DX-9065a free base 

DX-9065a (free base) is a selective, nonpeptidic, and orally active factor Xa (FXa) inhibitor with a K_i of 41 nM for human FXa. DX-9065a (free base) has low activity against other serine proteases. DX-9065a (free base) has strong anticoagulant actions^[1][2].

DX-9065a (free base) inhibits proliferation of vascular smooth muscle cells in cell culture systems^[1].
DX-9065a (free base) inactivates both free and fibrin-bound FXa^[1].
DX-9065a (free base) effectively affects the clot-associated procoagulant activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DX-9065a (free base) (i.v.) displays prolonged anti-factor Xa activity and inhibition of thrombin generation in rabbits^[1].
DX-9065a (free base) (p.o.) causes a reduction in tissue factor-induced mortality of mice with ED₅₀ value of 56 mg/kg^[1].
DX-9065a (free base) inhibits stasis-induced thrombosis after injection of tissue factor with ED₅₀ values of 0.03 mg/kg for i.v., 0.3 mg/kg for s.c. and 50.5 mg/kg for p.o., respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

444.53

C₂₆H₂₈N₄O₃

150612-55-8

N=C(N)C1=CC=C2C(C=C(C[C@H](C(O)=O)C3=CC=C(O[C@@H]4CN(C(C)=N)CC4)C=C3)C=C2)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Brigitte Kaiser. DX-9065a, a direct inhibitor of factor Xa. Cardiovasc Drug Rev. 2003 Summer;21(2):91-104.  [Content Brief]

  [2]. J M Herbert, et al. DX 9065A a novel, synthetic, selective and orally active inhibitor of factor Xa: in vitro and in vivo studies. J Pharmacol Exp Ther. 1996 Mar;276(3):1030-8.  [Content Brief]