Search Result
Results for "
thermal
" in MedChemExpress (MCE) Product Catalog:
14
Biochemical Assay Reagents
7
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N6875
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Others
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Metabolic Disease
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oleuropeinic acid is present initially in olive tissues or formed by the thermal treatment, possibly by the oxidation of oleuropein. Oleuropeinic acid is an antioxidant-soluble fiber .
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- HY-D0859A
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Biochemical Assay Reagents
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Others
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MOPS sodium salt is a buffering agent used in biology. MOPS buffer maintains the pH of mammalian cell culture media. MOPS sodium salt significantly improves the thermal stability of BSA (HY-D0842) .
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- HY-W248115
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Fluorescent Dye
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Others
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Pyrromethene 597 is a BODIPY laser dye. Pyrromethene 597 displays wide tuning range of lasing wavelengths and high photostability. Pyrromethene 597 can be used as a thermal probe .
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- HY-131986
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TRP Channel
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Neurological Disease
Inflammation/Immunology
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LASSBio-1135 (Compound 3a) is an orally active TRPV1 antagonist. LASSBio-1135 is an anti-inflammatory and analgesic compound. LASSBio-1135 inhibits moderately the human PGHS-2 enzyme activity (IC50 = 18.5 μM). LASSBio-1135 reverts the Capsaicin (HY-10448)-induced thermal hyperalgesia and reduces the carrageenan-induced rat paw edem .
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- HY-D0877
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Biochemical Assay Reagents
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Others
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TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) .
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- HY-151771
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ADC Linker
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Others
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DACN(Tos,Mal) is a click chemistry reagent containing an azide. DACN(Tos,Mal) possess high thermal and chemical stability along with comparable click reactivity .
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- HY-152469
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Epigenetic Reader Domain
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Cancer
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Eleven-Nineteen-Leukemia Protein IN-1 is an inhibitor of ENL YEATS domain with an IC50 value of 14.5 nM. Eleven-Nineteen-Leukemia Protein IN-1 interacts with ENL protein and enhances the thermal stability of ENL protein in vitro .
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- HY-103177
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Adenosine Receptor
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Inflammation/Immunology
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PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice .
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- HY-D1915
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Fluorescent Dye
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Others
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ATTO 390 is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy.
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- HY-129283
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Ras
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Others
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Goralatide is a compound that regulates the thermal sensitivity of hematopoietic progenitor cells. It can reduce the thermal sensitivity of normal hematopoietic progenitor cells and increase the difference in thermal sensitivity between leukemia progenitor cells and normal progenitor cells, thereby increasing the inhibition window of hyperthermia therapy.
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- HY-110099
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CXCR
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Inflammation/Immunology
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(±)-NBI-74330 is a potent and selective CXCR3 antagonist. (±)-NBI-74330 not only reduces tactile and thermal hypersensitivity but also enhances the analgesic properties of morphine. (±)-NBI-74330 can reduce microglial cell activation, increase astroglial cell activation, and downregulate the expression of some CXCR3 ligands in a rat neuropathic pain model .
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- HY-120476
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TRP Channel
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Neurological Disease
Inflammation/Immunology
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JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448)-induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474)- and CFA (HY-153808)-induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs .
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- HY-D1999
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Fluorescent Dye
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Others
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ATTO 665 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 665 NHS ester is an NHS ester derivative of ATTO 665 that can be used to label proteins or antibodies.
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- HY-D1939
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Fluorescent Dye
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Others
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ATTO 465 amine is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 465 amine is an amine derivative of ATTO 465 and can be used to label proteins or antibodies.
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- HY-D2038
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Fluorescent Dye
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Others
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ATTO 550 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 550 alkyne is an alkyne derivative of ATTO 550 and can be used to label proteins or antibodies.
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- HY-D1305
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Fluorescent Dye
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Others
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ATTO 488 carboxylic acid is a new fluorescent label based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 carboxylic acid is a carboxylic acid derivative of ATTO 488, which can be used to label proteins or antibodies.
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- HY-D1961
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Fluorescent Dye
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Others
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ATTO 565 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 maleimide is a maleimide derivative of ATTO 565, which can be used to label proteins or antibodies.
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- HY-D2046
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Fluorescent Dye
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Others
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ATTO 532 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 532 NHS ester is an NHS ester derivative of ATTO 532 that can be used to label proteins or antibodies.
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- HY-D1957
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Fluorescent Dye
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Others
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ATTO 633 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 633 NHS ester is an NHS ester derivative of ATTO 633 that can be used to label proteins or antibodies.
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- HY-D2019
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Fluorescent Dye
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Others
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ATTO 550 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 550 NHS ester is an NHS ester derivative of ATTO 550 that can be used to label proteins or antibodies.
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- HY-153524
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Fluorescent Dye
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Others
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ATTO 425 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 425 NHS ester is an NHS ester derivative of ATTO 425 that can be used to label proteins or antibodies.
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- HY-D1993
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Fluorescent Dye
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Others
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ATTO 647 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 647 NHS ester is an NHS ester derivative of ATTO 647 that can be used to label proteins or antibodies.
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- HY-D1929
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Fluorescent Dye
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Others
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ATTO 594 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 594 NHS ester is an NHS ester derivative of ATTO 594 that can be used to label proteins or antibodies.
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- HY-D2062
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Fluorescent Dye
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Others
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ATTO 740 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 740 NHS ester is an NHS ester derivative of ATTO 740 that can be used to label proteins or antibodies.
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- HY-D2014
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Fluorescent Dye
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Others
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ATTO 565 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 alkyne is an alkyne derivative of ATTO 565 and can be used to label proteins or antibodies.
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- HY-D2035
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Fluorescent Dye
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Others
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ATTO 514 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 514 alkyne is an alkyne derivative of ATTO 514 and can be used to label proteins or antibodies.
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- HY-D2002
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Fluorescent Dye
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Others
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ATTO 488 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 maleimide is a maleimide derivative of ATTO 488, which can be used to label proteins or antibodies.
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- HY-D2047
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Fluorescent Dye
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Others
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ATTO 532 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 532 maleimide is a maleimide derivative of ATTO 532, which can be used to label proteins or antibodies.
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- HY-D2016
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Fluorescent Dye
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Others
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ATTO 565 cadaverine is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 cadaverine is a cadaverine derivative of ATTO 565, which can be used to label proteins or antibodies.
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- HY-D1959
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Fluorescent Dye
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Others
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ATTO 565 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 NHS ester is an NHS ester derivative of ATTO 565 that can be used to label proteins or antibodies.
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- HY-D2063
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Fluorescent Dye
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Others
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ATTO 740 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 740 maleimide is a maleimide derivative of ATTO 740, which can be used to label proteins or antibodies.
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- HY-D2015
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Fluorescent Dye
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Others
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ATTO 488 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 alkyne is an alkyne derivative of ATTO 488 and can be used to label proteins or antibodies.
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- HY-D1933
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Fluorescent Dye
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Others
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ATTO 590 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 590 maleimide is a maleimide derivative of ATTO 590, which can be used to label proteins or antibodies.
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- HY-D2059
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Fluorescent Dye
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Others
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ATTO 700 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 700 maleimide is a maleimide derivative of ATTO 700, which can be used to label proteins or antibodies.
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- HY-D2058
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Fluorescent Dye
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Others
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ATTO 700 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 700 NHS ester is an NHS ester derivative of ATTO 700 that can be used to label proteins or antibodies.
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- HY-D2026
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Fluorescent Dye
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Others
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ATTO 514 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 514 NHS ester is an NHS ester derivative of ATTO 514 that can be used to label proteins or antibodies.
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- HY-D1932
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Fluorescent Dye
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Others
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ATTO 590 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 590 NHS ester is an NHS ester derivative of ATTO 590 that can be used to label proteins or antibodies.
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- HY-D2073
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Fluorescent Dye
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Others
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ATTO 680 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 680 NHS ester is an NHS ester derivative of ATTO 680 that can be used to label proteins or antibodies.
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- HY-D2074
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Fluorescent Dye
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Others
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ATTO 680 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 680 maleimide is a maleimide derivative of ATTO 680, which can be used to label proteins or antibodies.
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- HY-D2021
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Fluorescent Dye
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Others
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ATTO 550 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 550 maleimide is a maleimide derivative of ATTO 550, which can be used to label proteins or antibodies.
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- HY-D1917
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Fluorescent Dye
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Others
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ATTO 390 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 390 NHS ester is an NHS ester derivative of ATTO 390 that can be used to label proteins or antibodies.
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- HY-D2052
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Fluorescent Dye
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Others
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ATTO 532 iodacetamid is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 532 iodacetamid is an iodoacetamide derivative of ATTO 532, which can be used to label proteins or antibodies.
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- HY-D2001
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Fluorescent Dye
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Others
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ATTO 488 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 NHS ester is an NHS ester derivative of ATTO 488 that can be used to label proteins or antibodies.
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- HY-D1935
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Fluorescent Dye
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Others
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ATTO 465 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 465 NHS ester is an NHS ester derivative of ATTO 465 that can be used to label proteins or antibodies.
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- HY-D1946
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Fluorescent Dye
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Others
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ATTO 590 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 590 alkyne is an alkyne derivative of ATTO 590 and can be used to label proteins or antibodies.
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- HY-169498
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- HY-D2001A
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Fluorescent Dye
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Others
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TTO 488 NHS ester TEA is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. TTO 488 NHS ester TEA is an NHS ester derivative of ATTO 488 that can be used to label proteins or antibodies.
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- HY-162600
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CDK
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Inflammation/Immunology
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CDK8-IN-15 (Compound 46) is a potent CDK8 inhibitors with an IC50 value of 57 nM. It can enhance the thermal stability of CDK8 along with inhibition against NF-κB and have favourable selectivity across the CDK family and tyrosine kinase. Additionally, it also demostrates a positive effect in vitro psoriasis model induced by TNF-α and alleviats the inflammatory response enhancing the expression of Foxp3 and IL-10, which is promising for research of psoriasis diseases .
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- HY-N6600
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- HY-101482
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U75630
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COX
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Inflammation/Immunology
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Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
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- HY-125409A
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Amino Acid Derivatives
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Others
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(S,R)-Lysinoalanine is an unnatural amino acid that can be formed in food submitted to thermal treatment, especially in alkaline conditions .
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- HY-167629
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Phytohormone
Drug Intermediate
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Others
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Gibberellenic acid is an intermediate gibberellin compound with a tetracyclic diterpenoid skeleton, and can be generated by thermal decomposition of Gibberellic acid (GA3, HY-N1964) in aqueous solution. Gibberellenic acid is thermally unstable in water and can further convert into allogibberic acid (approximately 80%) and 9-epiallogibberic acid (approximately 10%). It plays an important role in the degradation pathway and structural elucidation of Gibberellins .
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- HY-N9929
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Others
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Others
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Docosane, a straight chain alkane, can be used to synthesize structural composites with thermal energy storage/release capability .
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- HY-P5874
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Calcium Channel
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Inflammation/Immunology
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Myr-TAT-CBD3 is CRMP2-CaV2.2 interaction inhibitor. Myr-tat-CBD3 can significantly attenuate carrageenan-induced thermal hypersensitivity and reverse thermal hypersensitivity induced in a rat model of postoperative pain. Myr-TAT-CBD3 can be used to study inflammation and postoperative pain .
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- HY-W342926
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- HY-151754
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ADC Linker
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Others
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DACN(Tos2,6-OH) is a click chemistry reagent containing an Azide. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. The reactivity of an alkyne heavily depends on the electronic and steric characteristics of the substituents as well as structural strain. In comparison to nonbent acyclic alkynes, cyclononyne alkynes show remarkably high reactivity. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. In comparison to cyclooctynes, DACNs possess high thermal and chemical stability along with comparable click reactivity . DACN(Tos2,6-OH) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-170490
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Photosensitizer
Apoptosis
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Cancer
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TTQ-SA is a near-infrared (NIR) spiro-AIEgen (aggregation-induced emission luminogen), that converts near-infrared light (NIR) into thermal energy, causing thermal damage and death of tumor cells. TTQ-SA exhibits cellular uptake and targeting ability in cancer cell MF-7. TTQ-SA silences the expression of survivin gene with combination of DNAzyme, enhances the sensitivity of tumor cells to photothermal therapy .
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- HY-111029
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GlyT
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Neurological Disease
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ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model .
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- HY-103368
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Chloride Channel
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Neurological Disease
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Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity .
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- HY-W011831
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3-(Benzyldimethylammonio)propane-1-sulfonate; PDA
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Biochemical Assay Reagents
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Others
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NDSB-256 is a non-stain remover sulfabetaine. NDSB-256 prevents protein aggregation and promotes denaturation of chemically and thermally denatured proteins .
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- HY-111029A
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GlyT
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Others
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ALX-1393 TFA, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model .
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- HY-N6600S
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Isotope-Labeled Compounds
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Others
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Octadecane-d38 is the deuterium labeled Octadecane . Octadecane is an alkane that is used to store thermal energy at ambient temperature as a phase change material .
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- HY-144220
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- HY-112013
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Cholinesterase (ChE)
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Neurological Disease
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Isodimethoate is a thermal decomposition product of Dimethoate (HY-B1946). Isodimethoate is a direct anticholinesterase agent and shows an inhibition to human red blood cell acetylcholinesterase (AChE) .
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- HY-N9929S
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Isotope-Labeled Compounds
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Others
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Docosane-d46 is the deuterium labeled Docosane . Docosane, a straight chain alkane, can be used to synthesize structural composites with thermal energy storage/release capability .
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- HY-148707
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- HY-101482R
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U75630 (Standard)
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Reference Standards
Others
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Inflammation/Immunology
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Ibuprofen piconol (Standard) is the analytical standard of Ibuprofen piconol. This product is intended for research and analytical applications. Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
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- HY-N9929R
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Reference Standards
Others
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Others
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Docosane (Standard) is the analytical standard of Docosane. This product is intended for research and analytical applications. Docosane, a straight chain alkane, can be used to synthesize structural composites with thermal energy storage/release capability .
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- HY-151794
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ADC Linker
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Others
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DACN(Ms) (hydrochloride) (compound 1ba) is a click chemistry reagent containing cyclononyne alkyne. DCN(Ms) (hydrochloride) has high thermal stability, chemical stability, water solubility, and high reactivity for cycloaddition reactions .
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- HY-120594
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Enterovirus
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Others
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R78206 is an antiviral pyridazinamine compound with the activity of protecting poliovirus from thermal inactivation, having different effects on different poliovirus strains at different concentrations, and having a highly effective stabilizing effect on Mahoney procapsids.
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- HY-D0859
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Biochemical Assay Reagents
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Others
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MOPS is a buffering agent used in biology. MOPS buffer maintains the pH of mammalian cell culture media. MOPS significantly improves the thermal stability of BSA (HY-D0842) .
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- HY-W040263
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TAPS Na
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Biochemical Assay Reagents
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Others
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TAPS sodium is a biological buffer that protects the structural integrity of lysozyme bacteria and prevents them from thermal denaturation at high temperatures. A pKa of 8.1 for TAPS results in half-maximal connexin channel activity .
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- HY-128454
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Endogenous Metabolite
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Others
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Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. Dimethyl trisulfide is a cyanide antidote. Dimethyl trisulfide formation requires the thermal degradation of Met .
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- HY-106841
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R-75231; R88021
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Adenosine Receptor
Nucleoside Transporters
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Inflammation/Immunology
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Draflazine (R-75231) is a ENT1 inhibitor. Draflazine (R-75231) completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia and the carrageenan inflammation model of thermal and mechanical hyperalgesia .
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- HY-124831
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Neurotensin Receptor
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Neurological Disease
|
|
NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2),with the EC50 of 238 nM. NTRC-844 plays an important role in analgesic animal research .
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-
- HY-Y1004
-
|
Decyl alcohol
|
Biochemical Assay Reagents
|
Others
|
|
1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.
|
-
- HY-125830
-
|
|
Biochemical Assay Reagents
|
Others
|
|
ITIC, non-fullerene acceptor, is an indacenodithienothiophene-based postfullerene electron acceptor, crystallizes in a profoundly different way as compared to fullerenes.
ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C.
|
-
- HY-P991321
-
|
|
Trk Receptor
|
Inflammation/Immunology
|
|
ABT-110 is a human monoclonal antibody (mAb) targeting NGF/bNGF. ABT-110 reduces established thermal and mechanical hypersensitivity in the CFA rat model. ABT-110 can be used in persistent/chronic inflammatory pain research .
|
-
- HY-B0352B
-
|
(R)-Org3770; (R)-6-Azamianserin
|
5-HT Receptor
|
Neurological Disease
|
|
(R)-Mirtazapine ((R)-Org3770) is a R( )-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4 .
|
-
- HY-147934
-
|
|
HDAC
Apoptosis
|
Cancer
|
|
HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines .
|
-
- HY-120546
-
|
Z944; PRAX-944
|
Calcium Channel
|
Neurological Disease
Inflammation/Immunology
|
|
Ulixacaltamide (Z944) is an orally available T-type calcium channel antagonist that can slow the progression of epilepsy. Ulixacaltamide effectively reduces tremor in a normal alkaline tremor animal model. Ulixacaltamide reverses thermal hyperalgesia and mediates pain relief .
|
-
- HY-W040240
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite generated by the thermal decomposition of β-D-glucopyranose and further isomerization .
|
-
- HY-B0352A
-
|
(S)-Org3770; (S)-6-Azamianserin
|
5-HT Receptor
|
Neurological Disease
|
|
(S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2 .
|
-
- HY-22445
-
|
|
c-Myc
|
Cancer
|
MY05 selectively targets c-MYC in cells and disrupts MYC-MAX interaction. MY05 engages intracellular c-MYC, modulates c-MYC thermal stability, reduces c-MYC transcriptional targets, and possesses anticancer activity (TNBC, Triple-Negative Breast Cancer) .
|
-
- HY-Y1324
-
|
Disodium hydrogen phosphate dodecahydrate; Disodium phosphate dodecahydrate
|
Biochemical Assay Reagents
|
Endocrinology
|
|
Phosphoric acid disodium dodecahydrate is an inorganic compound and food additive. Phosphoric acid disodium dodecahydrate promotes gel formation, improves food texture and thermal properties of materials. Phosphoric acid disodium dodecahydrate induces glomerular calcification. Phosphoric acid disodium dodecahydrate can be used in kidney disease research .
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-
- HY-131182
-
|
|
Sodium Channel
|
Neurological Disease
|
|
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects .
|
-
- HY-D0859S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
MOPS-d15 is the deuterium labeled MOPS (HY-D0859). MOPS is a buffering agent used in biology. MOPS buffer maintains the pH of mammalian cell culture media. MOPS significantly improves the thermal stability of BSA (HY-D0842) .
|
-
- HY-W142432
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Perfluoroundecanoic acid is an orally active inducer of oxidative stress and DNA damage. Perfluoroundecanoic acid exhibits genotoxicity and reproductive toxicity in swiss mice. Perfluoroundecanoic acid is utilized as a processing aid in the manufacture of fluoropolymer for its thermal and pressure stability, and properties of having both water-repellent and oil-repellent groups and hydrophilic groups on the same molecule .
|
-
- HY-128454R
-
|
|
Reference Standards
Endogenous Metabolite
|
Others
|
|
Dimethyl trisulfide (Standard) is the analytical standard of Dimethyl trisulfide. This product is intended for research and analytical applications. Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. Dimethyl trisulfide is a cyanide antidote. Dimethyl trisulfide formation requires the thermal degradation of Met .
|
-
- HY-B0352BS
-
|
(R)-Org3770 d3; (R)-6-Azamianserin d3
|
Isotope-Labeled Compounds
5-HT Receptor
|
Neurological Disease
|
|
(R)-Mirtazapine-d3 is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].
|
-
- HY-152471
-
|
|
Epigenetic Reader Domain
|
Cancer
|
|
Eleven-Nineteen-Leukemia Protein IN-3 is an orally active inhibitor of ENL YEATS domain with an IC50 value of 15.4 nM. Eleven-Nineteen-Leukemia Protein IN-3 down-regulates MYC expression through ENL in cells and can enhances the thermal stability of ENL protein in vitro .
|
-
- HY-W009641
-
|
PyM; 1-HMP
|
Biochemical Assay Reagents
|
Others
|
|
1-Pyrenemethanol is an organic compound that can be used to prepare graphene films with excellent thermal conductivity, flexibility and mechanical properties. 1-Pyrenemethanol binds to graphene oxide sheets through hydrogen bonds and π-π interactions to form GO-PyM films, increasing the dispersion and stability of the material .
|
-
- HY-E70308
-
|
|
Endogenous Metabolite
|
Others
|
|
Glucose isomerase (immobilized) is a glucose isomerase that catalyzes the reversible isomerization of D-glucose and D-xylose into D-fructose and D-xylulose, respectively. Glucose isomerase (immobilized) is thermally stable and can be used to produce fructose syrup at high temperatures above 90°C. Glucose isomerase (immobilized) is widely distributed in prokaryotes .
|
-
- HY-W073183
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H 2PtCl 6·6H 2O and FeCl 2·4H 2O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .
|
-
- HY-P5914
-
|
WaTx
|
TRP Channel
|
Neurological Disease
|
|
Wasabi Receptor Toxin is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin is the activator for TRPA1 ion channel with EC50 in nanomolar level, and prolongs the channel open time, but reduces Ca 2+ permeability. Wasabi Receptor Toxin causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .
|
-
- HY-B0352AS
-
|
(S)-Org3770 d3; (S)-6-Azamianserin d3
|
5-HT Receptor
|
Neurological Disease
|
|
(S)-Mirtazapine-d3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].
|
-
- HY-Y1004R
-
|
Decyl alcohol (Standard)
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
1-Decanol (Standard) is the analytical standard of 1-Decanol. This product is intended for research and analytical applications. 1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.
|
-
- HY-N8487
-
|
|
Cytochrome P450
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
7-Methoxyflavone is a flavonoid compound that can be isolated from Zornia brasiliensis. 7-Methoxyflavone can bind to human serum albumin and is an aromatase inhibitor. 7-Methoxyflavone has peripheral analgesic and certain antitumor activities. 7-Methoxyflavone is effective against chemical pain but has no significant effect on thermal pain .
|
-
- HY-116258
-
|
|
Liposome
|
Others
|
|
C16 Ceramide (d16:1,C16:0) is a bioactive sphingolipid that induces ordered- and gel-phase formation and thermal stabilization of palmitoylsphingomyelin-rich domains in palmitoylphosphocholine (POPC) bilayers. C16 Ceramide (d16:1,C16:0) is found in sphingomyelins in human erythrocytes .
|
-
- HY-168737
-
|
|
NOD-like Receptor (NLR)
NEKs
|
Inflammation/Immunology
|
|
NEK7-IN-2 (compound 23) is a potent inhibitor of NLRP3-NEK7 interaction. NEK7-IN-2 can enhance the thermal stability of NEK7 and regulatie NLRP3 inflammasome assembly. NEK7-IN-2 inhibits IL-1β releases .
|
-
- HY-Y1004S6
-
|
Decyl alcohol-d2-2
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
1-Decanol-d2-2 is deuterated labeled 1-Decanol (HY-Y1004). 1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.
|
-
- HY-151795
-
|
|
ADC Linker
|
Others
|
|
DACN(Tos) hydrochloride is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions, such strain-promoted azide-alkyne cycloadditions (SPAAC) by using cycloalkynes. DACNs possesses high thermal and chemical stability along with comparable click reactivity. DACN(Tos) hydrochloride can be used for the research of molecular conjugation .
|
-
- HY-Y1309
-
|
Furro ER; NSC 9586; Nako TRB
|
Endogenous Metabolite
|
Others
|
|
1-naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media .
|
-
- HY-W142432R
-
|
|
Reference Standards
Biochemical Assay Reagents
|
Others
|
|
Perfluoroundecanoic acid (Standard) is the analytical standard of Perfluoroundecanoic acid. This product is intended for research and analytical applications. Perfluoroundecanoic acid is an orally active inducer of oxidative stress and DNA damage. Perfluoroundecanoic acid exhibits genotoxicity and reproductive toxicity in swiss mice. Perfluoroundecanoic acid is utilized as a processing aid in the manufacture of fluoropolymer for its thermal and pressure stability, and properties of having both water-repellent and oil-repellent groups and hydrophilic groups on the same molecule .
|
-
- HY-144396
-
|
|
SHP2
Phosphatase
Akt
Apoptosis
|
Cancer
|
|
SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 ℃. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells .
|
-
- HY-18618
-
|
|
Opioid Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
SB-612111 is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model .
|
-
- HY-18617
-
|
|
Opioid Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
rel-SB-612111 hydrochloride is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). rel-SB-612111 hydrochloride exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. rel-SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model .
|
-
- HY-108298
-
|
PP 5; Perfluorodecahydronaphthalene
|
Biochemical Assay Reagents
|
Others
|
|
Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears . Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O2-carrier and used as artificial blood . Perfluorodecalin enhances bone regeneration and cell viability .
|
-
- HY-W250309
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Pentaerythritol tetra(3-mercaptopropionate)It is a class of organic compounds containing both pentaerythritol and mercaptopropionate groups. It is commonly used as a stabilizer and crosslinking agent in various chemical and industrial applications. Pentaerythritol tetra(3-mercaptopropionate)Has a variety of properties that make it suitable for these applications, including the ability to increase the mechanical strength, thermal stability and weatherability of polymers and coatings. Additionally, it can be used as a feedstock for the production of other specialty chemicals and materials.
|
-
- HY-P5704
-
|
|
Bacterial
|
Infection
|
|
K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability .
|
-
- HY-108035
-
|
MR04A3
|
GABA Receptor
|
Neurological Disease
|
|
(-)-JM-1232 (MR04A3) targets GABA A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA A receptors. (-)-JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI50 values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-)-JM-1232 can be used in research related to pain and analgesia .
|
-
- HY-W127717
-
|
Perfluoro-compound FC-40
|
Biochemical Assay Reagents
|
Others
|
|
Fluorinert FC-40 is a non-conductive liquid containing a mixture of fluorinated compounds. It is commonly used as a cooling and heat transfer fluid in electronics, especially in high-performance computer systems and electronic components that generate a lot of heat. Fluorinert FC-40 has various properties that make it ideal for these applications, including its low viscosity, high thermal stability and excellent dielectric strength. In addition, it can be used as an inert solvent in chemical reactions and a lubricant in mechanical systems.
|
-
- HY-151766
-
|
|
ADC Linker
|
Others
|
|
DACN(Tos,Suc-OH) is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. DACNs possess high thermal and chemical stability along with comparable click reactivity .
|
-
- HY-P5914A
-
|
WaTx TFA
|
TRP Channel
|
Neurological Disease
|
|
Wasabi Receptor Toxin TFA (WaTx TFA) is the TFA salt form of Wasabi Receptor Toxin (HY-P5914). Wasabi Receptor Toxin TFA is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin TFA is the activator for TRPA1 ion channel with EC50 in nanomolar level, and prolongs the channel open time, but reduces Ca 2+ permeability. Wasabi Receptor Toxin TFA causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .
|
-
- HY-161321
-
|
|
Phosphatase
Insulin Receptor
Akt
|
Metabolic Disease
|
|
PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT .
|
-
- HY-19745B
-
|
|
PD-1/PD-L1
Apoptosis
|
Cancer
|
|
BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity .
|
-
- HY-19745
-
BMS-202
Maximum Cited Publications
21 Publications Verification
|
PD-1/PD-L1
Apoptosis
|
Cancer
|
|
BMS-202 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 has antitumor activity .
|
-
- HY-P2917B
-
|
GyK, Flavobacterium meningosepticum
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glycerol kinase, Flavobacterium meningosepticum (GyK, Flavobacterium meningosepticum) is a thermostable glycerol kinase isolated from Flavobacterium meningosepticum. Glycerol kinase, Flavobacterium meningosepticum catalyzes the first step in glycerol metabolism by converting triol to glycerol-3-p (G3P). Glycerol kinase, Flavobacterium meningosepticum is essential for regulating glycerol uptake in cells that is independent of channels or facilitators and is useful for biochemical studies .
|
-
- HY-12914
-
|
|
TRP Channel
|
Neurological Disease
Inflammation/Immunology
|
|
V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC50=423.2 nM for CAP; IC50=180.3 nM for acid). V116517 can be used for the research of pain .
|
-
- HY-131445A
-
|
|
Orphan Receptor
|
Metabolic Disease
Inflammation/Immunology
|
|
SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability .
|
-
- HY-P2866A
-
|
NAG, Porcine kidney
|
Others
|
Others
|
|
β-N-Acetylhexosaminidase, Porcine kidney is a glycosidase with transglycosylation activity, used to generate health-beneficial human milk oligosaccharides, and it effectively interacts with low molecular weight sugar alcohols (such as glycerol, erythritol, and xylitol). The enzyme exhibits optimal activity at pH 5 and 40 °C, and shows high thermal stability (up to 55°C) when bound to the cell wall. β-N-Acetylhexosaminidase holds promise for applications in the biotransformation of Chitin (HY-126389) and research in the food health sector .
|
-
- HY-171035
-
|
|
Quinone Reductase
Keap1-Nrf2
Aminotransferases (Transaminases)
|
Metabolic Disease
|
|
PRL-295 is an orally active inhibitor targeting Keap1-Nrf2 interaction. PRL-295 increases the thermal stability of Keap1 and disrupts its interaction with Nrf2, thereby activating the Nrf2-dependent transcriptional target NAD(P)H:quinone oxidoreductase 1 (NQO1). PRL-295 protects against Acetaminophen (HY-66005)-induced liver injury in mice .
|
-
- HY-169780
-
|
|
TRP Channel
|
Neurological Disease
Inflammation/Immunology
|
|
(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca 2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models .
|
-
- HY-D1189
-
|
Lucifer Yellow 3-amino-D-alanine
|
Fluorescent Dye
|
Others
|
|
YADA (Lucifer Yellow 3-amino-D-alanine) is a conjugate of the fluorescent dyes Lucifer yellow and D-alanine, which is a green-yellow fluorescent dye. YADA is suitable for labeling peptidoglycans in living bacteria that can be incorporated into the cell wall where they are being synthesized. YADA has a large Stokes shift and a wide emission spectrum, allowing excitation through a purple light source and detection using a green filter. YADA showed good water solubility, light stability and thermal stability.
|
-
- HY-W007596
-
|
Ir(ppy)3; Tris[2-(pyridin-2-yl)phenyl]iridium
|
Biochemical Assay Reagents
|
Others
|
|
Tris(2-phenylpyridinato-C2,N)iridium(III) (Ir(ppy)3) is an iridium(III) containing organometallic complex, which is used as a phosphorescent light-emitting material. Tris(2-phenylpyridinato-C2,N)iridium(III) exhibits high luminous efficiency and good thermal stability, that can be used in organic optoelectronics, especially in improving the luminescence efficiency and stability of organic light-emitting diodes (OLEDs) .
|
-
- HY-163987
-
|
|
Sirtuin
|
Neurological Disease
|
|
SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner .
|
-
- HY-W105639A
-
|
Calcium lactate pentahydrate, meets USP testing specifications
|
Biochemical Assay Reagents
|
Others
|
|
Calcium L-lactate pentahydrate, meets USP testing specifications (Calcium lactate pentahydrate, meets USP testing specifications) is a biochemical reagent and serves as one of the important sources of calcium. Compared to other organic calcium salts, Calcium L-lactate pentahydrate, meets USP testing specifications exhibits excellent solubility and bioavailability. Calcium L-lactate pentahydrate, meets USP testing specifications possesses remarkable moisture resistance, thermal stability, and chemical stability and can be used in medical implants and drug delivery systems .
|
-
- HY-161071
-
|
|
Fungal
|
Infection
Cancer
|
|
Antioxidant/anticancer agent 1 (compound 5) is a pyrimidine-derivatized Schiff base based on pyrimidine hydroxy-1-naphthaldehyde and has antibacterial, antioxidant, antifungal, and anticancer properties. Antioxidant/anticancer agent 1 .
|
-
- HY-110150
-
|
|
Others
|
Inflammation/Immunology
Cancer
|
|
UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects .
|
-
- HY-116005
-
|
|
Adenosine Kinase
|
Neurological Disease
Inflammation/Immunology
|
|
A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC50 value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents .
|
-
- HY-137294
-
|
Y6
|
Endogenous Metabolite
|
Others
|
|
BTPTT-4F (Y6) is a non-fullerene acceptor-donor-acceptor (A-D-A) type small molecular acceptor (SMA) characterized by its flexible alkyl chains and centrally fused ring structure. Featuring a ladder-type electron-deficient core, BTPTT-4F can be effectively blended with PM6, showcasing significant potential for enhancing the performance of organic photovoltaic applications. Its tailored optical properties and adjustable electronic energy levels contribute to improved thermal and photochemical stability, making it a promising candidate for next-generation high-performance organic solar cells.
|
-
- HY-W250308
-
|
Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
|
Bacterial
|
Others
|
|
Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .
|
-
- HY-159924
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
DBPR116 is a prodrug of BPRMU191 (HY-159923) with blood-brain barrier penetration capability. DBPR116 significantly improves the delivery of centrally targeted drugs. In combination with the antagonist Naltrexone (HY-76711), DBPR116 demonstrated superior safety and analgesic efficacy compared to morphine in various in vivo pharmacological studies, including thermal pain models, cancer pain models, constipation, sedation, psychological dependence, heart rate, and respiratory frequency. As a prodrug strategy for peripheral administration, DBPR116 effectively alleviates pain while reducing adverse effects, showing potential as a safer opioid analgesic .
|
-
- HY-P1410B
-
-
- HY-W250308A
-
|
Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
|
Bacterial
|
Infection
|
|
ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
|
-
- HY-W087830
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (LAT1 and LAT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma .
|
-
- HY-P1410C
-
|
|
Piezo Channel
Calcium Channel
mTOR
PI3K
Akt
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca 2+]i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .
|
-
- HY-15929
-
TBHBA
1 Publications Verification
2,4,6-Tribromo-3-hydroxybenzoic acid
|
Biochemical Assay Reagents
|
Others
|
|
TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H2O2) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites .
|
-
- HY-W087905
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2,3-Dimethyl-2,3-diphenylbutane is a minor product formed during the thermal decomposition of dicumyl peroxide (DCP) in cumene, generated through radical coupling reactions. As an initiator capable of producing free radicals, 2,3-dimethyl-2,3-diphenylbutane promotes cross-linking or decomposition processes via initiating free radical reactions in fields such as polymer polymerization (e.g., modification of polyphenylene oxide processing), organic synthesis (e.g., DCP decomposition reactions), and coal processing (e.g., oxidation stabilization of coal tar pitch), thereby enhancing material properties or reaction efficiency .
|
-
- HY-W016638
-
|
1-Butyl-1-methylpyrrolidin-1-ium chloride
|
Biochemical Assay Reagents
|
Others
|
|
1-Butyl-1-methylpyrrolidin-1-ium chloride, also known as BMIM chloride, belongs to the class of ionic liquids and consists of a positively charged pyrrolidine cation and a negatively charged chloride anion. This compound is commonly used as a solvent for various chemical reactions, especially those involving organic compounds and metals. Its unique physical and chemical properties, such as low volatility, high thermal stability, and tunable solubility, make it useful in a range of applications in catalysis, electrochemistry, and separation science. Furthermore, 1-butyl-1-methylpyrrolidin-1-ium chloride may have potential applications as a green solvent in energy storage devices and various industrial processes.
|
-
- HY-168166
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
CHET3 is a sex-selective activator with potent analgesic activity. CHET3 was discovered to be a highly selective omnidirectional modulator of TASK-3-containing K2P channels, including TASK-3 homologues and TASK-3/TASK-1 heterologues. CHET3 exhibited significant analgesic effects in multiple acute and chronic pain models in mice, which could be abolished by pharmacological means or genetic knockout of TASK-3. CHET3 is able to functionally modulate the membrane excitability of specific small sensory neurons, which supports its analgesic effects on thermal hypersensitivity and mechanical hyperalgesia in chronic pain .
|
-
- HY-B0168A
-
|
|
Serotonin Transporter
PERK
|
Neurological Disease
|
|
Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
|
-
- HY-B0168AR
-
|
|
Reference Standards
Serotonin Transporter
PERK
|
Neurological Disease
|
|
Milnacipran (hydrochloride) (Standard) is the analytical standard of Milnacipran hydrochloride (HY-B0168A). This product is intended for research and analytical applications. Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
|
-
- HY-B0168
-
|
|
Serotonin Transporter
PERK
|
Neurological Disease
|
|
Milnacipran is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran inhibits pERK1/2 activation. Milnacipran has antidepressant, anxiolytic and analgesic properties. Milnacipran inhibits biting behavior in mice. Milnacipran can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
|
-
- HY-B0168AS
-
|
|
Isotope-Labeled Compounds
Serotonin Transporter
PERK
|
Neurological Disease
|
|
Milnacipran-d5 hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
|
-
- HY-P1319
-
|
|
Opioid Receptor
|
Inflammation/Immunology
|
|
Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo .
|
-
- HY-P1319A
-
|
|
Opioid Receptor
|
Inflammation/Immunology
|
|
Nociceptin (1-7) TFA is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) TFA is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) TFA combines with nociceptin reduces hyperalgesia in vivo .
|
-
- HY-N10159
-
|
|
Others
|
Cancer
|
|
1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-W248115
-
|
|
Fluorescent Dyes/Probes
|
|
Pyrromethene 597 is a BODIPY laser dye. Pyrromethene 597 displays wide tuning range of lasing wavelengths and high photostability. Pyrromethene 597 can be used as a thermal probe .
|
-
- HY-D1305
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 488 carboxylic acid is a new fluorescent label based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 carboxylic acid is a carboxylic acid derivative of ATTO 488, which can be used to label proteins or antibodies.
|
-
- HY-D1915
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 390 is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy.
|
-
- HY-D1999
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 665 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 665 NHS ester is an NHS ester derivative of ATTO 665 that can be used to label proteins or antibodies.
|
-
- HY-D1939
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 465 amine is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 465 amine is an amine derivative of ATTO 465 and can be used to label proteins or antibodies.
|
-
- HY-D2038
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 550 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 550 alkyne is an alkyne derivative of ATTO 550 and can be used to label proteins or antibodies.
|
-
- HY-D1961
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 565 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 maleimide is a maleimide derivative of ATTO 565, which can be used to label proteins or antibodies.
|
-
- HY-D2046
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 532 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 532 NHS ester is an NHS ester derivative of ATTO 532 that can be used to label proteins or antibodies.
|
-
- HY-D1957
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 633 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 633 NHS ester is an NHS ester derivative of ATTO 633 that can be used to label proteins or antibodies.
|
-
- HY-D2019
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 550 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 550 NHS ester is an NHS ester derivative of ATTO 550 that can be used to label proteins or antibodies.
|
-
- HY-153524
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 425 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 425 NHS ester is an NHS ester derivative of ATTO 425 that can be used to label proteins or antibodies.
|
-
- HY-D1993
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 647 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 647 NHS ester is an NHS ester derivative of ATTO 647 that can be used to label proteins or antibodies.
|
-
- HY-D1929
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 594 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 594 NHS ester is an NHS ester derivative of ATTO 594 that can be used to label proteins or antibodies.
|
-
- HY-D2062
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 740 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 740 NHS ester is an NHS ester derivative of ATTO 740 that can be used to label proteins or antibodies.
|
-
- HY-D2014
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 565 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 alkyne is an alkyne derivative of ATTO 565 and can be used to label proteins or antibodies.
|
-
- HY-D2035
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 514 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 514 alkyne is an alkyne derivative of ATTO 514 and can be used to label proteins or antibodies.
|
-
- HY-D2002
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 488 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 maleimide is a maleimide derivative of ATTO 488, which can be used to label proteins or antibodies.
|
-
- HY-D2047
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 532 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 532 maleimide is a maleimide derivative of ATTO 532, which can be used to label proteins or antibodies.
|
-
- HY-D2016
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 565 cadaverine is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 cadaverine is a cadaverine derivative of ATTO 565, which can be used to label proteins or antibodies.
|
-
- HY-D1959
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 565 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 NHS ester is an NHS ester derivative of ATTO 565 that can be used to label proteins or antibodies.
|
-
- HY-D2063
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 740 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 740 maleimide is a maleimide derivative of ATTO 740, which can be used to label proteins or antibodies.
|
-
- HY-D2015
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 488 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 alkyne is an alkyne derivative of ATTO 488 and can be used to label proteins or antibodies.
|
-
- HY-D1933
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 590 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 590 maleimide is a maleimide derivative of ATTO 590, which can be used to label proteins or antibodies.
|
-
- HY-D2059
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 700 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 700 maleimide is a maleimide derivative of ATTO 700, which can be used to label proteins or antibodies.
|
-
- HY-D2058
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 700 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 700 NHS ester is an NHS ester derivative of ATTO 700 that can be used to label proteins or antibodies.
|
-
- HY-D2026
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 514 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 514 NHS ester is an NHS ester derivative of ATTO 514 that can be used to label proteins or antibodies.
|
-
- HY-D1932
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 590 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 590 NHS ester is an NHS ester derivative of ATTO 590 that can be used to label proteins or antibodies.
|
-
- HY-D2073
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 680 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 680 NHS ester is an NHS ester derivative of ATTO 680 that can be used to label proteins or antibodies.
|
-
- HY-D2074
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 680 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 680 maleimide is a maleimide derivative of ATTO 680, which can be used to label proteins or antibodies.
|
-
- HY-D2021
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 550 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 550 maleimide is a maleimide derivative of ATTO 550, which can be used to label proteins or antibodies.
|
-
- HY-D1917
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 390 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 390 NHS ester is an NHS ester derivative of ATTO 390 that can be used to label proteins or antibodies.
|
-
- HY-D2052
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 532 iodacetamid is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 532 iodacetamid is an iodoacetamide derivative of ATTO 532, which can be used to label proteins or antibodies.
|
-
- HY-D2001
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 488 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 NHS ester is an NHS ester derivative of ATTO 488 that can be used to label proteins or antibodies.
|
-
- HY-D1935
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 465 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 465 NHS ester is an NHS ester derivative of ATTO 465 that can be used to label proteins or antibodies.
|
-
- HY-D1946
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 590 alkyne is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 590 alkyne is an alkyne derivative of ATTO 590 and can be used to label proteins or antibodies.
|
-
- HY-D2001A
-
|
|
Fluorescent Dyes/Probes
|
|
TTO 488 NHS ester TEA is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. TTO 488 NHS ester TEA is an NHS ester derivative of ATTO 488 that can be used to label proteins or antibodies.
|
-
- HY-D1189
-
|
Lucifer Yellow 3-amino-D-alanine
|
Fluorescent Dyes/Probes
|
|
YADA (Lucifer Yellow 3-amino-D-alanine) is a conjugate of the fluorescent dyes Lucifer yellow and D-alanine, which is a green-yellow fluorescent dye. YADA is suitable for labeling peptidoglycans in living bacteria that can be incorporated into the cell wall where they are being synthesized. YADA has a large Stokes shift and a wide emission spectrum, allowing excitation through a purple light source and detection using a green filter. YADA showed good water solubility, light stability and thermal stability.
|
| Cat. No. |
Product Name |
Type |
-
- HY-D0859A
-
|
|
Buffer Reagents
|
|
MOPS sodium salt is a buffering agent used in biology. MOPS buffer maintains the pH of mammalian cell culture media. MOPS sodium salt significantly improves the thermal stability of BSA (HY-D0842) .
|
-
- HY-D0877
-
|
|
Buffer Reagents
|
|
TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) .
|
-
- HY-W011831
-
|
3-(Benzyldimethylammonio)propane-1-sulfonate; PDA
|
Surfactants
|
|
NDSB-256 is a non-stain remover sulfabetaine. NDSB-256 prevents protein aggregation and promotes denaturation of chemically and thermally denatured proteins .
|
-
- HY-Y1324
-
|
Disodium hydrogen phosphate dodecahydrate; Disodium phosphate dodecahydrate
|
Buffer Reagents
|
|
Phosphoric acid disodium dodecahydrate is an inorganic compound and food additive. Phosphoric acid disodium dodecahydrate promotes gel formation, improves food texture and thermal properties of materials. Phosphoric acid disodium dodecahydrate induces glomerular calcification. Phosphoric acid disodium dodecahydrate can be used in kidney disease research .
|
-
- HY-W073183
-
|
|
Chelators
|
|
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H 2PtCl 6·6H 2O and FeCl 2·4H 2O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .
|
-
- HY-W250309
-
|
|
Biochemical Assay Reagents
|
|
Pentaerythritol tetra(3-mercaptopropionate)It is a class of organic compounds containing both pentaerythritol and mercaptopropionate groups. It is commonly used as a stabilizer and crosslinking agent in various chemical and industrial applications. Pentaerythritol tetra(3-mercaptopropionate)Has a variety of properties that make it suitable for these applications, including the ability to increase the mechanical strength, thermal stability and weatherability of polymers and coatings. Additionally, it can be used as a feedstock for the production of other specialty chemicals and materials.
|
-
- HY-W127717
-
|
Perfluoro-compound FC-40
|
Thickeners
|
|
Fluorinert FC-40 is a non-conductive liquid containing a mixture of fluorinated compounds. It is commonly used as a cooling and heat transfer fluid in electronics, especially in high-performance computer systems and electronic components that generate a lot of heat. Fluorinert FC-40 has various properties that make it ideal for these applications, including its low viscosity, high thermal stability and excellent dielectric strength. In addition, it can be used as an inert solvent in chemical reactions and a lubricant in mechanical systems.
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- HY-W250308
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Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
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Cell Assay Reagents
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Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .
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- HY-W040263
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TAPS Na
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Buffer Reagents
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TAPS sodium is a biological buffer that protects the structural integrity of lysozyme bacteria and prevents them from thermal denaturation at high temperatures. A pKa of 8.1 for TAPS results in half-maximal connexin channel activity .
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- HY-W105639A
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Calcium lactate pentahydrate, meets USP testing specifications
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Buffer Reagents
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Calcium L-lactate pentahydrate, meets USP testing specifications (Calcium lactate pentahydrate, meets USP testing specifications) is a biochemical reagent and serves as one of the important sources of calcium. Compared to other organic calcium salts, Calcium L-lactate pentahydrate, meets USP testing specifications exhibits excellent solubility and bioavailability. Calcium L-lactate pentahydrate, meets USP testing specifications possesses remarkable moisture resistance, thermal stability, and chemical stability and can be used in medical implants and drug delivery systems .
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- HY-W250308A
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Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
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Cell Assay Reagents
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ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
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- HY-W087830
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Biochemical Assay Reagents
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L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (LAT1 and LAT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma .
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- HY-15929
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TBHBA
1 Publications Verification
2,4,6-Tribromo-3-hydroxybenzoic acid
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Biochemical Assay Reagents
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TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H2O2) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites .
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- HY-W016638
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1-Butyl-1-methylpyrrolidin-1-ium chloride
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Biochemical Assay Reagents
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1-Butyl-1-methylpyrrolidin-1-ium chloride, also known as BMIM chloride, belongs to the class of ionic liquids and consists of a positively charged pyrrolidine cation and a negatively charged chloride anion. This compound is commonly used as a solvent for various chemical reactions, especially those involving organic compounds and metals. Its unique physical and chemical properties, such as low volatility, high thermal stability, and tunable solubility, make it useful in a range of applications in catalysis, electrochemistry, and separation science. Furthermore, 1-butyl-1-methylpyrrolidin-1-ium chloride may have potential applications as a green solvent in energy storage devices and various industrial processes.
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P5704
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Bacterial
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Infection
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K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability .
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- HY-P5914A
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WaTx TFA
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TRP Channel
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Neurological Disease
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Wasabi Receptor Toxin TFA (WaTx TFA) is the TFA salt form of Wasabi Receptor Toxin (HY-P5914). Wasabi Receptor Toxin TFA is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin TFA is the activator for TRPA1 ion channel with EC50 in nanomolar level, and prolongs the channel open time, but reduces Ca 2+ permeability. Wasabi Receptor Toxin TFA causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .
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- HY-P1410B
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- HY-P1410C
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Piezo Channel
Calcium Channel
mTOR
PI3K
Akt
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca 2+]i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .
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- HY-129283
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Ras
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Others
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Goralatide is a compound that regulates the thermal sensitivity of hematopoietic progenitor cells. It can reduce the thermal sensitivity of normal hematopoietic progenitor cells and increase the difference in thermal sensitivity between leukemia progenitor cells and normal progenitor cells, thereby increasing the inhibition window of hyperthermia therapy.
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- HY-P5874
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Calcium Channel
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Inflammation/Immunology
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Myr-TAT-CBD3 is CRMP2-CaV2.2 interaction inhibitor. Myr-tat-CBD3 can significantly attenuate carrageenan-induced thermal hypersensitivity and reverse thermal hypersensitivity induced in a rat model of postoperative pain. Myr-TAT-CBD3 can be used to study inflammation and postoperative pain .
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- HY-P3856
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Peptides
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Neurological Disease
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Endokinin C is a peptide component of endokinin. Endokinin C works as a neurotransmitter or modulator in the pain system. Pretreatment with endokinin C prevents induction of scratching behavior and thermal hyperalgesia of endokinin A/B in mice .
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- HY-P5914
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WaTx
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TRP Channel
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Neurological Disease
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Wasabi Receptor Toxin is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin is the activator for TRPA1 ion channel with EC50 in nanomolar level, and prolongs the channel open time, but reduces Ca 2+ permeability. Wasabi Receptor Toxin causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .
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- HY-P1319
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Opioid Receptor
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Inflammation/Immunology
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Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo .
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- HY-P1319A
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Opioid Receptor
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Inflammation/Immunology
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Nociceptin (1-7) TFA is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) TFA is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) TFA combines with nociceptin reduces hyperalgesia in vivo .
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P991321
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Trk Receptor
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Inflammation/Immunology
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ABT-110 is a human monoclonal antibody (mAb) targeting NGF/bNGF. ABT-110 reduces established thermal and mechanical hypersensitivity in the CFA rat model. ABT-110 can be used in persistent/chronic inflammatory pain research .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-N6875
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- HY-N9929
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- HY-128454
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- HY-Y1004
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Decyl alcohol
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Microorganisms
Source classification
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Biochemical Assay Reagents
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1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.
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- HY-W040240
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- HY-N8487
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- HY-Y1309
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- HY-N9929R
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- HY-128454R
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- HY-Y1004R
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Decyl alcohol (Standard)
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Microorganisms
Source classification
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Biochemical Assay Reagents
Reference Standards
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1-Decanol (Standard) is the analytical standard of 1-Decanol. This product is intended for research and analytical applications. 1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.
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- HY-N10159
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Structural Classification
Natural Products
Brassica oleracea L.
Source classification
Plants
Brassicaceae
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Others
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1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-B0352AS
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(S)-Mirtazapine-d3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].
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- HY-N6600S
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Octadecane-d38 is the deuterium labeled Octadecane . Octadecane is an alkane that is used to store thermal energy at ambient temperature as a phase change material .
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- HY-N9929S
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Docosane-d46 is the deuterium labeled Docosane . Docosane, a straight chain alkane, can be used to synthesize structural composites with thermal energy storage/release capability .
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- HY-D0859S
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MOPS-d15 is the deuterium labeled MOPS (HY-D0859). MOPS is a buffering agent used in biology. MOPS buffer maintains the pH of mammalian cell culture media. MOPS significantly improves the thermal stability of BSA (HY-D0842) .
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- HY-B0352BS
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(R)-Mirtazapine-d3 is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].
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- HY-Y1004S6
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1-Decanol-d2-2 is deuterated labeled 1-Decanol (HY-Y1004). 1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.
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- HY-B0168AS
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Milnacipran-d5 hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
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| Cat. No. |
Product Name |
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Classification |
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- HY-Y1324
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Disodium hydrogen phosphate dodecahydrate; Disodium phosphate dodecahydrate
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pH Modifiers
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Phosphoric acid disodium dodecahydrate is an inorganic compound and food additive. Phosphoric acid disodium dodecahydrate promotes gel formation, improves food texture and thermal properties of materials. Phosphoric acid disodium dodecahydrate induces glomerular calcification. Phosphoric acid disodium dodecahydrate can be used in kidney disease research .
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