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Results for "

protein tagging

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (5) Arrestin (1) Aurora Kinase (1) AUTACs (2) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (36) Deubiquitinase (1) Drug Derivative (2) Drug Intermediate (2) EGFR (2) Endonuclease (1) Epigenetic Reader Domain (2) Filovirus (1) FKBP (5) Fluorescent Dye (25) Histone Methyltransferase (2) Influenza Virus (1) Insulin Receptor (1) Interleukin Related (1) JNK (1) Ligands for E3 Ligase (1) Liposome (1) LXR (1) Microtubule/Tubulin (1) Molecular Glues (1) mRNA (1) Polo-like Kinase (PLK) (1) PROTACs (8) Protease Activated Receptor (PAR) (1) Proteasome (2) Pyruvate Kinase (1) Ser/Thr Protease (1) SGK (1) STAT (1) Thrombin (6) Transglutaminase (1) Virus Protease (1) WDR5 (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (5) Infection (2) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (3)
Click Chemistry:	Labeling and Fluorescence Imaging (3) Azide (6) Tetrazine (1) Alkynes (3)
Oligonucleotides:	mRNA (1)

107

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
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Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1288A

tris-NTA	Biochemical Assay Reagents	Others
tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins .

HY-P0327

T7 Tag Peptide 1 Publications Verification	Biochemical Assay Reagents	Others
T7 Tag Peptide is a protein tag consisting of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. T7 Tag Peptide can be fused to the N-terminus or C-terminus of proteins such as enhanced green fluorescent protein (EGFP). T7 Tag Peptide can be used in various immunoassays and affinity purification .

HY-P0327A

T7 Tag Peptide TFA 1 Publications Verification	Biochemical Assay Reagents	Others
T7 Tag Peptide TFA is a protein tag consisting of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. T7 Tag Peptide TFA can be fused to the N-terminus or C-terminus of proteins such as enhanced green fluorescent protein (EGFP). T7 Tag Peptide TFA can be used in various immunoassays and affinity purification .

HY-116677

Tris(benzyltriazolylmethyl)amine 5+ Cited Publications TBTA	Biochemical Assay Reagents	Others
Tris(benzyltriazolylmethyl)amine (TBTA) is a ligand that acts as a biochemical tool for the tagging of proteins and enzymes .

HY-160695

PT-179	Ligands for E3 Ligase Molecular Glues	Cancer
PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms .

HY-D1288

(Rac)-tris-NTA	Biochemical Assay Reagents	Others
(Rac)-tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins .

HY-D2941

BGAF SNAP-AF	Fluorescent Dye	Others
BGAF is a fluorescent diacetyl fluorescein-labeled SNAP tag fluorescent probe, specifically designed for the covalent labeling of SNAP-tag fusion proteins in living cells. BGAF utilizes the specific reaction of the human DNA repair protein hAGT to achieve specific fluorescent labeling of the target protein in the living cell environment .

HY-175417

VHL-SNAP2-5C	PROTACs	Cancer
VHL-SNAP2-5C is a SNAP-fusion protein PROTAC degrader basing on a self-labeling protein SNAP tag. VHL-SNAP2-5C by endogenous tagging enables the visualization and the selective depletion of a SNAP-fusion protein, such as CLCa andEGFP . Pink: SNAP-fusion protein ligand (HY-W128709); Blue: VHL ligase ligand (HY-112078); Black: linker (HY-Y1139)

HY-148958

SNAP-Biotin	Biochemical Assay Reagents	Others
SNAP-Biotin is a biotin-labeled SNAP tag probe. SNAP-Biotin can be used for protein biotinylation .

HY-D2931

SNAP-FAM	Fluorescent Dye	Others
SNAP-FAM is a FAM-labeled SNAP tag fluorescent probe (Ex/Em: 494 nm/526 nm), specifically designed for live-cell protein labeling and real-time imaging applications .

HY-D2955

BC‐AZIDE CLIP-AZIDE	Biochemical Assay Reagents	Others
BC-AZIDE is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .

HY-P11329

GFP11	Fluorescent Dye	Others
GFP11, 16 amino acids long, is a protein fusion tag. GFP11 presents proteins at the outer membrane of gram-negative bacteria and to label it with green fluorescence by complementation with externally added GFP1-10. GFP11 causes no significant perturbation of protein solubility and expression and alteration of the catalytic activity for enzyme CsBglA due to its small size. GFP11 can be used to form split-GFP system for biotechnological high-throughput and flow cytometry applications .

HY-P0325

V5 Epitope Tag Peptide TFA	Biochemical Assay Reagents	Others
V5 Epitope Tag Peptide TFA is a tag peptide derived from a small epitope present on the P and V proteins of the paramyxovirus of simian virus 5. V5 Epitope Tag Peptide TFA can be used for protein separation and purification, and competitive elution with target proteins .

HY-P5768

2× ST-tag II	Biochemical Assay Reagents	Others
2× ST-tag II is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. 2× ST-tag II is a peptide ligand of ST Tactin (STN). 2× ST-tag II specifically binds to ST Tactin. 2× ST-tag II can be used to construct DNA-protein hybrids .

HY-W705969

tris-NTA TFA	Biochemical Assay Reagents	Others
tris-NTA TFA is a His-tagged protein ligand. tris-NTA TFA can be used alone or in combination with a fluorophore for purification and detection of His-tagged proteins .

HY-P5768A

2× ST-tag II TFA	Biochemical Assay Reagents	Cancer
2× ST-tag II TFA is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. 2× ST-tag II is a peptide ligand of ST Tactin (STN). 2× ST-tag II TFA specifically binds to ST Tactin. 2× ST-tag II TFA can be used to construct DNA-protein hybrids .

HY-D2945

CLIP-Biotin	Fluorescent Dye	Others
CLIP-Biotin is a Biotin-labeled CLIP tag fluorescent probe. CLIP-Biotin can be used for marking the CLIP-tag fusion proteins in cells.

HY-D2270

Halo tag TMR 1 Publications Verification	Fluorescent Dye	Others
Halo tag TMR is a red fluorescent dye composed of Halo tag ligand molecules and TMR (TAMRA). Halo tag can quickly and stably covalently bind to Halo protein with high specificity and affinity (Ex/Em = 550/576 nm) .

HY-D2960

BC-OG CLIP-OG	Fluorescent Dye	Others
BC-OG is an oregon green labeled CLIP tag fluorescent probe. BC-OG can be used for labeling CLIP-tag fusion protein in cells .

HY-D2959

BC-DF CLIP-DF	Fluorescent Dye	Others
BC-DF is a diacetyl fluorescein labeled CLIP tag fluorescent probe. BC-DF can be used for labeling CLIP-tag fusion protein in cells .

HY-153631

Sulfo-TAG NHS ester disodium	Drug Intermediate	Inflammation/Immunology
Sulfo-TAG NHS ester (disodium) is an N-hydroxysuccinimide ester that can be coupled to proteins via primary amine groups. Sulfo-TAG NHS ester (disodium) can be used for antibody labeling .

HY-P3332

3x DYKDDDDK Tag	Biochemical Assay Reagents	Others
3x DYKDDDDK Tag is a useful tool for investigating the function and localization of proteins whose antibodies (Abs) are not available. Often it is also used in a 3X FLAG format (3x DYKDDDDK Tag) for purifying difficult proteins that accumulate in low abundance .

HY-P11316

DBCO-tag peptide P1	Biochemical Assay Reagents Antibody-Drug Conjugates (ADCs)	Others
DBCO-tag peptide P1 is a cysteine-containing peptide tag. DBCO-tag peptide P1 selectively reacts with dibenzocyclooctyne (DBCO) to yield stable dibenzocyclooctenyl thioethers. DBCO-tag peptide P1 enables site-selective mEGFP labeling and antibody (such as Trastuzumab (HY-P9907)) labelling without impairing the protein binding function. DBCO-tag peptide P1 can be used for ADC synthesis and mEGFP labeling research .

HY-D2948

SNAP-430	Fluorescent Dye	Others
SNAP-430 is a (diethylamino) coumarin-labeled SNAP tag fluorescent probe. SNAP-430 can be used for making SNAP-tag fusion proteins inside living cells, on cell surfaces, or in vitro.

HY-P3208A

Endoproteinase Lys-C (Tag-free)	Biochemical Assay Reagents	Others
Endoproteinase Lys-C (Tag-free) is a protease that cleaves proteins on the C-terminal side of lysine residues and is commonly used for protein sequencing .

HY-147169

Biotin-X-NTA	Fluorescent Dye	Others
Biotin-X-NTA can be used for detecting histidine-tagged proteins immobilized on nitrocellulose membranes .

HY-D2946

CLIP-TMR BC-TMR	Fluorescent Dye	Infection
CLIP-TMR is a TMR-labeled CLIP tag fluorescent probe. CLIP-TMR combines the high specificity recognition ability of the CLIP-tag and the excellent optical performance of the TMR fluorophore, and can be used for the specific labeling and visualization of the HCV NS5A protein .

HY-E70372

SUMO Protease	Biochemical Assay Reagents	Others
SUMO Protease is highly specific for proteins containing small ubiquitin-like modifier (SUMO) tags. SUMO Protease can be used to regulates the proteins splicing, controlls protein structure and function in vitro .

HY-178043

BTR2038	Epigenetic Reader Domain	Others
BTR2038 is a BRD9 degrader. BTR2038 induces targeted degradation of V5-tagged human BRD9. BTR2038 can be used for the study of biological processes and diseases associated with abnormal BRD9 protein function .

HY-P99759

Nogapendekin alfa (his tag) IL-15N72D	Interleukin Related	Inflammation/Immunology Cancer
Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL)-15 variant, is a superagonist of IL-15. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8 ⁺ T cells .

HY-N15871

18:1 DGS-NTA(Ni)	Liposome	Others
18:1 DGS-NTA(Ni) is a nickel chelating lipid. 18:1 DGS-NTA(Ni) has high affinity for histidine-tags and can bind histidine tags of recombinant proteins. 18:1 DGS-NTA(Ni) can be used for preparation of liposomes and nanosize multilamellar vesicles (NMVs) which are used in protein and peptide binding studies and antigen delivery .

HY-D2949

SNAP-549	Fluorescent Dye	Others
SNAP-549 is a DY-549P1-labeled SNAP tag fluorescent probe, specifically designed for single-molecule imaging and dynamic tracking of proteins in living cells. SNAP-549 only labels SNAP-tag fusion proteins, with low background signals and forming irreversible connections, making it suitable for long-term observation .

HY-D2939

BGSBD	Fluorescent Dye	Others
BGSBD is a SNAP-tag-based fluorescent probe (Ex/Em: 435 nm/516 nm) based on the environmentally sensitive fluorescent group SBD, specifically designed for protein labeling of live cells without washing. BGSBD achieves a 280-fold fluorescence enhancement after labeling by ingeniously utilizing the hydrophobic binding pocket of the SNAP-tag protein, providing an ideal tool for real-time monitoring of protein dynamics within cells .

HY-129652

HaloAUTAC tt15	AUTACs	Cancer
HaloAUTAC tt15 is an autophagy-targeting chimera (AUTAC), that targets the Halo Tag carrying proteins, and degrades via the autophagy mechanism .

HY-141676

HyT36	EGFR	Others
HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3 .

HY-D2926

BG-Tetrazine BG-Tz; SNAP-Tetrazine	Biochemical Assay Reagents	Others
BG-Tetrazine is a SNAP tag substrate that contains a methyl tetrazine group. BG-Tetrazine can specifically covalently label the target protein of the intracellular SNAP-tag fusion. The tetrazine group it carries can rapidly and efficiently undergo a bioorthogonal reaction with functional groups such as trans cyclooctene (TCO), thereby enabling multiple labeling, functionalization or enrichment of proteins. BG-Tetrazine can be applied in click chemistry .

HY-P0294

Hexa-His 6X His Tag	Biochemical Assay Reagents	Others
Hexa-His (6X His Tag) is a commonly used affinity tag made up of six histidine residues. HEXA-HIS can bind to affinity chromatography media containing transition metal ions like nickel (Ni ²⁺) or cobalt (Co ²⁺), making it useful for protein purification .

HY-P0223

FLAG peptide Maximum Cited Publications 22 Publications Verification	Biochemical Assay Reagents	Inflammation/Immunology
FLAG peptide is a multifunctional fusion tag for the purification of recombinant proteins. FLAG peptide maintances the natural folding of its fusing proteins. FLAG peptide can be removed by enterokinase, and eluted under non-denaturing conditions .

HY-D2981

CoDi1	Biochemical Assay Reagents	Others
CoDi1 is an effective chemical crosslinking agent. CoDi1 can achieve covalent and irreversible dimerization of AGT/SNAP tag fusion proteins in living cells .

HY-153887

HyT36(-Cl)	EGFR	Others
HyT36(-Cl) is the inactive control compound of HyT36, a small molecule hydrophobic tag compound that can be used in protein folding research .

HY-149679

PROTAC eDHFR Degrader-2	PROTACs Bacterial	Cancer
PROTAC eDHFR Degrader-2 (compound 7b) is a potent degrader targeting Escherichia coli dihydrofolate reductase (eDHFR), enabling robust degradation of eDHFR-tagged proteins .

HY-P0319

3X FLAG peptide 15+ Cited Publications	Biochemical Assay Reagents	Others
3X FLAG peptides are FLAG-tagged peptides containing three repeats of the Asp-Tyr-Lys-Xaa-Xaa-Asp motif. 3X FLAG peptide can be used for protein separation and purification, and competitive elution with target proteins.

HY-129265

Poloxin-2	Polo-like Kinase (PLK)	Cancer
Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins.

HY-114164D

Rat Thrombin	Thrombin	Cardiovascular Disease
Rat Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-114164F

Canine Thrombin	Thrombin	Cardiovascular Disease
Canine Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-114164E

Rabbit Thrombin	Thrombin	Cardiovascular Disease
Rabbit Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-114164C

Thrombin, Pig blood	Protease Activated Receptor (PAR) Thrombin	Cardiovascular Disease
Rabbit Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-P5969

Cys-V5 Peptide	Biochemical Assay Reagents	Others
Cys-V5 Peptide, a tag peptide, is the V5 Peptide with an N-terminal cysteine. Cys-V5 Peptide can be used to label proteins

HY-114164G

Murine Thrombin	Thrombin	Cardiovascular Disease
Murine Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-D2951

BG-Kaede chromophore	Fluorescent Dye	Others
BG-Kaede chromophore (Compound 4c) is a SNAP-tag-specific fluorescent probe, which is designed and synthesized using the chromophore of the red fluorescent protein Kaede as a template. BG-Kaede chromophore can be used as a tool for visualizing proteins in living cells .

Cat. No.	Product Name

HY-L918

Molecular Glue-like Compound Library

318 compounds

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 320 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Cat. No.	Product Name	Type

HY-D2270

Halo tag TMR 1 Publications Verification	Fluorescent Dye
Halo tag TMR is a red fluorescent dye composed of Halo tag ligand molecules and TMR (TAMRA). Halo tag can quickly and stably covalently bind to Halo protein with high specificity and affinity (Ex/Em = 550/576 nm) .

HY-D2941

BGAF SNAP-AF	Fluorescent Dye
BGAF is a fluorescent diacetyl fluorescein-labeled SNAP tag fluorescent probe, specifically designed for the covalent labeling of SNAP-tag fusion proteins in living cells. BGAF utilizes the specific reaction of the human DNA repair protein hAGT to achieve specific fluorescent labeling of the target protein in the living cell environment .

HY-148958

SNAP-Biotin	Fluorescent Dye
SNAP-Biotin is a biotin-labeled SNAP tag probe. SNAP-Biotin can be used for protein biotinylation .

HY-D2931

SNAP-FAM	Fluorescent Dye
SNAP-FAM is a FAM-labeled SNAP tag fluorescent probe (Ex/Em: 494 nm/526 nm), specifically designed for live-cell protein labeling and real-time imaging applications .

HY-D2955

BC‐AZIDE CLIP-AZIDE	Fluorescent Dye
BC-AZIDE is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .

HY-D2945

CLIP-Biotin	Fluorescent Dye
CLIP-Biotin is a Biotin-labeled CLIP tag fluorescent probe. CLIP-Biotin can be used for marking the CLIP-tag fusion proteins in cells.

HY-D2960

BC-OG CLIP-OG	Fluorescent Dye
BC-OG is an oregon green labeled CLIP tag fluorescent probe. BC-OG can be used for labeling CLIP-tag fusion protein in cells .

HY-D2959

BC-DF CLIP-DF	Fluorescent Dye
BC-DF is a diacetyl fluorescein labeled CLIP tag fluorescent probe. BC-DF can be used for labeling CLIP-tag fusion protein in cells .

HY-D2948

SNAP-430	Fluorescent Dye
SNAP-430 is a (diethylamino) coumarin-labeled SNAP tag fluorescent probe. SNAP-430 can be used for making SNAP-tag fusion proteins inside living cells, on cell surfaces, or in vitro.

HY-D2946

CLIP-TMR BC-TMR	Fluorescent Dye
CLIP-TMR is a TMR-labeled CLIP tag fluorescent probe. CLIP-TMR combines the high specificity recognition ability of the CLIP-tag and the excellent optical performance of the TMR fluorophore, and can be used for the specific labeling and visualization of the HCV NS5A protein .

HY-D2949

SNAP-549	Fluorescent Dye
SNAP-549 is a DY-549P1-labeled SNAP tag fluorescent probe, specifically designed for single-molecule imaging and dynamic tracking of proteins in living cells. SNAP-549 only labels SNAP-tag fusion proteins, with low background signals and forming irreversible connections, making it suitable for long-term observation .

HY-D2939

BGSBD

Fluorescent Dye

BGSBD is a SNAP-tag-based fluorescent probe (Ex/Em: 435 nm/516 nm) based on the environmentally sensitive fluorescent group SBD, specifically designed for protein labeling of live cells without washing. BGSBD achieves a 280-fold fluorescence enhancement after labeling by ingeniously utilizing the hydrophobic binding pocket of the SNAP-tag protein, providing an ideal tool for real-time monitoring of protein dynamics within cells .

HY-D2926

BG-Tetrazine

BG-Tz; SNAP-Tetrazine

Fluorescent Dye

BG-Tetrazine is a SNAP tag substrate that contains a methyl tetrazine group. BG-Tetrazine can specifically covalently label the target protein of the intracellular SNAP-tag fusion. The tetrazine group it carries can rapidly and efficiently undergo a bioorthogonal reaction with functional groups such as trans cyclooctene (TCO), thereby enabling multiple labeling, functionalization or enrichment of proteins. BG-Tetrazine can be applied in click chemistry .

HY-D2981

CoDi1	Fluorescent Dye
CoDi1 is an effective chemical crosslinking agent. CoDi1 can achieve covalent and irreversible dimerization of AGT/SNAP tag fusion proteins in living cells .

HY-D2951

BG-Kaede chromophore	Fluorescent Dye
BG-Kaede chromophore (Compound 4c) is a SNAP-tag-specific fluorescent probe, which is designed and synthesized using the chromophore of the red fluorescent protein Kaede as a template. BG-Kaede chromophore can be used as a tool for visualizing proteins in living cells .

HY-D2935

CoDi2	Fluorescent Dye
CoDi3 is a covalent dimerization inducer. CoDi3 can specifically, covalently and irreversibly induce the dimerization of two proteins that have been fused with O6-alkylguanine-DNA alkyltransferase (AGT, also known as SNAP-tag) in living cells. CoDi3 can act as a "sensor" for protein-protein interactions .

HY-D2995

CoDi3	Fluorescent Dye
CoDi3 is a covalent dimerization inducer. CoDi3 can specifically, covalently and irreversibly induce the dimerization of two proteins that have been fused with O6-alkylguanine-DNA alkyltransferase (AGT, also known as SNAP-tag) in living cells. CoDi3 can act as a "sensor" for protein-protein interactions .

HY-D2933

SNAP-505	Fluorescent Dye
SNAP-505 is a green fluorescent O6 benzylguanine derivative. SNAP-505 labels SNAP-tagged proteins covalently. SNAP-505 can be used to label cells (green) .

HY-D2956

BC-GLA-NHS

CLIP-GLA-NHS

Fluorescent Dye

BC-GLA-NHS is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

HY-D2930

BG-SS-SulfoCy5 SNAP-SS-SulfoCy5	Fluorescent Dye
BG-SS-SulfoCy5 is a SulfoCy5-labeled SNAP tag fluorescent probe, linked by a disulfide bond (Ex/Em: 649 nm/666 nm). BG-SS-SulfoCy5 combines the specific recognition of SNAP-tag, the cleavability of disulfide bond, and the excellent optical properties of SulfoCy5. BG-SS-SulfoCy5 can be used for tracking the internalization of cell surface proteins and multiple labeling experiments .

HY-D2943

BG-SS-SulfoCy3 SNAP-SS-SulfoCy3	Fluorescent Dye
BG-SS-SulfoCy3 is a SulfoCy3-labeled SNAP tag fluorescent probe, which is linked by a disulfide bond to achieve selective labeling and controllable cleavage. BG-SS-SulfoCy3 can be used to study the endocytosis and trafficking of membrane proteins such as GPCRs .

HY-D2940

SiR-SNAP SiR650-BG	Fluorescent Dye
SiR-SNAP is a SiR-labeled SNAP tag near-infrared fluorescent probe (Ex/Em: 645 nm/661 nm). SiR-SNAP combines excellent optical properties, good cell membrane permeability, and environmentally sensitive fluorescence characteristics, providing a powerful tool for the dynamic study of proteins in living cells .

HY-D2964

NBzF-BG

Fluorescent Dye

NBzF-BG is a novel H₂O₂-specific fluorescent probe. NBzF-BG shows visible absorption centered at 505 nm and weak fluorescence with an emission maximum at 525 nm. NBzF-BG is covalently and selectively conjugated with the SNAP-tag protein, leading to formation of the fluorophore-protein conjugate (SNAP-NBzF). SNAP-NBzF rapidly reacts with H₂O₂ and thereby shows an enhancement in fluorescence .

HY-D2984

BG-PEG-NH2 SNAP-PEG-NH2	Fluorescent Dye
BG-PEG-NH2 is an amine terminated phenylguanine derivative with a polyethylene glycol (PEG) chain. BG-PEG-NH2 is an important building block for synthesizing SNAP tag labeled probes. BG-PEG-NH2 is suitable for coupling reactions in aqueous or buffer solutions, coupling of markers, and labeling of intracellular or cell surface proteins .

HY-138658

Janelia Fluor® 526, SE

JF526, SE; JF526, NHS

Fluorescent Dye

Janelia Fluor 526, SE (JF526,SE) is a fluorogenic yellow fluorescent dye that contains NHS ester group. JF526 is a versatile scaffold for fluorogenic ligands, including labels for genetically encoded self-labeling protein tags and stains for endogenous structures . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-D2942

BDP-V BG-BODIPY

Fluorescent Dye

BDP-V BG-BODIPY is a SNAP tag fluorescent probe labeled with a BODIPY molecular motor. BDP-V BG-BODIPY contains a BODIPY molecular rotor that functions as a viscosity-sensitive fluorophore, which is highly responsive to local viscosity changes and enables the specific monitoring of the local microviscosity of proteins. BDP-V BG-BODIPY supports one-photon and two-photon imaging, with an excitation wavelength (Ex) of 488 nm (for one-photon excitation) and 850 nm (for two-photon excitation), and an emission wavelength (Em) of 500-600 nm .

HY-D1506

Fl-DIBO

Fluorescent Dye

Fl-DIBO (fluorogenic dibenzocyclooctyne) is a selective and high sensitivity fluorescent probe to azide compounds. Fl-DIBO can react rapidly with azide compounds to form new highly fluorescent products with a maximum emission wavelength of 469 nm and excitation wavelength of 363 nm. Fl-DIBO can be used to label diazo-tagged proteins without detectable background signal interference . Fl-DIBO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D2989

BG-NH2-Ac-N3 SNAP-NH2-Ac-N3	Fluorescent Dye
BG-NH2-Ac-N3 is a nitrogen-containing SNAP tag with a nitro group. BG-NH2-Ac-N3 can be used for click chemistry labeling .

HY-W800701

BP Fluor 546 DBCO

Fluorescent Dye

BP Fluor 546 DBCO is an azide-reactive probe that can be used for imaging azide-tagged biomolecules via a copper-free click reaction. The DBCO moiety reacts with azides to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 546 DBCO is an ideal alternative to copper-requiring fluorescent alkynes. BP Fluor 546 is a water-soluble, pH-insensitive (from pH 4-10), orange-fluorescent dye with absorption and emission maxima at 554 and 570 nm, respectively. It can be used with the 488 nm and 532 nm laser lines. BP Fluor 546 dye conjugates to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, which are often used for generating stable signals in imaging and flow cytometry.

Cat. No.	Product Name	Type

HY-P3152

Streptavidin 5 Publications Verification	Biochemical Assay Reagents
Streptavidin is a ～60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a K_D ～ 0.01 pM . Streptavidin has an immunosuppressive role .

HY-W039921

2-[(Azidoacety)amino]-2-deoxy-D-galactose N-Azidoacetylgalactosamine; GalNAz	Biochemical Assay Reagents
2-[(Azidoacety)amino]-2-deoxy-D-galactose targets O-GlcNAc-modified proteins. By detecting and targeting O-GlcNAc-modified proteins, 2-[(Azidoacety)amino]-2-deoxy-D-galactose can serve as a chemical tag for intracellular sugar chain metabolism .

Cat. No.	Product Name	Target	Research Area

HY-P0327

T7 Tag Peptide 1 Publications Verification	Biochemical Assay Reagents	Others
T7 Tag Peptide is a protein tag consisting of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. T7 Tag Peptide can be fused to the N-terminus or C-terminus of proteins such as enhanced green fluorescent protein (EGFP). T7 Tag Peptide can be used in various immunoassays and affinity purification .

HY-P0327A

T7 Tag Peptide TFA 1 Publications Verification	Biochemical Assay Reagents	Others
T7 Tag Peptide TFA is a protein tag consisting of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. T7 Tag Peptide TFA can be fused to the N-terminus or C-terminus of proteins such as enhanced green fluorescent protein (EGFP). T7 Tag Peptide TFA can be used in various immunoassays and affinity purification .

HY-P10531

ALFA-tag	Peptides	Others
ALFA-tag is a small and stable α-helical structure composed of 15 amino acids. ALFA-tag is highly hydrophilic and can be placed at the N-terminus, C-terminus, or between two independently folded domains of the target protein without affecting the function of the protein. ALFA-tag is widely used as an epitope tag and is used for the detection and manipulation of proteins in living cells .

HY-P5491

3X HA Tag	Peptides	Others
3X HA Tag is a biological active peptide. (This tag peptide may be used to detect proteins and peptides, and to facilitate functional analysis of proteins of interest.)

HY-P0325

V5 Epitope Tag Peptide TFA	Biochemical Assay Reagents	Others
V5 Epitope Tag Peptide TFA is a tag peptide derived from a small epitope present on the P and V proteins of the paramyxovirus of simian virus 5. V5 Epitope Tag Peptide TFA can be used for protein separation and purification, and competitive elution with target proteins .

HY-P11282

ST-tag peptide	Peptides	Others
ST-tag peptide is a short peptide light label with intrinsic binding affinity to streptavidin and is used as an affinity tag for recombinant proteins .

HY-P11329

GFP11	Fluorescent Dye	Others
GFP11, 16 amino acids long, is a protein fusion tag. GFP11 presents proteins at the outer membrane of gram-negative bacteria and to label it with green fluorescence by complementation with externally added GFP1-10. GFP11 causes no significant perturbation of protein solubility and expression and alteration of the catalytic activity for enzyme CsBglA due to its small size. GFP11 can be used to form split-GFP system for biotechnological high-throughput and flow cytometry applications .

HY-P10900

2x HA tag peptide	Peptides	Others
2x HA tag peptide is a tag peptide (YPYDVPDYAYPYDVPDYA) with a hemagglutinin HA tag. 2x HA tag peptide is often used to be fused to the 5' end of the target protein to label the protein .

HY-P11283

Avi tag	Peptides	Others
Avi tag is a short peptide tag commonly used in protein expression and biotin labeling .

HY-P5768

2× ST-tag II	Biochemical Assay Reagents	Others
2× ST-tag II is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. 2× ST-tag II is a peptide ligand of ST Tactin (STN). 2× ST-tag II specifically binds to ST Tactin. 2× ST-tag II can be used to construct DNA-protein hybrids .

HY-P5768A

2× ST-tag II TFA	Biochemical Assay Reagents	Cancer
2× ST-tag II TFA is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. 2× ST-tag II is a peptide ligand of ST Tactin (STN). 2× ST-tag II TFA specifically binds to ST Tactin. 2× ST-tag II TFA can be used to construct DNA-protein hybrids .

HY-P0329

X-press Tag Peptide	Peptides	Others
X-press Tag Peptide is a tag peptide used for protein purification. X-press Tag is also an N-terminal leader peptide; this N-terminal peptide contains a polyhistidine sequence, the Xpress epitope (part of bacteriophage T7 gene 10 protein) and an enterokinase cleavage site. Anti-Xpress antibodies recognize the Xpress epitope sequence found in this leader peptide.

HY-P3332

3x DYKDDDDK Tag	Biochemical Assay Reagents	Others
3x DYKDDDDK Tag is a useful tool for investigating the function and localization of proteins whose antibodies (Abs) are not available. Often it is also used in a 3X FLAG format (3x DYKDDDDK Tag) for purifying difficult proteins that accumulate in low abundance .

HY-P10632

HiBiT tag	Peptides	Others
HiBiT tag is a complimentary peptide (VSGWRLFKKIS), with high affinity for LgBiT. HiBiT tag is fused to the Gβ subunit of the receptor. The complementation of LgBiT and HiBiT facilitates the stabilization of ETR and G protein. HiBiT is attached to a protein of interest (GFP) to quantify transport to the cytosol .

HY-P10632A

HiBiT tag acetate	Peptides	Others
HiBiT tag acetate is a complimentary peptide (VSGWRLFKKIS), with high affinity for LgBiT. HiBiT tag acetate is fused to the Gβ subunit of the receptor. The complementation of LgBiT and HiBiT facilitates the stabilization of ETR and G protein. HiBiT is attached to a protein of interest (GFP) to quantify transport to the cytosol .

HY-P11316

DBCO-tag peptide P1	Biochemical Assay Reagents Antibody-Drug Conjugates (ADCs)	Others
DBCO-tag peptide P1 is a cysteine-containing peptide tag. DBCO-tag peptide P1 selectively reacts with dibenzocyclooctyne (DBCO) to yield stable dibenzocyclooctenyl thioethers. DBCO-tag peptide P1 enables site-selective mEGFP labeling and antibody (such as Trastuzumab (HY-P9907)) labelling without impairing the protein binding function. DBCO-tag peptide P1 can be used for ADC synthesis and mEGFP labeling research .

HY-P11103

WSHPQFEK	Peptides	Others
WSHPQFEK has a high affinity for Streptavidin and can be used as a tag peptide for recombinant protein separation, purification, and detection .

HY-P0294

Hexa-His 6X His Tag	Biochemical Assay Reagents	Others
Hexa-His (6X His Tag) is a commonly used affinity tag made up of six histidine residues. HEXA-HIS can bind to affinity chromatography media containing transition metal ions like nickel (Ni ²⁺) or cobalt (Co ²⁺), making it useful for protein purification .

HY-P11104

SsrA tag	Peptides	Others
SsrA tag is an 11-aa peptide added to the C-terminus of proteins stalled during translation, targeting them for degradation by ClpXP and ClpAP .

HY-P0223

FLAG peptide Maximum Cited Publications 22 Publications Verification	Biochemical Assay Reagents	Inflammation/Immunology
FLAG peptide is a multifunctional fusion tag for the purification of recombinant proteins. FLAG peptide maintances the natural folding of its fusing proteins. FLAG peptide can be removed by enterokinase, and eluted under non-denaturing conditions .

HY-P0319

3X FLAG peptide 15+ Cited Publications	Biochemical Assay Reagents	Others
3X FLAG peptides are FLAG-tagged peptides containing three repeats of the Asp-Tyr-Lys-Xaa-Xaa-Asp motif. 3X FLAG peptide can be used for protein separation and purification, and competitive elution with target proteins.

HY-P5969

Cys-V5 Peptide	Biochemical Assay Reagents	Others
Cys-V5 Peptide, a tag peptide, is the V5 Peptide with an N-terminal cysteine. Cys-V5 Peptide can be used to label proteins

HY-P0319A

3X FLAG peptide TFA 15+ Cited Publications	Peptides	Others
3X FLAG peptide TFA is a FLAG-tagged peptide containing three repeats of the Asp-Tyr-Lys-Xaa-Xaa-Asp motif. 3X FLAG peptide TFA can be used for protein separation and purification, and competitive elution with target proteins.

HY-P3332A

3x DYKDDDDK Tag TFA	Biochemical Assay Reagents	Others
DYKDDDDK peptide (FLAG) is a useful tool for investigating the function and localization of proteins whose antibodies (Abs) are not available. Often it is also used in a 3X FLAG format (3x DYKDDDDK Tag TFA) for purifying difficult proteins that accumulate in low abundance .

HY-P0239

HA Peptide 10+ Cited Publications	Influenza Virus	Inflammation/Immunology
HA Peptide (HA tag) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). HA Peptide is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry.

HY-P0223A

FLAG peptide TFA Maximum Cited Publications 22 Publications Verification	Biochemical Assay Reagents	Others
FLAG peptide TFA is the TFA salt form of FLAG peptide (HY-P0223). FLAG peptide TFA is a multifunctional fusion tag for the purification of recombinant proteins. FLAG peptide TFA maintances the natural folding of its fusing proteins. FLAG peptide TFA can be removed by enterokinase, and eluted under non-denaturing conditions .

HY-P2467

Biotin-TAT (47-57)	Fluorescent Dye	Metabolic Disease
Biotin-TAT (47-57), a biotin tagged TAT, is a transactivator of transcription. Biotin-TAT (47-57) is one of the most widely used protein transduction domains (PTDs) into different primary cells is ATP- and temperature-dependent, indicating the involvement of endocytosis .

HY-P5096

FITC-β-Ala-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
FITC-β-Ala-Amyloid β-Protein (1-42) is a FITC tagged Aβ1-42 peptide. Aβ1-42 plays a key role in the pathogenesis of Alzheimer’s disease .

HY-P3908

FITC-β-Ala-Amyloid β-Protein (1-42) ammonium 1 Publications Verification	Amyloid-β	Neurological Disease
FITC-β-Ala-Amyloid β-Protein (1-42) ammonium is a FITC tagged Aβ1-42 peptide. Aβ1-42 plays a key role in the pathogenesis of Alzheimer’s disease .

HY-P3385

Rilunermin alfa SCB-313	Drug Derivative Apoptosis	Cancer
Rilunermin alfa (SCB-313) is a recombinant fusion protein composed of the human C-propeptide of alpha1(I) collagen (Trimer-Tag) to the C-terminus of the mature human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; Apo2L). Rilunermin alfa has potential pro-apoptotic and antineoplastic activities .

HY-P10714

Ub4ix	Proteasome Apoptosis Deubiquitinase	Cancer
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC₅₀ value of 1.6 μM .

HY-P5112

Azido-PEG3-DYKDDDDK Azido-PEG3-FLAG	Biochemical Assay Reagents	Others
Azido-PEG3-DYKDDDDK (azide-PEG3-FLAG) is a multifunctional fusion tag for the purification of recombinant proteins. Azido-PEG3-DYKDDDDK is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-P5112A

Azido-PEG3-DYKDDDDK TFA Azido-PEG3-FLAG TFA	Biochemical Assay Reagents	Others
Azido-PEG3-DYKDDDDK (azide-PEG3-FLAG) TFA is a multifunctional fusion tag for the purification of recombinant proteins. Azido-PEG3-DYKDDDDK TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

Cat. No.	Product Name

HY-K0207

Anti-Flag Magnetic Beads Maximum Cited Publications 175 Publications Verification
MCE Anti-Flag Magnetic Beads are used for immunoprecipitation (IP) of specific Flag-tagged (DYKDDDDK) proteins expressed in bacterial and mammalian cells and in vitro expression systems, and also suitable for Co-immunoprecipitation and purification of Flag-tagged protein.

HY-K0210

Ni-NTA His-Tag Purification Agarose 20+ Cited Publications
MCE Ni-NTA His-Tag Purification Agarose, a 6% highly cross-linked agarose reagent, enables high-yield, high-purity purification of his-tagged proteins.

HY-K0249

Anti-V5 Magnetic Beads
MCE Anti-V5 Magnetic Beads are well suited for the detection and purification of V5-tagged fusion proteins, as well as for applications such as immunoprecipitation (IP) and co-immunoprecipitation (Co-IP).

HY-K0235

Anti-YFP Affinity Gel
MCE Anti-YFP Affinity Gel can be used for the detection and purification of proteins tagged with GFP and EGFP and IP assays.

HY-K0217

Anti-Flag Affinity Gel 4 Publications Verification
MCE Anti-Flag Affinity Gel is used for immunoprecipitation (IP) or protein purification of specific Flag-tagged (DYKDDDDK) proteins expressed in bacterial and mammalian cells and in vitro expression systems.

HY-K0221

Affinity Chromatography Column 1 Publications Verification
MCE Affinity Chromatography (AC) Columns are designed for purification of recombinant proteins with different tags, enzymes, antibodies, antigens and nucleic acids.

HY-K0240

Ni-IDA Magnetic Agarose Beads
MCE Ni-IDA Magnetic Agarose Beads can be used for the detection and purification of His-tag proteins from various expression sources.

HY-K0241

Ni-NTA Magnetic Agarose Beads 1 Publications Verification
MCE Ni-NTA Magnetic Agarose Beads can be used for the detection and purification of His-tag proteins from various expression sources.

HY-K0211

Glutathione Agarose 5+ Cited Publications
MCE Glutathione Agarose, a 4% highly cross-linked agarose reagent, enables high-yield, high-purity purification of GST-tagged proteins.

HY-K0238

Ni-IDA Agarose
MCE Ni-IDA Agarose can be used for the detection and purification of His-tag proteins.

HY-K0201

Anti-HA Magnetic Beads 110+ Cited Publications
MCE Anti-HA Magnetic Beads are used for immunoprecipitation (IP) of specific HA-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems.

HY-K0222

Anti-GST Magnetic Beads 15+ Cited Publications
MCE Anti-GST Magnetic Beads are used for immunoprecipitation (IP) of specific GST-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems.

HY-K0209

Anti-His Magnetic Beads 15+ Cited Publications
MCE Anti-His Magnetic Beads are used for immunoprecipitation (IP) of specific His-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems.

HY-K0250

Anti-MBP Magnetic Beads
Anti-MBP Magnetic Beads are suitable for the detection and purification of MBP-tagged fusion proteins, as well as for immunoprecipitation (IP) and co-immunoprecipitation (Co-IP) applications.

HY-K0234

Glutathione Magnetic Agarose Beads 2 Publications Verification
MCE Glutathione Magnetic Agarose Beads have high protein-binding capacity and stability, making it ideal for high performance purification of GST-tagged fusion proteins expressed in E. coli, yeast, insect and mammalian expression systems.

HY-K0206

Anti-c-Myc Magnetic Beads 60+ Cited Publications
MCE Anti-c-Myc Magnetic Beads are used for immunoprecipitation (IP) of specific c-Myc-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems.

HY-K0220

Ni-NTA 6FF Prepacked Column 1 Publications Verification
MCE Ni-NTA 6FF Prepacked Column is ideal for high performance purification of polyhistidine-tagged proteins expressed in E.coli, yeast, insect and mammalian expression systems.

HY-K0201A

Anti-HA Magnetic Beads (1 μm) 4 Publications Verification
MCE Anti-HA Magnetic Beads (1 μm) are used for immunoprecipitation (IP) of specific HA-tagged proteins expressed in bacterial and mammalian cells andin vitro expression systems.

HY-K0256

Chelating Agarose (IDA) 6FF
MCE Chelating Agarose (IDA) 6FF allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

HY-K0255

IMAC Agarose (NTA) 6FF

MCE IMAC Agarose (NTA) 6FF is prepared by covalently coupling tetradentate nitrilotriacetic acid (NTA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

Cat. No.	Product Name	Target	Research Area

HY-P99759

Nogapendekin alfa (his tag) IL-15N72D	Interleukin Related	Inflammation/Immunology Cancer
Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL)-15 variant, is a superagonist of IL-15. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8 ⁺ T cells .

HY-P99764

Odesivimab REGN-3471	Filovirus	Infection
Odesivimab is a human monoclonal antibody, targeting Ebola virus glycoprotein with a K_D value of 7.74 nM for recombinant histidine-tagged Makona strain Ebola virus glycoprotein ectodomain protein. Odesivimab can be used in research of Ebola virus infection .

HY-P3385

Rilunermin alfa SCB-313	Drug Derivative Apoptosis	Cancer
Rilunermin alfa (SCB-313) is a recombinant fusion protein composed of the human C-propeptide of alpha1(I) collagen (Trimer-Tag) to the C-terminus of the mature human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; Apo2L). Rilunermin alfa has potential pro-apoptotic and antineoplastic activities .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0239

HA Peptide 10+ Cited Publications	Natural Products Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Influenza Virus
HA Peptide (HA tag) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). HA Peptide is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry.

HY-N15871

18:1 DGS-NTA(Ni)	Lipid	Liposome
18:1 DGS-NTA(Ni) is a nickel chelating lipid. 18:1 DGS-NTA(Ni) has high affinity for histidine-tags and can bind histidine tags of recombinant proteins. 18:1 DGS-NTA(Ni) can be used for preparation of liposomes and nanosize multilamellar vesicles (NMVs) which are used in protein and peptide binding studies and antigen delivery .

HY-N15947

Trifunctional sphingosine	Lipid	Drug Derivative
Trifunctional sphingosine is a clickable sphingoid base derivative. Trifunctional sphingosine can be used to study the biological function of sphingoid bases. Trifunctional lipids may overcome several challenges in interrogating lipid biology: their fast metabolism, their weak and transient (but functionally important) interactions with proteins, and the difficulty in tagging them without disturbing the cellular location .

Cat. No.	Product Name		Classification

HY-164745

L-β-Ethynylserine		Alkynes
L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags, respectively.

HY-W039953

Ac4GlcNAz N-azidoacetylglucosamine-tetraacylated		Azide
Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC). It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu(I)-catalyzed azide-alkyne cycloaddition conditions.

HY-151645

Alkyne-SNAP		Labeling and Fluorescence Imaging Alkynes
Alkyne-SNAP (compound 3) is an Alkyne-conjugated benzylguanine. The benzylguanine moiety reacts with the SNAP-tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality for further click chemistry conjugation .

HY-151646

Alkyne-PEG5-SNAP Alkyne-PEG5-BG		Labeling and Fluorescence Imaging Alkynes
Alkyne-PEG5-SNAP is a click chemistry reagent containing an alkyne group. Alkyne-PEG5-SNAP can alkyne conjugated benzylguanine (BG), the BG moiety reacts specifically and rapidly with SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality suitable for further conjugation . Alkyne-PEG5-SNAP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W039921

2-[(Azidoacety)amino]-2-deoxy-D-galactose N-Azidoacetylgalactosamine; GalNAz		Azide
2-[(Azidoacety)amino]-2-deoxy-D-galactose targets O-GlcNAc-modified proteins. By detecting and targeting O-GlcNAc-modified proteins, 2-[(Azidoacety)amino]-2-deoxy-D-galactose can serve as a chemical tag for intracellular sugar chain metabolism .

HY-P5112A

Azido-PEG3-DYKDDDDK TFA Azido-PEG3-FLAG TFA		Azide
Azido-PEG3-DYKDDDDK (azide-PEG3-FLAG) TFA is a multifunctional fusion tag for the purification of recombinant proteins. Azido-PEG3-DYKDDDDK TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-D1506

Fl-DIBO		Labeling and Fluorescence Imaging
Fl-DIBO (fluorogenic dibenzocyclooctyne) is a selective and high sensitivity fluorescent probe to azide compounds. Fl-DIBO can react rapidly with azide compounds to form new highly fluorescent products with a maximum emission wavelength of 469 nm and excitation wavelength of 363 nm. Fl-DIBO can be used to label diazo-tagged proteins without detectable background signal interference . Fl-DIBO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D2955

BC‐AZIDE CLIP-AZIDE		Azide
BC-AZIDE is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .

HY-D2926

BG-Tetrazine BG-Tz; SNAP-Tetrazine		Tetrazine
BG-Tetrazine is a SNAP tag substrate that contains a methyl tetrazine group. BG-Tetrazine can specifically covalently label the target protein of the intracellular SNAP-tag fusion. The tetrazine group it carries can rapidly and efficiently undergo a bioorthogonal reaction with functional groups such as trans cyclooctene (TCO), thereby enabling multiple labeling, functionalization or enrichment of proteins. BG-Tetrazine can be applied in click chemistry .

HY-P5112

Azido-PEG3-DYKDDDDK Azido-PEG3-FLAG		Azide
Azido-PEG3-DYKDDDDK (azide-PEG3-FLAG) is a multifunctional fusion tag for the purification of recombinant proteins. Azido-PEG3-DYKDDDDK is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-D2989

BG-NH2-Ac-N3 SNAP-NH2-Ac-N3		Azide
BG-NH2-Ac-N3 is a nitrogen-containing SNAP tag with a nitro group. BG-NH2-Ac-N3 can be used for click chemistry labeling .

Cat. No.	Product Name		Classification

HY-174499

Cas9 Nickase D10A mRNA (5moU)		mRNA
Cas9 Nickase D10A mRNA expresses a version of the Streptococcus pyogenes SF370 Cas9 protein (CRISPR Associated Protein 9) that contains a D10A amino acid substitution. This mRNA also contains a C-terminal nuclear localization signal followed by a HA tag.Cas9 functions as part of the CRISPR (clustered regularly interspaced short palindromic repeats) genome editing system. In the CRISPR system, an RNA guide sequence targets the site of interest and the Cas9 protein is employed to perform the DNA cleavage. While wild-type Cas9 creates a double-stranded break at the target site, Cas9 nickase creates a single-stranded break. This favors homology-directed repair and decreases the occurrence of non-homologous end joining.

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