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Results for "

viral entry

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Cathepsin (3) CCR (2) CXCR (1) Dengue Virus (1) Enterovirus (1) Filovirus (2) Flavivirus (2) HBV (1) HIV (6) HSP (1) HSV (1) Influenza Virus (3) PAI-1 (1) PROTACs (1) SARS-CoV (10) Ser/Thr Protease (2) Virus Protease (2)
By Research Areas:	Cancer (3) Endocrinology (1) Infection (26) Inflammation/Immunology (4) Metabolic Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1034

DAPTA 2 Publications Verification D-Ala-peptide T-amide; Adaptavir	CCR HIV	Infection Endocrinology
DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.

HY-P99346

Regdanvimab CT-P59	SARS-CoV Angiotensin-converting Enzyme (ACE)	Infection
Regdanvimab (CT-P59) is a human monoclonal antibody that targets the receptor-binding domain of SARS-CoV-2 spike protein, blocking interaction with ACE2 for viral entry. Regdanvimab can be used for the research of COVID-19 .

HY-129116

SSAA09E1	SARS-CoV Cathepsin	Infection
SSAA09E1 is a cathepsin L blocker (IC₅₀: 5.33 μM).SSAA09E1 inhibits stages of viral entry. SSAA09E1 can be used for SARS-CoV infection research

HY-105086

Pamaqueside CP148623	SARS-CoV	Infection Metabolic Disease
Pamaqueside (CP148623) is a cholesterol absorption inhibitor and a potent binder of the SARS-CoV-2 receptor-binding domain (RBD), which may inhibit viral cellular entry. Pamaqueside can be utilized in metabolic and antiviral research .

HY-115488A

BNM-III-170	HIV	Infection
BNM-III-170 is able to inhibit HIV-1 viral entry into target cells.

HY-162512

CB-0821	CCR HIV	Infection
CB-0821 is a high affinity CCR5 inhibitor with a K_i of 0.04 nM. CB-0821 binds efficiently to the hydrophobic pocket of the CCR5 protein, to inhibit the interactions between viral protein and CCR5, thereby inhibiting viral entry. CB-0821 has the potential for anti-HIV research .

HY-161691

EBOV-IN-9	Filovirus	Infection
EBOV-IN-9 (compound 2b) is Diphyllin derivative that blocks Ebola viral entry with an EC₅₀ of 40 nM. EBOV-IN-9 against EBOV-infected monocyte-derived macrophages with an EC₅₀ of 107 nM .

HY-163029

CTSL/B-IN-1	Cathepsin SARS-CoV	Infection
CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and TMPRSS2 with IC₅₀s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research .

HY-122196

TYT-1	Flavivirus	Others
TYT-1 is a sulfonamide-thiourea compound that has inhibitory activity against West Nile virus replication with a 50% effective concentration of 0.7 microM, blocking a post-entry, pre-assembly step of viral replication.

HY-160880

EBOV-IN-5	Filovirus	Infection
EBOV-IN-5 (compound 14) is an antiviral agent that inhibits Ebola virus (EBOV) infection. EBOV-IN-5 inhibits the binding of the EBOV glycoprotein EBOV-GPcl to NPC1, an indispensable host receptor required for viral fusion/entry .

HY-138102

SSAA09E3	SARS-CoV	Infection
SSAA09E3 is a SARS-CoV entry inhibitor that inhibits SARS/HIV pseudotyped virus entry with an EC₅₀ of 9.7 μM in 293T cells and inhibits SARS-CoV infection of Vero cells with an EC₅₀ of 0.15 μM .

HY-108447

BC-11 hydrobromide	Ser/Thr Protease SARS-CoV PAI-1	Infection Cancer
BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC₅₀=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer .

HY-162550

Jobosic acid	SARS-CoV	Infection
Jobosic acid, a saturated fatty acid, is a selective SARS-CoV-2 inhibitor. Jobosic acid inhibits Mpro and spike-RBD/ACE-2 interaction with IC₅₀ values of 7.5 μg/mL and 3 μg/mL, respectively. Jobosic acid shows viral entry inhibition for the omicron SARS-CoV-2 variant .

HY-172216

EV-A71-IN-3	Enterovirus	Infection
EV-A71-IN-3 (Compound IRE-03-3) is the inhibitor for Enterovirus A71 EV-A71 that targets internal ribosomal entry site (IRES) of EV-A71, inhibits IRES-mediated translation, and inhibits the viral proliferation with an EC₅₀ of 11.96 μM .

HY-161902

MI-1904	Ser/Thr Protease Influenza Virus SARS-CoV	Infection
MI-1904 is the inhibitor for matriptase/TMPRSS2, that exhibits antiviral activity against influenza virus H1N1 and H9N2. MI-1904 blocks the cleavage of glycoproteins on the viral surface, prevents the virus from binding to host cell receptors, and thus inhibits the entry and replication of the virus .

HY-106055

Murabutide	HIV	Inflammation/Immunology
Murabutide is a safe synthetic immunomodulator. Murabutide can reduce CD4 and CCR5 receptor expression and secrete high levels of beta-chemokines. Murabutide enhances nonspecific resistance against viral infections. Murabutide did not affect virus entry, reverse transcriptase activity or early proviral DNA formation in the cytoplasm of infected cells .

HY-161777

SARS-CoV-2 Mpro-IN-23	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-23 (Compound 2) is an inhibitor for SARS-CoV-2 main protease (Mpro), which inhibits wildtype Mpro and mutant Mpro variants, with IC₅₀ of 0.057-0.92 μM. SARS-CoV-2 Mpro-IN-23 inhibits the post-entry viral processes of wild-type SARS-CoV-2 single-round infectious particles (SRIPs), suppresses the viral replication of Mpro wildtype and Mpro mutants with EC₅₀ of 0.02-0.52 μM .

HY-107577

Gedunin	HSP	Infection Inflammation/Immunology Cancer
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research .

HY-158028

PAN endonuclease-IN-2	Influenza Virus	Infection
PAN endonuclease-IN-2 (compound T-31) is a PA_N endonuclease inhibitor (IC₅₀: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication .

HY-172772

Anti-PEDV agent 1	Flavivirus	Infection
Anti-PEDV agent 1 (Compound D39) is a highly effective anti-Porcine epidemic diarrhea virus (PEDV) agent with an EC₅₀ value of 0.09 μM. Anti-PEDV agent 1 blocks the early internalization of PEDV during viral entry by modulating intracellular Ca ²⁺ homeostasis. Anti-PEDV agent 1 is promising for research of PEDV infections .

HY-P991246

VRC01LS	Virus Protease HIV	Infection
VRC01LS is a humanized monoclonal antibody inhibitor targeting the CD4-binding site of HIV-1 envelope glycoprotein (Env). VRC01LS blocks the binding of HIV-1 to host cell CD4 receptor, inhibiting viral entry. VRC01LS is promising for research of HIV-1 infection .

HY-P991069

VRC-01	HIV	Infection
VRC-01 is a fully human IgG1 antibody that targets envelope glycoprotein gp120 Protein. VRC-01 blocks viral entry by partially mimicking the interaction of the CD4 receptor with HIV-1 gp120 envelope glycoprotein. The isotype control for VRC-01 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990015

Tobevibart VIR-3434	HBV	Infection
Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda1, Isotype Control (HY-P99992) .

HY-161342

CTSL/CAPN1-IN-2	Cathepsin SARS-CoV	Infection Inflammation/Immunology
CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both CTSL and CAPN1, with IC₅₀ values of 6.88 nM and 347.6 nM, respectively. CTSL/CAPN1-IN-2 possesses anti-inflammatory properties and favorable pharmacokinetic characteristics. CTSL/CAPN1-IN-2 exhibits broad-spectrum antiviral activity against coronaviruses by blocking viral entry .

HY-P3161

Lactoferrin from Bovine milk	HSV	Infection Inflammation/Immunology Cancer
Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities .

HY-P10429

RCP168	CXCR	Infection
RCP168 is a highly selective and affinity CXCR4 receptor antagonist (IC₅₀=5 nM). RCP168 has a stronger ability than natural chemical factors to inhibit the entry of HIV-1 (human immunodeficiency virus type 1) into host cells via CXCR4 receptors. RCP168 inhibits HIV-1 infection by blocking viral binding sites or inducing receptor internalization. RCP168 can be used to analyze the interaction between CXCR4 receptor and other chemical factor receptors .

HY-131069A

MBX2329	Influenza Virus	Infection
MBX2329, a potent influenza virus inhibitor, specifically inhibits hemagglutinin (HA)-mediated viral entry with HIV/HA(H5) displaying IC₉₀ of 8.6 μM. MBX2329 inhibits a wide spectrum of influenza A viruses, which includes the 2009 pandemic influenza virus A/H1N1/2009, highly pathogenic avian influenza (HPAI) virus A/H5N1, and oseltamivir-resistant A/H1N1 strains .

HY-161804

GNF-2-deg	PROTACs Dengue Virus	Infection
GNF-2-deg is a PROTAC degrader for dengue virus envelope protein (DENV E protein) with DC₅₀ of 0.83 μM. GNF-2-deg prevents viral entry by inhibiting E-mediated membrane fusion, prevents virion production by protein degradation, and thereby exhibits antiviral activity against DENV 2 with EC₉₀ of 3.5 μM. GNF-2-deg exhibits antiviral activity against ZIKV, JEV, WNV and YFV with EC₉₀ of 1.96-7.79 μM. (Pink: ligand for target protein (HY-161805); Black: linker (HY-42149); Blue: ligand for E3 ligase (HY-23095))

Cat. No.	Product Name	Type

HY-P3161

Lactoferrin from Bovine milk	Native Proteins
Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities .

Lactoferrin from Bovine milk

Native Proteins

Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities .

Cat. No.	Product Name	Target	Research Area