Search Result

Results for "

transformation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (5) Antifolate (2) Apoptosis (8) Arginase (1) Aryl Hydrocarbon Receptor (1) Autophagy (5) Bacterial (14) Bcr-Abl (1) Biochemical Assay Reagents (5) c-Myc (2) COX (2) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (8) Drug Metabolite (4) EGFR (1) Endogenous Metabolite (13) Epigenetic Reader Domain (1) ERK (2) Factor Xa (2) Farnesyl Transferase (1) Ferroptosis (2) FGFR (1) FXR (4) G protein-coupled Bile Acid Receptor 1 (4) GCGR (1) Guanylate Cyclase (1) Herbicide (1) Histamine Receptor (1) Histone Methyltransferase (3) Insecticide (1) Isotope-Labeled Compounds (2) JNK (1) MEK (1) NADPH Oxidase (1) NF-κB (1) NO Synthase (2) P2Y Receptor (2) Parasite (3) PARP (1) PDHK (2) PDK-1 (1) Ras (3) Reactive Oxygen Species (1) Reference Standards (1) ROCK (1) Salt-inducible Kinase (SIK) (1) Ser/Thr Protease (2) TGF-beta/Smad (1) Thrombin (2) TREM receptor (1) Trk Receptor (1) TRP Channel (1) VD/VDR (1)
By Research Areas:	Cancer (41) Cardiovascular Disease (7) Endocrinology (2) Infection (15) Inflammation/Immunology (8) Metabolic Disease (14) Neurological Disease (3)

By Targets:

Androgen Receptor (1)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (5)

Antifolate (2)

Apoptosis (8)

Arginase (1)

Aryl Hydrocarbon Receptor (1)

Autophagy (5)

Bacterial (14)

Bcr-Abl (1)

Biochemical Assay Reagents (5)

c-Myc (2)

COX (2)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (8)

Drug Metabolite (4)

EGFR (1)

Endogenous Metabolite (13)

Epigenetic Reader Domain (1)

ERK (2)

Factor Xa (2)

Farnesyl Transferase (1)

Ferroptosis (2)

FGFR (1)

FXR (4)

G protein-coupled Bile Acid Receptor 1 (4)

GCGR (1)

Guanylate Cyclase (1)

Herbicide (1)

Histamine Receptor (1)

Histone Methyltransferase (3)

Insecticide (1)

Isotope-Labeled Compounds (2)

JNK (1)

MEK (1)

NADPH Oxidase (1)

NF-κB (1)

NO Synthase (2)

P2Y Receptor (2)

Parasite (3)

PARP (1)

PDHK (2)

PDK-1 (1)

Ras (3)

Reactive Oxygen Species (1)

Reference Standards (1)

ROCK (1)

Salt-inducible Kinase (SIK) (1)

Ser/Thr Protease (2)

TGF-beta/Smad (1)

Thrombin (2)

TREM receptor (1)

Trk Receptor (1)

TRP Channel (1)

VD/VDR (1)

By Research Areas:

Cancer (41)

Cardiovascular Disease (7)

Endocrinology (2)

Infection (15)

Inflammation/Immunology (8)

Metabolic Disease (14)

Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011788

Triphenylmethanol Trt-OH	Biochemical Assay Reagents	Cancer
Triphenylmethanol is a specific clathrate host for methanol and dimethyl sulphoxide. Triphenylmethanol inhibits neoplastic transformation of cells .

HY-16659

EHT 1864 15+ Cited Publications	Ras	Neurological Disease Cancer
EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The K_d values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG .

HY-126979

Mycro2	c-Myc	Cancer
Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .

HY-N0881

Desacetylcinobufagin Deacetylcinobufagin	Others	Others
Desacetylcinobufagin is a natural compound used for microbial transformation.

HY-17527

Cloxyfonac	Insecticide	Others
Cloxyfonac is a plant growth regulator and a chemical transformation product pesticide.

HY-21509

8-Hydroxycoumarin 1 Publications Verification	NADPH Oxidase	Others
8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone .

HY-N3687

Dasycarpol	Others	Cancer
Dasycarpol (compound 2) is a product of microbial transformation of fraxinellone by Aspergillus niger (AS 3.421). Dasycarpol shows moderate cytotoxicity against A549 cells ,with the IC₅₀ of 20 ug/mL .

HY-N9507

Picrasidine Q	Apoptosis FGFR	Cancer
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity .

HY-125636

Mycro1	c-Myc	Cancer
Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .

HY-162836

Rifamycin B 4-O-(Carboxymethyl)-Rifamycin	Antibiotic Bacterial	Infection
Rifamycin B (4-O-(Carboxymethyl)-Rifamycin) is a member of ansamycin antibiotics family with an anti-mycobacterial activity against tuberculosis, leprosy and AIDS-related mycobacterial infections. Rifamycin B is a metabolic product of Nocardia inediterranei, which can yield Rifamycin O and Rifamycin S (HY-125365) by microbial transformation .

HY-N12167

3-epi-Bufalin	Others	Others
3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide .

HY-W011579

4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone	Biochemical Assay Reagents	Others
4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone, is a heterocyclic compound with a five-membered ring structure, which can be used as a starting material for organic synthesis, a reagent for organic transformation, and a biological probe for studying biological processes. 4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences .

HY-100885

Acelarin 1 Publications Verification NUC-1031	DNA/RNA Synthesis	Cancer
Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.

HY-116131

DAC-2-25	Others	Others
DAC-2-25 is a molecule that causes a homeotic transformation of body column into tentacle zone .

HY-N3391

Leuconolam	Others	Metabolic Disease
Leuconolam is an alkaloid that undergoes various chemical transformations, including base-induced cyclization to produce diisomeric products .

HY-12656

SCH 51344	Ras	Cancer
SCH 51344 inhibits Ras induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts .

HY-142129

Pyrocholecalciferol	VD/VDR	Endocrinology
Pyrocholecalciferol, a vitamin D analogue, produced by photochemical transformation of 7-dehydrocholesterol (7-DHC) .

HY-130465

7α-Thiospironolactone Deacetylspironolactone; Mercaptospironolactone	Drug Metabolite	Metabolic Disease
7α-Thiospironolactone is the transformation product of spironolactone (HY-B0561), which can be obtained by the metabolism of Thermomyces lanuginosus .

HY-126490

Phleomycin 1 Publications Verification	Bacterial Antibiotic DNA/RNA Synthesis	Infection Cancer
Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research .

HY-122903B

(+)-TK216	DNA/RNA Synthesis	Others
(+)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor .

HY-129273

L-731735	Farnesyl Transferase	Cancer
L-731735 is a selective FPTase inhibitor that can inhibit ras-dependent cell transformation. L-731735 can be used in cancer research .

HY-121665

Rosaprostol	Others	Others
Rosaprostol is a compound with antiulcer activity, and its enantiomers can be synthesized from the corresponding building blocks via a specific synthetic route involving multistep reactions and stereoselective transformations.

HY-136441

Triclosan-methyl	Bacterial	Infection
Triclosan-methyl is a transformation product of triclosan. Triclosan is a bactericide in personal care products such as toothpaste, shampoos, and soaps. Triclosan is also a stabilizing agent in a multitude of detergents and cosmetics .

HY-163650

DTPD-Q	Others	Others
DTPD-Q is the transformation products (TATPs) of tire additives N,N′-diphenyl-p-phenylenediamine (DTPD). DTPD-Q accumulates and rises the ecological risk in the environment .

HY-15876

Clopidogrel thiolactone	Drug Metabolite P2Y Receptor	Cardiovascular Disease
Clopidogrel thiolactone is an important intermediate in the metabolism of clopidogrel (HY-15283). Clopidogrel thiolactone has antiplatelet aggregatione effects. Clopidogrel is a P2Y12 receptor inhibitor that exerts antiplatelet effects .

HY-112023

Lumisterol 3 (>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C	Endogenous Metabolite	Metabolic Disease
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D .

HY-15876R

Clopidogrel thiolactone (Standard)	Drug Metabolite P2Y Receptor	Cardiovascular Disease
Cyhalofop (Standard) is the analytical standard of Cyhalofop. This product is intended for research and analytical applications. Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture .

HY-162596

NRL-1049 BA-1049	ROCK	Neurological Disease
NRL-1049 (BA-1049) is a ROCK2 selective inhibitor (IC₅₀: 0.59 µM and 26 µM for ROCK2 and ROCK1 respectively). NRL-1049 reduces Lysophosphatidic acid induced ROCK activation in endothelial cells. NRL-1049 reduces lesion volume and hemorrhagic transformation in a mouse model of cavernous angiomas. NRL-1049 also preserves the BBB and suppresses seizures after brain injury, and inhibits hemorrhagic transformation after ischemic stroke in mice .

HY-W012218

(±)-Camphor-10-sulfonic acid (±)-10-Camphorsulfonic acid	Biochemical Assay Reagents	Others
(±)-Camphor-10-sulfonic acid is a racemate of Camphor-10-sulfonic acid. (±)-Camphor-10-sulfonic acid can be used as an organocatalyst in performing a huge array of organic transformations .

HY-171732

FANFT	Drug Metabolite	Cancer
FANFT is an orally active and potent uroepithelial carcinogen. FANFT is metabolized to ANFT in vivo, which induces gene mutations and malignant cell transformation. FANFT efficiently induces bladder tumors in mice .

HY-P2741

Maltose phosphorylase E.C. 2.4.1.8	Endogenous Metabolite	Metabolic Disease
Maltose phosphorylase is a dimerase which catalyzes the transformation of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose. Maltose phosphorylases have been classified in family 65 of the glycoside hydrolases .

HY-122903A

(-)-TK216	DNA/RNA Synthesis	Cancer
(-)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity .

HY-N14767

Naphthablin	DNA/RNA Synthesis Bcr-Abl	Cancer
Naphthablin is a naphthoquinone compound that inhibits Abl oncogene functions. Naphthablin inhibits Abl-induced morphological transformation in v-ablts-NIH3T3 cells and inhibits RNA synthesis .

HY-N3494

γ-Costic acid Isocostic acid	Others	Others
γ-Costic acid (compound 13）is a kind of terpenoid. γ-Costic acid can be obtained by chemical transformation. γ-Costic acid has effective antifeedant and cytotoxic doses with EC₅₀ 0.5 μg/ml against L. decemlineata .

HY-120221

SE 175	Guanylate Cyclase NO Synthase	Cardiovascular Disease
SE 175 is an organic nitrate compound that acts as an NO donor in vivo following reductive transformation of the nitrate group to nitric oxide. SE 175 stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC₅₀ of 0.20 µM .

HY-136441S

Triclosan-methyl-d3	Bacterial	Infection
Triclosan-methyl-d₃ is the deuterium labeled Triclosan-methyl. Triclosan-methyl is a transformation product of triclosan. Triclosan is a bactericide in personal care products such as toothpaste, shampoos, and soaps. Triclosan is also a stabilizing agent in a multitude of detergents and cosmetics .

HY-127039

Antipain	Ser/Thr Protease DNA/RNA Synthesis	Metabolic Disease Cancer
Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain restricts uterine DNA synthesis and function in mice .

HY-127034

Antipain dihydrochloride	Ser/Thr Protease DNA/RNA Synthesis	Metabolic Disease Cancer
Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice .

HY-W749520

Zymosterone	Dihydrofolate reductase (DHFR)	Metabolic Disease
Zymosterone is converted into zymosterol, an intermediate in cholesterol synthesis, through the action of the enzyme hydroxysteroid (17β) dehydrogenase 7 (HSD17B7), and this transformation, catalyzed by 3-keto sterol reductase (ERG27), plays a crucial role in the biosynthesis of ergosterol in yeast.

HY-139743

Aditoprime Aditoprim	Antifolate Bacterial	Infection
Aditoprime (Aditoprim), a selective bacterial dihydrofolate reductase (DHFR) inhibitor, inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime inhibits E.coli and L.casei DHFR with IC₅₀ of 47 and 520 nM, respectively. Aditoprime has a broad antimicrobial spectrum, good antibacterial activity and excellent pharmacokinetics .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-W009884

Acetosyringone 1 Publications Verification	Endogenous Metabolite	Others
Acetosyringone is a phenolic compound from wounded plant cells, enables virA gene which encodes a membrane-bound kinase to phosphorylate itself and activate the virG gene product, which stimulates the transcription of other vir genes and itself . Acetosyringone enhances efficient Dunaliella transformation of Agrobacterium strains .

HY-P2454

CSP1	Bacterial	Infection
CSP1 is a potent and selective ComD1 receptor agonist, with an IC₅₀ of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-P10019

Pegsebrenatide	GCGR	Neurological Disease
Pegsebrenatide (NLY01) is a long-acting GLP-1R agonist. Pegsebrenatide has an extended half-life and favorable blood-brain barrier penetration. Pegsebrenatide can block A1 astrocyte transformation, reducing dopaminergic cell death, and improving motor symptoms in mouse models of PD .

HY-W010270A

Aurothiomalate disodium	TRP Channel NF-κB NO Synthase TREM receptor Arginase	Metabolic Disease Inflammation/Immunology
Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and iNOS expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of TREM-2 and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis .

HY-157925

Bicyclo-PGE1 Bicyclo Prostaglandin E1	Endogenous Metabolite	Others
Bicyclo-PGE1 (Bicyclo Prostaglandin E1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. Bicyclo-PGE1 can be used to estimate the biosynthesis and metabolism of PGE1 in vivo .

HY-12041

SP600125 Maximum Cited Publications 497 Publications Verification	JNK Autophagy Apoptosis Ferroptosis	Cancer
SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC₅₀s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis .

HY-W012218R

(±)-Camphor-10-sulfonic acid (Standard)	Biochemical Assay Reagents	Others
(±)-Camphor-10-sulfonic acid (Standard) is the analytical standard of (±)-Camphor-10-sulfonic acid. This product is intended for research and analytical applications. (±)-Camphor-10-sulfonic acid is a racemate of Camphor-10-sulfonic acid. (±)-Camphor-10-sulfonic acid can be used as an organocatalyst in performing a huge array of organic transformations .

HY-121497

3-Methoxybenzamide 3-MBA	PARP Bacterial	Cancer
3-Methoxybenzamide (3-MBA), an inhibitor of ADP-ribosyltransferase (ADPRTs) and PARP, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells . 3-Methoxybenzamide (3-MBA) enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum) .

Cat. No.	Product Name

HY-L189

Amino Acid Metabolism Compound Library

270 compounds

Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases.

MCE designs a unique collection of 270 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.

HY-L010

MAPK Compound Library

762 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 762 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

HY-L058

Glycolysis Compound Library

956 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 956 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L079

Anti-Blood Cancer Compound Library

3,386 compounds

Blood cancers, also called hematologic cancers, occur when abnormal blood cells start growing out of control, interrupting the function of normal blood cells, which fight off infection and produce new blood cells. Most blood cancers start in the bone marrow, which is where blood is produced. There are three main types of blood cancers: leukemia, lymphoma and myeloma, which afflict millions of children and adults every year, and are often deadly.

Some common blood cancer treatments include stem cell transplantation, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. As we begin to understand the key signaling pathways and molecular drivers of malignant transformation in haematological disorders, new treatment strategies will continue to be developed.

MCE offers a unique collection of 3,386 compounds with identified and potential anti-blood cancer activity. These compounds target blood cancer’s major targets and signaling pathways. MCE anti-blood cancer compound library is a useful tool for anti-blood cancer drugs screening and other related research.

Cat. No.	Product Name	Type

HY-W011579

4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone

Biochemical Assay Reagents

4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone, is a heterocyclic compound with a five-membered ring structure, which can be used as a starting material for organic synthesis, a reagent for organic transformation, and a biological probe for studying biological processes. 4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences .

HY-W012218

(±)-Camphor-10-sulfonic acid (±)-10-Camphorsulfonic acid	Biochemical Assay Reagents
(±)-Camphor-10-sulfonic acid is a racemate of Camphor-10-sulfonic acid. (±)-Camphor-10-sulfonic acid can be used as an organocatalyst in performing a huge array of organic transformations .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Cell Assay Reagents
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Cell Assay Reagents
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-W012218R

(±)-Camphor-10-sulfonic acid (Standard)	Biochemical Assay Reagents
(±)-Camphor-10-sulfonic acid (Standard) is the analytical standard of (±)-Camphor-10-sulfonic acid. This product is intended for research and analytical applications. (±)-Camphor-10-sulfonic acid is a racemate of Camphor-10-sulfonic acid. (±)-Camphor-10-sulfonic acid can be used as an organocatalyst in performing a huge array of organic transformations .

Cat. No.	Product Name	Target	Research Area

HY-P2454

CSP1	Bacterial	Infection
CSP1 is a potent and selective ComD1 receptor agonist, with an IC₅₀ of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent .

HY-P10019

Pegsebrenatide	GCGR	Neurological Disease
Pegsebrenatide (NLY01) is a long-acting GLP-1R agonist. Pegsebrenatide has an extended half-life and favorable blood-brain barrier penetration. Pegsebrenatide can block A1 astrocyte transformation, reducing dopaminergic cell death, and improving motor symptoms in mouse models of PD .

HY-P10793

Cyclic(YCDGFYACYMDV)	EGFR Apoptosis	Cancer
Cyclic(YCDGFYACYMDV) is a HER2 signaling pathway inhibitor with anti-cancer activity. This compound self-assembles into nanoparticles in aqueous solution and transforms into nanofibers upon specific binding to HER2 on cancer cells. This transformation disrupts HER2 dimerization and subsequent downstream signaling events, leading to cancer cell apoptosis (Apoptosis). The inhibitory effects on HER2 positive breast cancer have been demonstrated to be effective in a murine xenograft model .

HY-P10529

Ganglioside GM1-binding peptides p3	Trk Receptor	Infection
Ganglioside GM1-binding peptides p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of GM1 ganglioside. The dynamic transformation of Ganglioside GM1-binding peptides p3 may play an important role in the function of GM1 as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptides p3 can be used to study the interaction between GM1 and its ligands .

HY-P10851

HVEM(14-39)	Apoptosis	Inflammation/Immunology Cancer
HVEM(14-39) is a B- and T-lymphocyte attenuator (BTLA) peptide inhibitor. HVEM (14-39) can be combined with BTLA with a K_D of 0.102 μM. HVEM(14-39) enhances the activation and proliferation of T cells by regulating the expression of BTLA and HVEM in T cells, and promotes the transformation of cells into effector memory T cells. HVEM(14-39) inhibits tumor cell proliferation and promotes late apoptosis. HVEM(14-39) has immunomodulatory effects and can be used in the study of cancer .

Cat. No.	Product Name	Target	Research Area

HY-P991226

RG7287	Inhibitory Antibodies	Cancer
RG7287 is an activating antibody inhibitor targeting human CDCP1. RG7287 prevents the loss of contact inhibition caused by the co-transformation of NIH3T3 cells with CDCP1 and Src in focus formation assays. RG7287 inhibits tumor cell proliferation and leads to a significant reduction in CDCP1 levels .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0881

Desacetylcinobufagin Deacetylcinobufagin	Classification of Application Fields Animals Source classification Other Diseases Disease Research Fields Steroids	Others
Desacetylcinobufagin is a natural compound used for microbial transformation.

HY-126490

Phleomycin 1 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics	Bacterial Antibiotic DNA/RNA Synthesis
Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research .

HY-112023

Lumisterol 3 (>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D .

HY-W009884

Acetosyringone 1 Publications Verification	Structural Classification Monophenols Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Plants Disease Research Fields	Endogenous Metabolite
Acetosyringone is a phenolic compound from wounded plant cells, enables virA gene which encodes a membrane-bound kinase to phosphorylate itself and activate the virG gene product, which stimulates the transcription of other vir genes and itself . Acetosyringone enhances efficient Dunaliella transformation of Agrobacterium strains .

HY-N3687

Dasycarpol	Structural Classification Natural Products Microorganisms Source classification	Others
Dasycarpol (compound 2) is a product of microbial transformation of fraxinellone by Aspergillus niger (AS 3.421). Dasycarpol shows moderate cytotoxicity against A549 cells ,with the IC₅₀ of 20 ug/mL .

HY-N9507

Picrasidine Q	Alkaloids Structural Classification other families Classification of Application Fields Source classification Quinoline Alkaloids Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis FGFR
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity .

HY-N12167

3-epi-Bufalin	Structural Classification Natural Products Microorganisms Source classification	Others
3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide .

HY-N3391

Leuconolam	Apocynaceae Structural Classification Alkaloids Source classification Plants Indole Alkaloids	Others
Leuconolam is an alkaloid that undergoes various chemical transformations, including base-induced cyclization to produce diisomeric products .

HY-N14767

Naphthablin	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis Bcr-Abl
Naphthablin is a naphthoquinone compound that inhibits Abl oncogene functions. Naphthablin inhibits Abl-induced morphological transformation in v-ablts-NIH3T3 cells and inhibits RNA synthesis .

HY-N3494

γ-Costic acid Isocostic acid	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Apalochlamys spectabilis (Labill.) J.H.Willis	Others
γ-Costic acid (compound 13）is a kind of terpenoid. γ-Costic acid can be obtained by chemical transformation. γ-Costic acid has effective antifeedant and cytotoxic doses with EC₅₀ 0.5 μg/ml against L. decemlineata .

HY-N2459

Peonidin chloride YGM-6 chloride	Structural Classification Classification of Application Fields Source classification Plants Food Research Anthocyans Flavonoids Microorganisms Paeonia lactiflora Pall. Phenols Polyphenols Pigments Paeoniaceae Disease Research Fields Cancer	COX
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

HY-14650

DHEA Maximum Cited Publications 32 Publications Verification Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Androgen Receptor Endogenous Metabolite
DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-N2329

Piperlongumine 5+ Cited Publications Piplartine	Piper longum Linn. Infection Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Piperaceae Plants Disease Research Fields	ERK Reactive Oxygen Species Autophagy Apoptosis Bacterial Ferroptosis
Piperlongumine is a alkaloid , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities . Piperlongumine induces ROS, and induces apoptosis in cancer cell lines . Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome .

HY-W009884R

Acetosyringone (Standard)	Structural Classification Monophenols Microorganisms other families Ketones, Aldehydes, Acids Source classification Phenols Plants	Endogenous Metabolite
Acetosyringone (Standard) is the analytical standard of Acetosyringone. This product is intended for research and analytical applications. Acetosyringone is a phenolic compound from wounded plant cells, enables virA gene which encodes a membrane-bound kinase to phosphorylate itself and activate the virG gene product, which stimulates the transcription of other vir genes and itself[1]. Acetosyringone enhances efficient Dunaliella transformation of Agrobacterium strains[2].

HY-N2459R

Peonidin (chloride) (Standard)	Structural Classification Anthocyans Flavonoids Microorganisms Paeonia lactiflora Pall. Source classification Phenols Polyphenols Plants Paeoniaceae	COX
Peonidin (chloride) (Standard) is the analytical standard of Peonidin (chloride). This product is intended for research and analytical applications. Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

HY-13771A

Ursodeoxycholic acid sodium 15+ Cited Publications Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Inflammation/Immunology Disease Research Fields Steroids	G protein-coupled Bile Acid Receptor 1 FXR Endogenous Metabolite
Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active .

HY-13771

Ursodeoxycholic acid 15+ Cited Publications Ursodeoxycholate; Ursodiol; UDCA	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields Steroids Cancer	G protein-coupled Bile Acid Receptor 1 FXR Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active .

HY-13771R

Ursodeoxycholic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Source classification Disease markers Endogenous metabolite Steroids	G protein-coupled Bile Acid Receptor 1 FXR Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Ursodeoxycholic acid (Standard) is the analytical standard of Ursodeoxycholic acid. This product is intended for research and analytical applications. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active .

Species:	Human (3)
Tag:	His (3) MBP (2) Flag (2)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71191

	PDCD4 Protein, Human (His) Programmed Cell Death Protein 4; Neoplastic transformation Inhibitor Protein; Nuclear Antigen H731-Like; Protein 197/15a; PDCD4; H731	Human	E. coli
	PDCD4 inhibits translation initiation by disrupting the EIF4A1-EIF4G interaction and inhibiting EIF4A helicase activity. It regulates JUN kinase activation and downregulates MAP4K1, inhibiting invasion and tumorigenesis. PDCD4 Protein, Human (His) is the recombinant human-derived PDCD4 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P701382

	TRPA1 Protein, Human (HEK293, His, MBP, FLAG) TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; transformation-sensitive protein p120; Wasabi receptor	Human	HEK293
	The TRPA1 protein is a receptor-activated nonselective cation channel that is critical for pain detection and may affect cold sensation, oxygen sensing, cough reflex, itch, and inner ear function. It responds to inflammatory mediators and irritants such as allyl thiocyanate (AITC), cinnamic aldehyde, diallyl disulfide (DADS), and acrolein. TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived TRPA1 protein, expressed by HEK293 , with N-10*His, N-MBP, C-Flag labeled tag.

HY-P702035

	SLC37A4 Protein, Human (sf9, His, MBP, FLAG) SLC37A4; Glucose-6-phosphate exchanger SLC37A4; Glucose-5-phosphate transporter; Glucose-6-phosphate translocase; Solute carrier family 37 member 4; transformation-related gene 19 protein; TRG-19	Human	Sf9 insect cells
	SLC37A4 protein, an endoplasmic reticulum antiporter, transports glucose-6-phosphate into the endoplasmic reticulum lumen while moving inorganic phosphate in the opposite direction. This function is integral to glucose production through glycogenolysis and gluconeogenesis, underscoring SLC37A4's central role in regulating blood glucose levels and maintaining metabolic balance. SLC37A4 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC37A4 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-136441S

Triclosan-methyl-d3
Triclosan-methyl-d₃ is the deuterium labeled Triclosan-methyl. Triclosan-methyl is a transformation product of triclosan. Triclosan is a bactericide in personal care products such as toothpaste, shampoos, and soaps. Triclosan is also a stabilizing agent in a multitude of detergents and cosmetics .

HY-113478S

Ursodeoxycholic acid-2,2,4,4-d4

Ursodeoxycholic acid-2,2,4,4-d₄ is the deuterium labeled Ursodeoxycholic acid (HY-13771). Ursodeoxycholic acid is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection .

HY-W750600

Acetonitrile-15N

Acetonitrile-15N (Methyl cyanide-15N) is a stable isotope labeled organic compound with important applications in metabolic research and molecular labeling. Acetonitrile-15N is used in biolabeling experiments to track metabolic pathways and help understand the chemical reaction mechanisms in organisms. Acetonitrile-15N is also widely used in environmental science to study the migration and transformation processes of pollutants.

HY-13771S1

Ursodeoxycholic acid-13C

Ursodeoxycholic acid- ¹³C is the ¹³C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80317

	S100A4 Antibody (YA084) 18A2 antibody; 42A antibody; calcium Placental protein antibody; Calvasculin antibody; CAPL antibody; Fibroblast specific protein 1 (FSP1) antibody; Fibroblast specific protein 1 antibody; Fibroblast specific protein antibody; FSP1 antibody; Leukemia multidrug resistance associated protein antibody; Malignant transformation suppression 1 (MTS1) antibody; Malignant transformation suppression 1 antibody; Metastasin antibody; MTS1 antibody; OTTHUMP00000015467 antibody; OTTHUMP00000015468 antibody; P9KA antibody; PEL98 antibody; Placental calcium-binding protein antibody; Protein Mts1 antibody; Protein S100 A4 antibody; Protein S100-A4 antibody; S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) antibody; S100 calcium binding protein A4 antibody; S100 calcium-binding protein A4 antibody; S100a4 antibody; S10A4_HUMAN antibody;	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	S100A4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 12 kDa, targeting to S100A4. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P81449

	hnRNP K Antibody (YA1194) HNRNPK; HNRPK; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; transformation up-regulated nuclear protein; TUNP	IHC-P	Human
	hnRNP K Antibody (YA1194) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1194), targeting hnRNP K. hnRNP K Antibody (YA1194) can be used for IHC-P experiment in human background.

HY-P83584

	BNIP1 Antibody (YA3329) BCL2 adenovirus E1B 19kD interacting protein 1; BNIP1; Nip1; sec20; SEC20L; transformation-related gene 8 protein; TRG8; Vesicle transport protein SEC20	WB, IHC-P	Human, Mouse, Rat
	BNIP1 Antibody (YA3329) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3329), targeting BNIP1, with a predicted molecular weight of 26 kDa (observed band size: 26 kDa). BNIP1 Antibody (YA3329) can be used for WB, IHC-P experiment in human, mouse, rat background.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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