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Results for "

lactate dehydrogenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lactate Dehydrogenase (46) PDHK (1) 5 alpha Reductase (1) 5-HT Receptor (1) AIM2 (1) Apoptosis (13) Atg8/LC3 (1) Autophagy (1) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (3) Calcium Channel (1) Caspase (2) Cytochrome P450 (1) Drug Derivative (1) Endogenous Metabolite (6) Endonuclease (2) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) Fungal (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (2) JNK (1) Keap1-Nrf2 (2) MDM-2/p53 (2) NF-κB (1) NKCC (1) NO Synthase (1) NOD-like Receptor (NLR) (1) Oxidative Phosphorylation (1) p62 (1) Parasite (3) PDI (1) PDK-1 (1) Potassium Channel (2) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (9) Reference Standards (4) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (38) Cardiovascular Disease (4) Endocrinology (2) Infection (7) Inflammation/Immunology (7) Metabolic Disease (17) Neurological Disease (4)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended:

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2807F

Lactate Dehydrogenase (LDH), Bovine Heart LAD, LD, L-LDH, (S)-lactate: NAD+ oxidoreductase	Lactate Dehydrogenase	Others
Lactate Dehydrogenase (LDH), Bovine Heart (LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase) is a biological material or organic compound that can be used in life science research .

HY-P2807I

*L-Lactate* Dehydrogenase, rabbit muscle**	Lactate Dehydrogenase	Others
L-Lactate Dehydrogenase, rabbit muscle is a biological material or organic compound that can be used in life science research .

HY-P2807

*L-Lactate* dehydrogenase, Microorganism** LAD	Endogenous Metabolite	Inflammation/Immunology Cancer
L-Lactate dehydrogenase, Microorganism (LAD) is a redox enzyme. L-Lactate dehydrogenase catalyzes the reduction of pyruvate to L-lactate by NADH in vivo with absolute enantiospecificity .

HY-P2897

*D-Lactate* dehydrogenase, Microorganism** D-LDH	Lactate Dehydrogenase	Others
D-Lactate dehydrogenase, Microorganism (D-LDH) is an oxidoreductase that uses NAD ⁺ or NADP ⁺ as an acceptor and acts on the donor CH-OH group, and can catalyze the oxidation of D-lactate to pyruvate. D-Lactate dehydrogenase widely exists in bacteria and fungi, and is often used in biochemical research .

HY-131485

3-Acetylpyridine adenine dinucleotide, 90% 3-APAD, 90%; 3-Acetylpyridine NAD, 90%	Lactate Dehydrogenase	Metabolic Disease
3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .

HY-P2807A

Lactate Dehydrogenase (LDH), Porcine Heart LDH, Lactic dehydrogenase	Biochemical Assay Reagents	Others
Lactate Dehydrogenase (LDH), Porcine Heart (LDH, Lactic Dehydrogenase) is a biological material or organic compound that can be used in life science research .

HY-P2807G

Lactate Dehydrogenase (LDH), Chicken Heart LAD, LD, L-LDH, (S)-lactate, LDH	Lactate Dehydrogenase	Others
Lactate Dehydrogenase (LDH), Chicken Heart (LAD, LD, L-LDH, (S)-Lactate, LDH) is a biological material or organic compound that can be used in life science research .

HY-P2807J

*L-Lactate* Dehydrogenase (L-LDH), pig muscle**	Lactate Dehydrogenase	Metabolic Disease
L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC₅₀ values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes .

HY-P2807K

*L-Lactate* Dehydrogenase, bovine muscle**	Endogenous Metabolite	Metabolic Disease
L-Lactate Dehydrogenase, bovine muscle is an oxidoreductase. L-Lactate Dehydrogenase, bovine muscle catalyzes the reversible conversion of lactate to pyruvate with the reduction of NAD+ to NADH .

HY-132606

Nedosiran DCR-PHXC	Small Interfering RNA (siRNA) Lactate Dehydrogenase	Metabolic Disease
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate .

HY-139319

LDHA-IN-3 2 Publications Verification	Lactate Dehydrogenase	Cancer
LDHA-IN-3 (compound 2), as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC₅₀=145.2 nM). LDHA-IN-3 can be used for the research of cancer .

HY-34154

4-(Dimethylamino)phenol	Reactive Oxygen Species (ROS)	Metabolic Disease
4-(Dimethylamino)phenol increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. 4-(Dimethylamino)phenol cannot decreases the ATP content until the membrane becomes permeable to LDH .

HY-110119

Galloflavin potassium	Lactate Dehydrogenase Apoptosis	Others
Galloflavin potassium is a novel **lactate dehydrogenase inhibitor that can be used for the research of cancer. Galloflavin inhibits aerobic glycolysis in PLC/PRF/5 cells and triggers cell death via apoptosis** .

HY-150753

RS6212	Oxidative Phosphorylation Lactate Dehydrogenase	Cancer
RS6212 is a specific LDH (lactate *dehydrogenase) inhibitor with an IC₅₀* value of 12.03 μM . RS6212 inhibits tumor growth and exhibits potent anticancer activity in multiple cancer cell lines .

HY-120180

BMS-188107	Calcium Channel	Cardiovascular Disease
BMS-188107 is a calcium antagonist that exerts anti-ischemic effects. BMS-188107 improves postischemic contractile function and reduces lactate dehydrogenase release. BMS-188107 can be utilized in cardiovascular research .

HY-34154R

4-(Dimethylamino)phenol (Standard)	Reactive Oxygen Species (ROS)	Metabolic Disease
4-(Dimethylamino)phenol (Standard) is the analytical standard of 4-(Dimethylamino)phenol. This product is intended for research and analytical applications. 4-(Dimethylamino)phenol increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. 4-(Dimethylamino)phenol cannot decreases the ATP content until the membrane becomes permeable to LDH .

HY-147216A

AXKO-0046 dihydrochloride 4 Publications Verification	Lactate Dehydrogenase	Metabolic Disease Inflammation/Immunology Cancer
AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC₅₀ value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism .

HY-W016203

Phenylpyruvic acid sodium Sodium phenylpyruvate	Endogenous Metabolite PDI	Infection Metabolic Disease
Phenylpyruvic acid sodium is a endogenous metabolite that participates in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .

HY-151243

NCATS-SM1441	Lactate Dehydrogenase	Cancer
NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC₅₀=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells. NCATS-SM1441 can be used to study cancer metabolism .

HY-157992

LM-021	Interleukin Related Caspase Lactate Dehydrogenase Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, **lactate dehydrogenase release and ROS** level. LM-021 can be used for neurological research .

HY-N2498

Glomeratose A	Lactate Dehydrogenase	Others
Glomeratose A is a **lactate dehydrogenase** inhibitor, isolated from Polygala tenuifolia .

HY-D0808

Meldola blue	Fluorescent Dye
Meldola blue is a biosensor for measuring lactate in serum based on screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.

HY-100742B

(S)-GNE-140	Lactate Dehydrogenase	Cancer
(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

HY-100681

GSK2837808A 30+ Cited Publications	Lactate Dehydrogenase	Cancer
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC₅₀s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.

HY-154865

Anticancer agent 121	Lactate Dehydrogenase	Cancer
Anticancer agent 121, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research .

HY-154866

Anticancer agent 122	Lactate Dehydrogenase	Cancer
Anticancer agent 122, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research .

HY-111108

LDH-IN-1 2 Publications Verification	Lactate Dehydrogenase	Cancer
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC₅₀s of 32 and 27 nM for LDHA and LDHB, respectively.

HY-W012530S

Phenylpyruvic acid-13C6 sodium Sodium phenylpyruvate-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite	Others
Phenylpyruvic acid- ¹³C₆ sodium is the ¹³C-labeled Phenylpyruvic acid. Phenylpyruvic acid is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase .

HY-162627

LDHA-IN-6	Lactate Dehydrogenase	Cancer
LDHA-IN-6 (compound 6) is an oral bioactive inhibitor of lactate dehydrogenase-A (LDHA), with the IC₅₀ of 46 nM. LDHA-IN-6 has antitumor activity .

HY-18968

AZ-33 1 Publications Verification LDHA-IN-4	Lactate Dehydrogenase	Cancer
AZ-33 (LDHA-IN-4) (compound 33) is a selective lactate dehydrogenase A (LDHA) inhibitor with an IC₅₀ of 0.5 μM and a K_d of 0.093 μM .

HY-142063

Petasitenine Fukinotoxin	Endogenous Metabolite	Others
Petasitenine (Fukinotoxin) is a pyrrolizidine alkaloid that can be found in the plant Petasites japonicus, which is a carcinogenic metabolite of neopetasitenine. Petasitenine causes lactate dehydrogenase leakage, and exhibits hepatotoxicity .

HY-162629

LDHA-IN-7	Lactate Dehydrogenase	Cancer
LDHA-IN-7 (compound 21) is an oral bioactive inhibitor of lactate dehydrogenase-A (LDHA) and LDHB, with the IC₅₀s of 72 nM and 1.2 Μm, respectively .

HY-W013032

Oxamic acid Maximum Cited Publications 38 Publications Verification Oxamidic acid	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid is a **lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis** .

HY-100742

GNE-140 racemate 5+ Cited Publications	Lactate Dehydrogenase	Cancer
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor .

HY-W040073

Nifurtimox	Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of **lactate dehydrogenase (LDH**).

HY-W013032A

Oxamic acid sodium Maximum Cited Publications 38 Publications Verification Sodium oxamate	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (oxamate) sodium salt is a **lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis** .

HY-131485A

3-Acetylpyridine adenine dinucleotide, 95% 3-APAD, 95%; 3-Acetylpyridine NAD, 95%	Lactate Dehydrogenase	Metabolic Disease
3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .

HY-100742A

(R)-GNE-140 10+ Cited Publications	Lactate Dehydrogenase	Cancer
(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC₅₀s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.

HY-W040118

Galloflavin 5+ Cited Publications	Lactate Dehydrogenase	Cancer
Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated K_is for pyruvate are 5.46 μM (LDH-A) and 15.06 μM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production .

HY-W040073S

Nifurtimox-d4	Isotope-Labeled Compounds Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-176798

NCI-006	Lactate Dehydrogenase Reactive Oxygen Species (ROS) Apoptosis	Cancer
NCI-006 is an orally active **lactate dehydrogenase (LDH) inhibitor (LDHA IC₅₀ = 0.06 μM; LDHB IC₅₀ = 0.03 μM). NCI-006 inhibits intratumoral LDH** activity, lactate production, and tumor growth in a mouse pancreatic cancer model. NCI-006 inhibits glycolysis and induces apoptosis in vitro. NCI-006 enhances the radiosensitivity of glycolytic tumor cell lines while sparing non-glycolytic/normal cells (1522, skin fibroblasts) in combination with ionizing radiation (IR). NCI-006 exhibits synergistic antitumor effects in combination with IACS-010759 (HY-112037) against colorectal and gastric cancers. NCI-006 targets glycolysis by inhibiting lactate dehydrogenase impairs tumor growth in an Ewing sarcoma model .

HY-132606A

Nedosiran sodium DCR-PHXC sodium	Small Interfering RNA (siRNA) Lactate Dehydrogenase	Metabolic Disease
Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate .

HY-W040073R

Nifurtimox (Standard)	Reference Standards Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox (Standard) is the analytical standard of Nifurtimox. This product is intended for research and analytical applications. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of **lactate dehydrogenase (LDH**).

HY-147216

AXKO-0046 4 Publications Verification	Lactate Dehydrogenase	Cancer
AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC₅₀ value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism .

HY-W013032R

Oxamic acid (Standard) Oxamidic acid (Standard)	Reference Standards Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (Standard) is the analytical standard of Oxamic acid. This product is intended for research and analytical applications. Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

HY-N2177

3-Dehydrotrametenolic acid	Lactate Dehydrogenase Apoptosis	Cancer
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity .

HY-169060

LDHA-IN-8	Lactate Dehydrogenase	Cancer
LDHA-IN-8 (Compound 6) is a lactate dehydrogenase (LDHA) inhibitor. LDHA-IN-8 inhibits LDHA catalysis of pyruvate in a dose-dependent manner (EC₅₀ value of 14.54 μM), reduces intracellular lactate levels, and increases intracellular reactive oxygen species (ROS) levels, thereby inhibiting the proliferation of pancreatic cancer cells and lung cancer cells. LDHA-IN-8 holds promise for research in the field of LDHA-related antitumor therapies .

HY-N7393

Isomalt Palatinitol	Lactate Dehydrogenase	Metabolic Disease
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-N10574

Queuine	Bacterial	Metabolic Disease Cancer
Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-N10574A

Queuine dihydrochloride	Others	Metabolic Disease Cancer
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

Cat. No.	Product Name	Type

HY-D0808

Meldola blue	Dyes
Meldola blue is a biosensor for measuring lactate in serum based on screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.

Cat. No.	Product Name	Type

HY-131485

3-Acetylpyridine adenine dinucleotide, 90% 3-APAD, 90%; 3-Acetylpyridine NAD, 90%	Gene Sequencing and Synthesis
3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .

HY-130502

5β,6β-epoxycholestanol Cholesterol 5beta,6beta-epoxide	Drug Delivery
5β,6β-epoxycholestanol is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue .

HY-131485A

3-Acetylpyridine adenine dinucleotide, 95% 3-APAD, 95%; 3-Acetylpyridine NAD, 95%	Gene Sequencing and Synthesis
3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .

Cat. No.	Product Name	Target	Research Area

HY-P3509A

PNC-28 acetate	MDM-2/p53	Cancer
PNC-28 acetate is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 acetate can be used for pancreatic cancer research .

HY-P3148

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species (ROS) JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

HY-P3509

PNC-28	MDM-2/p53	Cancer
PNC-28 is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2498

Glomeratose A	Classification of Application Fields Source classification Polygalaceae Other Diseases Other Phenylpropanoids Phenylpropanoids Plants Disease Research Fields Polygala tenuifolia Willd.	Lactate Dehydrogenase
Glomeratose A is a **lactate dehydrogenase** inhibitor, isolated from Polygala tenuifolia .

HY-W013032

Oxamic acid 35+ Cited Publications Oxamidic acid	Microorganisms Source classification	Lactate Dehydrogenase Apoptosis
Oxamic acid is a **lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis** .

HY-N2177

3-Dehydrotrametenolic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Poria cocos Plants Disease Research Fields Cancer	Lactate Dehydrogenase Apoptosis
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity .

HY-N7393

Isomalt Palatinitol	other families Source classification Metabolic Disease Plants Disease Research Fields Saccharides	Lactate Dehydrogenase
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-N10574

Queuine	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Bacterial
Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-N10574A

Queuine dihydrochloride	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Others
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-W013032R

Oxamic acid (Standard) Oxamidic acid (Standard)	Microorganisms Source classification	Reference Standards Lactate Dehydrogenase Apoptosis
Oxamic acid (Standard) is the analytical standard of Oxamic acid. This product is intended for research and analytical applications. Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

HY-N7393R

Isomalt (Standard) Palatinitol (Standard)	other families Source classification Plants Saccharides	Reference Standards Lactate Dehydrogenase
Isomalt (Standard) is the analytical standard of Isomalt. This product is intended for research and analytical applications. Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-N0440R

Germacrone (Standard)	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Zingiberaceae	Reference Standards Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 inﬂuenza A viruses and the inﬂuenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .

HY-P3148

Astin B	Structural Classification Alkaloids Other Alkaloids Source classification Plants Compositae Erythrina latissima E. Mey.	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species (ROS) JNK Bcl-2 Family Caspase
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

Species:	Human (5) Mouse (2) Rat (1) E.coli (1)
Tag:	His (10) Tag Free (1) Strep (1)
Source:	HEK293 (1) Sf9 insect cells (3) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P70259

	LDHA Protein, Mouse (HEK293, His) rMuL-lactate dehydrogenase, His; LDHA; Ldh1; L-lactate dehydrogenase	Mouse	HEK293
	LDHA protein catalyzes the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the reciprocal interconversion of NADH and NAD(+).LDHA Protein, Mouse (HEK293, His) is the recombinant mouse-derived LDHA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71522

	IIdD Protein, E.coli (His) lldD; EcHS_A3817L-lactate dehydrogenase	E.coli	E. coli
	GLO1/Glyoxalase I Protein catalyzes the conversion of hemimercaptal to S-lactoylglutathione, detoxifying cytotoxic methylglyoxal produced in glycolysis. Beyond detoxification, GLO1 regulates NF-kappa-B transcriptional activity in TNF-induced pathways, indicating its role in inflammation. Additionally, GLO1 is crucial for normal osteoclastogenesis, emphasizing its broader involvement in cellular processes. IIdD Protein, E.coli (His) is the recombinant E. coli-derived IIdD protein, expressed by E. coli , with N-His labeled tag.

HY-P77134

	PfLDH Protein, P. falciparum (His) L-lactate dehydrogenase; PF3D7_1324900	Others	E. coli
	The pfHPRT (Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase) protein is a member of the LDH/MDH (lactate dehydrogenase/malate dehydrogenase) superfamily. It plays a crucial role in the purine metabolism salvage pathway of the malaria-causing parasite Plasmodium falciparum. PfLDH Protein, P. falciparum (His) is the recombinant PfLDH protein, expressed by E. coli , with C-His labeled tag.

HY-P70265

	LDHB Protein, Human (His) rHuL-lactate dehydrogenase B chain/LDH-B, His; L-lactate dehydrogenase B Chain; LDH-B; LDH Heart Subunit; LDH-H; Renal Carcinoma Antigen NY-REN-46; LDHB	Human	E. coli
	The LDHB protein, also known as lactate dehydrogenase B, is an enzyme that plays a crucial role in cellular energy metabolism. References indicate that the LDHB protein effectively catalyzes the simultaneous, stereospecific interconversion of pyruvate and lactate. LDHB Protein, Human (His) is the recombinant human-derived LDHB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P73271

	LDHA Protein, Rat (His) L-lactate dehydrogenase A chain; LDH-A; LDH-M; Ldha; Ldh-1	Rat	E. coli
	The LDHA protein facilitates the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the concomitant exchange of NADH and NAD(+).LDHA Protein, Rat (His) is the recombinant rat-derived LDHA protein, expressed by E.coli , with N-His labeled tag.

HY-P70225

	LDHA Protein, Human (His) rHuL-lactate dehydrogenase A chain/LDH-A, His; L-lactate dehydrogenase A Chain; LDH-A; Cell Proliferation-Inducing Gene 19 Protein; LDH Muscle Subunit; LDH-M; Renal Carcinoma Antigen NY-REN-59; LDHA	Human	E. coli
	LDHA protein catalyzes the stereospecific interconversion of pyruvate and lactate, concomitantly exchanging NADH and NAD(+). LDHA Protein, Human (His) is the recombinant human-derived LDHA protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74637

	pfHPRT Protein, P. falciparum (His) L-lactate dehydrogenase; PF3D7_1324900	Others	E. coli
	The pfHPRT (Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase) protein is a member of the LDH/MDH (lactate dehydrogenase/malate dehydrogenase) superfamily. It plays a crucial role in the purine metabolism salvage pathway of the malaria-causing parasite Plasmodium falciparum. pfHPRT Protein, P. falciparum (His) is the recombinant pfHPRT protein, expressed by E. coli , with N-His labeled tag.

HY-P73270

	LDHA Protein, Mouse (His) L-lactate dehydrogenase A chain; LDH-A; LDH-M; Ldha; Ldh-1	Mouse	E. coli
	LDHA protein catalyzes the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the reciprocal interconversion of NADH and NAD(+).LDHA Protein, Mouse (His) is the recombinant mouse-derived LDHA protein, expressed by E.coli , with N-His labeled tag.

HY-P701500

	UEVLD Protein, Human (sf9) UEVLD; Ubiquitin-conjugating enzyme E2 variant 3; UEV-3; EV and lactate/malate dehydrogenase domain-containing protein	Human	Sf9 insect cells
	UEVLD proteins are considered potential negative regulators of polyubiquitination, possibly controlling the ubiquitin-proteasome system. Its ability to form homodimers suggests that it has self-interacting properties, which may contribute to its role in regulating polyubiquitin chains. UEVLD Protein, Human (sf9) is the recombinant human-derived UEVLD protein, expressed by sf9 insect cells , with tag free.

HY-P701499

	UEVLD Protein, Human (sf9, His, StrepⅡ) UEVLD; Ubiquitin-conjugating enzyme E2 variant 3; UEV-3; EV and lactate/malate dehydrogenase domain-containing protein	Human	Sf9 insect cells
	UEVLD proteins are considered potential negative regulators of polyubiquitination, possibly controlling the ubiquitin-proteasome system. Its ability to form homodimers suggests that it has self-interacting properties, which may contribute to its role in regulating polyubiquitin chains. UEVLD Protein, Human (sf9, His, Strep) is the recombinant human-derived UEVLD protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P702855

	LDHC Protein, Human (sf9, His) L-lactate dehydrogenase C chain; EC:1.1.1.27; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X; LDH3; LDHX	Human	Sf9 insect cells
	LDHC Protein, Human (sf9, His) is the recombinant human-derived LDHC, expressed by Sf9 insect cells , with N-6*His labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-W012530S

Phenylpyruvic acid-13C6 sodium
Phenylpyruvic acid- ¹³C₆ sodium is the ¹³C-labeled Phenylpyruvic acid. Phenylpyruvic acid is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase .

HY-W040073S

Nifurtimox-d4
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

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HY-P80422

	Lactate Dehydrogenase Antibody (YA316)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
	Lactate Dehydrogenase Antibody (YA316) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase.

HY-P80738

	Lactate Dehydrogenase A Antibody (YA317) LDHA; LDH-M; LDH1; PIG19; GSD11; TRG5; Proliferation inducing gene 19	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
	Lactate Dehydrogenase A Antibody (YA317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

HY-P82325

	Lactate Dehydrogenase B Antibody (YA2070) HEL S 281; LDH B; LDH H; LDH-B; LDH-H; LDHB; LDHBD; LDHH; TRG5	WB, IHC-P, ICC/IF, IP, FC	Human
	Lactate Dehydrogenase B Antibody (YA2070) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase B.

HY-P80994

	Lactate Dehydrogenase A Antibody (YA3482)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Lactate Dehydrogenase A Antibody (YA3482) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

HY-P86628

	Lactate Dehydrogenase Isoenzyme V Antibody (YA6320)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lactate Dehydrogenase Isoenzyme V Antibody (YA6320) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase Isoenzyme V.

HY-P80739

	Lactate Dehydrogenase C Antibody (YA315) CT32; LDH3; LDHX	WB	Human
	Lactate Dehydrogenase C Antibody (YA315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase C.

HY-P86602

	Lactate Dehydrogenase Antibody (YA6294) LDHA; PIG19; LDHB; LDHC; LDH3; LDHX; L-lactate dehydrogenase A chain; LDH-A; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59; L-lactate dehydrogenase B chain; LDH-B; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46; L-lactate dehydrogenase C chain; LDH-C; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lactate Dehydrogenase Antibody (YA6294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase.

HY-P86942

	LDHD Antibody (YA6635) D lactate dehydrogenase antibody; DLD antibody; lactate dehydrogenase D antibody; Ldhd antibody; LDHD_HUMAN antibody; MGC57726 antibody; mitochondrial antibody; Probable D lactate dehydrogenase mitochondrial antibody; Probable D-lactate dehydrogenase antibody;	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	LDHD Antibody (YA6635) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LDHD.

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Cat. No.	Product Name		Classification

HY-132606A

Nedosiran sodium DCR-PHXC sodium		siRNAs siRNA drugs
Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate .

HY-132606

Nedosiran DCR-PHXC		siRNAs siRNA drugs
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate .

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lactate dehydrogenase

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