HO1 Antibody (YA5399)

HO1 Antibody (YA5399) is a mouse-derived and non-conjugated monoclonal antibody, targeting to HO1. It can be applicated for IHC-P, WB, ICC/IF assays, in the background of human, mouse, rat.

HO-1 protein, through its catalytic activity, orchestrates the oxidative cleavage of heme at the alpha-methene bridge carbon, leading to the release of carbon monoxide (CO) and the generation of biliverdin IXalpha. Simultaneously, it liberates the central heme iron chelate as ferrous iron. This enzymatic process not only provides a mechanism for the breakdown of heme but also exerts a cytoprotective effect by preventing the sensitization of cells to programmed cell death or apoptosis. The ability of HO-1 to catabolize free heme underscores its crucial role in cellular defense mechanisms, contributing to cell survival and protection against various stressors.

P09601

Observed band size: 28 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

ICC/IF: 1:50-200; IHC: 50-200; WB: 1:1000-2000

IHC-P, WB, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Synthesized peptide derived from human HO-1