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Results for "

p-glycoprotein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P-glycoprotein (180) 5-HT Receptor (8) ADC Payload (5) Adrenergic Receptor (11) Akt (4) AMPK (2) Antibiotic (8) Apoptosis (31) Autophagy (16) Bacterial (7) Bcl-2 Family (2) BCRP (10) Biochemical Assay Reagents (1) Bradykinin Receptor (1) c-Met/HGFR (2) Calcium Channel (17) CaMK (5) Cannabinoid Receptor (1) Carbonic Anhydrase (1) Caspase (3) CDK (1) CFTR (5) Chloride Channel (2) Cholinesterase (ChE) (1) Cytochrome P450 (21) Dipeptidyl Peptidase (2) DNA-PK (1) DNA/RNA Synthesis (3) Dopamine Receptor (14) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (7) EGFR (1) Endogenous Metabolite (14) ERK (1) Ferroptosis (3) GSK-3 (1) HIV (10) HIV Protease (9) IAP (2) iGluR (3) Influenza Virus (5) Isotope-Labeled Compounds (23) JNK (1) Microtubule/Tubulin (9) Mitochondrial Metabolism (7) Monoamine Oxidase (1) mTOR (1) Na+/K+ ATPase (1) NF-κB (3) NO Synthase (3) Opioid Receptor (2) p38 MAPK (1) Parasite (7) Phosphatase (1) PI3K (5) PKA (1) Potassium Channel (8) PPAR (2) PROTACs (1) Ras (1) Reactive Oxygen Species (ROS) (6) Reference Standards (30) SARS-CoV (10) Serotonin Transporter (1) Sigma Receptor (3) SOS1 (1) TAM Receptor (2) Taste Receptor (1) Toll-like Receptor (TLR) (3) Topoisomerase (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (161) Cardiovascular Disease (29) Endocrinology (1) Infection (29) Inflammation/Immunology (13) Metabolic Disease (24) Neurological Disease (26)

By Targets:

P-glycoprotein (180)

5-HT Receptor (8)

ADC Payload (5)

Adrenergic Receptor (11)

Akt (4)

AMPK (2)

Antibiotic (8)

Apoptosis (31)

Autophagy (16)

Bacterial (7)

Bcl-2 Family (2)

BCRP (10)

Biochemical Assay Reagents (1)

Bradykinin Receptor (1)

c-Met/HGFR (2)

Calcium Channel (17)

CaMK (5)

Cannabinoid Receptor (1)

Carbonic Anhydrase (1)

Caspase (3)

CDK (1)

CFTR (5)

Chloride Channel (2)

Cholinesterase (ChE) (1)

Cytochrome P450 (21)

Dipeptidyl Peptidase (2)

DNA-PK (1)

DNA/RNA Synthesis (3)

Dopamine Receptor (14)

Drug Derivative (1)

Drug Intermediate (1)

Drug Metabolite (7)

EGFR (1)

Endogenous Metabolite (14)

ERK (1)

Ferroptosis (3)

GSK-3 (1)

HIV (10)

HIV Protease (9)

IAP (2)

iGluR (3)

Influenza Virus (5)

Isotope-Labeled Compounds (23)

JNK (1)

Microtubule/Tubulin (9)

Mitochondrial Metabolism (7)

Monoamine Oxidase (1)

mTOR (1)

Na+/K+ ATPase (1)

NF-κB (3)

NO Synthase (3)

Opioid Receptor (2)

p38 MAPK (1)

Parasite (7)

Phosphatase (1)

PI3K (5)

PKA (1)

Potassium Channel (8)

PPAR (2)

PROTACs (1)

Ras (1)

Reactive Oxygen Species (ROS) (6)

Reference Standards (30)

SARS-CoV (10)

Serotonin Transporter (1)

Sigma Receptor (3)

SOS1 (1)

TAM Receptor (2)

Taste Receptor (1)

Toll-like Receptor (TLR) (3)

Topoisomerase (3)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (161)

Cardiovascular Disease (29)

Endocrinology (1)

Infection (29)

Inflammation/Immunology (13)

Metabolic Disease (24)

Neurological Disease (26)

233

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

ONT-093 OC 144-093; OC 144093	P-glycoprotein	Cancer
ONT-093 is a potent inhibitor of P-glycoprotein pump. ONT-093 has the potential for the research cancer diseases .

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Bacterial Antibiotic	Infection
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of *P-glycoprotein* and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

Elacridar 25+ Cited Publications GF120918; GW0918; GG918; GW120918	P-glycoprotein BCRP	Cancer
Elacridar is an orally active P-glycoprotein (Pgp) and *breast cancer resistance protein* (BCRP)** inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer .

PGP-4008	P-glycoprotein	Cancer
PGP-4008 is a specific *P-glycoprotein* (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin .

Talinolol Cordanum	Adrenergic Receptor	Cardiovascular Disease
Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .

NIK250	Bacterial	Infection
NIK250 is a potent multiple drug resistance (MDR) reversal agent that inhibits P-glycoprotein .

BIBW 22 BIBW22BS	Others	Cancer
BIBW 22 (BIBW22BS) is a dipyridamole analogue. BIBW 22 is a potent bifunctional modulator that affects p-glycoprotein and nucleoside transport in tumor cells .

Niguldipine monohydrochloride	Calcium Channel P-glycoprotein	Cancer
Niguldipine monohydrochloride is a calcium channel blocker that inhibits P-glycoprotein and can be used in tumor research. Niguldipine monohydrochloride inhibits Cav 3.2, with an IC₅₀ of 0.9 μM .

P-gp inhibitor 16	P-glycoprotein Apoptosis	Cancer
P-gp inhibitor 16 (compound 14) is a *p-glycoprotein* inhibitor. P-gp inhibitor 16 significantly increases Doxorubicin-induced apoptosis and shows anticancer effects .

N-Desmethyl-loperamide	Opioid Receptor	Neurological Disease
N-Desmethyl-loperamide is a major metabolite of loperamide, a drug that selectively activates peripheral μopioid receptors with a K_i value of 0.16 nM. N-Desmethyl-loperamide is a substrate of the ATP-dependent efflux transporter P-glycoprotein .

Elacridar hydrochloride 25+ Cited Publications GF120918A	P-glycoprotein BCRP	Cancer
Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and *breast cancer resistance protein* (BCRP)** inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer .

Pristinamycin IA (Standard) Mikamycin B (Standard); Mikamycin IA (Standard)	Reference Standards Bacterial Antibiotic	Infection
Pristinamycin IA (Standard) is the analytical standard of Pristinamycin IA. This product is intended for research and analytical applications. Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus[1].

RMS3	P-glycoprotein Apoptosis	Cancer
RMS3, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS3 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS3 has strong anticancer property .

Elacridar (Standard)	P-glycoprotein BCRP	Cancer
Elacridar (Standard) is the analytical standard of Elacridar. This product is intended for research and analytical applications. Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer .

P-gp inhibitor 22	P-glycoprotein Apoptosis	Cancer
P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase .

KR30031	P-glycoprotein	Cardiovascular Disease Cancer
KR30031, a Verapamil (HY-14275) analog, is an orally active *P-glycoprotein* (P-gp) inhibitor. KR30031 enhances the cytotoxicity of anticancer agents by inhibiting P-gp with fewer cardiovascular adverse effects. KR30031 can be used to study multidrug resistance (MDR) reversal in cancer .

MS-073 CP162398	P-glycoprotein	Cancer
MS-073 (CP162398) is a *P-glycoprotein* (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein .

Phellamurin	P-glycoprotein Apoptosis	Metabolic Disease Cancer
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal *P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis* and has anti-tumor activity .

Elacridar hydrochloride (Standard)	P-glycoprotein BCRP	Cancer
Elacridar (hydrochloride) (Standard) is the analytical standard of Elacridar (hydrochloride). This product is intended for research and analytical applications. Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer .

MCI826	P-glycoprotein	Cancer
MCI826 is a *P-glycoprotein* (P-gp) antagonist.

Benzquinamide hydrochloride P2647 hydrochloride; BZQ hydrochloride; Benzoquinamide hydrochloride	Adrenergic Receptor	Cancer
Benzquinamide (P2647) is an antiemetic which can bind to the α_2A, α_2B, and α_2C adrenergic receptors (α2-AR) with K_i values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells .

AB8939	Microtubule/Tubulin Apoptosis	Cancer
AB8939 is an effective small moleculeMicrotubule/Tubulin polymerization inhibitor with anti-tumor activity (it inhibits tumor cell proliferation with an IC₅₀ of less than 10 nM). AB8939 can effectively evade resistance mechanisms mediated by things like P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis in cells .

NSC23925	P-glycoprotein	Cancer
NSC23925 is a novel, selective and effective *P-glycoprotein* (Pgp) inhibitor.

Encequidar mesylate 4 Publications Verification HM30181 mesylate; HM30181A mesylate	P-glycoprotein	Cancer
Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent *P-glycoprotein* inhibitor.

Encequidar 4 Publications Verification HM30181; HM30181A	P-glycoprotein	Metabolic Disease Cancer
Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of *P-glycoprotein*.

Selamectin	Parasite Chloride Channel P-glycoprotein Bacterial	Infection
Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, *Lymphatic filariae, and nematode* infection. Selamectin is also a potent *P-glycoprotein* substrate and a *P-glycoprotein* inhibitor with an IC₅₀ of 120 nM .

HTT-D3	P-glycoprotein	Neurological Disease
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research .

Glesatinib MGCD265	TAM Receptor c-Met/HGFR	Cancer
Glesatinib (MGCD265) is an orally active, potent MET/SMO dual inhibitor. Glesatinib, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) .

Glesatinib hydrochloride 2 Publications Verification MGCD265 hydrochloride	TAM Receptor c-Met/HGFR	Cancer
Glesatinib hydrochloride (MGCD265 hydrochloride) is an orally active, potent MET/SMO dual inhibitor. Glesatinib hydrochloride, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) .

Dofequidar sesquifumarate MS-209 sesquifumarate	P-glycoprotein	Cancer
Dofequidar (MS-209) sesquifumarate is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar sesquifumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar sesquifumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect .

Tariquidar dimesylate XR9576 dimesylate	P-glycoprotein	Cardiovascular Disease Others
Tariquidar dimesylate (XR9576 dimesylate) is a *P-glycoprotein* (P-gp) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to *P-glycoprotein*, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance .

FM04	P-glycoprotein	Cancer
FM04 is a potent *P-glycoprotein* (P-gp) inhibitor (EC₅₀=83 nM). FM04 inhibits P-gp in 2 mechanism: (1)FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2)FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp .

9,10-trans-Dehydroepothilone D	P-glycoprotein	Cancer
9,10-trans-Dehydroepothilone D shows an antiproliferative activity against a paclitaxel-resistant cell lines overexpressing *P-glycoprotein*. 9,10-trans-Dehydroepothilone D also shows tubulin polymerization activity. 9,10-trans-Dehydroepothilone D is given by lactonization of Seco acid, which is promising for research of cancers .

Tariquidar methanesulfonate, hydrate 50+ Cited Publications XR9576 methanesulfonate, hydrate	P-glycoprotein	Cancer
Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of *P-glycoprotein* (P-gp) with a K_d of 5.1 nM.

Valspodar 15+ Cited Publications PSC 833	P-glycoprotein	Cancer
Valspodar (PSC 833) is a selective *P-glycoprotein* inhibitor that has been used as an experimental cancer treatment and chemosensitizer.

P-gp inhibitor 3	P-glycoprotein	Cancer
P-gp inhibitor 3 is an effective *P-glycoprotein* (P-gp) inhibitor. P-gp inhibitor 3 inhibits the efflux function of P-gp by activating P-gp ATPase. P-gp inhibitor 3 has relatively stronger multidrug resistance (MDR) reversal ability and enhances the anti-tumor activity of Paclitaxel .

Schisandrol B 2 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy	Cancer
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of *P-glycoprotein* and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

P-gp modulator 2	P-glycoprotein	Cancer
P-gp modulator 2 (Compound 27) is a potent, competitive, allosteric P-glycoprotein (P-gp) modulator .

P-gp modulator 3	P-glycoprotein	Cancer
P-gp modulator 3 (Compound 37) is a potent, competitive, allosteric P-glycoprotein (P-gp) modulator .

Selamectin (Standard)	Reference Standards Parasite Chloride Channel P-glycoprotein Bacterial	Infection
Selamectin (Standard) is the analytical standard of Selamectin. This product is intended for research and analytical applications. Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, *Lymphatic filariae, and nematode* infection. Selamectin is also a potent *P-glycoprotein* substrate and a *P-glycoprotein* inhibitor with an IC₅₀ of 120 nM .

Reversin 121	P-glycoprotein	Cancer
Reversin 121 is a *P-glycoprotein* inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers .

RMS5	P-glycoprotein Apoptosis	Cancer
RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property .

Tariquidar dihydrochloride XR9576 dihydrochloride	P-glycoprotein	Cancer
Tariquidar dihydrochloride (XR9576 dihydrochloride) is a potent and specific inhibitor of *P-glycoprotein* (P-gp) with the high affinity (K_d=5.1 nM) .

SNRI-IN-1	Serotonin Transporter	Endocrinology
SNRI-IN-1 (Compound 7a) is a dual serotonin and noradrenaline monoamine reuptake inhibitor, P-glycoprotein Efflux Ratio is 20 .

Tariquidar 50+ Cited Publications XR9576	P-glycoprotein	Cancer
Tariquidar (XR9576) is a potent and specific inhibitor of *P-glycoprotein* (P-gp) with the high affinity (K_d=5.1 nM) .

Biricodar 1 Publications Verification VX-710	P-glycoprotein	Cancer
Biricodar (VX-710) is a modulator of *P-glycoprotein* and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

Cat. No.	Product Name	Type

HY-133948

1-Monopalmitolein Glyceryl palmitoleate	Biochemical Assay Reagents
1-Palmitoleoyl glycerol is a biologically active monoacylglycerol. It increases daunomycin accumulation, shown to inhibit P-glycoprotein in Caco-2 cells. 1-Palmitoleoyl glycerol induces thymocyte apoptosis.

Cat. No.	Product Name	Target	Research Area

HY-125486

Reversin 121	P-glycoprotein	Cancer
Reversin 121 is a *P-glycoprotein* inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers .

HY-P10856

CPI1	P-glycoprotein	Cancer
CPI1 is a potent and highly specific multidrug resistance protein 1 (MRP1) inhibitor. CPI1 inhibits MRP1 (K_i: 100 nM) with nanomolar potency but shows minimal inhibition of P-glycoprotein (Pgp). CPI1 and LTC4 compete to bind to the same site of MRP1, inhibiting ATP hydrolysis and substrate transport. CPI1 can be used to study drug delivery and chemotherapy resistance in cancer .

HY-136934

Reversin 205 [Boc-Glu(Obzl)]2-Lys-Ome	P-glycoprotein	Cancer
Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a *P-glycoprotein* (ABCB1) inhibitor. Reversin 205 is a peptide chemosensitizer .

HY-162396

P-gp inhibitor 21	P-glycoprotein	Cancer
P-gp inhibitor 21 (Compound 56) is an inhibitor for P-glycoprotein (P-gp) transport, which reverses P-gp-mediated multidrug resistance (MDR) and exhibits antitumor efficacy in mice without significant cytotoxicity .

Cat. No.	Product Name	Target	Research Area

HY-P990196

Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2)	P-glycoprotein	Cancer
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) is an anti-monkey/human MDR-1/CD243 IgG2a monoclonal antibody. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can efficiently inhibit *P-glycoprotein*. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) enhances the inhibitory effect on multidrug resistance (MDR) by suppressing drug efflux. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can be used for research on cancer .

Cat. No.	Compare	Product Name	Species	Source

HY-P7621

	*ABCB5 Protein, Human (Trx)* rHuABCB5, N-Trx; ATP-binding cassette sub-family B member 5; P-glycoprotein ABCB5; ABCB5	Human	E. coli
	ABCB5, N-Trx Protein, Human is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.

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Cat. No.	Product Name	Chemical Structure

HY-135328AS

Norverapamil-d7 hydrochloride
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-W654320

Piperin-d10
Piperin-d₁₀ is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of *P-glycoprotein* and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-110232

Risperidone-d4
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-A0064S

Verapamil-d3 hydrochloride

Verapamil-d₃ (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-W699430

Norverapamil-d6 hydrochloride
Norverapamil-d₆ ((±)-Norverapamil-d₆) hydrochloride is deuterium labeled Norverapamil (hydrochloride). Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-135336S

(R)-Verapamil-d7 hydrochloride
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .

HY-W702292

(R)-(+)-Verapamil-d6 hydrochloride
(R)-(+)-Verapamil-d₆ (hydrochloride) is deuterium labeled (R)-Verapamil (hydrochloride). (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a *P-Glycoprotein* inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .

HY-W777317

Elacridar-d4(Major)
Elacridar-d₄(Major) is the deuterium labeled Elacridar (HY-50879). Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer .

HY-108286S

(Rac)-Talinolol-d5
(Rac)-Talinolol-d₅ is the racemate of Talinolol. Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .

HY-14275S

Verapamil-d3
Verapamil-d₃ ((±)-Verapamil-d₃) is deuterium labeled Verapamil. Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-14275S2

Verapamil-d6
Verapamil-d₆ ((±)-Verapamil-d₆) is deuterium labeled Verapamil. Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-14275S1

Verapamil-d7
Verapamil-d₇ is the deuterium labeled Verapamil (HY-14275). Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-N0007S

Bisdemethoxycurcumin-d8

Bisdemethoxycurcumin-d₈ (Curcumin III-d₈) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A). Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases .

HY-11018S2

Risperidone-d6
Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively .

HY-11018S1

Risperidone-d4-1
Risperidone-d4-1 (R 64 766-d4-1) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, *P-Glycoprotein* inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-A0064S1

Verapamil-d6 hydrochloride

Verapamil-d₆ (CP-16533-1-d₆) hydrochloride is the deuterium labled Verapamil (hydrochloride) (HY-A0064). Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

HY-17367S4

Atazanavir-d6
Atazanavir-d₆ is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367S3

Atazanavir-d5
Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367S2

Atazanavir-d9
Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-B0532AS

Trifluoperazine-d3 dihydrochloride

Trifluoperazine-d₃ (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis .

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-B0777S

Moxidectin-d3

Moxidectin-d₃ (CL-301423-d₃) is deuterium labeled Moxidectin. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk .

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S2

Glibenclamide-13C6

Glibenclamide- ¹³C₆ (Glyburide- ¹³C₆) is ¹³C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-17367S5

Atazanavir-d24

Atazanavir-d₂₄ (BMS-232632-d₂₄) is deuterium labeled Atazanavir. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80772

	P Glycoprotein Antibody (YA255) 2 Publications Verification p-pg; PGP; ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243	WB	Human
	P Glycoprotein Antibody (YA255) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P Glycoprotein.

HY-P80527

	ABCB5 Antibody (YA836) ABCB5 P-gp; ATP binding cassette sub family B (MDR/TAP) member 5; P glycoprotein ABCB5	WB, ICC/IF	Human
	ABCB5 Antibody (YA836) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ABCB5.

HY-P85934

	P Glycoprotein Antibody (YA5626) ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	P Glycoprotein Antibody (YA5626) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P Glycoprotein.

HY-P86055

	P Glycoprotein Antibody (YA5747) ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1	IHC-P, ELISA	Human, Mouse,
	P Glycoprotein Antibody (YA5747) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P Glycoprotein.

HY-P86336

	P Glycoprotein Antibody (YA6028) ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1	WB, IHC-P, ICC/IF, IP, ELISA	Human
	P Glycoprotein Antibody (YA6028) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P Glycoprotein.

HY-P86662

	P Glycoprotein Antibody (YA6354) ABC20; ABCB1; ATP binding cassette, sub family B(MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; PGY1.	IHC-P, IF-Tissue, IHC-F, WB	Human, Mouse, Rat
	P Glycoprotein Antibody (YA6354) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P Glycoprotein.

HY-P85662

	ABCB5 Antibody (YA5354) ABCB5; ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5	WB, IHC-P, ICC/IF,	Human
	ABCB5 Antibody (YA5354) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ABCB5.