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Results for "

oxygenase-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Heme Oxygenase (HO) (8) Akt (1) Apoptosis (5) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (2) Endogenous Metabolite (7) Epigenetic Reader Domain (2) Ferroptosis (1) GSK-3 (1) IFNAR (2) Influenza Virus (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (10) Mitochondrial Metabolism (2) NF-κB (2) NO Synthase (3) p38 MAPK (2) Prostaglandin Receptor (3) Reactive Oxygen Species (ROS) (20) Reference Standards (6) Ribosomal S6 Kinase (RSK) (2) TNF Receptor (2) Tyrosinase (1) β-catenin (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (6) Infection (6) Inflammation/Immunology (15) Metabolic Disease (3) Neurological Disease (7)

By Targets:

Heme Oxygenase (HO) (8)

Akt (1)

Apoptosis (5)

Autophagy (2)

Bacterial (2)

Biochemical Assay Reagents (2)

Endogenous Metabolite (7)

Epigenetic Reader Domain (2)

Ferroptosis (1)

GSK-3 (1)

IFNAR (2)

Influenza Virus (2)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (10)

Mitochondrial Metabolism (2)

NF-κB (2)

NO Synthase (3)

p38 MAPK (2)

Prostaglandin Receptor (3)

Reactive Oxygen Species (ROS) (20)

Reference Standards (6)

Ribosomal S6 Kinase (RSK) (2)

TNF Receptor (2)

Tyrosinase (1)

β-catenin (1)

By Research Areas:

Cancer (21)

Cardiovascular Disease (6)

Infection (6)

Inflammation/Immunology (15)

Metabolic Disease (3)

Neurological Disease (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Heme Oxygenase (HO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101194

Tin protoporphyrin IX dichloride 15+ Cited Publications Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX	Reactive Oxygen Species (ROS)	Cancer
Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model ^[1].

HY-111798

*Heme Oxygenase-1-IN-1* 5+ Cited Publications	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC₅₀ of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research ^[1].

HY-111798A

*Heme Oxygenase-1-IN-1 hydrochloride* 5+ Cited Publications	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC₅₀ of 0.25 μM ^[1].

HY-B2184

Sofalcone 1 Publications Verification	Autophagy Bacterial	Infection Inflammation/Immunology
Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

HY-101193

Zinc Protoporphyrin Maximum Cited Publications 59 Publications Verification Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9	Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial. It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity ^[1] .

HY-153020

HIF-PHD-IN-3	Reactive Oxygen Species (ROS)	Cardiovascular Disease
HIF-PHD-IN-3 (compound 4) is a potent hiPSC-CM cardioprotective scaffold. HIF-PHD-IN-3 can induce upregulation of heme oxygenase-1 ^[1].

HY-115713

*Heme Oxygenase-1-IN-2*	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-2 is a novel heme oxygenase-1 inhibitor (IC₅₀ = 0.95 μM) with potent in vitro antiproliferative activity.

HY-162857

*Heme Oxygenase-1-IN-3*	Heme Oxygenase (HO)	Neurological Disease Cancer
Heme Oxygenase-1-IN-3 (compound 4) is a highly selective heme oxygenase-1 (HO-1) inhibitor (K_d=141 nM) that can be used in the research of cancer and neurodegenerative diseases ^[1].

HY-101193R

Zinc Protoporphyrin (Standard) Zn(II)-protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 ^[1]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

HY-B2184S

Sofalcone-d4	Isotope-Labeled Compounds	Infection Inflammation/Immunology
Sofalcone-d₄ is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

HY-B2184R

Sofalcone (Standard)	Reference Standards Autophagy Bacterial	Infection Inflammation/Immunology
Sofalcone (Standard) is the analytical standard of Sofalcone. This product is intended for research and analytical applications. Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

HY-134608

Cobalt protoporphyrin IX Co-PPIX	Reactive Oxygen Species (ROS) Influenza Virus	Infection
Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV) ^[1].

HY-161601

Ferroptosis inducer-2	Ferroptosis Reactive Oxygen Species (ROS)	Cancer
Ferroptosis inducer-2 (Compound 24) is an inducer for heme oxygenase-1 (HO-1). Ferroptosis inducer-2 exhibits anticancer activity against triple-negative breast cancer (TNBC) cells through induction of ferroptosis ^[1].

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) ^[1].

HY-124815

CP-312	Reactive Oxygen Species (ROS)	Others
CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress ^[1].

HY-N0061

Ethyl ferulate 2 Publications Verification	Reactive Oxygen Species (ROS)	Neurological Disease
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress ^[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .

HY-171705

KMS99220	Keap1-Nrf2	Neurological Disease
KMS99220 is an orally active Nrf2 inhibitory protein *Keap-1* activator. KMS99220 promotes Nrf2 nuclear translocation, up-regulates the gene expression of antioxidant enzymes (such as heme oxygenase-1, etc.) and proteasome subunits, alleviates oxidative stress and protein aggregation damage. KMS99220 can be used in the research of Parkinson’s disease (PD) ^[1].

HY-W478741

Pyrraline	Endogenous Metabolite Keap1-Nrf2 NF-κB	Metabolic Disease Cancer
Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers ^[1] .

HY-N0761A

trans-Isoferulic acid trans-3-Hydroxy-4-methoxycinnamic acid	NO Synthase Prostaglandin Receptor	Inflammation/Immunology
trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity ^[1].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

HY-N2535

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities ^[1].

HY-124815R

CP-312 (Standard)	Reactive Oxygen Species (ROS)	Others
CP-312 (Standard) is the analytical standard of CP-312. This product is intended for research and analytical applications. CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress ^[1].

HY-N0761AS

trans-Isoferulic acid-d3	Prostaglandin Receptor NO Synthase	Inflammation/Immunology
trans-Isoferulic acid-d₃ is the deuterium labeled trans-Isoferulic acid ^[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

HY-N1745A

3-Deoxysappanchalcone 2 Publications Verification	Influenza Virus	Infection Inflammation/Immunology
3-Deoxysappanchalcone is a naturally-occurring chalcone compound found in Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC₅₀ = 1.06 μM) ^[1] .

HY-N2535R

Coniferaldehyde (Standard) 4-Hydroxy-3-methoxycinnamaldehyde (Standard)	Reference Standards Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities ^[1].

HY-N0761AR

trans-Isoferulic acid (Standard) trans-3-Hydroxy-4-methoxycinnamic acid (Standard)	Reference Standards NO Synthase Prostaglandin Receptor	Inflammation/Immunology
trans-Isoferulic acid (Standard) is the analytical standard of trans-Isoferulic acid. This product is intended for research and analytical applications. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity ^[1].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

HY-170867

Nrf2/HO-1 activator 3	Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 *HO-1. Nrf*2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H₂O₂- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy ^[1].

HY-W013812

Ethyl linoleate Linoleic Acid ethyl ester; Mandenol	Tyrosinase Akt GSK-3 β-catenin Biochemical Assay Reagents NF-κB Heme Oxygenase (HO)	Cardiovascular Disease Inflammation/Immunology
Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces heme oxygenase-1 and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics ^[1]

HY-175660

KCL-HO-1i	Heme Oxygenase (HO)	Cancer
KCL-HO-1i is an orally active heme oxygenase-1 (HO-1) inhibitor (rat *HO-1: IC₅₀* = 123 nM) and human HO-1: IC₅₀ = 128 nM). KCL-HO-1i targets immunosuppressive LYVE-1 ⁺ perivascular tumor-associated macrophages (PvTAMs) in the tumor microenvironment (TME), reduces PvTAM-mediated immune exclusion. KCL-HO-1i demonstrates synergistic anti-tumor efficacy with chemotherapy in MMTV-PyMT spontaneous breast cancer mice or C57Bl/6 mice bearing subcutaneous MN-MCA1 sarcomas. KCL-HO-1i can be used for the study of cancer ^[1].

HY-118487A

OB-24 free base	Others	Cancer
OB-24 free base is a compound that potently and selectively inhibits heme oxygenase 1 (HO-1) and has the potential to inhibit advanced prostate cancer. OB-24 significantly reduces protein carbonylation and the formation of reactive oxygen species by selectively inhibiting HO-1 activity in prostate cancer cells. OB-24 significantly inhibited cell proliferation in vitro and inhibited tumor growth and lymph node and lung metastasis in vivo. OB-24 exhibits powerful synergy when used in combination with Taxol ^[1].

HY-106359A

Delmitide acetate RDP-58 acetate	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Cancer
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis ^[1] .

HY-106359

Delmitide RDP-58	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis ^[1] .

HY-N0643

Carnosol 10+ Cited Publications	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM ^[1]. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-W424839

Probucol dithiobisphenol DTBP	Heme Oxygenase (HO)	Cardiovascular Disease
Probucol dithiobisphenol (DTBP) is the derivative of Probucol (HY-B0388). Probucol dithiobisphenol induces the production of heme oxygenase 1 (HO-1), and exhibits antioxidant activity. Probucol dithiobisphenol inhibits atherosclerotic lesions in Apoe ^−/− mice aorta, promotes re-endothelialization of aorta and inhibits restenosis in rabbit arterial injury models. Probucol dithiobisphenol is orally active ^[1].

HY-136234

9-cis-β-Carotene 9Z β-Carotene	Endogenous Metabolite	Others
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus ^[1].

HY-N1326

Santamarine Santamarin; Balchanin	Keap1-Nrf2	Inflammation/Immunology
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities ^[1] .

HY-131592

Tricetin 1 Publications Verification	Apoptosis Keap1-Nrf2	Neurological Disease Inflammation/Immunology Cancer
Tricetin is a potent competitive inhibitor of the *Keap1-Nrf2* Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway ^[1].

HY-N0643R

Carnosol (Standard)	Reference Standards Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM ^[1]. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-N1506

Ganodermanontriol	Epigenetic Reader Domain p38 MAPK	Cancer
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity ^[1] .

HY-N1506R

Ganodermanontriol (Standard)	Reference Standards Epigenetic Reader Domain Others p38 MAPK	Cancer
Karbutilate (Standard) is the analytical standard of Karbutilate. This product is intended for research and analytical applications. Karbutilate (NIA-11092) is a nonselective soil-active herbicide which is used to kill one-leaf pinyon saplings ^[1].

HY-118487

OB-24 1 Publications Verification	Heme Oxygenase (HO) Reactive Oxygen Species (ROS)	Cancer
OB-24 is a selective small-molecule *HO-1* inhibitor (IC₅₀ = 1.9 μM for HO-1 and IC₅₀ for HO-2 >100 μM). OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis ^[1] .

HY-120251

Leteprinim AIT-082 free acid	Reactive Oxygen Species (ROS)	Neurological Disease
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases *heme-oxygenase* 1 and 2 mRNA levels that play role in cellular defense against *reactive oxygen* species** ^[1] .

HY-120251A

Leteprinim potassium AIT-082	Reactive Oxygen Species (ROS)	Neurological Disease
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases *heme-oxygenase* 1 and 2 mRNA levels that play role in cellular defense against *reactive oxygen* species** ^[1] .

HY-112749

ME-344	Heme Oxygenase (HO) Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Cancer
ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research ^[1].

HY-147517

Keap1-Nrf2-IN-9	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells ^[1].

HY-112749B

(3S,4R)-ME-344	Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cancer
(3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344 (HY-112749). ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research ^[1].

Cat. No.	Product Name	Type

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Cell Assay Reagents
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) ^[1].

Cat. No.	Product Name	Target	Research Area

HY-106359A

Delmitide acetate RDP-58 acetate	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Cancer
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis ^[1] .

HY-106359

Delmitide RDP-58	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis ^[1] .

Species:	Human (1) Mouse (1)
Tag:	His (1) Tag Free (1)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70276

	HO-1 Protein, Human 1 Publications Verification rHuHeme oxygenase 1/HO-1; Heme oxygenase 1; HO-1; HMOX1; HO; HO1	Human	E. coli
	HO-1 Protein, an enzyme, plays a critical role in cellular defense against oxidative stress and inflammation. Dysregulation of HO-1 Protein has been implicated in several diseases, including cardiovascular disorders and neuroinflammatory conditions. Targeting HO-1 Protein may offer potential therapeutic interventions by enhancing antioxidant defenses, reducing inflammation, and potentially treating these diseases. HO-1 Protein, Human is the recombinant human-derived HO-1 protein, expressed by E. coli , with tag free.

HY-P700495

	HO-1 Protein, Mouse (P. pastoris, His) rHuHeme oxygenase 1/HO-1; Heme oxygenase 1; HO-1; HMOX1; HO; HO1	Mouse	P. pastoris
	HO-1 Protein catalyzes the oxidative cleavage of heme, releasing carbon monoxide (CO) and ferrous iron. It provides protection against programmed cell death by catabolizing free heme, preventing apoptosis sensitization. HO-1 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived HO-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

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HY-B2184S

Sofalcone-d4
Sofalcone-d₄ is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

HY-N0761AS

trans-Isoferulic acid-d3

trans-Isoferulic acid-d₃ is the deuterium labeled trans-Isoferulic acid ^[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P85707

	*Heme Oxygenase 1* Antibody (YA5399)** Heme oxygenase 1; HO-1;	IHC-P, WB, ICC/IF	Human, Mouse, Rat
	Heme Oxygenase 1 Antibody (YA5399) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Heme Oxygenase 1.

HY-P86395

	*Heme Oxygenase 1* Antibody (YA6087)** Heme oxygenase 1 (HO-1) (EC 1.14.99.3)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Heme Oxygenase 1 Antibody (YA6087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Heme Oxygenase 1.

HY-P80499

	*Heme Oxygenase 1* Antibody (YA389)**	WB, IHC-P, IP, FC	Human
	Heme Oxygenase 1 Antibody (YA389) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Heme Oxygenase 1.

HY-P84030

	*Heme Oxygenase 1* Antibody (YA3727)** HO-1; HSP32; HMOX1D; bK286B10	IHC-P, FC, ELISA	Human
	Heme Oxygenase 1 Antibody (YA3727) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Heme Oxygenase 1.