Sodium phosphate dibasic dodecahydrate (Synonyms: Disodium hydrogen phosphate dodecahydrate; Disodium phosphate dodecahydrate)

Cat. No.: HY-Y1324 Purity: ≥98.0%: Data Sheet
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Phosphoric acid disodium dodecahydrate is an inorganic compound and food additive. Phosphoric acid disodium dodecahydrate promotes gel formation, improves food texture and thermal properties of materials. Phosphoric acid disodium dodecahydrate induces glomerular calcification. Phosphoric acid disodium dodecahydrate can be used in kidney disease research.

For research use only. We do not sell to patients.

Sodium phosphate dibasic dodecahydrate Chemical Structure

CAS No. : 10039-32-4

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1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
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Description

In Vitro

Phosphoric acid disodium dodecahydrate (0.5-1.5 M) induces the gelation of thiolated citrus high-methoxyl pectin (TCHMP)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Phosphoric acid disodium (284-408 mg/kg; bolus i.v.; once daily; 14 days) dodecahydrate induces glomerular calcification, glomerular epithelial cell degeneration and proteinuria in Sprague-Dawley rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague–Dawley rats (Jcl:SD), 5 weeks old^[3]
Dosage:	1, 28, 284, 408 mg/kg
Administration:	Intravenous bolus injection via the tail vein, once daily, for 14 days
Result:	Caused treatment-related proteinuria on days 7 and 13. Caused a pale kidney appearance. Caused the deposition of dense basophilic granules in the glomeruli (von Kossa-positive) and a dose-dependent degeneration of the glomerular and parietal epithelium. Caused podocyte fusion, increased microvilli, abundant debris in Bowman's spaces, and low-density lamellar structures in various parts of the glomerulus. Showed particles containing phosphorus and calcium mixed with a lamellar structure.

Molecular Weight

358.14

Formula

H₂₅Na₂O₁₆P

CAS No.

10039-32-4

Appearance

<35°C Solid,>35°C Liquid

Color

Colorless to off-white

SMILES

[Na2HPO4 ?12H2O]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (139.61 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7922 mL	13.9610 mL	27.9220 mL
5 mM	0.5584 mL	2.7922 mL	5.5844 mL
10 mM	0.2792 mL	1.3961 mL	2.7922 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (242 KB)

Handling Instructions (2659 KB)

References

[1]. Chen J, et al. The gelation behavior of thiolated citrus high-methoxyl pectin induced by sodium phosphate dibasic dodecahydrate. Carbohydr Polym. 2022;277:118849. [Content Brief]

[2]. Shen Z, et al. Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage. Int J Biol Macromol. 2021 Mar 31;174:402-412. [Content Brief]

[3]. Tsuchiya N, et al. Glomerular calcification induced by bolus injection with dibasic sodium phosphate solution in Sprague-Dawley rats. Toxicol Pathol. 2004 Jul-Aug;32(4):408-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.7922 mL	13.9610 mL	27.9220 mL	69.8051 mL
	5 mM	0.5584 mL	2.7922 mL	5.5844 mL	13.9610 mL
	10 mM	0.2792 mL	1.3961 mL	2.7922 mL	6.9805 mL
	15 mM	0.1861 mL	0.9307 mL	1.8615 mL	4.6537 mL
	20 mM	0.1396 mL	0.6981 mL	1.3961 mL	3.4903 mL
	25 mM	0.1117 mL	0.5584 mL	1.1169 mL	2.7922 mL
	30 mM	0.0931 mL	0.4654 mL	0.9307 mL	2.3268 mL
	40 mM	0.0698 mL	0.3490 mL	0.6981 mL	1.7451 mL
	50 mM	0.0558 mL	0.2792 mL	0.5584 mL	1.3961 mL
	60 mM	0.0465 mL	0.2327 mL	0.4654 mL	1.1634 mL
	80 mM	0.0349 mL	0.1745 mL	0.3490 mL	0.8726 mL
	100 mM	0.0279 mL	0.1396 mL	0.2792 mL	0.6981 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sodium phosphate dibasic dodecahydrate Related Classifications

Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium phosphate dibasic dodecahydrate10039-32-4Disodium hydrogen phosphate dodecahydrate Disodium phosphate dodecahydrateBiochemical Assay ReagentsSprague-Dawley ratsglomerular calcificationgelationfood additiveInhibitorinhibitorinhibit

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Sodium phosphate dibasic dodecahydrate (Synonyms: Disodium hydrogen phosphate dodecahydrate; Disodium phosphate dodecahydrate)

Sodium phosphate dibasic dodecahydrate Related Antibodies

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