2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dihydropyrimidine Dehydrogenase (DPD)

Dihydropyrimidine Dehydrogenase (DPD)

Dihydropyrimidine Dehydrogenase

Dihydropyrimidine Dehydrogenase (DPD) is a pyrimidine catabolic enzyme that catalyzes the two-electron reduction of pyrimidine bases uracil and thymine. Dihydropyrimidine dehydrogenase catalyzes the first step of pyrimidine catabolism by promoting the reduction of the 5,6-vinylic bond of thymine or uracil with electrons acquired from NADPH. Mammalian Dihydropyrimidine dehydrogenase is a functional homodimer and each subunit contains an FAD, an FMN and four Fe4S4 centers with two Fe4S4 centers from each subunit forming an electron transfer conduit that link the flavins within each subunit. Dihydropyrimidine dehydrogenase accepts the pervasive chemotherapeutic 5-Fluorouracil as a substrate, severely shortening its pharmacological half-life and dictating the use of elaborate compensatory administration protocols to achieve efficacious toxicity[1].

Dihydropyrimidine Dehydrogenase (DPD) Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-17469
    Gimeracil
    		99.72%
    Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD).
    Gimeracil
  • HY-W777340
    Gimeracil-13C3
    Gimeracil-13C3 (Gimestat-13C3) is the 13C-labeled Gimeracil (HY-17469). Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD).
    Gimeracil-<sup>13</sup>C<sub>3</sub>
  • HY-17469R
    Gimeracil (Standard)
    Gimeracil (Standard) is the analytical standard of Gimeracil. This product is intended for research and analytical applications. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD).
    Gimeracil (Standard)