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Results for "

factor xa

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Factor Xa (82) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (3) COX (1) Cytochrome P450 (1) Drug Metabolite (4) Endogenous Metabolite (3) ERK (1) Factor VIIa (2) Isotope-Labeled Compounds (5) JNK (1) Kallikrein (3) MMP (2) Proteasome (2) Reference Standards (8) SARS-CoV (2) Ser/Thr Protease (11) Thrombin (30) Tissue Factor Pathway Inhibitor (TFPI) (2)
By Research Areas:	Cancer (18) Cardiovascular Disease (85) Infection (3) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Aptamers (2)

105

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Factor Xa

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3009

Factor Xa	Factor Xa	Cardiovascular Disease
Factor Xa, a trypsin-like serine protease, is an important player in the coagulation cascade responsible for thrombin generation .

HY-10724

Fidexaban	Factor Xa	Cardiovascular Disease
Fidexaban is a Factor Xa inhibitor and can be used in research of cardiovascular disease .

HY-10268S

Betrixaban-d6 PRT054021-d₆	Factor Xa	Cardiovascular Disease
Betrixaban-d₆ is a deuterium labeled Betrixaban. Betrixaban is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor .

HY-129973

4-Chlorophenylurea NSC-12971; 4-Chlorophenylurea	Factor Xa	Others
4-Chlorophenylurea is metabolite of diflubenzuron (HY-B1973). 4-Chlorophenylurea can be used to form factor Xa inhibitors .

HY-P3009A

*Canine Factor* Xa**	Factor Xa	Cardiovascular Disease
Canine Factor Xa is prepared by activating purified Canine Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-P3009D

*Rat Factor* Xa**	Factor Xa	Cardiovascular Disease
Rat Factor Xa is prepared by activating purified Rat Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-P3009C

*Rabbit Factor* Xa**	Factor Xa	Cardiovascular Disease
Rabbit Factor Xa is prepared by activating purified Rabbit Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-P3009B

*Porcine Factor* Xa**	Factor Xa	Cardiovascular Disease
Porcine Factor Xa is prepared by activating purified Porcine Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-12605

SAR107375	Thrombin	Metabolic Disease
SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-10756

BMS-740808	Factor Xa	Cardiovascular Disease
BMS-740808 is a potent, selective and orally active factor Xa inhibitor with a K_i of 30 pM. BMS-740808 shows >1000-fold for factor Xa than other proteases .

HY-19442

Idrabiotaparinux	Thrombin	Cardiovascular Disease
Idrabiotaparinux, a derivative of Idraparinux (HY-19691), is a novel synthetic anticoagulant that links Idraparinux, a specific, indirect factor Xa inhibitor, to biotin .

HY-10782

KFA-1982	Factor Xa	Cardiovascular Disease
KFA-1982 is a potent, selective and orally active factor Xa inhibitor. KFA-1982 can be used for the research of cardiovascular disease, such as thrombosis .

HY-125528

Ro 09-1679	Thrombin	Cardiovascular Disease
Ro 09-1679 is a thrombin inhibitor, with an IC₅₀ of 33.6 μM. Ro 09-1679 inhibits the enzyme activities, with IC₅₀ values of 3.3, 0.04 and 0.0346 μM for factor Xa, trypsin and papain, respectively .

HY-W854549

Heparin pentasaccharide Fondaparinux free acid	Factor Xa	Cardiovascular Disease
Heparin pentasaccharide (Fondaparinux) is a chemically synthesized selective factor Xa inhibitor with anticoagulant activity. Heparin pentasaccharide can be utilized in researches related to venous thromboembolic events .

HY-10777

EMD 495235	Factor Xa	Cardiovascular Disease
EMD 495235 is a potent and orally active *coagulation factor* Xa inhibitor with an IC₅₀ of 5.5 nM and a K_i** of 6.8 nM. EMD 495235 shows anticoagulant activities .

HY-10779

BMS-344577	Factor Xa Cytochrome P450	Cardiovascular Disease
BMS-344577 (Compound 22) is a potent and orally active factor Xa inhibitor (IC₅₀ = 4 nM, EC2xPT = 7 μM). BMS-344577 shows potent CYP3A4 inhibition activity (IC₅₀ = 0.3 μM). BMS-344577 can be used for the research of cardiovascular disease .

HY-119124

Edoxaban M4 D21-2393	Drug Metabolite	Metabolic Disease
Edoxaban M4, an active metabolite of Edoxaban, shows reproducible, but concentration-dependent matrix effects. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor .

HY-50667

Apixaban 10+ Cited Publications BMS-562247-01	Factor Xa	Cardiovascular Disease Cancer
Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .

HY-10769

ZK-813039	Factor Xa	Cardiovascular Disease
ZK-813039 is a potent and orally active factor Xa inhibitor. ZK-813039 can prolong prothrombin time. ZK-813039 can be used for the research of cardiovascular disease .

HY-18660

Ciraparantag PER977	Factor Xa Thrombin	Cardiovascular Disease
Ciraparantag (PER977) is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-10778

BMS-269223	Factor Xa	Cardiovascular Disease
BMS-269223 is a potent, selective and orally active factor Xa inhibitor (K_i = 6.5 nM, EC2xPT = 32 μM). BMS-269223 can prolong prothrombin time and inhibit thrombosis formation. BMS-269223 can be used for the research of cardiovascular disease .

HY-18660A

Ciraparantag TFA PER977 TFA	Factor Xa Thrombin	Cardiovascular Disease
Ciraparantag (PER977) TFA is a thrombin and factor Xa inhibitor. Ciraparantag TFA is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-P5027

Cbz-Lys-Arg-pNA	Ser/Thr Protease Kallikrein Factor Xa Thrombin	Cardiovascular Disease
Cbz-Lys-Arg-pNA is a peptide substrate containing pNA as the chromogenic group. Cbz-Lys-Arg-pNA is widely used in enzymatic analysis, including thrombin, plasmin, factor Xa and Kallikrein .

HY-76971

Dechloro Rivaroxaban	Factor Xa	Cardiovascular Disease
Dechloro Rivaroxaban is a highly selective, orally active inhibitor of Factor Xa. Dechloro Rivaroxaban inhibits human free FXa with a K_i of 0.4 nM. Dechloro Rivaroxaban inhibits prothrombinase activity and fibrin-associated FXa activity with IC₅₀s of 2.1 nM and 92 nM, respectively .

HY-50667R

Apixaban (Standard) BMS-562247-01 (Standard)	Reference Standards Factor Xa	Cardiovascular Disease Cancer
Apixaban (Standard) is the analytical standard of Apixaban. This product is intended for research and analytical applications. Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .

HY-50667S

Apixaban-13C,d3 BMS-562247-01-¹³C,d₃	Factor Xa	Cardiovascular Disease
Apixaban- ¹³C,d₃ (BMS-562247-01- ¹³C,d₃) is a deuterium and ¹³C labeled Apixaban (HY-50667). Apixaban is a highly selective, reversible inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively .

HY-174285

NAPAP	Thrombin	Cardiovascular Disease
NAPAP is a thrombin inhibitor. It has potent antithrombin activity (K_i: 2.1 nM). NAPAP selectively inhibits thrombin via a rapid binding mechanism, and has weaker inhibitory effects on trypsin, factor Xa, and plasmin. NAPAP can be used in the study of thrombotic diseases (e.g., venous thrombosis, myocardial infarction) .

HY-11090A

DPC423	Factor Xa Kallikrein Thrombin Ser/Thr Protease	Cardiovascular Disease
DPC423 is a selective and orally active factor Xa inhibitor with a K_is of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits K_is of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 has demonstrated antithrombotic effects in animal models, and when used in combination with Aspirin (HY-14654), it shows a strong synergistic effect. DPC423 can be used for the study of anticoagulation of arterial thrombosis .

HY-11090

DPC423 free base	Factor Xa Kallikrein Thrombin Ser/Thr Protease	Cardiovascular Disease
DPC423 free base is a selective and orally active factor Xa inhibitor with a K_is of 0.15 (human) and 0.3 (rabbit) nM. DPC423 free base exhibits K_is of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 free base blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 free base has demonstrated antithrombotic effects in animal models, and when used in combination with Aspirin (HY-14654), it shows a strong synergistic effect. DPC423 free base can be used for the study of anticoagulation of arterial thrombosis .

HY-B0597

Fondaparinux sodium 4 Publications Verification Fondaparin sodium; SR-90107A	Factor Xa	Cardiovascular Disease Cancer
Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor.

HY-106404

RPR 130737	Factor Xa	Cardiovascular Disease
RPR 130737 is a selective, potent and competitive inhibitor for factor Xa with a K_i of 2.4 nM. RPR 130737 shows selectivity of more than 1000-fold over thrombin, activated protein C, plasmin, tissue-plasminogen activator and trypsin. RPR 130737 can prolong plasma activated partial thromboplastin time and prothrombin time. RPR 130737 shows no effect on platelet aggregation. RPR 130737 can be used for the research of cardiovascular disease, such as thrombosis .

HY-12605S

SAR107375-d11 Tartrate	Isotope-Labeled Compounds Thrombin	Metabolic Disease
SAR107375-d₁₁ (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-10780

JTV-803 mesylate	Endogenous Metabolite	Cardiovascular Disease
JTV-803 mesylate is a human factor Xa inhibitor with oral anticoagulant activity. JTV-803 exhibits competitive inhibition of human factor Xa, with a K_i value of 0.019μM and IC₅₀Value is 0.081μM. JTV-803 is 100 times more selective at inhibiting human factor Xa than its comparator. JTV-803 is an effective oral anticoagulant for the prevention of thrombosis .

HY-E70541A

*Bovine Factor* IX**	Biochemical Assay Reagents	Cardiovascular Disease
Bovine Factor IX is prepared from freshly collected bovine plasma. Factor IX activated by the Factor VIIa/tissue factor/phospholipid complex is responsible for the activation of Factor X to Factor Xa .

HY-E70541B

*Canine Factor* IX**	Biochemical Assay Reagents	Cardiovascular Disease
Canine Factor IX is prepared from freshly collected canine plasma. Factor IX activated by the Factor VIIa/tissue factor/phospholipid complex is responsible for the activation of Factor X to Factor Xa .

HY-11091

Razaxaban hydrochloride BMS 561389 hydrochloride; DPC 906 hydrochloride	Factor Xa Thrombin	Cardiovascular Disease
Razaxaban hydrochloride (BMS 561389 hydrochloride) is a highly potent, selective and orally active factor Xa inhibitor with a K_i of 0.19 nM. Razaxaban hydrochloride exhibits excellent selectivity (>5000-fold) for factor Xa over other related serine proteases. Razaxaban hydrochloride is also a potent thrombin inhibitor with a K_i of 540 nM. Razaxaban hydrochloride has strongly antithrombotic activity .

HY-P3126

Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride	Factor Xa	Others
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride is a factor Xa specific chromogenic substrate .

HY-172316

BAY 3389934	Factor Xa	Cardiovascular Disease
BAY 3389934 is a dual factor IIa and factor Xa inhibitor with anticoagulation and organ protection effects. BAY 3389934 reduces coagulopathy and organ dysfunction in a baboon model of Staphylococcus aureus sepsis .

HY-B0597R

Fondaparinux sodium (Standard) Fondaparin sodium (Standard); SR-90107A (Standard)	Reference Standards Factor Xa	Cardiovascular Disease Cancer
Fondaparinux (sodium) (Standard) is the analytical standard of Fondaparinux (sodium). This product is intended for research and analytical applications. Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor.

HY-153829

CH3OCO-D-CHA-Gly-Arg-pNA acetate	Factor Xa	Cardiovascular Disease
CH3OCO-D-CHA-Gly-Arg-pNA acetate is a chromogenic substrate for factor Xa .

HY-B0385

Gabexate mesylate 4 Publications Verification FOY	Proteasome Factor Xa	Inflammation/Immunology
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

HY-17567A

Heparin sodium salt Maximum Cited Publications 52 Publications Verification Sodium heparin; Sodium heparinate	Thrombin Factor Xa Autophagy	Cardiovascular Disease Cancer
Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes *thrombin factor* IIa** and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions.

HY-153817

FXIa-IN-13	Factor Xa	Cardiovascular Disease
FXIa-IN-13 (example 1) is an Factor Xa inhibitor with antithrombotic activity. FXIa-IN-13 inhibits arteriovenous thrombosis in vivo and in vitro .

HY-P4576

Methoxycarbonyl-D-Nle-Gly-Arg-pNA	Factor Xa	Others
Methoxycarbonyl-D-Nle-Gly-Arg-pNA is a synthetic trypsin that can serve as a substrate for *coagulation factors* IXa (FIXa) and Xa (FXa**) .

HY-B0385R

Gabexate mesylate (Standard) FOY (Standard)	Reference Standards Proteasome Factor Xa	Inflammation/Immunology
Gabexate (mesylate) (Standard) is the analytical standard of Gabexate (mesylate). This product is intended for research and analytical applications. Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

HY-10268B

Betrixaban hydrochloride PRT054021 hydrochloride	Factor Xa	Cardiovascular Disease
Betrixaban (PRT054021) hydrochloride is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban hydrochloride shows antithrombotic effect .

HY-10268

Betrixaban 5 Publications Verification PRT054021	Factor Xa	Cardiovascular Disease
Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

HY-10268A

Betrixaban maleate 5 Publications Verification PRT054021 maleate	Factor Xa	Cardiovascular Disease
Betrixaban (PRT054021) maleate is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban maleate shows antithrombotic effect .

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-E70554A

Bovine Prothrombin	Biochemical Assay Reagents	Cardiovascular Disease
Bovine Prothrombin is a glycoprotein with a molecular weight of 70 kDa and is composed of a single polypeptide chain. Prothrombin is activated by factors Va, Xa, and phospholipids to produce the serine protease thrombin .

Cat. No.	Product Name	Type

HY-P2185

NFF-3	Dyes
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

Cat. No.	Product Name	Type

HY-W087937

Benzamidine hydrochloride hydrate 3 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Biochemical Assay Reagents
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

HY-W854549

Heparin pentasaccharide Fondaparinux free acid	Carbohydrates
Heparin pentasaccharide (Fondaparinux) is a chemically synthesized selective factor Xa inhibitor with anticoagulant activity. Heparin pentasaccharide can be utilized in researches related to venous thromboembolic events .

Cat. No.	Product Name	Target	Research Area

HY-P3126

Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride	Factor Xa	Others
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride is a factor Xa specific chromogenic substrate .

HY-P2185A

NFF-3 TFA	MMP	Others
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P5027

Cbz-Lys-Arg-pNA	Ser/Thr Protease Kallikrein Factor Xa Thrombin	Cardiovascular Disease
Cbz-Lys-Arg-pNA is a peptide substrate containing pNA as the chromogenic group. Cbz-Lys-Arg-pNA is widely used in enzymatic analysis, including thrombin, plasmin, factor Xa and Kallikrein .

HY-P4576

Methoxycarbonyl-D-Nle-Gly-Arg-pNA	Factor Xa	Others
Methoxycarbonyl-D-Nle-Gly-Arg-pNA is a synthetic trypsin that can serve as a substrate for *coagulation factors* IXa (FIXa) and Xa (FXa**) .

HY-P2185

NFF-3	MMP	Others
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P6023

D-Leu-Pro-Arg-Rh110-D-Pro	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity .

HY-P6023B

D-Leu-Pro-Arg-Rh110-D-Pro acetate	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro acetate consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity .

HY-P6023A

D-Leu-Pro-Arg-Rh110-D-Pro TFA	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro TFA consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro TFA can be used to detect FXIa activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Typhaceae Classification of Application Fields Typha angustifolia L. Source classification Phenols Polyphenols Plants Disease Research Fields	Thrombin COX ERK JNK Factor Xa
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

HY-N13950

Bacithrocin A	Natural Products Microorganisms Source classification	Thrombin Factor Xa Ser/Thr Protease
Bacithrocin A is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC₅₀s of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively .

HY-N13957

Bacithrocin C	Natural Products Microorganisms Source classification	Thrombin Factor Xa Ser/Thr Protease
Bacithrocin C is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC₅₀s of 80 μM, 15 μM, 1.3 μM, and 0.02 μM, respectively .

HY-N13955

Bacithrocin B	Natural Products Microorganisms Source classification	Thrombin Factor Xa Ser/Thr Protease
Bacithrocin B is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC₅₀s of 84 μM, 17 μM, 1.7 μM, and 0.02 μM, respectively .

HY-N13960

Bacithrocin D Thiolstatin D	Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Thrombin Factor Xa
Bacithrocin D (Thiolstatin D) inhibits multiple proteases and can prolong the clotting time. Bacithrocin D has IC₅₀ values of 124, 9, 0.85, and 0.01 μM for thrombin, factor Xa, trypsin, and papain, respectively .

Cat. No.	Product Name	Chemical Structure

HY-10268S

Betrixaban-d6
Betrixaban-d₆ is a deuterium labeled Betrixaban. Betrixaban is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor .

HY-50667S

Apixaban-13C,d3
Apixaban- ¹³C,d₃ (BMS-562247-01- ¹³C,d₃) is a deuterium and ¹³C labeled Apixaban (HY-50667). Apixaban is a highly selective, reversible inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively .

HY-50903S

Rivaroxaban-d4 1 Publications Verification
Rivaroxaban-d₄ (BAY 59-7939-d₄) is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent，selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC₅₀ 0.7 nM; K_i 0.4 nM) .

HY-50667S1

Apixaban-d3
Apixaban-d₃ (BMS-562247-01-d₃) is the deuterium labeled Apixaban (HY-50667) . Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .

HY-10264S

Edoxaban-d6

Edoxaban-d₆ is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment .

HY-12605S

SAR107375-d11 Tartrate
SAR107375-d₁₁ (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-10268S2

Betrixaban-13C6
Betrixaban- ¹³C₆ (PRT054021- ¹³C₆) is ¹³C labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

HY-10268S1

Betrixaban-d4
Betrixaban-d₄ (PRT054021-d₄) is deuterium labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

HY-18660S

Ciraparantag-d8 (tetra(hydrochloride) diacetate)

Ciraparantag-d₈ (PER977-d₈) tetrahydrochloride diacetate is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81604

	Factor X Antibody (YA1349) Activated factor xa heavy chain; Coagulation factor X; F10; factor xa; Fxa; Prothrombinase; Stuart factor	WB, IHC-P	Human
	Factor X Antibody (YA1349) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Factor X.

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Cat. No.	Product Name		Classification

HY-153480A

ARC19499 sodium BAX499 sodium		Aptamers
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-153480

ARC19499 BAX499		Aptamers
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

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