
Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-B2156S

Menaquinone-4-d7
Menaquinone-4-d₇ (Vitamin K2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-B0332S

Menadione-d3
Menadione-d₃ is the deuterium labeled Menadione. Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

HY-112499S

Menaquinone-7-d7

Menaquinone-7-d₇ is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .

HY-113164S

Vitamin K1 2,3-epoxide-d7
Vitamin K1 2,3-epoxide-d₇ is the deuterium labeled Vitamin K1 2,3-epoxide .

HY-N0684S4

Vitamin K1-d3
Vitamin K1-d₃ (Phylloquinone-d₃; Phytomenadione-d₃) is deuterium-labeled Vitamin K1 (HY-N0684) .

HY-B2156S1

Menaquinone-4-13C6
Menaquinone-4- ¹³C₆ is the ¹³C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-N0684AS

*cis-Vitamin* K1-d7**
cis-Vitamin K1-d₇ is the deuterium labeled cis-Vitamin K1, is an endogenous metabolite of Vitamin K .

HY-B0325S

Phenindione-d5
Phenindione-d₅ is deuterium labeled Phenindione, which is an anticoagulant which functions as a Vitamin K antagonist.

HY-B1014S

Acenocoumarol-d5
Acenocoumarol-d₅ is the deuterium labeled Acenocoumarol. Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist .

HY-14854S

Tecarfarin-13C,d3
Tecarfarin- ¹³C,d₃ (ATI-5923- ¹³C,d₃) is ¹³C labeled Tecarfarin. Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X . Tecarfarin has the antithrombotic activity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82716

	Protein C Antibody (YA2461) PROC; vitamin K-dependent protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV	WB	Human
	Protein C Antibody (YA2461) is a non-conjugated IgG antibody, targeting Protein C, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). Protein C Antibody (YA2461) can be used for WB experiment in human background.